BR112015013260A2 - uso de inibidores de telomerase para o tratamento de distúrbios mieloproliferativos e neoplasias mieloproliferativas - Google Patents
uso de inibidores de telomerase para o tratamento de distúrbios mieloproliferativos e neoplasias mieloproliferativasInfo
- Publication number
- BR112015013260A2 BR112015013260A2 BR112015013260-0A BR112015013260A BR112015013260A2 BR 112015013260 A2 BR112015013260 A2 BR 112015013260A2 BR 112015013260 A BR112015013260 A BR 112015013260A BR 112015013260 A2 BR112015013260 A2 BR 112015013260A2
- Authority
- BR
- Brazil
- Prior art keywords
- myeloproliferative
- telomerase inhibitors
- treatment
- myeloproliferative disorders
- neoplasms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
resumo uso de inibidores de telomerase para o tratamento de distúrbios mieloproliferativos e neoplasias mieloproliferativas são fornecidos neste documento métodos para reduzir a proliferação de células progenitoras neoplásicas e para aliviar os sintomas associados em indivíduos diagnosticados ou com suspeita de ter distúrbios mieloproliferativos, tais como trombocitemia essencial (et). também são fornecidos neste documento métodos para usar inibidores de telomerase para manter as contagens de plaquetas sanguíneas em intervalos relativamente normais no sangue de indivíduos diagnosticados ou com supeita de ter distúrbios mieloproliferativos, tais como et.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261734941P | 2012-12-07 | 2012-12-07 | |
US61/734,941 | 2012-12-07 | ||
US201361799069P | 2013-03-15 | 2013-03-15 | |
US13/841,711 US9375485B2 (en) | 2012-12-07 | 2013-03-15 | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
US13/841,711 | 2013-03-15 | ||
US61/799,069 | 2013-03-15 | ||
US201361900347P | 2013-11-05 | 2013-11-05 | |
US61/900,347 | 2013-11-05 | ||
PCT/US2013/070437 WO2014088785A1 (en) | 2012-12-07 | 2013-11-15 | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015013260A2 true BR112015013260A2 (pt) | 2018-02-06 |
Family
ID=50883867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015013260-0A BR112015013260A2 (pt) | 2012-12-07 | 2013-11-15 | uso de inibidores de telomerase para o tratamento de distúrbios mieloproliferativos e neoplasias mieloproliferativas |
Country Status (33)
Country | Link |
---|---|
EP (3) | EP2928477B1 (pt) |
JP (5) | JP6433911B2 (pt) |
KR (2) | KR20230028590A (pt) |
CN (2) | CN104936602B (pt) |
AP (1) | AP2015008504A0 (pt) |
AU (3) | AU2013356533B2 (pt) |
BR (1) | BR112015013260A2 (pt) |
CA (2) | CA3188494A1 (pt) |
CL (2) | CL2015001530A1 (pt) |
CY (2) | CY1122169T1 (pt) |
DK (3) | DK3456333T3 (pt) |
EA (1) | EA032973B1 (pt) |
ES (2) | ES2789176T3 (pt) |
HK (2) | HK1210940A1 (pt) |
HR (2) | HRP20191784T1 (pt) |
HU (2) | HUE049858T2 (pt) |
IL (2) | IL239266B (pt) |
LT (2) | LT2928477T (pt) |
MA (2) | MA38193B1 (pt) |
ME (1) | ME03538B (pt) |
MX (3) | MX2015007169A (pt) |
MY (1) | MY180634A (pt) |
NZ (1) | NZ708920A (pt) |
PH (1) | PH12015501282A1 (pt) |
PL (2) | PL3456333T3 (pt) |
PT (2) | PT3456333T (pt) |
RS (2) | RS60401B1 (pt) |
SG (3) | SG10202103341SA (pt) |
SI (2) | SI3456333T1 (pt) |
TN (1) | TN2015000249A1 (pt) |
UA (2) | UA117116C2 (pt) |
WO (1) | WO2014088785A1 (pt) |
ZA (2) | ZA201504124B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE054463T2 (hu) | 2004-07-02 | 2021-09-28 | Geron Corp | Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise |
AU2014346840B2 (en) * | 2013-11-06 | 2020-02-06 | Mayo Foundation For Medical Education And Research | Methods and materials for treating hematological malignancies |
SI3286203T1 (sl) | 2015-04-23 | 2020-10-30 | Geron Corporation | Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli |
EP3318276A1 (en) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
WO2019023667A1 (en) | 2017-07-28 | 2019-01-31 | Janssen Biotech, Inc. | METHODS OF TREATING MYELODYSPLASTIC SYNDROME |
CA3098606A1 (en) * | 2018-04-30 | 2019-11-07 | Kartos Therapeutics, Inc. | Methods of treating cancer |
CN115666588A (zh) * | 2019-11-04 | 2023-01-31 | 美国杰龙生物医药公司 | Janus激酶抑制剂和端粒酶抑制剂用于治疗骨髓增殖性肿瘤的用途 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5489508A (en) | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
US5656638A (en) | 1995-04-18 | 1997-08-12 | Geron Corporation | Telomerase inhibitors |
US5760062A (en) | 1995-04-18 | 1998-06-02 | Geron Corporation | Telomerase inhibitors |
US5863936A (en) | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
US5770613A (en) | 1995-09-29 | 1998-06-23 | Geron Corporation | Telomerase inhibitors |
US5767278A (en) | 1995-10-06 | 1998-06-16 | Geron Corporation | Telomerase inhibitors |
US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
US6444650B1 (en) | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
EP0951568A1 (en) | 1996-12-20 | 1999-10-27 | Geron Corporation | Methods for detecting and inhibiting the rna component of telomerase |
US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
CA2515000A1 (en) * | 2003-01-31 | 2004-08-19 | Jessie L.-S. Au | Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors |
CN1244592C (zh) * | 2003-07-11 | 2006-03-08 | 暨南大学 | 抑制白血病细胞端粒酶活性的反义核酸及其应用 |
KR101298493B1 (ko) | 2003-09-09 | 2013-08-21 | 제론 코포레이션 | 텔로머라제 억제를 위한 변형 올리고뉴클레오티드 |
US20050282893A1 (en) | 2004-01-30 | 2005-12-22 | Au Jessie L | Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors |
HUE054463T2 (hu) | 2004-07-02 | 2021-09-28 | Geron Corp | Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise |
FR2877013A1 (fr) | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
US20060166221A1 (en) | 2005-01-21 | 2006-07-27 | Bahou Wadie F | Methods of diagnosing essential thrombocythemia |
ATE553198T1 (de) | 2005-04-15 | 2012-04-15 | Geron Corp | Behandlung von krebs durch die kombinierte hemmung der proteasom- und telomeraseaktivitäten |
WO2006113426A2 (en) * | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and tubulin activities |
US20070224598A1 (en) | 2006-03-15 | 2007-09-27 | The Methodist Hospital Research Institute | System and method for detection of mutations in JAK2 polynucleotides |
US20080021013A1 (en) | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
CN101220044B (zh) * | 2008-01-21 | 2010-06-02 | 中国药科大学 | 端粒酶抑制剂及其制备方法和用途 |
-
2013
- 2013-11-15 PT PT181966904T patent/PT3456333T/pt unknown
- 2013-11-15 HU HUE18196690A patent/HUE049858T2/hu unknown
- 2013-11-15 AP AP2015008504A patent/AP2015008504A0/xx unknown
- 2013-11-15 PL PL18196690T patent/PL3456333T3/pl unknown
- 2013-11-15 MX MX2015007169A patent/MX2015007169A/es active IP Right Grant
- 2013-11-15 BR BR112015013260-0A patent/BR112015013260A2/pt not_active Application Discontinuation
- 2013-11-15 JP JP2015546492A patent/JP6433911B2/ja active Active
- 2013-11-15 DK DK18196690.4T patent/DK3456333T3/da active
- 2013-11-15 RS RS20200723A patent/RS60401B1/sr unknown
- 2013-11-15 MA MA38193A patent/MA38193B1/fr unknown
- 2013-11-15 CA CA3188494A patent/CA3188494A1/en active Pending
- 2013-11-15 RS RSP20191271 patent/RS59363B1/sr unknown
- 2013-11-15 SG SG10202103341SA patent/SG10202103341SA/en unknown
- 2013-11-15 AU AU2013356533A patent/AU2013356533B2/en active Active
- 2013-11-15 ME MEP-2019-273A patent/ME03538B/me unknown
- 2013-11-15 DK DK19187756.2T patent/DK3646876T3/da active
- 2013-11-15 SG SG10201802926XA patent/SG10201802926XA/en unknown
- 2013-11-15 WO PCT/US2013/070437 patent/WO2014088785A1/en active Application Filing
- 2013-11-15 EA EA201590878A patent/EA032973B1/ru unknown
- 2013-11-15 LT LTEP13861008.4T patent/LT2928477T/lt unknown
- 2013-11-15 DK DK13861008.4T patent/DK2928477T3/da active
- 2013-11-15 MA MA45504A patent/MA45504B1/fr unknown
- 2013-11-15 MY MYPI2015001459A patent/MY180634A/en unknown
- 2013-11-15 EP EP13861008.4A patent/EP2928477B1/en active Active
- 2013-11-15 EP EP18196690.4A patent/EP3456333B8/en active Active
- 2013-11-15 CN CN201380069553.6A patent/CN104936602B/zh active Active
- 2013-11-15 UA UAA201505480A patent/UA117116C2/uk unknown
- 2013-11-15 CN CN202010575187.3A patent/CN111617252A/zh active Pending
- 2013-11-15 KR KR1020237005641A patent/KR20230028590A/ko not_active Application Discontinuation
- 2013-11-15 SI SI201331716T patent/SI3456333T1/sl unknown
- 2013-11-15 PT PT138610084T patent/PT2928477T/pt unknown
- 2013-11-15 LT LTEP18196690.4T patent/LT3456333T/lt unknown
- 2013-11-15 HU HUE13861008A patent/HUE045098T2/hu unknown
- 2013-11-15 ES ES18196690T patent/ES2789176T3/es active Active
- 2013-11-15 PL PL13861008T patent/PL2928477T3/pl unknown
- 2013-11-15 SG SG11201504383TA patent/SG11201504383TA/en unknown
- 2013-11-15 ES ES13861008T patent/ES2744790T3/es active Active
- 2013-11-15 SI SI201331556T patent/SI2928477T1/sl unknown
- 2013-11-15 UA UAA201800703A patent/UA126015C2/uk unknown
- 2013-11-15 CA CA2892907A patent/CA2892907C/en active Active
- 2013-11-15 KR KR1020157017240A patent/KR102294819B1/ko active IP Right Grant
- 2013-11-15 NZ NZ708920A patent/NZ708920A/en unknown
- 2013-11-15 EP EP19187756.2A patent/EP3646876B1/en active Active
-
2015
- 2015-06-04 CL CL2015001530A patent/CL2015001530A1/es unknown
- 2015-06-05 MX MX2022015437A patent/MX2022015437A/es unknown
- 2015-06-05 MX MX2020003276A patent/MX2020003276A/es unknown
- 2015-06-05 TN TNP2015000249A patent/TN2015000249A1/fr unknown
- 2015-06-05 PH PH12015501282A patent/PH12015501282A1/en unknown
- 2015-06-07 IL IL23926615A patent/IL239266B/en active IP Right Grant
- 2015-06-08 ZA ZA2015/04124A patent/ZA201504124B/en unknown
- 2015-11-27 HK HK15111700.1A patent/HK1210940A1/xx unknown
-
2016
- 2016-01-08 HK HK16100186.6A patent/HK1212226A1/xx unknown
-
2017
- 2017-08-24 CL CL2017002156A patent/CL2017002156A1/es unknown
- 2017-12-04 JP JP2017232485A patent/JP6998191B2/ja active Active
-
2018
- 2018-12-20 AU AU2018282364A patent/AU2018282364A1/en not_active Abandoned
-
2019
- 2019-10-02 HR HRP20191784TT patent/HRP20191784T1/hr unknown
- 2019-10-14 CY CY20191101076T patent/CY1122169T1/el unknown
- 2019-12-23 JP JP2019231517A patent/JP2020041001A/ja active Pending
-
2020
- 2020-06-23 CY CY20201100568T patent/CY1123206T1/el unknown
- 2020-06-24 HR HRP20200993TT patent/HRP20200993T1/hr unknown
- 2020-11-09 AU AU2020267142A patent/AU2020267142A1/en active Pending
-
2021
- 2021-01-13 IL IL280144A patent/IL280144A/en unknown
- 2021-11-12 ZA ZA2021/08991A patent/ZA202108991B/en unknown
-
2022
- 2022-01-06 JP JP2022000951A patent/JP7288098B2/ja active Active
- 2022-10-12 JP JP2022163881A patent/JP2022179684A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015013260A2 (pt) | uso de inibidores de telomerase para o tratamento de distúrbios mieloproliferativos e neoplasias mieloproliferativas | |
CA2900335C (en) | Synthetic analogs of epipolythiodioxopiperazines and uses thereof | |
CL2012003745A1 (es) | Compuestos derivados de aminopirazoloquinazolinas, como inhibidores frente a la actividad fosforilante del receptor igf-1 localizado en membranas celulares; preparacion farmaceutica que los contiene; y su uso en el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias. | |
NI201500067A (es) | Compuestos de pirrolopirimidina como inhibidores de quinasa | |
GT201400147A (es) | Pirimidinas y triazinas fusionadas sustituidas y su uso | |
TR201902516T4 (tr) | Glukagon-glp-1-gıp üçlü agonist bileşikleri. | |
CL2015002609A1 (es) | 2-azabiciclos sustituidos y su uso como moduladores de rectores de orexina. | |
BR112016009200A8 (pt) | uso de um inibidor de btk e um inibidor imune do ponto de verificação | |
AR089993A1 (es) | Macrociclos peptidomimeticos | |
EA201691032A1 (ru) | Производные изохромена в качестве ингибиторов фосфоинозитид-3-киназ | |
BR112014011925A2 (pt) | mutações no receptor notch humano e seu uso | |
UY34566A (es) | 1,4?dihidropirimidinas 4,4?disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b | |
EA201270619A1 (ru) | Применение бетанехола для лечения ксеростомии | |
ECSP14026138A (es) | Uracilos sustituidos bicíclicamente y uso de los mismos | |
EA201391773A1 (ru) | Клетки-предшественники мезодермальной линии | |
BR112015021423A2 (pt) | métodos de tratamento de câncer, de células de câncer e de câncer resistente a antagonista de egfr, métodos de aumento da sensibilidade e da eficácia de tratamento de câncer e métodos de atraso, de tratamento de indivíduos com câncer e de extensão | |
UY34271A (es) | Anticuerpos anti-tie2 y usos de los mismos | |
EA201790939A1 (ru) | ТРИАЗОЛО[4,5-d]ПИРИМИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ КАННАБИНОИДНЫХ РЕЦЕПТОРОВ ТИПА 2 | |
DOP2014000114A (es) | Nuevos 2hindazoles como antagonistas del receptor ep2 | |
EA201590503A1 (ru) | Альфа-1-микроглобулин для применения в лечении заболеваний, связанных с митохондриями | |
EA201890439A1 (ru) | ИММУНООНКОЛОГИЧЕСКАЯ МЕЗОДЕРМАЛЬНАЯ КЛЕТКА-ПРЕДШЕСТВЕННИК (ioMP-КЛЕТКА) | |
CO7151543A2 (es) | Combinaciones terapéuticas y métodos para tratar el melanoma | |
CL2016000939A1 (es) | Compuestos derivados de pirimidina con actividad inhibidora de syk uso en el tratamiento de una condición inmune, enfermedades inflamatorias, trastornos alérgicos, lupus eritomatosos, epoc, bronquitis, rinitis alérgica, asma, entre otras composición farmacéutica que los comprende. | |
EA201490562A1 (ru) | Способы лечения связанной с инсультом сенсорно-двигательной недостаточности с использованием аминопиридинов | |
EA201490938A1 (ru) | Производные спиротиенопиранпиперидина в качестве антагонистов рецептора orl-1 для применения для лечения алкогольной зависимости и злоупотребления алкоголем |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: GERON CORPORATION (US) |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |