EA201490938A1 - Производные спиротиенопиранпиперидина в качестве антагонистов рецептора orl-1 для применения для лечения алкогольной зависимости и злоупотребления алкоголем - Google Patents

Производные спиротиенопиранпиперидина в качестве антагонистов рецептора orl-1 для применения для лечения алкогольной зависимости и злоупотребления алкоголем

Info

Publication number
EA201490938A1
EA201490938A1 EA201490938A EA201490938A EA201490938A1 EA 201490938 A1 EA201490938 A1 EA 201490938A1 EA 201490938 A EA201490938 A EA 201490938A EA 201490938 A EA201490938 A EA 201490938A EA 201490938 A1 EA201490938 A1 EA 201490938A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alcohol
orl
antagonists
receptor
spirothyene
Prior art date
Application number
EA201490938A
Other languages
English (en)
Other versions
EA022874B1 (ru
Inventor
Линда Рорик Кен
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201490938A1 publication Critical patent/EA201490938A1/ru
Publication of EA022874B1 publication Critical patent/EA022874B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Предложено применение антагонистов рецептора ORL-1 формулыдля лечения нарушений, связанных с употреблением алкоголя.
EA201490938A 2011-12-06 2012-11-29 Производные спиротиенопиранпиперидина в качестве антагонистов рецептора orl-1 для применения для лечения алкогольной зависимости и злоупотребления алкоголем EA022874B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161567242P 2011-12-06 2011-12-06
PCT/US2012/066918 WO2013085781A1 (en) 2011-12-06 2012-11-29 Spirothienopyran- piperidine derivatives as orl-1 receptor antagonists for their use in the treatment of alcohol dependence and abuse

Publications (2)

Publication Number Publication Date
EA201490938A1 true EA201490938A1 (ru) 2014-09-30
EA022874B1 EA022874B1 (ru) 2016-03-31

Family

ID=47279166

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490938A EA022874B1 (ru) 2011-12-06 2012-11-29 Производные спиротиенопиранпиперидина в качестве антагонистов рецептора orl-1 для применения для лечения алкогольной зависимости и злоупотребления алкоголем

Country Status (28)

Country Link
US (1) US9371335B2 (ru)
EP (1) EP2787995B1 (ru)
JP (1) JP6002778B2 (ru)
KR (1) KR101638265B1 (ru)
CN (1) CN103987387B (ru)
AP (1) AP3880A (ru)
AU (1) AU2012348140B2 (ru)
BR (1) BR112014012849A2 (ru)
CA (1) CA2853500C (ru)
DK (1) DK2787995T3 (ru)
EA (1) EA022874B1 (ru)
ES (1) ES2600911T3 (ru)
HK (1) HK1196943A1 (ru)
HR (1) HRP20161351T1 (ru)
HU (1) HUE029439T2 (ru)
IL (1) IL232654A (ru)
LT (1) LT2787995T (ru)
MX (1) MX352997B (ru)
MY (1) MY172809A (ru)
PL (1) PL2787995T3 (ru)
PT (1) PT2787995T (ru)
RS (1) RS55182B1 (ru)
SG (1) SG11201402745UA (ru)
SI (1) SI2787995T1 (ru)
TW (1) TWI582096B (ru)
UA (1) UA113859C2 (ru)
WO (1) WO2013085781A1 (ru)
ZA (1) ZA201403927B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105821A1 (es) * 2015-09-09 2017-11-15 Lilly Co Eli COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T
DK3589637T3 (da) * 2017-03-02 2021-06-14 Lilly Co Eli Forbindelser, der er anvendelige til inhibering af ROR-GAMMA-T
PL3589638T3 (pl) 2017-03-02 2021-09-27 Eli Lilly And Company Związki użyteczne do hamowania ror-gamma-t
CN109400618B (zh) * 2018-11-09 2021-08-10 中国药科大学 一种色满衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140032A (en) * 1990-10-01 1992-08-18 Radecki Thomas E Drug therapy for alcohol abusers
EP1873150A1 (en) * 2006-06-30 2008-01-02 Nikem Research S.R.L. Fluorinated indoleamides useful as ligands of the ORL-1 receptor
EP2089030B1 (en) * 2006-10-16 2011-09-14 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
CA2781041C (en) * 2009-11-16 2015-01-06 Eli Lilly And Company Spiropiperidine compounds as orl-1 receptor antagonists
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors

Also Published As

Publication number Publication date
AP3880A (en) 2016-10-31
TWI582096B (zh) 2017-05-11
ZA201403927B (en) 2016-01-27
DK2787995T3 (en) 2016-11-28
CN103987387B (zh) 2016-12-28
LT2787995T (lt) 2016-11-25
HUE029439T2 (en) 2017-02-28
JP2015502956A (ja) 2015-01-29
WO2013085781A1 (en) 2013-06-13
AP2014007675A0 (en) 2014-06-30
SI2787995T1 (sl) 2016-10-28
EP2787995B1 (en) 2016-08-17
BR112014012849A2 (pt) 2017-06-13
MY172809A (en) 2019-12-12
AU2012348140A1 (en) 2014-05-22
IL232654A0 (en) 2014-06-30
CA2853500C (en) 2016-10-04
JP6002778B2 (ja) 2016-10-05
AU2012348140B2 (en) 2015-09-17
KR101638265B1 (ko) 2016-07-08
MX352997B (es) 2017-12-15
EP2787995A1 (en) 2014-10-15
PL2787995T3 (pl) 2017-02-28
US20140309251A1 (en) 2014-10-16
CA2853500A1 (en) 2013-06-13
EA022874B1 (ru) 2016-03-31
RS55182B1 (sr) 2017-01-31
HK1196943A1 (zh) 2014-12-24
ES2600911T3 (es) 2017-02-13
US9371335B2 (en) 2016-06-21
MX2014006824A (es) 2015-02-12
PT2787995T (pt) 2016-09-21
CN103987387A (zh) 2014-08-13
UA113859C2 (xx) 2017-03-27
HRP20161351T1 (hr) 2016-12-02
TW201335163A (zh) 2013-09-01
SG11201402745UA (en) 2014-06-27
IL232654A (en) 2017-09-28
NZ624201A (en) 2016-06-24
KR20140088894A (ko) 2014-07-11

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KZ RU