MA33085B1 - Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives - Google Patents

Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives

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Publication number
MA33085B1
MA33085B1 MA33952A MA33952A MA33085B1 MA 33085 B1 MA33085 B1 MA 33085B1 MA 33952 A MA33952 A MA 33952A MA 33952 A MA33952 A MA 33952A MA 33085 B1 MA33085 B1 MA 33085B1
Authority
MA
Morocco
Prior art keywords
treatment
asthma
antagonists
premedine
copd
Prior art date
Application number
MA33952A
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Arabic (ar)
English (en)
Inventor
Heiner Ebel
Sara Frattini
Riccardo Giovannini
Christoph Hoenke
Thomas Trieselmann
Patrick Tielmann
Stefan Scheuerer
Silke Marie Katrin Hobbie
Frank Buettner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42049604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33085(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA33085B1 publication Critical patent/MA33085B1/fr

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract

CETTE INVENTION CONCERNE DE NOUVEAUX ANTAGONISTES DE CCR2 (RÉCEPTEUR 2 DE CHIMIOKINE CC) ET LEUR UTILISATION DANS DES MÉDICAMENTS DESTINÉS AU TRAITEMENT D'ÉTATS PATHOLOGIQUES ET DE MALADIES, EN PARTICULIER DE L'ASTHME ET LES BRONCHO-PNEUMOPATHIES CHRONIQUES OBSTRUCTIVES, COMME REPRÉSENTÉ DANS LA FORMULE (I), OÙ A EST PRIS DANS UNE LIAISON UNIQUE, =CH-, -CH2-, -O-, -S-, AND -NH-; N VAUT 1, 2 OU 3; Z EST C OU N, LES AUTRES VARIABLES ÉTANT COMME DÉFINIES DANS LES REVENDICATIONS, AINSI QUE LEURS FORMES DE SELS D'ADJONCTION ACIDES AVEC DES ACIDES DE QUALITÉ PHARMACOLOGIQUE.
MA33952A 2008-12-19 2009-12-17 Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives MA33085B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08172336 2008-12-19
EP09160416 2009-05-15
PCT/EP2009/067378 WO2010070032A1 (fr) 2008-12-19 2009-12-17 Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du récepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives

Publications (1)

Publication Number Publication Date
MA33085B1 true MA33085B1 (fr) 2012-03-01

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MA33952A MA33085B1 (fr) 2008-12-19 2009-12-17 Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives

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US (3) US20120053164A1 (fr)
EP (2) EP2816040B1 (fr)
JP (2) JP2012512834A (fr)
KR (1) KR101754698B1 (fr)
CN (2) CN103724328B (fr)
AR (1) AR074814A1 (fr)
AU (1) AU2009327127C1 (fr)
BR (1) BRPI0923051B1 (fr)
CA (1) CA2747677C (fr)
CL (1) CL2011001322A1 (fr)
CO (1) CO6382124A2 (fr)
DK (1) DK2379525T3 (fr)
EA (1) EA020548B1 (fr)
EC (1) ECSP11011163A (fr)
ES (1) ES2551557T3 (fr)
HK (1) HK1159099A1 (fr)
HU (1) HUE025547T2 (fr)
IL (1) IL212605A (fr)
MA (1) MA33085B1 (fr)
MX (1) MX2011005150A (fr)
NZ (1) NZ592723A (fr)
PE (1) PE20120061A1 (fr)
PL (1) PL2379525T3 (fr)
SG (1) SG172289A1 (fr)
TN (1) TN2011000310A1 (fr)
TW (1) TWI478913B (fr)
WO (1) WO2010070032A1 (fr)
ZA (1) ZA201103158B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN103724328A (zh) 2014-04-16
US8835440B2 (en) 2014-09-16
HUE025547T2 (en) 2016-02-29
DK2379525T3 (en) 2015-10-19
CA2747677A1 (fr) 2010-06-24
US20130324517A1 (en) 2013-12-05
ZA201103158B (en) 2011-12-28
JP2012512834A (ja) 2012-06-07
AR074814A1 (es) 2011-02-16
EA201100942A1 (ru) 2012-01-30
WO2010070032A1 (fr) 2010-06-24
BRPI0923051A2 (pt) 2021-06-15
TN2011000310A1 (en) 2012-12-17
US20140336374A1 (en) 2014-11-13
EA020548B1 (ru) 2014-12-30
IL212605A (en) 2015-06-30
TWI478913B (zh) 2015-04-01
CN103724328B (zh) 2015-10-14
TW201026683A (en) 2010-07-16
KR101754698B1 (ko) 2017-07-26
CN102256963B (zh) 2014-06-11
PL2379525T3 (pl) 2016-01-29
EP2379525A1 (fr) 2011-10-26
ECSP11011163A (es) 2011-07-29
AU2009327127A1 (en) 2010-06-24
CO6382124A2 (es) 2012-02-15
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SG172289A1 (en) 2011-07-28
US9067951B2 (en) 2015-06-30
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HK1159099A1 (en) 2012-07-27
EP2816040B1 (fr) 2018-10-17
NZ592723A (en) 2013-06-28
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EP2816040A1 (fr) 2014-12-24
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AU2009327127C1 (en) 2017-03-09
PE20120061A1 (es) 2012-02-19
MX2011005150A (es) 2011-05-30
ES2551557T3 (es) 2015-11-19
US20120053164A1 (en) 2012-03-01
BRPI0923051B1 (pt) 2022-07-19
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KR20110111380A (ko) 2011-10-11
CL2011001322A1 (es) 2011-11-11

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