HK1196943A1 - 作為用於治療酒精依賴和濫用的 受體拮抗劑的螺噻吩並吡喃-呱啶衍生物 - Google Patents

作為用於治療酒精依賴和濫用的 受體拮抗劑的螺噻吩並吡喃-呱啶衍生物

Info

Publication number
HK1196943A1
HK1196943A1 HK14110358.9A HK14110358A HK1196943A1 HK 1196943 A1 HK1196943 A1 HK 1196943A1 HK 14110358 A HK14110358 A HK 14110358A HK 1196943 A1 HK1196943 A1 HK 1196943A1
Authority
HK
Hong Kong
Prior art keywords
orl
spirothienopyran
abuse
treatment
receptor antagonists
Prior art date
Application number
HK14110358.9A
Other languages
English (en)
Inventor
Linda Rorick Kehn
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1196943A1 publication Critical patent/HK1196943A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HK14110358.9A 2011-12-06 2014-10-16 作為用於治療酒精依賴和濫用的 受體拮抗劑的螺噻吩並吡喃-呱啶衍生物 HK1196943A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161567242P 2011-12-06 2011-12-06
PCT/US2012/066918 WO2013085781A1 (en) 2011-12-06 2012-11-29 Spirothienopyran- piperidine derivatives as orl-1 receptor antagonists for their use in the treatment of alcohol dependence and abuse

Publications (1)

Publication Number Publication Date
HK1196943A1 true HK1196943A1 (zh) 2014-12-24

Family

ID=47279166

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14110358.9A HK1196943A1 (zh) 2011-12-06 2014-10-16 作為用於治療酒精依賴和濫用的 受體拮抗劑的螺噻吩並吡喃-呱啶衍生物

Country Status (28)

Country Link
US (1) US9371335B2 (zh)
EP (1) EP2787995B1 (zh)
JP (1) JP6002778B2 (zh)
KR (1) KR101638265B1 (zh)
CN (1) CN103987387B (zh)
AP (1) AP3880A (zh)
AU (1) AU2012348140B2 (zh)
BR (1) BR112014012849A2 (zh)
CA (1) CA2853500C (zh)
DK (1) DK2787995T3 (zh)
EA (1) EA022874B1 (zh)
ES (1) ES2600911T3 (zh)
HK (1) HK1196943A1 (zh)
HR (1) HRP20161351T1 (zh)
HU (1) HUE029439T2 (zh)
IL (1) IL232654A (zh)
LT (1) LT2787995T (zh)
MX (1) MX352997B (zh)
MY (1) MY172809A (zh)
PL (1) PL2787995T3 (zh)
PT (1) PT2787995T (zh)
RS (1) RS55182B1 (zh)
SG (1) SG11201402745UA (zh)
SI (1) SI2787995T1 (zh)
TW (1) TWI582096B (zh)
UA (1) UA113859C2 (zh)
WO (1) WO2013085781A1 (zh)
ZA (1) ZA201403927B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105821A1 (es) * 2015-09-09 2017-11-15 Lilly Co Eli COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T
US11008336B2 (en) 2017-03-02 2021-05-18 Eli Lilly And Company Compounds useful for inhibiting RORγt
DK3589637T3 (da) * 2017-03-02 2021-06-14 Lilly Co Eli Forbindelser, der er anvendelige til inhibering af ROR-GAMMA-T
CN109400618B (zh) * 2018-11-09 2021-08-10 中国药科大学 一种色满衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140032A (en) * 1990-10-01 1992-08-18 Radecki Thomas E Drug therapy for alcohol abusers
EP1873150A1 (en) * 2006-06-30 2008-01-02 Nikem Research S.R.L. Fluorinated indoleamides useful as ligands of the ORL-1 receptor
US8207201B2 (en) * 2006-10-16 2012-06-26 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
US20120214784A1 (en) * 2009-11-16 2012-08-23 Eli Lilly And Company Spiropiperidine compounds as orl-1 receptor antagonists
UA107943C2 (en) * 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors

Also Published As

Publication number Publication date
CA2853500A1 (en) 2013-06-13
KR20140088894A (ko) 2014-07-11
HUE029439T2 (en) 2017-02-28
SI2787995T1 (sl) 2016-10-28
EA022874B1 (ru) 2016-03-31
US9371335B2 (en) 2016-06-21
MX352997B (es) 2017-12-15
JP2015502956A (ja) 2015-01-29
US20140309251A1 (en) 2014-10-16
MY172809A (en) 2019-12-12
CN103987387A (zh) 2014-08-13
DK2787995T3 (en) 2016-11-28
NZ624201A (en) 2016-06-24
AP3880A (en) 2016-10-31
EA201490938A1 (ru) 2014-09-30
EP2787995B1 (en) 2016-08-17
SG11201402745UA (en) 2014-06-27
PT2787995T (pt) 2016-09-21
TW201335163A (zh) 2013-09-01
PL2787995T3 (pl) 2017-02-28
RS55182B1 (sr) 2017-01-31
TWI582096B (zh) 2017-05-11
MX2014006824A (es) 2015-02-12
AU2012348140B2 (en) 2015-09-17
ES2600911T3 (es) 2017-02-13
UA113859C2 (xx) 2017-03-27
ZA201403927B (en) 2016-01-27
JP6002778B2 (ja) 2016-10-05
WO2013085781A1 (en) 2013-06-13
EP2787995A1 (en) 2014-10-15
LT2787995T (lt) 2016-11-25
KR101638265B1 (ko) 2016-07-08
CA2853500C (en) 2016-10-04
AU2012348140A1 (en) 2014-05-22
AP2014007675A0 (en) 2014-06-30
HRP20161351T1 (hr) 2016-12-02
IL232654A0 (en) 2014-06-30
CN103987387B (zh) 2016-12-28
BR112014012849A2 (pt) 2017-06-13
IL232654A (en) 2017-09-28

Similar Documents

Publication Publication Date Title
HK1249401A1 (zh) Ep-4受體拮抗劑在治療il-23介導疾病中的用途
HRP20151103T1 (en) Substituted triazolopyridines and their use as ttk inhibitors
ZA201307797B (en) Bicyclic heterocycle compounds and their uses in therapy
FI3785730T3 (fi) Alumiiniyhdisteet terapiassa ja rokotteissa käyttöä varten
HK1207304A1 (zh) 用於治療 活性過度病人之 拮抗劑
EP2709991A4 (en) USE OF CXCR4 ANTAGONISTS
AP2013007331A0 (en) TRPM8 antagonists and their use in treatments
GB201120993D0 (en) Novel compounds and their use in therapy
ZA201309683B (en) Neutraling prolactin receptor antibody mat3 and its therapeutic use
HK1198031A1 (zh) 有用於治療濫用藥物及酒精的 衍生物
EP2719697A4 (en) PYRIDONAPHTHYRIDINE PI3K / MTOR DUALHEMMER AND THE PREPARATION AND USE THEREOF
EP2817304A4 (en) NOVEL COMPOUNDS AND THEIR THERAPEUTIC USE
HK1196943A1 (zh) 作為用於治療酒精依賴和濫用的 受體拮抗劑的螺噻吩並吡喃-呱啶衍生物
ZA201206898B (en) Piperazinotriazines as pi3k inhibitors for use in the treatment antiproliferatiive disorders
GB201207102D0 (en) CRHR1 antagonists for use in the treatment of patients having CRH overactivity
GB201109846D0 (en) Artemisinin and its derivatives for use in medicine
PT2709991T (pt) Uso de antagonistas de cxcr4 para tratar síndrome de whim, mielocatexia, neutropenia e linfocitopenia

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20201201