DK3296312T3 - Syntese af beskyttede 3'-amino-5'-phosphoramidit-nukleosidmonomerer - Google Patents

Syntese af beskyttede 3'-amino-5'-phosphoramidit-nukleosidmonomerer Download PDF

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Publication number
DK3296312T3
DK3296312T3 DK17184430.1T DK17184430T DK3296312T3 DK 3296312 T3 DK3296312 T3 DK 3296312T3 DK 17184430 T DK17184430 T DK 17184430T DK 3296312 T3 DK3296312 T3 DK 3296312T3
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Prior art keywords
synthesis
protected
amino
nucleoside monomers
phosphoramidite nucleoside
Prior art date
Application number
DK17184430.1T
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English (en)
Inventor
Sergei M Gryaznov
Krisztina Pongracz
Daria Zielinska
Original Assignee
Geron Corp
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Publication of DK3296312T3 publication Critical patent/DK3296312T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
DK17184430.1T 2004-07-02 2005-06-30 Syntese af beskyttede 3'-amino-5'-phosphoramidit-nukleosidmonomerer DK3296312T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58519304P 2004-07-02 2004-07-02
EP05768112.4A EP1778711B1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3'-amino nucleoside monomers

Publications (1)

Publication Number Publication Date
DK3296312T3 true DK3296312T3 (da) 2021-05-03

Family

ID=35478430

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05768112.4T DK1778711T3 (da) 2004-07-02 2005-06-30 Syntese af beskyttede 3'-aminonukleosidmonomerer
DK17184430.1T DK3296312T3 (da) 2004-07-02 2005-06-30 Syntese af beskyttede 3'-amino-5'-phosphoramidit-nukleosidmonomerer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05768112.4T DK1778711T3 (da) 2004-07-02 2005-06-30 Syntese af beskyttede 3'-aminonukleosidmonomerer

Country Status (18)

Country Link
US (8) US7485717B2 (da)
EP (2) EP1778711B1 (da)
KR (1) KR101279393B1 (da)
CN (1) CN100558739C (da)
CA (1) CA2571601C (da)
CY (2) CY1119536T1 (da)
DK (2) DK1778711T3 (da)
ES (2) ES2868452T3 (da)
HK (1) HK1252664A1 (da)
HR (2) HRP20171705T1 (da)
HU (2) HUE037166T2 (da)
LT (2) LT1778711T (da)
ME (1) ME02933B (da)
PL (2) PL1778711T3 (da)
PT (2) PT1778711T (da)
RS (2) RS56361B1 (da)
SI (2) SI1778711T1 (da)
WO (1) WO2006014387A1 (da)

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CN101293908B (zh) 2003-09-09 2015-05-06 杰龙公司 用于端粒酶抑制的改性寡核苷酸
DE602004031975D1 (de) 2003-11-04 2011-05-05 Geron Corp Rna-amidate und thioamidateur rnai
DK1778711T3 (da) 2004-07-02 2017-10-02 Geron Corp Syntese af beskyttede 3'-aminonukleosidmonomerer
WO2007127163A2 (en) * 2006-04-24 2007-11-08 Geron Corporation Cns-tumor treatment method and composition
EP2898887B1 (en) 2006-10-30 2018-09-26 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
WO2008112129A2 (en) * 2007-03-09 2008-09-18 Geron Corporation Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors
DK3029154T3 (da) 2008-10-17 2017-12-11 Geron Corp Fremgangsmåde til identificering af en patients følsomhed over for en telomerase-inhiberende terapi
KR102348240B1 (ko) 2012-11-30 2022-01-10 제론 코포레이션 텔로머라제 억제자로 세포 증식성 질환 치료용 진단 마커
KR102294819B1 (ko) 2012-12-07 2021-09-01 제론 코포레이션 골증식성 장애 및 골증식성 신생물의 치료를 위한 텔로메라제 저해제들의 용도
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
CN104231008B (zh) * 2013-06-07 2017-03-01 沈阳药科大学 核苷类药物5’‑位氨基酸酯的区域选择性合成方法
JP6794258B2 (ja) 2013-09-30 2020-12-02 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ オリゴヌクレオチドについてのホスホロジアミデート骨格結合
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
TN2017000411A1 (en) 2015-04-23 2019-01-16 Geron Corp Methods of polynucleotide preparation using multivalent cation salt compositions
JP7199410B2 (ja) 2017-07-10 2023-01-05 ジェロン・コーポレーション 改善されたイメテルスタットの調製方法
CN117143942A (zh) * 2023-10-30 2023-12-01 泰兴合全药业有限公司 3’-氨基-2’,3’-双脱氧鸟苷5’-三磷酸的合成方法

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US5185444A (en) * 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
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PL316434A1 (en) * 1994-03-18 1997-01-06 Lynx Therapeutics Oligonucleotidic phosphoramides n3'-p5', their compositions, synthesising and hydridising methods as well as immunological properties in respect to nuclease
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
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JP2002060341A (ja) 2000-08-21 2002-02-26 Terumo Corp 止血剤
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CN101293908B (zh) 2003-09-09 2015-05-06 杰龙公司 用于端粒酶抑制的改性寡核苷酸
DE602004031975D1 (de) 2003-11-04 2011-05-05 Geron Corp Rna-amidate und thioamidateur rnai
DK1778711T3 (da) 2004-07-02 2017-10-02 Geron Corp Syntese af beskyttede 3'-aminonukleosidmonomerer
JP5732196B2 (ja) 2006-11-01 2015-06-10 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． 低ｐＨおよび二価カチオンを用いる生物高分子を単離する方法
KR102294819B1 (ko) 2012-12-07 2021-09-01 제론 코포레이션 골증식성 장애 및 골증식성 신생물의 치료를 위한 텔로메라제 저해제들의 용도
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Also Published As

Publication number Publication date
EP3296312B1 (en) 2021-03-17
US20150038692A1 (en) 2015-02-05
HRP20210787T1 (hr) 2021-06-25
CA2571601A1 (en) 2006-02-09
PL3296312T3 (pl) 2021-10-25
KR101279393B1 (ko) 2013-07-04
HK1252664A1 (zh) 2019-05-31
CN1997658A (zh) 2007-07-11
CA2571601C (en) 2013-01-08
SI3296312T1 (sl) 2021-08-31
US20090105468A1 (en) 2009-04-23
ME02933B (me) 2018-04-20
US10738073B2 (en) 2020-08-11
US20230089101A1 (en) 2023-03-23
ES2643296T3 (es) 2017-11-22
US9365606B2 (en) 2016-06-14
LT1778711T (lt) 2017-10-25
US8748593B2 (en) 2014-06-10
DK1778711T3 (da) 2017-10-02
HUE037166T2 (hu) 2018-08-28
RS56361B1 (sr) 2017-12-29
CN100558739C (zh) 2009-11-11
RS61840B1 (sr) 2021-06-30
CY1119536T1 (el) 2018-03-07
SI1778711T1 (sl) 2017-11-30
PT1778711T (pt) 2017-10-19
EP1778711A1 (en) 2007-05-02
US20060009636A1 (en) 2006-01-12
US20240034748A1 (en) 2024-02-01
PL1778711T3 (pl) 2018-01-31
US20160362440A1 (en) 2016-12-15
KR20070042155A (ko) 2007-04-20
US20200377543A1 (en) 2020-12-03
HUE054463T2 (hu) 2021-09-28
EP1778711B1 (en) 2017-08-16
PT3296312T (pt) 2021-05-11
US7485717B2 (en) 2009-02-03
EP3296312A1 (en) 2018-03-21
ES2868452T3 (es) 2021-10-21
US10035815B2 (en) 2018-07-31
WO2006014387A1 (en) 2006-02-09
LT3296312T (lt) 2021-06-10
US20190031707A1 (en) 2019-01-31
HRP20171705T1 (hr) 2017-12-15
CY1124335T1 (el) 2022-07-22

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