WO2007110364A1 - Benzothiazoles presentant une activité sur le récepteur h3 de l'histamine - Google Patents

Benzothiazoles presentant une activité sur le récepteur h3 de l'histamine Download PDF

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Publication number
WO2007110364A1
WO2007110364A1 PCT/EP2007/052751 EP2007052751W WO2007110364A1 WO 2007110364 A1 WO2007110364 A1 WO 2007110364A1 EP 2007052751 W EP2007052751 W EP 2007052751W WO 2007110364 A1 WO2007110364 A1 WO 2007110364A1
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WIPO (PCT)
Prior art keywords
alkyl
piperazin
mmol
fumarate
benzothiazole
Prior art date
Application number
PCT/EP2007/052751
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English (en)
Inventor
Florencio Zaragoza DÖRWALD
Knud Erik Andersen
Rolf Hohlweg
Inge Thoger Christensen
Jane Marie Lundbeck
Original Assignee
High Point Pharmaceuticals, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2008011123A priority Critical patent/MX2008011123A/es
Priority to CN2007800109712A priority patent/CN101410385B/zh
Priority to ES07727226T priority patent/ES2388681T3/es
Priority to NZ570524A priority patent/NZ570524A/en
Priority to EP07727226A priority patent/EP1999120B1/fr
Priority to BRPI0709187-7A priority patent/BRPI0709187A2/pt
Priority to JP2009502034A priority patent/JP2009531376A/ja
Priority to KR1020087023919A priority patent/KR101280333B1/ko
Application filed by High Point Pharmaceuticals, Llc filed Critical High Point Pharmaceuticals, Llc
Priority to CA002645581A priority patent/CA2645581A1/fr
Priority to AU2007229492A priority patent/AU2007229492B2/en
Priority to EA200870376A priority patent/EA015569B1/ru
Priority to US12/294,756 priority patent/US8394842B2/en
Publication of WO2007110364A1 publication Critical patent/WO2007110364A1/fr
Priority to ZA2008/06985A priority patent/ZA200806985B/en
Priority to IL193441A priority patent/IL193441A0/en
Priority to HK09107300.1A priority patent/HK1129102A1/xx
Priority to US13/660,045 priority patent/US8772285B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D277/62—Benzothiazoles
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

L'invention concerne certains nouveaux benzothiazoles et benzoxazoles, par exemple les 2-(pipérazin-1-yl)benzothiazoles et les 2-(pipérazin-1-yl)benzoxazoles, éventuellement substitués au niveau des positions 3 et/ou 4 des cycles pipérazine, de formule générale (1), présentant une activité antagoniste sur le récepteur H3 de l'histamine pouvant être utilisés dans des compositions pharmaceutiques.
PCT/EP2007/052751 2006-03-28 2007-03-22 Benzothiazoles presentant une activité sur le récepteur h3 de l'histamine WO2007110364A1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CA002645581A CA2645581A1 (fr) 2006-03-28 2007-03-22 Benzothiazoles presentant une activite sur le recepteur h3 de l'histamine
CN2007800109712A CN101410385B (zh) 2006-03-28 2007-03-22 具有组胺h3受体活性的苯并噻唑类
AU2007229492A AU2007229492B2 (en) 2006-03-28 2007-03-22 Benzothiazoles having histamine H3 receptor activity
EP07727226A EP1999120B1 (fr) 2006-03-28 2007-03-22 Benzothiazoles présentant une activité sur le récepteur h3 de l'histamine
BRPI0709187-7A BRPI0709187A2 (pt) 2006-03-28 2007-03-22 benzotiazóis tendo atividade no receptor h3 de histamina
JP2009502034A JP2009531376A (ja) 2006-03-28 2007-03-22 ヒスタミンｈ３受容体活性を有するベンゾチアゾール
KR1020087023919A KR101280333B1 (ko) 2006-03-28 2007-03-22 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸
MX2008011123A MX2008011123A (es) 2006-03-28 2007-03-22 Benzotiazoles que tienen actividad de receptor h3 de histamina.
ES07727226T ES2388681T3 (es) 2006-03-28 2007-03-22 Benzotiazoles con actividad de los receptores de histamina H3
NZ570524A NZ570524A (en) 2006-03-28 2007-03-22 Benzothiazoles having histamine H3 receptor activity
EA200870376A EA015569B1 (ru) 2006-03-28 2007-03-22 Бензотиазолы, обладающие антагонистической активностью по отношению к h3-рецептору гистамина, и фармацевтические композиции, включающие эти соединения
US12/294,756 US8394842B2 (en) 2006-03-28 2007-03-22 Benzothiazoles having histamine H3 receptor activity
ZA2008/06985A ZA200806985B (en) 2006-03-28 2008-08-13 Benzothiazole having histamine h3 receptor activity
IL193441A IL193441A0 (en) 2006-03-28 2008-08-14 Benzothiazoles having histamine h3 receptor activity
HK09107300.1A HK1129102A1 (en) 2006-03-28 2009-08-10 Benzothiazoles having histamine h3 receptor activity
US13/660,045 US8772285B2 (en) 2006-03-28 2012-10-25 Benzothiazoles having histamine H3 receptor activity

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
EP06111820.4 2006-03-28
EP06111820 2006-03-28
US78747806P 2006-03-30 2006-03-30
US60/787,478 2006-03-30
EP06112425 2006-04-10
EP06112425.1 2006-04-10
US79428806P 2006-04-21 2006-04-21
US60/794,288 2006-04-21
EP06026875 2006-12-24
EP06026875.2 2006-12-24
US90350307P 2007-02-26 2007-02-26
US60/903,503 2007-02-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US29475608A Substitution 2006-03-28 2008-09-26
US13/660,045 Division US8772285B2 (en) 2006-03-28 2012-10-25 Benzothiazoles having histamine H3 receptor activity

Publications (1)

Publication Number Publication Date
WO2007110364A1 true WO2007110364A1 (fr) 2007-10-04

Family

ID=43124961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/052751 WO2007110364A1 (fr) 2006-03-28 2007-03-22 Benzothiazoles presentant une activité sur le récepteur h3 de l'histamine

Country Status (16)

Country Link
US (2) US8394842B2 (fr)
EP (1) EP1999120B1 (fr)
JP (1) JP2009531376A (fr)
KR (1) KR101280333B1 (fr)
CN (1) CN101410385B (fr)
AU (1) AU2007229492B2 (fr)
CA (1) CA2645581A1 (fr)
EA (1) EA015569B1 (fr)
ES (1) ES2388681T3 (fr)
HK (1) HK1129102A1 (fr)
IL (1) IL193441A0 (fr)
MX (1) MX2008011123A (fr)
NZ (1) NZ570524A (fr)
SG (1) SG170785A1 (fr)
WO (1) WO2007110364A1 (fr)
ZA (1) ZA200806985B (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021740A2 (fr) 2007-08-15 2009-02-19 Sanofis-Aventis Nouvelles tétrahydronaphtalines substituées, leurs procédés de préparation et leur utilisation comme médicaments
WO2010109084A3 (fr) * 2009-03-24 2011-01-06 Sanofi-Aventis DERIVES D'AZACARBOLINES 9H-PYRROLO[2,3-b:5,4-c']DIPYRIDINE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE
JP2011507884A (ja) * 2007-12-20 2011-03-10 アボット・ラボラトリーズ ベンゾチアゾールおよびベンゾオキサゾール誘導体ならびに使用方法
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
JP2013514990A (ja) * 2009-12-18 2013-05-02 ヤンセン ファーマシューティカ エヌ．ベー． Ｄｐｐ−１の阻害剤として有用な置換ベンゾチアゾール誘導体及び置換ベンゾオキサゾール誘導体
WO2016207785A1 (fr) 2015-06-22 2016-12-29 Actelion Pharmaceuticals Ltd Inhibiteurs de la nadph oxydase 4
WO2017153601A1 (fr) * 2016-03-11 2017-09-14 Ac Immune Sa Composés bicycliques pour diagnostic et traitement
US9777018B2 (en) 2011-06-09 2017-10-03 Rhizen Pharmaceuticals Sa Compounds as modulators of GPR-119
US20210284660A1 (en) * 2018-06-27 2021-09-16 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
US11780839B2 (en) 2018-03-27 2023-10-10 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
US11858941B2 (en) 2018-06-27 2024-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
ES2375929T3 (es) 2005-07-04 2012-03-07 High Point Pharmaceuticals, Llc Antagonistas del receptor histamina h3.
CA2653062A1 (fr) * 2006-05-23 2007-11-29 Transtech Pharma, Inc. Nouveaux medicaments
PT2079732E (pt) * 2006-05-29 2012-02-02 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)- piridazina, os seus sais e solvatos e a sua utilização a título de antagonista do receptor h3 de histamina
EP2014656A3 (fr) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Nouveaux antagonistes d'hétéocycliques h3
WO2012029070A1 (fr) * 2010-09-02 2012-03-08 Suven Life Sciences Limited Composés hétérocyclyle comme ligands des récepteurs h3 de l'histamine
TWI650321B (zh) * 2011-10-14 2019-02-11 美商安比特生物科學公司 雜環化合物及其使用方法
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Citations (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2825407A1 (de) * 1977-06-10 1978-12-14 Science Union & Cie Piperazindithiocarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0214826A2 (fr) 1985-08-30 1987-03-18 Novo Nordisk A/S Analogues d'insuline et leur méthode de préparation
EP0368187A2 (fr) 1988-11-08 1990-05-16 Hoechst Aktiengesellschaft Dérivés d'insuline, leur emploi et une composition pharmaceutique les contenant
JPH02306916A (ja) * 1989-05-22 1990-12-20 Otsuka Pharmaceut Co Ltd 血小板粘着抑制剤
US5504188A (en) 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
EP0705275A1 (fr) 1993-06-21 1996-04-10 Novo Nordisk A/S Cristaux d'insuline asp?b28
WO1997026265A1 (fr) 1996-01-17 1997-07-24 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee et de 1,4-thiazine fusionnee, leur preparation et utilisation
EP0792290A1 (fr) 1993-09-17 1997-09-03 Novo Nordisk A/S Insuline acylee
WO1997041120A1 (fr) 1996-07-26 1997-11-06 Dr. Reddy's Research Foundation Composes de thiazolidinedione presentant des proprietes antidiabetiques, hypolipidemiantes, antihypertensives, leur procede de preparation et compositions pharmaceutiques les contenant
WO1997041119A1 (fr) 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Nouveaux composes anti-diabetiques avec proprietes hypolipidemiantes et anti-hypertensives, procede pour les preparer et compositions pharmaceutiques contenant ces composes
WO1997041097A2 (fr) 1996-12-31 1997-11-06 Dr. Reddy's Research Foundation Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees
WO1998008871A1 (fr) 1996-08-30 1998-03-05 Novo Nordisk A/S Derives de glp-1
WO1998045292A1 (fr) 1997-12-02 1998-10-15 Dr. Reddy's Research Foundation Derives de thiazolidinedione et d'oxazolidinedione ayant des proprietes antidiabetiques, hypolipidemiques et antihypertenseurs
WO1999001423A1 (fr) 1997-07-01 1999-01-14 Novo Nordisk A/S Antagonistes/agonistes inverses du glucagon
WO1999003861A1 (fr) 1997-07-16 1999-01-28 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee, leur preparation et utilisation
WO1999019313A1 (fr) 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
JPH11199573A (ja) * 1998-01-07 1999-07-27 Yamanouchi Pharmaceut Co Ltd ５ｈｔ３受容体作動薬及び新規ベンゾチアゾール誘導体
WO2000023415A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, preparation et utilisation correspondantes
WO2000023451A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023445A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023417A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023425A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, preparation et utilisation correspondantes
WO2000023416A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000037474A1 (fr) 1998-12-18 2000-06-29 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnes, leur preparation et utilisation
WO2000039088A1 (fr) 1998-12-23 2000-07-06 Novo Nordisk A/S Antagonistes de glucagon/agonistes inverses
WO2000041121A1 (fr) 1999-01-07 2000-07-13 Ccrewards.Com Procede et dispositif d'emission et de gestion de bons numeriques et d'offres de vente
WO2000042026A1 (fr) 1999-01-15 2000-07-20 Novo Nordisk A/S Agonistes non peptidiques de glp-1
WO2000050414A1 (fr) 1999-02-24 2000-08-31 Dr.Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ceux-ci et composition pharmaceutique les contenant
US6130217A (en) * 1995-09-20 2000-10-10 Pfizer Inc Compounds enhancing antitumor activity of other cytotoxic agents
WO2000063189A1 (fr) 1999-04-16 2000-10-26 Novo Nordisk A/S Formes cristallines de r-guanidines, d'arginine ou de (l)-arginine (2s-2-ethoxy-3-{4-[2-(10h-phenoxazin-10-yl)ethoxy]phenyl}propanoate
WO2000063196A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000063192A1 (fr) 1999-04-16 2000-10-26 Dr. Reddy's Research Foundation Nouvelles formes polymorphes d'un agent antidiabetique, leur procede de preparation et compositions pharmaceutiques les renfermant
WO2000063209A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, preparation et utilisation associees
WO2000063153A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, preparation et utilisation de ces derniers
WO2000063190A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et utilisation
WO2000063191A1 (fr) 1999-04-16 2000-10-26 Dr. Reddy's Research Foundation Nouvelles formes polymorphes d'un agent antidiabetique: procede de preparation et composition pharmaceutique contenant ces dernieres
EP1134220A1 (fr) 1998-11-20 2001-09-19 Meiji Seika Kaisha Ltd. Derives de benzoxazole et produits a base de ces derniers utilises comme ingredient actif
WO2002014271A1 (fr) * 2000-08-10 2002-02-21 Mitsubishi Pharma Corporation Dérivés de proline et leur utilisation comme médicaments
US20030073672A1 (en) * 2001-09-05 2003-04-17 Breitenbucher J. Guy Method for treating allergies using substituted pyrazoles
WO2003066604A2 (fr) * 2002-02-05 2003-08-14 Novo Nordisk A/S Nouvelles aryl- et heteroarylpiperazines
WO2004101559A1 (fr) * 2003-05-07 2004-11-25 Abbott Laboratories Amines substituees bicycliques hybrides servant de ligands au recepteur d'histamine 3
US20050059663A1 (en) * 2003-03-12 2005-03-17 Kudos Pharmaceuticals Limited Phthalazinone derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO156497C (no) 1984-10-18 1987-09-30 Helge Boe Anordning for sammenfoeyning av to plateformede elementer.
DE3511110A1 (de) 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
FI91859C (fi) 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
JP2637303B2 (ja) 1991-04-16 1997-08-06 明治製菓株式会社 新規ベンゾチアゾール誘導体
DE4223589A1 (de) 1992-07-17 1994-01-20 Fluehs Drehtechnik Gmbh Ventiloberteil
WO1994022846A1 (fr) 1993-03-30 1994-10-13 Pfizer Inc. Composes stimulant l'activite antitumorale d'autres agents cytotoxiques
JP3193560B2 (ja) 1993-04-16 2001-07-30 明治製菓株式会社 新規ベンゾオキサゾール誘導体
JP3520177B2 (ja) 1996-05-09 2004-04-19 明治製菓株式会社 セロトニン５−ｈｔ３受容体部分活性薬
CN1239570A (zh) 1997-07-17 1999-12-22 索尼公司 磁记录介质和使用该介质的磁记录/再现装置
ES2267873T3 (es) 1997-10-27 2007-03-16 Agouron Pharmaceuticals, Inc. Derivados de 4-aminotiazol, su preparacion y uso como inhibidores de kinasas dependientes de ciclina.
AU1045300A (en) 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel heterocyclyl-substituted oxazolidone derivatives
GB0003254D0 (en) 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US6436939B2 (en) 2000-03-31 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
DE60138605D1 (de) 2000-03-31 2009-06-18 Ortho Mcneil Pharm Inc Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
US7576084B2 (en) 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
CN101312968A (zh) 2005-09-23 2008-11-26 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑、吡唑并吡啶、异噻唑并吡啶及其制备和用途

Patent Citations (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2825407A1 (de) * 1977-06-10 1978-12-14 Science Union & Cie Piperazindithiocarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0214826A2 (fr) 1985-08-30 1987-03-18 Novo Nordisk A/S Analogues d'insuline et leur méthode de préparation
EP0368187A2 (fr) 1988-11-08 1990-05-16 Hoechst Aktiengesellschaft Dérivés d'insuline, leur emploi et une composition pharmaceutique les contenant
JPH02306916A (ja) * 1989-05-22 1990-12-20 Otsuka Pharmaceut Co Ltd 血小板粘着抑制剤
EP0705275A1 (fr) 1993-06-21 1996-04-10 Novo Nordisk A/S Cristaux d'insuline asp?b28
EP0792290A1 (fr) 1993-09-17 1997-09-03 Novo Nordisk A/S Insuline acylee
US5504188A (en) 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US6130217A (en) * 1995-09-20 2000-10-10 Pfizer Inc Compounds enhancing antitumor activity of other cytotoxic agents
WO1997026265A1 (fr) 1996-01-17 1997-07-24 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee et de 1,4-thiazine fusionnee, leur preparation et utilisation
WO1997041120A1 (fr) 1996-07-26 1997-11-06 Dr. Reddy's Research Foundation Composes de thiazolidinedione presentant des proprietes antidiabetiques, hypolipidemiantes, antihypertensives, leur procede de preparation et compositions pharmaceutiques les contenant
WO1998008871A1 (fr) 1996-08-30 1998-03-05 Novo Nordisk A/S Derives de glp-1
WO1997041097A2 (fr) 1996-12-31 1997-11-06 Dr. Reddy's Research Foundation Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees
WO1997041119A1 (fr) 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Nouveaux composes anti-diabetiques avec proprietes hypolipidemiantes et anti-hypertensives, procede pour les preparer et compositions pharmaceutiques contenant ces composes
WO1999001423A1 (fr) 1997-07-01 1999-01-14 Novo Nordisk A/S Antagonistes/agonistes inverses du glucagon
WO1999003861A1 (fr) 1997-07-16 1999-01-28 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee, leur preparation et utilisation
WO1999019313A1 (fr) 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
WO1998045292A1 (fr) 1997-12-02 1998-10-15 Dr. Reddy's Research Foundation Derives de thiazolidinedione et d'oxazolidinedione ayant des proprietes antidiabetiques, hypolipidemiques et antihypertenseurs
JPH11199573A (ja) * 1998-01-07 1999-07-27 Yamanouchi Pharmaceut Co Ltd ５ｈｔ３受容体作動薬及び新規ベンゾチアゾール誘導体
WO2000023417A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023415A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, preparation et utilisation correspondantes
WO2000023451A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023425A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, preparation et utilisation correspondantes
WO2000023416A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000023445A1 (fr) 1998-10-21 2000-04-27 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
EP1134220A1 (fr) 1998-11-20 2001-09-19 Meiji Seika Kaisha Ltd. Derives de benzoxazole et produits a base de ces derniers utilises comme ingredient actif
WO2000037474A1 (fr) 1998-12-18 2000-06-29 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnes, leur preparation et utilisation
WO2000039088A1 (fr) 1998-12-23 2000-07-06 Novo Nordisk A/S Antagonistes de glucagon/agonistes inverses
WO2000041121A1 (fr) 1999-01-07 2000-07-13 Ccrewards.Com Procede et dispositif d'emission et de gestion de bons numeriques et d'offres de vente
WO2000042026A1 (fr) 1999-01-15 2000-07-20 Novo Nordisk A/S Agonistes non peptidiques de glp-1
WO2000050414A1 (fr) 1999-02-24 2000-08-31 Dr.Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ceux-ci et composition pharmaceutique les contenant
WO2000063192A1 (fr) 1999-04-16 2000-10-26 Dr. Reddy's Research Foundation Nouvelles formes polymorphes d'un agent antidiabetique, leur procede de preparation et compositions pharmaceutiques les renfermant
WO2000063193A1 (fr) 1999-04-16 2000-10-26 Dr. Reddy's Research Foundation Nouvelles formes polymorphes d'un agent antidiabetique: leur procede de preparation et composition pharmaceutique contenant lesdites formes
WO2000063191A1 (fr) 1999-04-16 2000-10-26 Dr. Reddy's Research Foundation Nouvelles formes polymorphes d'un agent antidiabetique: procede de preparation et composition pharmaceutique contenant ces dernieres
WO2000063189A1 (fr) 1999-04-16 2000-10-26 Novo Nordisk A/S Formes cristallines de r-guanidines, d'arginine ou de (l)-arginine (2s-2-ethoxy-3-{4-[2-(10h-phenoxazin-10-yl)ethoxy]phenyl}propanoate
WO2000063196A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
WO2000063209A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, preparation et utilisation associees
WO2000063153A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, preparation et utilisation de ces derniers
WO2000063190A1 (fr) 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et utilisation
WO2002014271A1 (fr) * 2000-08-10 2002-02-21 Mitsubishi Pharma Corporation Dérivés de proline et leur utilisation comme médicaments
US20030073672A1 (en) * 2001-09-05 2003-04-17 Breitenbucher J. Guy Method for treating allergies using substituted pyrazoles
WO2003066604A2 (fr) * 2002-02-05 2003-08-14 Novo Nordisk A/S Nouvelles aryl- et heteroarylpiperazines
US20050059663A1 (en) * 2003-03-12 2005-03-17 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2004101559A1 (fr) * 2003-05-07 2004-11-25 Abbott Laboratories Amines substituees bicycliques hybrides servant de ligands au recepteur d'histamine 3

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
"Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING CO.
ARCH PHARM PHARM MED
ARCH PHARM PHARM MED CHEM, vol. 332, 1999, pages 389 - 98
CELANIRE ET AL: "Keynote review: Histamine H3 receptor antagonists reach out for the clinic", DDT - DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 10, no. 23-24, December 2005 (2005-12-01), pages 1613 - 1627, XP005222014, ISSN: 1359-6446 *
CHEM. PHARM. BULL., vol. 46, 1998, pages 445 - 451
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IWAOKA, KIYOSHI ET AL: "Benzothiazoles and 5-HT3 receptor agonists containing them", XP002396638, retrieved from STN Database accession no. 1999:463258 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KITAJIMA, HIROSHI ET AL: "Preparation of proline derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors and use thereof as drugs", XP002396637, retrieved from STN Database accession no. 2002:142666 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NISHI, TAKAO ET AL: "Preparation of benzothiazoles and benzimidazoles as blood platelet aggregation inhibitors", XP002396639, retrieved from STN Database accession no. 1991:207259 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SATO, YASUO ET AL: "Preparation of benzothiazoles as cardiotonics", XP002396640, retrieved from STN Database accession no. 1993:161060 *
DRUGS FUT, vol. 21, 1996, pages 507 - 20
EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 9, 2000, pages 2537 - 42
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 10, 2000, pages 1045 - 55
J MED CHEM, vol. 43, 2000, pages 2362 - 70
J PHARM SCI, vol. 66, 1977, pages 2
J. MED. CHEM, vol. 41, 1998, pages 3015 - 3021
J. MED. CHEM, vol. 48, 2005, pages 7075 - 7079
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101 - 7
NATURE, vol. 408, 2000, pages 860 - 4
PROGRESS IN DRUG RESEARCH, vol. 45, 1995, pages 107 - 65
SATO Y ET AL: "Benzoxazole Derivatives as Novel 5-HT3 Receptor Partial Agonists in the Gut", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 16, 1998, pages 3015 - 3021, XP002180160, ISSN: 0022-2623 *
THE JOURNAL OF PHANTIACOLOGYAND EXPERIMENTAL THERAPEUTICS, vol. 287, 1998, pages 43 - 50
YAMADA M ET AL: "A new 5-HT3 receptor ligand. II. Structure-activity analysis of 5-HT3 receptor agonist action in the gut", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 46, no. 3, 1998, pages 445 - 451, XP002403658, ISSN: 0009-2363 *
YOSHIDA, SATOSHI ET AL: "Orally Active Benzoxazole Derivative as 5-HT3 Receptor Partial Agonist for Treatment of Diarrhea-Predominant Irritable Bowel Syndrome", JOURNAL OF MEDICINAL CHEMISTRY , 48(22), 7075-7079 CODEN: JMCMAR; ISSN: 0022-2623, 2005, XP002437776 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021740A2 (fr) 2007-08-15 2009-02-19 Sanofis-Aventis Nouvelles tétrahydronaphtalines substituées, leurs procédés de préparation et leur utilisation comme médicaments
JP2011507884A (ja) * 2007-12-20 2011-03-10 アボット・ラボラトリーズ ベンゾチアゾールおよびベンゾオキサゾール誘導体ならびに使用方法
WO2010109084A3 (fr) * 2009-03-24 2011-01-06 Sanofi-Aventis DERIVES D'AZACARBOLINES 9H-PYRROLO[2,3-b:5,4-c']DIPYRIDINE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE
CN102365282A (zh) * 2009-03-24 2012-02-29 赛诺菲 9H-吡咯并[2，3-b：5，4-c’]二吡啶氮杂咔啉衍生物、其制备方法及其治疗用途
JP2013514990A (ja) * 2009-12-18 2013-05-02 ヤンセン ファーマシューティカ エヌ．ベー． Ｄｐｐ−１の阻害剤として有用な置換ベンゾチアゾール誘導体及び置換ベンゾオキサゾール誘導体
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US9777018B2 (en) 2011-06-09 2017-10-03 Rhizen Pharmaceuticals Sa Compounds as modulators of GPR-119
WO2016207785A1 (fr) 2015-06-22 2016-12-29 Actelion Pharmaceuticals Ltd Inhibiteurs de la nadph oxydase 4
US10584118B2 (en) 2015-06-22 2020-03-10 Actelion Pharmaceuticals Ltd NADPH oxidase 4 inhibitors
US11136317B2 (en) 2015-06-22 2021-10-05 Actelion Pharmaceuticals Ltd NADPH oxidase 4 inhibitors
WO2017153601A1 (fr) * 2016-03-11 2017-09-14 Ac Immune Sa Composés bicycliques pour diagnostic et traitement
EP4001277A3 (fr) * 2016-03-11 2022-09-14 AC Immune SA Composes bicycliques pour le diagnostic et le traitement
KR20220151042A (ko) * 2016-03-11 2022-11-11 에이씨 이뮨 에스에이 진단 및 치료를 위한 바이사이클릭 화합물
KR102646115B1 (ko) * 2016-03-11 2024-03-12 에이씨 이뮨 에스에이 진단 및 치료를 위한 바이사이클릭 화합물
US11780839B2 (en) 2018-03-27 2023-10-10 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
US20210284660A1 (en) * 2018-06-27 2021-09-16 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
US11858941B2 (en) 2018-06-27 2024-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease

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MX2008011123A (es) 2008-09-30
US20100298316A1 (en) 2010-11-25
US8772285B2 (en) 2014-07-08
KR20080104042A (ko) 2008-11-28
CA2645581A1 (fr) 2007-10-04
AU2007229492A1 (en) 2007-10-04
US20130079340A1 (en) 2013-03-28
SG170785A1 (en) 2011-05-30
EP1999120B1 (fr) 2012-06-27
AU2007229492B2 (en) 2011-11-03
KR101280333B1 (ko) 2013-07-02
JP2009531376A (ja) 2009-09-03
US8394842B2 (en) 2013-03-12
EP1999120A1 (fr) 2008-12-10
CN101410385A (zh) 2009-04-15
CN101410385B (zh) 2011-08-24
NZ570524A (en) 2011-08-26
EA015569B1 (ru) 2011-10-31
ZA200806985B (en) 2010-12-29
HK1129102A1 (en) 2009-11-20
ES2388681T3 (es) 2012-10-17
IL193441A0 (en) 2009-05-04
EA200870376A1 (ru) 2009-04-28

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