MX2015016965A - Compuesto de amida heterociclica aromatica que contiene nitrogeno biciclico. - Google Patents
Compuesto de amida heterociclica aromatica que contiene nitrogeno biciclico.Info
- Publication number
- MX2015016965A MX2015016965A MX2015016965A MX2015016965A MX2015016965A MX 2015016965 A MX2015016965 A MX 2015016965A MX 2015016965 A MX2015016965 A MX 2015016965A MX 2015016965 A MX2015016965 A MX 2015016965A MX 2015016965 A MX2015016965 A MX 2015016965A
- Authority
- MX
- Mexico
- Prior art keywords
- breast cancer
- aromatic heterocyclic
- containing aromatic
- amide compound
- cell line
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Abstract
Problema. Se proporciona un compuesto que es útil como un agente para el tratamiento de cáncer de mama. Medios para solución Como consecuencia de intensivos estudios sobre un compuesto que tiene el efecto inhibitorio del Complejo I y el efecto de activación de AMPK, los presentes inventores encontraron que un compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico de la presente invención tiene excelentes efectos inhibitorios del Complejo I y el efecto de activación de AMPK; además, tiene un efecto inhibitorio de la proliferación celular con respecto no solo a líneas celulares de cáncer de mama positivas para la mutación PIK3CA humana en las cuales MCT4 no se expresa, sino, además, líneas celulares de cáncer de mama humanas que no tienen la mutación de PIK3CA donde MCT4 no se expresa; y muestra un efecto antitumoral en una célula de la línea celular de cáncer de mama positiva para la mutación PIK3CA humana MDA-MB-453 en un ratón portador de cáncer en el cual el MCT4 no se expresa para completar la presente invención. Un compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico de la presente invención se puede usar como un agente para el tratamiento de cáncer de mama, en particular, cáncer de mama en el cual el MCT4 no se expresa, y entre otros, cáncer de mama positivo para la mutación PIK3CA en el cual el MCT4 no se expresa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013122180 | 2013-06-10 | ||
| PCT/JP2014/065181 WO2014199933A1 (ja) | 2013-06-10 | 2014-06-09 | 二環式含窒素芳香族ヘテロ環アミド化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015016965A true MX2015016965A (es) | 2016-04-25 |
Family
ID=52022229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015016965A MX2015016965A (es) | 2013-06-10 | 2014-06-09 | Compuesto de amida heterociclica aromatica que contiene nitrogeno biciclico. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9428501B2 (es) |
| EP (1) | EP3009424B1 (es) |
| JP (1) | JP5924453B2 (es) |
| KR (1) | KR20160018686A (es) |
| CN (1) | CN105308024B (es) |
| AR (1) | AR096552A1 (es) |
| AU (1) | AU2014279240A1 (es) |
| BR (1) | BR112015030248A2 (es) |
| CA (1) | CA2914982A1 (es) |
| EA (1) | EA028545B1 (es) |
| ES (1) | ES2661259T3 (es) |
| HK (1) | HK1220446A1 (es) |
| IL (1) | IL242997A (es) |
| MX (1) | MX2015016965A (es) |
| PH (1) | PH12015502744A1 (es) |
| PL (1) | PL3009424T3 (es) |
| PT (1) | PT3009424T (es) |
| SA (1) | SA515370253B1 (es) |
| SG (1) | SG11201510125WA (es) |
| TW (1) | TW201536771A (es) |
| WO (1) | WO2014199933A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2016068099A1 (ja) * | 2014-10-28 | 2017-08-10 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有する複素環誘導体 |
| MA41158A (fr) * | 2014-12-09 | 2017-10-17 | Astellas Pharma Inc | Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenat de l'azote bicyclique en tant que principe actif |
| JPWO2016093255A1 (ja) * | 2014-12-09 | 2017-09-21 | アステラス製薬株式会社 | 二環式含窒素芳香族ヘテロ環アミド化合物を有効成分とする医薬組成物 |
| MA41157A (fr) * | 2014-12-09 | 2017-10-17 | Astellas Pharma Inc | Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenant de l'azote bicyclique en tant que composant actif |
| WO2017196936A1 (en) * | 2016-05-12 | 2017-11-16 | Regents Of The University Of Minnesota | Indole and indazole cyanocinnamate compounds and therapeutic uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19932314A1 (de) * | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzofuranderivate |
| WO2002020008A1 (en) | 2000-09-06 | 2002-03-14 | The Scripps Research Institute | Inhibitors of nadh:ubiquinone oxidoreductase |
| US8394842B2 (en) * | 2006-03-28 | 2013-03-12 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
| US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| JP5420566B2 (ja) * | 2007-12-21 | 2014-02-19 | スリーエム イノベイティブ プロパティズ カンパニー | 微生物系及び流体試料分析の方法 |
| PE20091157A1 (es) * | 2007-12-21 | 2009-09-03 | Astrazeneca Ab | Derivados biciclicos para usar en el tratamiento de afecciones asociadas con el receptor de androgeno - 155 |
| JP5658138B2 (ja) * | 2008-04-23 | 2015-01-21 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝障害の処置のためのカルボキサミド化合物 |
| JP5889895B2 (ja) | 2010-07-29 | 2016-03-22 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｍｐｋ活性化複素環化合物およびその使用方法 |
| WO2013116491A1 (en) | 2012-02-01 | 2013-08-08 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds and methods for using them |
-
2014
- 2014-06-09 BR BR112015030248A patent/BR112015030248A2/pt active Search and Examination
- 2014-06-09 AU AU2014279240A patent/AU2014279240A1/en not_active Abandoned
- 2014-06-09 JP JP2015522759A patent/JP5924453B2/ja not_active Expired - Fee Related
- 2014-06-09 CA CA2914982A patent/CA2914982A1/en not_active Abandoned
- 2014-06-09 AR ARP140102215A patent/AR096552A1/es unknown
- 2014-06-09 CN CN201480033143.0A patent/CN105308024B/zh not_active Expired - Fee Related
- 2014-06-09 TW TW103119885A patent/TW201536771A/zh unknown
- 2014-06-09 KR KR1020167000279A patent/KR20160018686A/ko not_active Application Discontinuation
- 2014-06-09 ES ES14810281.7T patent/ES2661259T3/es active Active
- 2014-06-09 EP EP14810281.7A patent/EP3009424B1/en active Active
- 2014-06-09 US US14/418,672 patent/US9428501B2/en active Active
- 2014-06-09 SG SG11201510125WA patent/SG11201510125WA/en unknown
- 2014-06-09 WO PCT/JP2014/065181 patent/WO2014199933A1/ja active Application Filing
- 2014-06-09 PL PL14810281T patent/PL3009424T3/pl unknown
- 2014-06-09 MX MX2015016965A patent/MX2015016965A/es active IP Right Grant
- 2014-06-09 EA EA201592301A patent/EA028545B1/ru not_active IP Right Cessation
- 2014-06-09 PT PT148102817T patent/PT3009424T/pt unknown
-
2015
- 2015-12-09 PH PH12015502744A patent/PH12015502744A1/en unknown
- 2015-12-09 IL IL242997A patent/IL242997A/en not_active IP Right Cessation
- 2015-12-09 SA SA515370253A patent/SA515370253B1/ar unknown
-
2016
- 2016-07-15 HK HK16108380.3A patent/HK1220446A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160018686A (ko) | 2016-02-17 |
| SG11201510125WA (en) | 2016-01-28 |
| US20150266869A1 (en) | 2015-09-24 |
| US9428501B2 (en) | 2016-08-30 |
| CN105308024B (zh) | 2017-10-27 |
| EA028545B1 (ru) | 2017-11-30 |
| ES2661259T3 (es) | 2018-03-28 |
| JP5924453B2 (ja) | 2016-05-25 |
| EA201592301A1 (ru) | 2016-05-31 |
| PL3009424T3 (pl) | 2018-03-30 |
| CN105308024A (zh) | 2016-02-03 |
| EP3009424A4 (en) | 2016-11-30 |
| CA2914982A1 (en) | 2014-12-18 |
| PH12015502744A1 (en) | 2016-03-21 |
| HK1220446A1 (zh) | 2017-05-05 |
| EP3009424B1 (en) | 2017-12-20 |
| AU2014279240A1 (en) | 2016-01-07 |
| TW201536771A (zh) | 2015-10-01 |
| SA515370253B1 (ar) | 2017-03-06 |
| JPWO2014199933A1 (ja) | 2017-02-23 |
| PT3009424T (pt) | 2018-01-16 |
| AR096552A1 (es) | 2016-01-13 |
| BR112015030248A2 (pt) | 2017-07-25 |
| EP3009424A1 (en) | 2016-04-20 |
| IL242997A (en) | 2017-04-30 |
| WO2014199933A1 (ja) | 2014-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |