AU2001288899A1 - Inhibitors of nadh:ubiquinone oxidoreductase - Google Patents

Inhibitors of nadh:ubiquinone oxidoreductase

Info

Publication number
AU2001288899A1
AU2001288899A1 AU2001288899A AU8889901A AU2001288899A1 AU 2001288899 A1 AU2001288899 A1 AU 2001288899A1 AU 2001288899 A AU2001288899 A AU 2001288899A AU 8889901 A AU8889901 A AU 8889901A AU 2001288899 A1 AU2001288899 A1 AU 2001288899A1
Authority
AU
Australia
Prior art keywords
nadh
inhibitors
ubiquinone oxidoreductase
ubiquinone
oxidoreductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001288899A
Inventor
Guo-Qiang Cao
Kyriacos C Nicolaou
Jeffrey Pfefferkorn
Anthony J. Roecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU2001288899A1 publication Critical patent/AU2001288899A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001288899A 2000-09-06 2001-09-06 Inhibitors of nadh:ubiquinone oxidoreductase Abandoned AU2001288899A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23063000P 2000-09-06 2000-09-06
US60230630 2000-09-06
PCT/US2001/028104 WO2002020008A1 (en) 2000-09-06 2001-09-06 Inhibitors of nadh:ubiquinone oxidoreductase

Publications (1)

Publication Number Publication Date
AU2001288899A1 true AU2001288899A1 (en) 2002-03-22

Family

ID=22865967

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001288899A Abandoned AU2001288899A1 (en) 2000-09-06 2001-09-06 Inhibitors of nadh:ubiquinone oxidoreductase

Country Status (3)

Country Link
US (1) US7410998B2 (en)
AU (1) AU2001288899A1 (en)
WO (1) WO2002020008A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
ES2767973T3 (en) 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Contrast agents for applications involving perfusion imaging
WO2010006189A2 (en) * 2008-07-11 2010-01-14 Emory University Small-molecule inhibitors of hif and angiogenesis
US9687571B2 (en) 2009-04-15 2017-06-27 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
SG183134A1 (en) 2010-02-08 2012-09-27 Lantheus Medical Imaging Inc Methods and apparatus for synthesizing imaging agents, and intermediates thereof
CN102911180B (en) * 2011-06-30 2015-10-14 四川大学 8H-chromene [2,3-f]-4-ketone derivatives and its production and use
US9381260B2 (en) 2011-12-27 2016-07-05 Emory University Hypoxia inducible factor-1 pathway inhibitors and uses as anticancer and imaging agents
CN103382195B (en) * 2012-05-04 2015-06-10 四川大学 Benzopyran chalcone compound, and preparation method and application thereof
EP2871187B1 (en) * 2012-07-04 2017-09-20 SNU R&DB Foundation Novel compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
KR101414722B1 (en) * 2013-03-25 2014-07-04 서울대학교산학협력단 A novel Deguelin derivatives or its pharmaceutically acceptable salts and pharmaceutical composition containing the same as an active ingredient
PT3009424T (en) * 2013-06-10 2018-01-16 Astellas Pharma Inc Bicyclic nitrogen-containing aromatic heterocyclic amide compound
BR112017012355A2 (en) * 2014-12-09 2018-02-27 Astellas Pharma Inc. pharmaceutical composition comprising aromatic heterocyclic amide compound containing bicyclic nitrogen as active ingredient
MA41157A (en) * 2014-12-09 2017-10-17 Astellas Pharma Inc PHARMACEUTICAL COMPOSITION CONSISTING OF AN AROMATIC HETEROCYCLIC AMIDE COMPOUND CONTAINING BICYCLIC NITROGEN AS ACTIVE COMPONENT
MA41158A (en) * 2014-12-09 2017-10-17 Astellas Pharma Inc PHARMACEUTICAL COMPOSITION CONSISTING OF AN AROMATIC HETEROCYCLIC AMIDE COMPOUND CONTAINING BICYCLIC NITROGEN AS ACTIVE INGREDIENT
KR20170135904A (en) * 2015-04-14 2017-12-08 아카데미아 시니카 Anti-VEGFR2 human antibodies for anti-angiogenesis and targeted cancer therapy
ITUA20162695A1 (en) * 2016-03-30 2017-09-30 Alberto Chiarugi USE OF COMPOUND WITH ANTITUMORAL ACTION
KR102293709B1 (en) * 2018-08-23 2021-09-16 주식회사 테라캔 A Novel Quinoline Derivatives or its Pharmaceutically Acceptable Salts and Pharmaceutical Composition Containing the Same as an Active Ingredient
KR102304532B1 (en) * 2018-08-23 2021-09-24 주식회사 테라캔 A Novel Benzopyran Derivatives or its Pharmaceutically Acceptable Salts and Pharmaceutical Composition Containing the Same as an Active Ingredient
CN111454286B (en) * 2020-05-09 2023-08-08 合肥工业大学 Synthesis method of difluoro alkenyl boron compound

Also Published As

Publication number Publication date
US20040034239A1 (en) 2004-02-19
US7410998B2 (en) 2008-08-12
WO2002020008A1 (en) 2002-03-14

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