BR112015030248A2 - composto de amida heterocíclica aromática contendo nitrogênio bicíclico - Google Patents
composto de amida heterocíclica aromática contendo nitrogênio bicíclicoInfo
- Publication number
- BR112015030248A2 BR112015030248A2 BR112015030248A BR112015030248A BR112015030248A2 BR 112015030248 A2 BR112015030248 A2 BR 112015030248A2 BR 112015030248 A BR112015030248 A BR 112015030248A BR 112015030248 A BR112015030248 A BR 112015030248A BR 112015030248 A2 BR112015030248 A2 BR 112015030248A2
- Authority
- BR
- Brazil
- Prior art keywords
- breast cancer
- mct4
- expressed
- aromatic heterocyclic
- containing aromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
resumo “composto de amida heterocíclica aromática contendo nitrogênio bicíclico” é proposto um composto útil como agente para tratar o câncer de mama. como resultado de estudos intensivos sobre um composto com efeito inibitório contra o complexo i e efeito de ativação da ampk, os presente inventores descobriram que os compostos de amida heterocíclica aromática contendo nitrogênio bicíclico da presente invenção possuem excelente efeito inibitório contra o complexo i e efeito de ativação da ampk, além disso, possuem inibitório contra a proliferação celular no que se refere não só a linhas celulares do câncer de mama positivas para mutação da pik3ca humana em que o mct4 não é expresso mas também a linhas celulares do câncer de mama humano sem mutação da pik3ca em que o mct4 não é expresso e demonstram efeito antitumoral em células da linha celular do câncer de mama mda-mb-453 positiva para mutação da pik3ca em um camundongo com câncer em que o mct4 não é expresso, estabelecendo assim a presente invenção. o composto de amida heterocíclica aromática contendo nitrogênio bicíclico da presente invenção pode ser usado como agente para tratar o câncer de mama, em especial, o câncer de mama em que o mct4 não é expresso e, entre outros, o câncer de mama positivo para mutação da pik3ca em que o mct4 não é expresso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013122180 | 2013-06-10 | ||
| PCT/JP2014/065181 WO2014199933A1 (ja) | 2013-06-10 | 2014-06-09 | 二環式含窒素芳香族ヘテロ環アミド化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015030248A2 true BR112015030248A2 (pt) | 2017-07-25 |
Family
ID=52022229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015030248A BR112015030248A2 (pt) | 2013-06-10 | 2014-06-09 | composto de amida heterocíclica aromática contendo nitrogênio bicíclico |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9428501B2 (pt) |
| EP (1) | EP3009424B1 (pt) |
| JP (1) | JP5924453B2 (pt) |
| KR (1) | KR20160018686A (pt) |
| CN (1) | CN105308024B (pt) |
| AR (1) | AR096552A1 (pt) |
| AU (1) | AU2014279240A1 (pt) |
| BR (1) | BR112015030248A2 (pt) |
| CA (1) | CA2914982A1 (pt) |
| EA (1) | EA028545B1 (pt) |
| ES (1) | ES2661259T3 (pt) |
| HK (1) | HK1220446A1 (pt) |
| IL (1) | IL242997A (pt) |
| MX (1) | MX2015016965A (pt) |
| PH (1) | PH12015502744A1 (pt) |
| PL (1) | PL3009424T3 (pt) |
| PT (1) | PT3009424T (pt) |
| SA (1) | SA515370253B1 (pt) |
| SG (1) | SG11201510125WA (pt) |
| TW (1) | TW201536771A (pt) |
| WO (1) | WO2014199933A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3214076A4 (en) * | 2014-10-28 | 2018-07-25 | Shionogi & Co., Ltd. | Heterocyclic derivative having ampk activating effect |
| MA41157A (fr) * | 2014-12-09 | 2017-10-17 | Astellas Pharma Inc | Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenant de l'azote bicyclique en tant que composant actif |
| CN106999489A (zh) * | 2014-12-09 | 2017-08-01 | 安斯泰来制药株式会社 | 以二环式含氮芳香族杂环酰胺化合物作为有效成分的药物组合物 |
| MA41158A (fr) * | 2014-12-09 | 2017-10-17 | Astellas Pharma Inc | Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenat de l'azote bicyclique en tant que principe actif |
| US20190135747A1 (en) * | 2016-05-12 | 2019-05-09 | Regents Of The University Of Minnesota | Indole and indazole cyanocinnamate compounds and therapeutic uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19932314A1 (de) * | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzofuranderivate |
| AU2001288899A1 (en) * | 2000-09-06 | 2002-03-22 | The Scripps Research Institute | Inhibitors of nadh:ubiquinone oxidoreductase |
| AU2007229492B2 (en) * | 2006-03-28 | 2011-11-03 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
| US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| JP5420566B2 (ja) * | 2007-12-21 | 2014-02-19 | スリーエム イノベイティブ プロパティズ カンパニー | 微生物系及び流体試料分析の方法 |
| CN101952286A (zh) * | 2007-12-21 | 2011-01-19 | 阿斯利康(瑞典)有限公司 | 用于治疗和雄激素受体有关的病症的双环衍生物 |
| US8314107B2 (en) | 2008-04-23 | 2012-11-20 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds and methods for using the same |
| KR101764952B1 (ko) * | 2010-07-29 | 2017-08-03 | 리겔 파마슈티칼스, 인크. | Ａｍｐｋ-활성화 헤테로시클릭 화합물 및 그의 사용 방법 |
| WO2013116491A1 (en) | 2012-02-01 | 2013-08-08 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds and methods for using them |
-
2014
- 2014-06-09 PT PT148102817T patent/PT3009424T/pt unknown
- 2014-06-09 EP EP14810281.7A patent/EP3009424B1/en active Active
- 2014-06-09 BR BR112015030248A patent/BR112015030248A2/pt active Search and Examination
- 2014-06-09 PL PL14810281T patent/PL3009424T3/pl unknown
- 2014-06-09 MX MX2015016965A patent/MX2015016965A/es active IP Right Grant
- 2014-06-09 JP JP2015522759A patent/JP5924453B2/ja not_active Expired - Fee Related
- 2014-06-09 CA CA2914982A patent/CA2914982A1/en not_active Abandoned
- 2014-06-09 AU AU2014279240A patent/AU2014279240A1/en not_active Abandoned
- 2014-06-09 US US14/418,672 patent/US9428501B2/en active Active
- 2014-06-09 ES ES14810281.7T patent/ES2661259T3/es active Active
- 2014-06-09 SG SG11201510125WA patent/SG11201510125WA/en unknown
- 2014-06-09 EA EA201592301A patent/EA028545B1/ru not_active IP Right Cessation
- 2014-06-09 AR ARP140102215A patent/AR096552A1/es unknown
- 2014-06-09 KR KR1020167000279A patent/KR20160018686A/ko not_active Application Discontinuation
- 2014-06-09 WO PCT/JP2014/065181 patent/WO2014199933A1/ja active Application Filing
- 2014-06-09 CN CN201480033143.0A patent/CN105308024B/zh active Active
- 2014-06-09 TW TW103119885A patent/TW201536771A/zh unknown
-
2015
- 2015-12-09 SA SA515370253A patent/SA515370253B1/ar unknown
- 2015-12-09 PH PH12015502744A patent/PH12015502744A1/en unknown
- 2015-12-09 IL IL242997A patent/IL242997A/en not_active IP Right Cessation
-
2016
- 2016-07-15 HK HK16108380.3A patent/HK1220446A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2661259T3 (es) | 2018-03-28 |
| IL242997A (en) | 2017-04-30 |
| WO2014199933A1 (ja) | 2014-12-18 |
| HK1220446A1 (zh) | 2017-05-05 |
| US20150266869A1 (en) | 2015-09-24 |
| PL3009424T3 (pl) | 2018-03-30 |
| JP5924453B2 (ja) | 2016-05-25 |
| SG11201510125WA (en) | 2016-01-28 |
| PH12015502744A1 (en) | 2016-03-21 |
| EA028545B1 (ru) | 2017-11-30 |
| EA201592301A1 (ru) | 2016-05-31 |
| JPWO2014199933A1 (ja) | 2017-02-23 |
| EP3009424A1 (en) | 2016-04-20 |
| AR096552A1 (es) | 2016-01-13 |
| AU2014279240A1 (en) | 2016-01-07 |
| CN105308024B (zh) | 2017-10-27 |
| MX2015016965A (es) | 2016-04-25 |
| US9428501B2 (en) | 2016-08-30 |
| CN105308024A (zh) | 2016-02-03 |
| EP3009424B1 (en) | 2017-12-20 |
| KR20160018686A (ko) | 2016-02-17 |
| TW201536771A (zh) | 2015-10-01 |
| CA2914982A1 (en) | 2014-12-18 |
| EP3009424A4 (en) | 2016-11-30 |
| SA515370253B1 (ar) | 2017-03-06 |
| PT3009424T (pt) | 2018-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |