WO2003066604A2 - Nouvelles aryl- et heteroarylpiperazines - Google Patents
Nouvelles aryl- et heteroarylpiperazines Download PDFInfo
- Publication number
- WO2003066604A2 WO2003066604A2 PCT/DK2003/000071 DK0300071W WO03066604A2 WO 2003066604 A2 WO2003066604 A2 WO 2003066604A2 DK 0300071 W DK0300071 W DK 0300071W WO 03066604 A2 WO03066604 A2 WO 03066604A2
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- WIPO (PCT)
- Prior art keywords
- alkyl
- compound according
- aryl
- compound
- alkoxy
- Prior art date
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- 0 Cc1cc(*)c(*)c(*)c1 Chemical compound Cc1cc(*)c(*)c(*)c1 0.000 description 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- IQDOKRJHIXMXIX-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nc(cc2)c1cc2O Chemical compound CC(C)N(CC1)CCN1c(cc1)nc(cc2)c1cc2O IQDOKRJHIXMXIX-UHFFFAOYSA-N 0.000 description 1
- CLIQMYWBSFOVQL-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C)c(F)c2 Chemical compound CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C)c(F)c2 CLIQMYWBSFOVQL-UHFFFAOYSA-N 0.000 description 1
- YYQNORIOTNAMTP-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nnc1-c(cc1F)ccc1OC Chemical compound CC(C)N(CC1)CCN1c(cc1)nnc1-c(cc1F)ccc1OC YYQNORIOTNAMTP-UHFFFAOYSA-N 0.000 description 1
- WHVUZVJVBAZLDP-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c(cc1)ccc1C(c1ccccc1)=O Chemical compound CCC(CC)N(CC1)CCN1c(cc1)ccc1C(c1ccccc1)=O WHVUZVJVBAZLDP-UHFFFAOYSA-N 0.000 description 1
- DBKYTFXGAAKYHK-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c(cc1)nc(cc2)c1cc2OC Chemical compound CCC(CC)N(CC1)CCN1c(cc1)nc(cc2)c1cc2OC DBKYTFXGAAKYHK-UHFFFAOYSA-N 0.000 description 1
- TWXMGMCCWJCKLP-UHFFFAOYSA-N COc(c(F)c1)ccc1-c(cc1)nnc1N1CCN(CC2CC2)CC1 Chemical compound COc(c(F)c1)ccc1-c(cc1)nnc1N1CCN(CC2CC2)CC1 TWXMGMCCWJCKLP-UHFFFAOYSA-N 0.000 description 1
- KLICDCLQKNALRB-UHFFFAOYSA-N COc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 Chemical compound COc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 KLICDCLQKNALRB-UHFFFAOYSA-N 0.000 description 1
- DIRYVCVQJRNPKY-UHFFFAOYSA-N Cc1cc(cc(c(OC)c2)OC)c2nc1N(CC1)CCN1C1CC1 Chemical compound Cc1cc(cc(c(OC)c2)OC)c2nc1N(CC1)CCN1C1CC1 DIRYVCVQJRNPKY-UHFFFAOYSA-N 0.000 description 1
- KOERNORNYVRJPN-UHFFFAOYSA-N Clc(cc1)ccc1-c(cc1)nnc1N1CCN(CC2CC2)CC1 Chemical compound Clc(cc1)ccc1-c(cc1)nnc1N1CCN(CC2CC2)CC1 KOERNORNYVRJPN-UHFFFAOYSA-N 0.000 description 1
- BLMVXXMCPCUUTM-UHFFFAOYSA-N FC(Oc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1)(F)F Chemical compound FC(Oc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1)(F)F BLMVXXMCPCUUTM-UHFFFAOYSA-N 0.000 description 1
- ITESUNPODOQZSA-UHFFFAOYSA-N Fc1ccc(COc(cc2)cc(cc3)c2nc3N(CC2)CCN2C2CC2)cc1 Chemical compound Fc1ccc(COc(cc2)cc(cc3)c2nc3N(CC2)CCN2C2CC2)cc1 ITESUNPODOQZSA-UHFFFAOYSA-N 0.000 description 1
- ACUDYEDEHGVEKZ-UHFFFAOYSA-N O=C(c(cc1)ccc1F)c(cc1F)cc(F)c1N1CCN(CC2CC2)CC1 Chemical compound O=C(c(cc1)ccc1F)c(cc1F)cc(F)c1N1CCN(CC2CC2)CC1 ACUDYEDEHGVEKZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0307429-3A BR0307429A (pt) | 2002-02-05 | 2003-02-05 | Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com receptor de histamina h3 |
KR10-2004-7011995A KR20040081177A (ko) | 2002-02-05 | 2003-02-05 | 신규 아릴- 및 헤테로아릴피페라진 |
CA002474214A CA2474214A1 (fr) | 2002-02-05 | 2003-02-05 | Nouvelles aryl- et heteroarylpiperazines |
EP03701482A EP1474401A2 (fr) | 2002-02-05 | 2003-02-05 | Nouvelles aryl- et heteroarylpiperazines |
JP2003565978A JP4607458B2 (ja) | 2002-02-05 | 2003-02-05 | 新規なアリールおよびへテロアリールピペラジン |
MXPA04007612A MXPA04007612A (es) | 2002-02-05 | 2003-02-05 | Aril- y heteroarilpiperazinas novedosas. |
IL16285903A IL162859A0 (en) | 2002-02-05 | 2003-02-05 | Novel aryl-and heteroarylpiperazines |
AU2003203148A AU2003203148A1 (en) | 2002-02-05 | 2003-02-05 | Novel aryl- and heteroarylpiperazines |
UA20040705946A UA83187C2 (en) | 2002-02-05 | 2003-02-05 | Aryl- and heteroarylpiperazines |
US10/383,310 US20030236259A1 (en) | 2002-02-05 | 2003-03-07 | Novel aryl- and heteroarylpiperazines |
ZA2004/05694A ZA200405694B (en) | 2002-02-05 | 2004-07-16 | Novel aryl-and heteroarylpiperazines |
NO20043709A NO328714B1 (no) | 2002-02-05 | 2004-09-03 | Aryl- og heteroarylpiperaziner, farmasoytiske preparater som omfatter minst en slik forbindelse, samt anvendelser av slike forbindelser til fremstilling av farmasoytiske preparater |
US12/367,952 US20090264435A1 (en) | 2002-02-05 | 2009-02-09 | Novel Aryl- and Heteroarylpiperazines |
AU2010200135A AU2010200135A1 (en) | 2002-02-05 | 2010-01-13 | Novel aryl-and heteroarylpiperazines |
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EP (1) | EP1474401A2 (fr) |
JP (1) | JP4607458B2 (fr) |
CN (1) | CN1628109A (fr) |
AU (2) | AU2003203148A1 (fr) |
BR (1) | BR0307429A (fr) |
CA (1) | CA2474214A1 (fr) |
IL (1) | IL162859A0 (fr) |
MX (1) | MXPA04007612A (fr) |
NO (1) | NO328714B1 (fr) |
PL (1) | PL372390A1 (fr) |
WO (1) | WO2003066604A2 (fr) |
ZA (1) | ZA200405694B (fr) |
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US11613532B2 (en) | 2020-03-31 | 2023-03-28 | Nuevolution A/S | Compounds active towards nuclear receptors |
US11780843B2 (en) | 2020-03-31 | 2023-10-10 | Nuevolution A/S | Compounds active towards nuclear receptors |
Also Published As
Publication number | Publication date |
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EP1474401A2 (fr) | 2004-11-10 |
NO328714B1 (no) | 2010-05-03 |
CN1628109A (zh) | 2005-06-15 |
BR0307429A (pt) | 2004-12-28 |
WO2003066604A3 (fr) | 2003-12-04 |
AU2010200135A1 (en) | 2010-02-04 |
IL162859A0 (en) | 2005-11-20 |
ZA200405694B (en) | 2005-09-28 |
PL372390A1 (en) | 2005-07-25 |
AU2003203148A1 (en) | 2003-09-02 |
NO20043709L (no) | 2004-09-03 |
JP4607458B2 (ja) | 2011-01-05 |
JP2005533747A (ja) | 2005-11-10 |
MXPA04007612A (es) | 2004-11-10 |
CA2474214A1 (fr) | 2003-08-14 |
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