MX2022015437A - Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas. - Google Patents

Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Info

Publication number
MX2022015437A
MX2022015437A MX2022015437A MX2022015437A MX2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A
Authority
MX
Mexico
Prior art keywords
myeloproliferative
telomerase inhibitors
treatment
myeloproliferative disorders
disorders
Prior art date
Application number
MX2022015437A
Other languages
English (en)
Inventor
Monic J Stuart
Stephen Kelsey
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Publication of MX2022015437A publication Critical patent/MX2022015437A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

En la presente se proporcionan métodos para reducir la proliferación de células progenitoras neoplásicas y aliviar los síntomas asociados en individuos diagnosticados con MPN o MDS o que se cree que tienen trastornos mieloproliferativos, tal como la trombocitopenia esencial (ET). En la presente también se proporcionan métodos para usar inhibidores de la telomerasa para mantener los conteos de plaquetas en la sangre en intervalos relativamente normales en la sangre de individuos diagnosticados o que se sospecha que tienen trastornos mieloproliferativos, tales como ET.
MX2022015437A 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas. MX2022015437A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05

Publications (1)

Publication Number Publication Date
MX2022015437A true MX2022015437A (es) 2023-01-11

Family

ID=50883867

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2015007169A MX372753B (es) 2012-12-07 2013-11-15 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.
MX2022015437A MX2022015437A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.
MX2020003276A MX2020003276A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015007169A MX372753B (es) 2012-12-07 2013-11-15 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020003276A MX2020003276A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Country Status (37)

Country Link
EP (3) EP3456333B8 (es)
JP (6) JP6433911B2 (es)
KR (4) KR20230028590A (es)
CN (2) CN104936602B (es)
AP (1) AP2015008504A0 (es)
AU (4) AU2013356533B2 (es)
BR (1) BR112015013260A2 (es)
CA (2) CA3188494A1 (es)
CL (2) CL2015001530A1 (es)
CY (3) CY1122169T1 (es)
DK (3) DK2928477T3 (es)
EA (1) EA032973B1 (es)
ES (3) ES2982897T3 (es)
FI (2) FI3646876T3 (es)
FR (1) FR25C1016I2 (es)
HK (1) HK1210940A1 (es)
HR (3) HRP20191784T1 (es)
HU (4) HUE049858T2 (es)
IL (3) IL280144B2 (es)
LT (4) LT3646876T (es)
MA (2) MA38193B1 (es)
ME (1) ME03538B (es)
MX (3) MX372753B (es)
MY (2) MY180634A (es)
NL (1) NL301326I2 (es)
NZ (1) NZ708920A (es)
PH (2) PH12019501008A1 (es)
PL (3) PL3646876T3 (es)
PT (3) PT2928477T (es)
RS (2) RS60401B1 (es)
SG (3) SG10202103341SA (es)
SI (3) SI3456333T1 (es)
SM (2) SMT201900567T1 (es)
TN (1) TN2015000249A1 (es)
UA (3) UA128370C2 (es)
WO (1) WO2014088785A1 (es)
ZA (3) ZA201504124B (es)

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CN100558739C (zh) 2004-07-02 2009-11-11 杰龙公司 合成被保护的3’-氨基核苷单体
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
SG11201600815WA (en) 2013-08-07 2016-03-30 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
RS58659B1 (sr) * 2013-11-06 2019-05-31 Mayo Found Medical Education & Res Postupci i materijali za tretiranje hematoloških maligniteta
CN113564168B (zh) * 2015-04-23 2024-10-25 美国杰龙生物医药公司 使用多价阳离子盐组合物制备多核苷酸的方法
EP3318276A1 (en) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
WO2019023667A1 (en) * 2017-07-28 2019-01-31 Janssen Biotech, Inc. METHODS OF TREATING MYELODYSPLASTIC SYNDROME
IL308399B2 (en) 2018-04-30 2025-08-01 Kartos Therapeutics Inc Methods of treating cancer
EP3801476A4 (en) * 2018-05-25 2022-07-06 Kartos Therapeutics, Inc. METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS
CN112770783B (zh) * 2018-07-31 2025-02-25 美国杰龙生物医药公司 鉴定可能从端粒酶抑制剂治疗中受益的患者的方法
EP3887537A4 (en) 2018-11-29 2023-04-12 Geron Corporation METHODS OF TREATMENT OF MYELODYSPLASTIC SYNDROME
TW202133854A (zh) 2019-11-04 2021-09-16 美商傑龍公司 詹納斯(janus)激酶抑制劑及端粒酶抑制劑於治療骨髓增生性腫瘤之用途
JP2021157248A (ja) * 2020-03-25 2021-10-07 パイオニア株式会社 状況出力装置
CN115776909A (zh) * 2020-07-17 2023-03-10 美国杰龙生物医药公司 皮下端粒酶抑制剂组合物及其使用方法
JP2024504367A (ja) * 2021-01-22 2024-01-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア がんを治療及び改善するための方法
WO2024259369A1 (en) * 2023-06-14 2024-12-19 Rarecells Inc. Compositions targeting giant cells in blood disorders

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UA128370C2 (uk) 2024-06-26
RS59363B1 (sr) 2019-11-29
FI3646876T3 (fi) 2024-05-14
CN111617252A (zh) 2020-09-04
HK1212226A1 (en) 2016-06-10
HK1210940A1 (zh) 2016-05-13
CN104936602B (zh) 2020-07-17
WO2014088785A8 (en) 2015-07-16
AU2013356533A1 (en) 2014-06-12
JP2020041001A (ja) 2020-03-19
AU2013356533B2 (en) 2018-09-27
CL2017002156A1 (es) 2018-05-04
HUS2500019I1 (hu) 2025-05-28
EP2928477A1 (en) 2015-10-14
MA38193A1 (fr) 2017-12-29
CN104936602A (zh) 2015-09-23
ES2789176T3 (es) 2020-10-26
KR20150091130A (ko) 2015-08-07
JP7288098B2 (ja) 2023-06-06
AU2020267142B2 (en) 2024-05-16
AU2020267142C1 (en) 2024-08-08
IL239266B (en) 2019-11-28
CL2015001530A1 (es) 2016-03-28
IL280144B1 (en) 2025-01-01
EP2928477A4 (en) 2016-09-21
PH12015501282B1 (en) 2015-08-24
SI3456333T1 (sl) 2020-10-30
IL317233A (en) 2025-01-01
MA45504A1 (fr) 2020-05-29
LTPA2025517I1 (es) 2025-05-26
PT2928477T (pt) 2019-10-25
CA2892907C (en) 2023-03-21
DK3646876T3 (da) 2024-05-06
DK3456333T3 (da) 2020-05-18
AU2018282364A1 (en) 2019-05-23
EP3456333B8 (en) 2020-05-13
JP6433911B2 (ja) 2018-12-05
JP2016504307A (ja) 2016-02-12
MA45504B1 (fr) 2021-10-29
PL2928477T3 (pl) 2020-03-31
PL3646876T3 (pl) 2024-07-22
EP2928477B1 (en) 2019-07-24
KR20250114449A (ko) 2025-07-29
CA3188494A1 (en) 2014-06-12
ME03538B (me) 2020-07-20
ZA202212327B (en) 2025-03-26
HRP20191784T1 (hr) 2019-12-27
IL280144A (en) 2021-03-01
MX2020003276A (es) 2020-07-20
JP2022050537A (ja) 2022-03-30
JP2025109842A (ja) 2025-07-25
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HUE049858T2 (hu) 2020-11-30
KR20230028590A (ko) 2023-02-28
JP2022179684A (ja) 2022-12-02
ZA201504124B (en) 2017-05-31
PH12015501282A1 (en) 2015-08-24
SI3646876T1 (sl) 2024-07-31
SG11201504383TA (en) 2015-07-30
RS60401B1 (sr) 2020-07-31
PL3456333T3 (pl) 2020-09-21
FR25C1016I1 (fr) 2025-06-20
NL301326I2 (nl) 2025-07-31
PT3646876T (pt) 2024-05-15
HRP20240624T1 (hr) 2024-08-02
HUE066402T2 (hu) 2024-07-28
KR20210107906A (ko) 2021-09-01
ES2982897T3 (es) 2024-10-18
AU2024203138A1 (en) 2024-07-25
MX2015007169A (es) 2016-03-31
SMT201900567T1 (it) 2019-11-13
KR102662590B1 (ko) 2024-05-03
SI2928477T1 (sl) 2019-11-29
EP3456333B1 (en) 2020-04-01
LT2928477T (lt) 2019-10-10
CA2892907A1 (en) 2014-06-12
ZA202108991B (en) 2023-05-31
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
LT3646876T (lt) 2024-05-10
CY1122169T1 (el) 2020-11-25
EA032973B1 (ru) 2019-08-30
TN2015000249A1 (en) 2016-10-03
FR25C1016I2 (fr) 2026-04-17
SMT202000328T1 (it) 2020-07-08
SG10202103341SA (en) 2021-05-28
EA201590878A1 (ru) 2016-04-29
LT3456333T (lt) 2020-06-25
UA117116C2 (uk) 2018-06-25
PT3456333T (pt) 2020-06-01
MA38193B1 (fr) 2018-12-31
PH12019501008A1 (en) 2022-11-14
NZ748134A (en) 2020-10-30
JP2018035196A (ja) 2018-03-08
FIC20250019I1 (fi) 2025-05-07
CY2025015I2 (el) 2026-02-25
ES2744790T3 (es) 2020-02-26
EP3646876B1 (en) 2024-02-14
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AP2015008504A0 (en) 2015-06-30
KR102294819B1 (ko) 2021-09-01
CY2025015I1 (el) 2026-02-25
IL239266A0 (en) 2015-07-30
DK2928477T3 (da) 2019-10-07
EP3646876A1 (en) 2020-05-06
MY180634A (en) 2020-12-03
JP6998191B2 (ja) 2022-02-04
WO2014088785A1 (en) 2014-06-12
UA126015C2 (uk) 2022-08-03
EP3456333A1 (en) 2019-03-20
MX372753B (es) 2020-06-26
BR112015013260A2 (pt) 2018-02-06
SG10201802926XA (en) 2018-05-30
IL280144B2 (en) 2025-05-01
NZ708920A (en) 2020-08-28
AU2020267142A1 (en) 2020-12-03

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