EA032973B1 - Способ облегчения симптома, являющегося следствием миелофиброза или миелодиспластического синдрома, способы уменьшения пролиферации неопластических клеток-предшественников, ослабления фиброза костного мозга у индивидуума с диагнозом или с подозрением на миелофиброз или миелодиспластический синдром - Google Patents

Способ облегчения симптома, являющегося следствием миелофиброза или миелодиспластического синдрома, способы уменьшения пролиферации неопластических клеток-предшественников, ослабления фиброза костного мозга у индивидуума с диагнозом или с подозрением на миелофиброз или миелодиспластический синдром

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Publication number
EA032973B1
EA032973B1 EA201590878A EA201590878A EA032973B1 EA 032973 B1 EA032973 B1 EA 032973B1 EA 201590878 A EA201590878 A EA 201590878A EA 201590878 A EA201590878 A EA 201590878A EA 032973 B1 EA032973 B1 EA 032973B1
Authority
EA
Eurasian Patent Office
Prior art keywords
myelofibrosis
alleviating
myelodysplastic syndrome
methods
symptom associated
Prior art date
Application number
EA201590878A
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English (en)
Other versions
EA201590878A1 (ru
Inventor
Моник Дж. Стюарт
Стивен Келси
Original Assignee
Джерон Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Джерон Корпорейшн filed Critical Джерон Корпорейшн
Publication of EA201590878A1 publication Critical patent/EA201590878A1/ru
Publication of EA032973B1 publication Critical patent/EA032973B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Предлагаются способ облегчения по меньшей мере одного симптома, являющегося следствием миелофиброза (МФ) или миелодиспластического синдрома, а также способы уменьшения пролиферации неопластических клеток-предшественников и ослабления фиброза костного мозга у индивидуума с диагнозом или с подозрением на миелофиброз или миелодиспластический синдром. Способы включают введение индивидууму клинически эффективного количества ингибитора теломеразы, который представляет собой иметелстат или его фармацевтически приемлемую соль.
EA201590878A 2012-12-07 2013-11-15 Способ облегчения симптома, являющегося следствием миелофиброза или миелодиспластического синдрома, способы уменьшения пролиферации неопластических клеток-предшественников, ослабления фиброза костного мозга у индивидуума с диагнозом или с подозрением на миелофиброз или миелодиспластический синдром EA032973B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
PCT/US2013/070437 WO2014088785A1 (en) 2012-12-07 2013-11-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms

Publications (2)

Publication Number Publication Date
EA201590878A1 EA201590878A1 (ru) 2016-04-29
EA032973B1 true EA032973B1 (ru) 2019-08-30

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EA201590878A EA032973B1 (ru) 2012-12-07 2013-11-15 Способ облегчения симптома, являющегося следствием миелофиброза или миелодиспластического синдрома, способы уменьшения пролиферации неопластических клеток-предшественников, ослабления фиброза костного мозга у индивидуума с диагнозом или с подозрением на миелофиброз или миелодиспластический синдром

Country Status (34)

Country Link
EP (3) EP3456333B8 (ru)
JP (5) JP6433911B2 (ru)
KR (3) KR102662590B1 (ru)
CN (2) CN104936602B (ru)
AP (1) AP2015008504A0 (ru)
AU (3) AU2013356533B2 (ru)
BR (1) BR112015013260A2 (ru)
CA (2) CA3188494A1 (ru)
CL (2) CL2015001530A1 (ru)
CY (2) CY1122169T1 (ru)
DK (3) DK3646876T3 (ru)
EA (1) EA032973B1 (ru)
ES (2) ES2789176T3 (ru)
FI (1) FI3646876T3 (ru)
HK (2) HK1210940A1 (ru)
HR (2) HRP20191784T1 (ru)
HU (2) HUE045098T2 (ru)
IL (2) IL239266B (ru)
LT (3) LT3456333T (ru)
MA (2) MA38193B1 (ru)
ME (1) ME03538B (ru)
MX (3) MX2015007169A (ru)
MY (1) MY180634A (ru)
NZ (1) NZ708920A (ru)
PH (1) PH12015501282A1 (ru)
PL (2) PL3456333T3 (ru)
PT (2) PT3456333T (ru)
RS (2) RS60401B1 (ru)
SG (3) SG10201802926XA (ru)
SI (2) SI3456333T1 (ru)
TN (1) TN2015000249A1 (ru)
UA (2) UA117116C2 (ru)
WO (1) WO2014088785A1 (ru)
ZA (2) ZA201504124B (ru)

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SG11201707893RA (en) * 2015-04-23 2017-11-29 Geron Corp Methods of polynucleotide preparation using multivalent cation salt compositions
EP3318276A1 (en) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
BR112020001749A2 (pt) * 2017-07-28 2020-07-21 Geron Corporation métodos de tratamento da síndrome mielodisplásica
JOP20200273A1 (ar) * 2018-04-30 2020-11-01 Kartos Therapeutics Inc طرق علاج السرطان
TW202133854A (zh) * 2019-11-04 2021-09-16 美商傑龍公司 詹納斯(janus)激酶抑制劑及端粒酶抑制劑於治療骨髓增生性腫瘤之用途

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HUE049858T2 (hu) 2020-11-30
MX2015007169A (es) 2016-03-31
LT3456333T (lt) 2020-06-25
KR102662590B1 (ko) 2024-05-03
IL280144A (en) 2021-03-01
IL239266B (en) 2019-11-28
DK2928477T3 (da) 2019-10-07
EP3646876A1 (en) 2020-05-06
MX2022015437A (es) 2023-01-11
MX2020003276A (es) 2020-07-20
CA3188494A1 (en) 2014-06-12
JP7288098B2 (ja) 2023-06-06
PL3456333T3 (pl) 2020-09-21
DK3456333T3 (da) 2020-05-18
AU2020267142B2 (en) 2024-05-16
FI3646876T3 (fi) 2024-05-14
EA201590878A1 (ru) 2016-04-29
SG10202103341SA (en) 2021-05-28
CA2892907A1 (en) 2014-06-12
HK1212226A1 (en) 2016-06-10
UA117116C2 (uk) 2018-06-25
UA126015C2 (uk) 2022-08-03
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
PT2928477T (pt) 2019-10-25
AU2020267142A1 (en) 2020-12-03
TN2015000249A1 (en) 2016-10-03
EP3456333A1 (en) 2019-03-20
AU2013356533A1 (en) 2014-06-12
PH12015501282B1 (en) 2015-08-24
EP2928477B1 (en) 2019-07-24
WO2014088785A1 (en) 2014-06-12
NZ748134A (en) 2020-10-30
ZA202108991B (en) 2023-05-31
KR20210107906A (ko) 2021-09-01
SI2928477T1 (sl) 2019-11-29
MA45504A1 (fr) 2020-05-29
EP2928477A1 (en) 2015-10-14
JP2022050537A (ja) 2022-03-30
ME03538B (me) 2020-07-20
CY1123206T1 (el) 2021-10-29
JP6998191B2 (ja) 2022-02-04
DK3646876T3 (da) 2024-05-06
EP3646876B1 (en) 2024-02-14
PT3456333T (pt) 2020-06-01
CN104936602A (zh) 2015-09-23
AU2018282364A1 (en) 2019-05-23
HRP20191784T1 (hr) 2019-12-27
CL2015001530A1 (es) 2016-03-28
PH12015501282A1 (en) 2015-08-24
MA45504B1 (fr) 2021-10-29
EP2928477A4 (en) 2016-09-21
NZ708920A (en) 2020-08-28
CN104936602B (zh) 2020-07-17
ES2789176T3 (es) 2020-10-26
SI3456333T1 (sl) 2020-10-30
SG11201504383TA (en) 2015-07-30
BR112015013260A2 (pt) 2018-02-06
KR20230028590A (ko) 2023-02-28
CL2017002156A1 (es) 2018-05-04
ES2744790T3 (es) 2020-02-26
MA38193A1 (fr) 2017-12-29
CY1122169T1 (el) 2020-11-25
JP2018035196A (ja) 2018-03-08
KR20150091130A (ko) 2015-08-07
JP6433911B2 (ja) 2018-12-05
ZA201504124B (en) 2017-05-31
LT3646876T (lt) 2024-05-10
HK1210940A1 (en) 2016-05-13
JP2022179684A (ja) 2022-12-02
KR102294819B1 (ko) 2021-09-01
WO2014088785A8 (en) 2015-07-16
RS59363B1 (sr) 2019-11-29
EP3456333B1 (en) 2020-04-01
CA2892907C (en) 2023-03-21
JP2020041001A (ja) 2020-03-19
MY180634A (en) 2020-12-03
SG10201802926XA (en) 2018-05-30
PL2928477T3 (pl) 2020-03-31
LT2928477T (lt) 2019-10-10
MA38193B1 (fr) 2018-12-31
RS60401B1 (sr) 2020-07-31
JP2016504307A (ja) 2016-02-12
CN111617252A (zh) 2020-09-04
EP3456333B8 (en) 2020-05-13
AP2015008504A0 (en) 2015-06-30
IL239266A0 (en) 2015-07-30
AU2013356533B2 (en) 2018-09-27

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