HUE054463T2 - Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise - Google Patents

Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise

Info

Publication number
HUE054463T2
HUE054463T2 HUE17184430A HUE17184430A HUE054463T2 HU E054463 T2 HUE054463 T2 HU E054463T2 HU E17184430 A HUE17184430 A HU E17184430A HU E17184430 A HUE17184430 A HU E17184430A HU E054463 T2 HUE054463 T2 HU E054463T2
Authority
HU
Hungary
Prior art keywords
synthesis
protected
amino
nucleoside monomers
phosphoramidite nucleoside
Prior art date
Application number
HUE17184430A
Other languages
English (en)
Inventor
Sergei M Gryaznov
Krisztina Pongracz
Daria Zielinska
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of HUE054463T2 publication Critical patent/HUE054463T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
HUE17184430A 2004-07-02 2005-06-30 Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise HUE054463T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58519304P 2004-07-02 2004-07-02

Publications (1)

Publication Number Publication Date
HUE054463T2 true HUE054463T2 (hu) 2021-09-28

Family

ID=35478430

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE05768112A HUE037166T2 (hu) 2004-07-02 2005-06-30 Védett 3'-amino-nukleozid monomerek szintézise
HUE17184430A HUE054463T2 (hu) 2004-07-02 2005-06-30 Védett 3'-amino 5'-foszforamidit nukleozid monomerek szintézise

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE05768112A HUE037166T2 (hu) 2004-07-02 2005-06-30 Védett 3'-amino-nukleozid monomerek szintézise

Country Status (18)

Country Link
US (8) US7485717B2 (hu)
EP (2) EP1778711B1 (hu)
KR (1) KR101279393B1 (hu)
CN (1) CN100558739C (hu)
CA (1) CA2571601C (hu)
CY (2) CY1119536T1 (hu)
DK (2) DK1778711T3 (hu)
ES (2) ES2643296T3 (hu)
HK (1) HK1252664A1 (hu)
HR (2) HRP20171705T1 (hu)
HU (2) HUE037166T2 (hu)
LT (2) LT3296312T (hu)
ME (1) ME02933B (hu)
PL (2) PL1778711T3 (hu)
PT (2) PT1778711T (hu)
RS (2) RS61840B1 (hu)
SI (2) SI1778711T1 (hu)
WO (1) WO2006014387A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3682903A1 (en) 2003-09-09 2020-07-22 Geron Corporation Modified oligonucleotides for telomerase inhibition
EP1694842B1 (en) 2003-11-04 2011-03-23 Geron Corporation Rna amidates and thioamidates for rnai
PT1778711T (pt) 2004-07-02 2017-10-19 Geron Corp Síntese de monómeros nucleosídeos 3'-amino protegidos
WO2007127163A2 (en) * 2006-04-24 2007-11-08 Geron Corporation Cns-tumor treatment method and composition
HUE041448T2 (hu) 2006-10-30 2019-05-28 Geron Corp Kombinált telomerázgátló és gemcitabin rák kezelésére
WO2008112129A2 (en) * 2007-03-09 2008-09-18 Geron Corporation Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors
HUE027213T2 (hu) 2008-10-17 2016-10-28 Geron Corp Eljárás páciens telomerázgátló terápiára való érzékenységének azonosítására
WO2014085632A1 (en) 2012-11-30 2014-06-05 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
UA117116C2 (uk) 2012-12-07 2018-06-25 Джерон Корпорейшн Використання інгібітора теломерази для лікування мієлопроліферативних неоплазм
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
CN104231008B (zh) * 2013-06-07 2017-03-01 沈阳药科大学 核苷类药物5’‑位氨基酸酯的区域选择性合成方法
EP3052512A4 (en) 2013-09-30 2017-02-22 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
SI3286203T1 (sl) 2015-04-23 2020-10-30 Geron Corporation Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli
PT3652187T (pt) * 2017-07-10 2021-12-16 Geron Corp Processo melhorado para a preparação de imetelstat
CN117143942A (zh) * 2023-10-30 2023-12-01 泰兴合全药业有限公司 3’-氨基-2’,3’-双脱氧鸟苷5’-三磷酸的合成方法

Family Cites Families (30)

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US4046720A (en) 1974-01-17 1977-09-06 California Institute Of Technology Crosslinked, porous, polyacrylate beads
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US5185444A (en) * 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
DE69120821T2 (de) 1990-08-31 1997-01-23 Univ Minnesota Polyethylenglykol-Derivate für Festphasenanwendungen
US5281701A (en) 1991-07-12 1994-01-25 Applied Biosystems, Inc. Process and compounds for RNA synthesis
US5476925A (en) * 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
AU704549B2 (en) * 1994-03-18 1999-04-29 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5705621A (en) 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
WO1998028442A1 (en) 1996-12-20 1998-07-02 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US5998604A (en) * 1997-09-15 1999-12-07 The Perkin-Elmer Corporation Polynucleotide purification method
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
DE60038495T2 (de) * 1999-09-10 2009-04-09 Geron Corp., Menlo Park Oligonukleotid n3'-p5' thiophosphoramidate: ihre synthese und verwendung
WO2001053307A1 (en) 2000-01-21 2001-07-26 Geron Corporation 2'-arabino-fluorooligonucleotide n3'→p5'phosphoramidates: their synthesis and use
JP2002060341A (ja) 2000-08-21 2002-02-26 Terumo Corp 止血剤
EP1365754A2 (en) 2001-01-30 2003-12-03 Medstar Research Institute Inhibition of proteasomes to prevent restenosis
US7563618B2 (en) * 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
AU2002245717A1 (en) 2001-03-23 2002-10-08 Geron Corporation Oligonucleotide conjugates
EP3682903A1 (en) 2003-09-09 2020-07-22 Geron Corporation Modified oligonucleotides for telomerase inhibition
US20120329858A1 (en) 2010-08-04 2012-12-27 Geron Corporation Modified oligonucleotides for telomerase inhibition
EP1694842B1 (en) 2003-11-04 2011-03-23 Geron Corporation Rna amidates and thioamidates for rnai
PT1778711T (pt) 2004-07-02 2017-10-19 Geron Corp Síntese de monómeros nucleosídeos 3'-amino protegidos
TWI442965B (zh) 2006-11-01 2014-07-01 Biogen Idec Inc 使用低ｐＨ及二價陽離子分離生物巨分子的方法
UA117116C2 (uk) 2012-12-07 2018-06-25 Джерон Корпорейшн Використання інгібітора теломерази для лікування мієлопроліферативних неоплазм
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Also Published As

Publication number Publication date
EP3296312B1 (en) 2021-03-17
EP3296312A1 (en) 2018-03-21
CA2571601C (en) 2013-01-08
LT3296312T (lt) 2021-06-10
CA2571601A1 (en) 2006-02-09
US7485717B2 (en) 2009-02-03
WO2006014387A1 (en) 2006-02-09
KR101279393B1 (ko) 2013-07-04
US20060009636A1 (en) 2006-01-12
HRP20171705T1 (hr) 2017-12-15
EP1778711B1 (en) 2017-08-16
CY1119536T1 (el) 2018-03-07
ES2868452T3 (es) 2021-10-21
LT1778711T (lt) 2017-10-25
US20240034748A1 (en) 2024-02-01
CN1997658A (zh) 2007-07-11
US20090105468A1 (en) 2009-04-23
US20190031707A1 (en) 2019-01-31
US20150038692A1 (en) 2015-02-05
ES2643296T3 (es) 2017-11-22
SI3296312T1 (sl) 2021-08-31
PT3296312T (pt) 2021-05-11
EP1778711A1 (en) 2007-05-02
RS61840B1 (sr) 2021-06-30
KR20070042155A (ko) 2007-04-20
ME02933B (me) 2018-04-20
HK1252664A1 (zh) 2019-05-31
US20160362440A1 (en) 2016-12-15
US10035815B2 (en) 2018-07-31
US20230089101A1 (en) 2023-03-23
PT1778711T (pt) 2017-10-19
DK3296312T3 (da) 2021-05-03
CN100558739C (zh) 2009-11-11
RS56361B1 (sr) 2017-12-29
US20200377543A1 (en) 2020-12-03
US10738073B2 (en) 2020-08-11
PL1778711T3 (pl) 2018-01-31
HUE037166T2 (hu) 2018-08-28
DK1778711T3 (en) 2017-10-02
US9365606B2 (en) 2016-06-14
US8748593B2 (en) 2014-06-10
HRP20210787T1 (hr) 2021-06-25
PL3296312T3 (pl) 2021-10-25
SI1778711T1 (sl) 2017-11-30
CY1124335T1 (el) 2022-07-22

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