JP2009535352A5 - - Google Patents
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- Publication number
- JP2009535352A5 JP2009535352A5 JP2009507893A JP2009507893A JP2009535352A5 JP 2009535352 A5 JP2009535352 A5 JP 2009535352A5 JP 2009507893 A JP2009507893 A JP 2009507893A JP 2009507893 A JP2009507893 A JP 2009507893A JP 2009535352 A5 JP2009535352 A5 JP 2009535352A5
- Authority
- JP
- Japan
- Prior art keywords
- hiv
- compound
- pharmaceutically acceptable
- group
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 2
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000840 anti-viral Effects 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 239000002835 hiv fusion inhibitor Substances 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- 229940121354 immunomodulators Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000036436 anti-hiv Effects 0.000 claims 1
- 230000002924 anti-infective Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- IPAJQRVHTUTWHY-UHFFFAOYSA-O O=C(C(N(CC1)CCN1c1c(-c2ccccc2)nccn1)=[OH+])c1c[nH]c2c(-[n]3nncc3)ncc(F)c12 Chemical compound O=C(C(N(CC1)CCN1c1c(-c2ccccc2)nccn1)=[OH+])c1c[nH]c2c(-[n]3nncc3)ncc(F)c12 IPAJQRVHTUTWHY-UHFFFAOYSA-O 0.000 description 1
Claims (6)
- 請求項1に記載の化合物、またはその医薬的に許容される塩の抗ウイルス有効量、および一つ以上の医薬的に許容される担体、賦形剤または希釈剤を含む、医薬組成物。
- 抗HIV活性を有する第2の化合物をさらに含む、請求項2に記載の組成物。
- (a)抗AIDSウイルス薬;
(b)抗感染症薬;
(c)免疫調節剤; および
(d)HIV侵入阻害剤
:からなる群から選択されるAIDS治療薬の抗ウイルス有効量をさらに含む、HIVによる感染を治療するための請求項2に記載の医薬組成物。 - HIVを治療するための医薬の製造における、請求項1に記載の化合物、またはその医薬的に許容される塩の使用。
- HIVを治療するための医薬の製造における、請求項1に記載の化合物、またはその医薬的に許容される塩、ならびに、抗AIDSウイルス薬; 抗感染症薬; 免疫調節剤; およびHIV侵入阻害剤からなる群から選択されるAIDS治療薬の使用。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79470306P | 2006-04-25 | 2006-04-25 | |
US79470006P | 2006-04-25 | 2006-04-25 | |
US60/794,703 | 2006-04-25 | ||
US60/794,700 | 2006-04-25 | ||
US11/733,283 US7807671B2 (en) | 2006-04-25 | 2007-04-10 | Diketo-piperazine and piperidine derivatives as antiviral agents |
US11/733,283 | 2007-04-10 | ||
PCT/US2007/066700 WO2007127635A2 (en) | 2006-04-25 | 2007-04-16 | Diketo-piperazine and piperidine derivatives as antiviral agents |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009535352A JP2009535352A (ja) | 2009-10-01 |
JP2009535352A5 true JP2009535352A5 (ja) | 2010-06-03 |
JP5214590B2 JP5214590B2 (ja) | 2013-06-19 |
Family
ID=38335673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009507893A Active JP5214590B2 (ja) | 2006-04-25 | 2007-04-16 | 抗ウイルス薬としてのジケト−ピペラジンおよびピペリジン誘導体 |
Country Status (17)
Country | Link |
---|---|
US (2) | US7807671B2 (ja) |
EP (1) | EP2010525B1 (ja) |
JP (1) | JP5214590B2 (ja) |
KR (1) | KR101450349B1 (ja) |
AR (1) | AR060658A1 (ja) |
AU (1) | AU2007242989B2 (ja) |
BR (1) | BRPI0710919A2 (ja) |
CA (1) | CA2650382C (ja) |
EA (1) | EA014957B1 (ja) |
ES (1) | ES2432758T3 (ja) |
IL (1) | IL194540A (ja) |
MX (1) | MX2008013265A (ja) |
NO (1) | NO341412B1 (ja) |
NZ (1) | NZ571995A (ja) |
PE (1) | PE20080318A1 (ja) |
TW (1) | TWI394754B (ja) |
WO (1) | WO2007127635A2 (ja) |
Families Citing this family (46)
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JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
EP2571870B1 (en) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2 antagonists and uses thereof |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
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JP5613461B2 (ja) * | 2010-06-02 | 2014-10-22 | 日本農薬株式会社 | ピリミジン誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法 |
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ES2585396T3 (es) | 2010-12-02 | 2016-10-05 | VIIV Healthcare UK (No.5) Limited | Alquilamidas como inhibidores de la unión del VIH |
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WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
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ES2616492T3 (es) * | 2012-08-09 | 2017-06-13 | VIIV Healthcare UK (No.5) Limited | Derivados de piperidina amida como inhibidores de la fijación del VIH |
MX2015002887A (es) | 2012-09-06 | 2015-07-06 | Plexxikon Inc | Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello. |
UA115156C2 (uk) | 2012-12-11 | 2017-09-25 | Такеда Фармасьютікал Компані Лімітед | Гетероциклічна сполука |
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EA032927B1 (ru) | 2015-01-15 | 2019-08-30 | Идорсия Фармасьютиклз Лтд | Производные гидроксиалкилпиперазина в качестве модуляторов cxcr3 рецептора |
EP3317270B1 (en) | 2015-07-02 | 2020-05-13 | Centrexion Therapeutics Corporation | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
TWI784207B (zh) | 2018-11-02 | 2022-11-21 | 美商默沙東有限責任公司 | 作為nav1.8 抑制劑之2-胺基-n-雜芳基-菸鹼醯胺 |
CN111004213B (zh) * | 2019-12-26 | 2021-07-20 | 北京欣奕华科技有限公司 | 一种有机电致发光化合物及其应用 |
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US20060100209A1 (en) | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US7183284B2 (en) | 2004-12-29 | 2007-02-27 | Bristol-Myers Squibb Company | Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents |
US7396830B2 (en) | 2005-10-04 | 2008-07-08 | Bristol-Myers Squibb Company | Piperazine amidines as antiviral agents |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
US7501419B2 (en) | 2006-04-25 | 2009-03-10 | Bristol-Myers Squibb Company | 4-Squarylpiperazine derivatives as antiviral agents |
US7504399B2 (en) * | 2006-06-08 | 2009-03-17 | Bristol-Meyers Squibb Company | Piperazine enamines as antiviral agents |
US7572810B2 (en) * | 2006-06-08 | 2009-08-11 | Bristol-Myers Squibb Company | Alkene piperidine derivatives as antiviral agents |
-
2007
- 2007-04-10 US US11/733,283 patent/US7807671B2/en active Active
- 2007-04-16 AU AU2007242989A patent/AU2007242989B2/en not_active Ceased
- 2007-04-16 JP JP2009507893A patent/JP5214590B2/ja active Active
- 2007-04-16 KR KR1020087028634A patent/KR101450349B1/ko active IP Right Grant
- 2007-04-16 CA CA2650382A patent/CA2650382C/en not_active Expired - Fee Related
- 2007-04-16 ES ES07760706T patent/ES2432758T3/es active Active
- 2007-04-16 NZ NZ571995A patent/NZ571995A/en not_active IP Right Cessation
- 2007-04-16 BR BRPI0710919-9A patent/BRPI0710919A2/pt not_active Application Discontinuation
- 2007-04-16 EP EP07760706.7A patent/EP2010525B1/en active Active
- 2007-04-16 MX MX2008013265A patent/MX2008013265A/es active IP Right Grant
- 2007-04-16 WO PCT/US2007/066700 patent/WO2007127635A2/en active Application Filing
- 2007-04-16 EA EA200802203A patent/EA014957B1/ru not_active IP Right Cessation
- 2007-04-25 TW TW096114657A patent/TWI394754B/zh not_active IP Right Cessation
- 2007-04-25 PE PE2007000513A patent/PE20080318A1/es not_active Application Discontinuation
- 2007-04-25 AR ARP070101807A patent/AR060658A1/es not_active Application Discontinuation
- 2007-10-23 US US11/877,001 patent/US7807676B2/en active Active
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2008
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