WO1997041097A2 - Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees - Google Patents

Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees Download PDF

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Publication number
WO1997041097A2
WO1997041097A2 PCT/US1997/011522 US9711522W WO9741097A2 WO 1997041097 A2 WO1997041097 A2 WO 1997041097A2 US 9711522 W US9711522 W US 9711522W WO 9741097 A2 WO9741097 A2 WO 9741097A2
Authority
WO
WIPO (PCT)
Prior art keywords
oxo
formula
methyl
compound
group
Prior art date
Application number
PCT/US1997/011522
Other languages
English (en)
Inventor
Vidya Bhushan Lohray
Braj Bhushan Lohray
Rao Bheema Paraselli
Ranga Madhavan Gurram
Rajagopalan Ramanujam
Ranjan Chakrabarti
Sarma K. S. Pakala
Original Assignee
Dr. Reddy's Research Foundation
Reddy-Cheminor, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/777,627 external-priority patent/US5885997A/en
Priority to IL14264997A priority Critical patent/IL142649A/en
Priority to AT97934041T priority patent/ATE246190T1/de
Priority to DE69723869T priority patent/DE69723869T2/de
Priority to DK97934041T priority patent/DK0958296T3/da
Priority to AU37198/97A priority patent/AU744518B2/en
Priority to BRPI9711098-1A priority patent/BR9711098B1/pt
Priority to KR1019980710542A priority patent/KR100579765B1/ko
Application filed by Dr. Reddy's Research Foundation, Reddy-Cheminor, Inc. filed Critical Dr. Reddy's Research Foundation
Priority to IL12729697A priority patent/IL127296A/xx
Priority to CA002258949A priority patent/CA2258949C/fr
Priority to EP97934041A priority patent/EP0958296B1/fr
Priority to JP53930797A priority patent/JP4339402B2/ja
Priority to UA98126783A priority patent/UA64713C2/uk
Priority to PL342608A priority patent/PL192664B1/pl
Priority to HU0301101A priority patent/HUP0301101A3/hu
Publication of WO1997041097A2 publication Critical patent/WO1997041097A2/fr
Priority to NO19986055A priority patent/NO313699B1/no
Priority to HK00103109A priority patent/HK1026204A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

La présente invention se rapporte à des nouveaux composés antidiabétiques, aux formes tautomères, aux dérivés, aux stéréo-isomères et aux polymorphes de ces composés, aux sels et aux solvates de ces composés, acceptables sur le plan pharmacologique, ainsi qu'aux compositions les contenant et acceptables sur le plan pharmaceutique. L'invention concerne notamment des nouveaux dérivés azolidinediones de la formule générale (I), ainsi que les sels et solvates de ceux-ci, acceptables sur le plan pharmacologique, et les compositions pharmaceutiques contenant ces dérivés.
PCT/US1997/011522 1996-07-01 1997-06-30 Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees WO1997041097A2 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IL12729697A IL127296A (en) 1996-12-31 1997-06-30 Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
CA002258949A CA2258949C (fr) 1996-07-01 1997-06-30 Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees
AT97934041T ATE246190T1 (de) 1996-12-31 1997-06-30 Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
EP97934041A EP0958296B1 (fr) 1996-12-31 1997-06-30 Composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees
AU37198/97A AU744518B2 (en) 1996-07-01 1997-06-30 Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BRPI9711098-1A BR9711098B1 (pt) 1996-07-01 1997-06-30 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
KR1019980710542A KR100579765B1 (ko) 1996-07-01 1997-06-30 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도
IL14264997A IL142649A (en) 1996-12-31 1997-06-30 Azole derivatives
HU0301101A HUP0301101A3 (en) 1996-12-31 1997-06-30 Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
DE69723869T DE69723869T2 (de) 1996-12-31 1997-06-30 Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
DK97934041T DK0958296T3 (da) 1996-12-31 1997-06-30 Heterocykliske forbindelser, fremgangsmåde til deres fremstilling og farmaceutiske præparater, der indeholder dem, og deres anvendelse i behandlingen af diabetes og beslægtede sygdomme
JP53930797A JP4339402B2 (ja) 1996-12-31 1997-06-30 新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用
UA98126783A UA64713C2 (uk) 1996-12-31 1997-06-30 Похідні азолідиндіону, спосіб їх одержання (варіанти), фармацевтичні композиції на їх основі, спосіб попередження або лікування, спосіб зниження рівня глюкози і проміжна сполука
PL342608A PL192664B1 (pl) 1996-12-31 1997-06-30 Pochodne azolidynodionu, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne, ich zastosowanie w leczeniu cukrzycy i związanych z nią chorób oraz związki pośrednie
NO19986055A NO313699B1 (no) 1996-12-31 1998-12-22 Nye heterocykliske forbindelser, deres fremstilling, farmasöytiske preparater inneholdende forbindelsene samtmellomprodukter til bruk ved fremstillingen
HK00103109A HK1026204A1 (en) 1996-12-31 2000-05-24 Heterocyclic compounds process for their preparation and pharmaceutical compositions containing themand their use in the treatment of diabetes and related diseases.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/777,627 1996-12-31
US08/777,627 US5885997A (en) 1996-07-01 1996-12-31 Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Publications (1)

Publication Number Publication Date
WO1997041097A2 true WO1997041097A2 (fr) 1997-11-06

Family

ID=25110787

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011522 WO1997041097A2 (fr) 1996-07-01 1997-06-30 Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees

Country Status (16)

Country Link
EP (1) EP0958296B1 (fr)
JP (1) JP4339402B2 (fr)
CN (1) CN1190434C (fr)
AT (1) ATE246190T1 (fr)
DE (1) DE69723869T2 (fr)
DK (1) DK0958296T3 (fr)
ES (1) ES2199366T3 (fr)
HK (1) HK1026204A1 (fr)
HU (1) HUP0301101A3 (fr)
IL (2) IL127296A (fr)
NO (1) NO313699B1 (fr)
PL (1) PL192664B1 (fr)
PT (1) PT958296E (fr)
RU (1) RU2200161C2 (fr)
UA (1) UA64713C2 (fr)
WO (1) WO1997041097A2 (fr)

Cited By (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045291A1 (fr) * 1997-12-02 1998-10-15 Dr. Reddy's Research Foundation Oxalidinedione et thiazolidinedione a substitution, antidiabetiques, hypolipidemiques et antihypertenseurs
WO1999008501A2 (fr) * 1998-04-23 1999-02-25 Dr. Reddy's Research Foundation Nouveaux composes heterocycliques, leur utilisation en medecine, leur procede de preparation et compositions pharmaceutiques les contenant
US6030973A (en) * 1997-04-15 2000-02-29 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemia and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO2000015638A1 (fr) * 1998-09-14 2000-03-23 Dr. Reddy's Research Foundation Procede ameliore de preparation de derives de thiazolidine-2,4-dione
US6054453A (en) * 1997-10-27 2000-04-25 Redd's Research Foundation Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
WO2000026200A1 (fr) * 1998-10-29 2000-05-11 Dr. Reddy's Research Foundation Technique amelioree de preparation de nouveaux agents antidiabetiques
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EP0958296A1 (fr) 1999-11-24
DE69723869T2 (de) 2004-04-22
PT958296E (pt) 2003-11-28
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PL342608A1 (en) 2001-06-18
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NO986055L (no) 1998-12-22
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IL127296A (en) 2003-01-12
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IL127296A0 (en) 1999-09-22
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RU2200161C2 (ru) 2003-03-10
IL142649A (en) 2004-12-15
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ATE246190T1 (de) 2003-08-15

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