AR096552A1 - Compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico - Google Patents

Compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico

Info

Publication number
AR096552A1
AR096552A1 ARP140102215A ARP140102215A AR096552A1 AR 096552 A1 AR096552 A1 AR 096552A1 AR P140102215 A ARP140102215 A AR P140102215A AR P140102215 A ARP140102215 A AR P140102215A AR 096552 A1 AR096552 A1 AR 096552A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
halogen
amida
same
compound containing
Prior art date
Application number
ARP140102215A
Other languages
English (en)
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of AR096552A1 publication Critical patent/AR096552A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se provee un compuesto que es útil como un agente para el tratamiento de cáncer de mama. Reivindicación 1: Un compuesto de la fórmula (1) o una de sus sales, en la fórmula, R¹ es arilo o heteroarilo que contiene nitrógeno monocíclico, cada uno de los cuales puede estar sustituido con grupos seleccionados del grupo que consiste en halógeno, alquilo inferior, -O-alquilo inferior, halógeno-alquilo inferior, -O- halógeno-alquilo inferior, -CN, dimetilamino y cicloalquilo; X es CH, N o C; ⁻ ⁻ ⁻ ⁻ ⁻ es i) un enlace simple en el caso donde X es CH o N y ii) un enlace doble en el caso donde X es C; Y es un grupo cíclico seleccionado del grupo de fórmulas (2) aquí, Y¹ es CRʰ o N; Y² es CRⁱ o N, siempre que Y¹ e Y² no sean N al mismo tiempo; Rᵃ, Rʰ y Rⁱ, que son iguales o diferentes entre sí, son H o halógeno; Rᵇ es H o alquilo inferior; Rᶜ es alquilo inferior; Y³ es CH o N; Rᵈ y Rᵉ son iguales o diferentes entre sí, son H, halógeno, alquilo inferior; Rᶠ es H o alquilo inferior; Y⁴ es O ó S; Y⁵ es CH o N; Y⁶ es CH o N; Rᵍ es H o alquilo inferior; R² es H o alquilo inferior; y R³ y R⁴, que son iguales o diferentes entre sí, son H, halógeno, alquilo inferior -O-alquilo inferior, halógeno-alquilo inferior, -O-halógeno-alquilo inferior cicloalquilo, o -CN, o R³ y R⁴ pueden formar 2,2-difluoro-1,3-benzodioxol mediante la unión entre sí con el anillo benceno al cual R³ y R⁴ están enlazados.
ARP140102215A 2013-06-10 2014-06-09 Compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico AR096552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013122180 2013-06-10

Publications (1)

Publication Number Publication Date
AR096552A1 true AR096552A1 (es) 2016-01-13

Family

ID=52022229

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140102215A AR096552A1 (es) 2013-06-10 2014-06-09 Compuesto de amida heterocíclica aromática que contiene nitrógeno bicíclico

Country Status (21)

Country Link
US (1) US9428501B2 (es)
EP (1) EP3009424B1 (es)
JP (1) JP5924453B2 (es)
KR (1) KR20160018686A (es)
CN (1) CN105308024B (es)
AR (1) AR096552A1 (es)
AU (1) AU2014279240A1 (es)
BR (1) BR112015030248A2 (es)
CA (1) CA2914982A1 (es)
EA (1) EA028545B1 (es)
ES (1) ES2661259T3 (es)
HK (1) HK1220446A1 (es)
IL (1) IL242997A (es)
MX (1) MX2015016965A (es)
PH (1) PH12015502744A1 (es)
PL (1) PL3009424T3 (es)
PT (1) PT3009424T (es)
SA (1) SA515370253B1 (es)
SG (1) SG11201510125WA (es)
TW (1) TW201536771A (es)
WO (1) WO2014199933A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016068099A1 (ja) * 2014-10-28 2016-05-06 塩野義製薬株式会社 Ampk活性化作用を有する複素環誘導体
MA41158A (fr) * 2014-12-09 2017-10-17 Astellas Pharma Inc Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenat de l'azote bicyclique en tant que principe actif
MA41157A (fr) * 2014-12-09 2017-10-17 Astellas Pharma Inc Composition pharmaceutique comprenant un composé d'amide hétérocyclique aromatique contenant de l'azote bicyclique en tant que composant actif
JPWO2016093255A1 (ja) * 2014-12-09 2017-09-21 アステラス製薬株式会社 二環式含窒素芳香族ヘテロ環アミド化合物を有効成分とする医薬組成物
US20190135747A1 (en) * 2016-05-12 2019-05-09 Regents Of The University Of Minnesota Indole and indazole cyanocinnamate compounds and therapeutic uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19932314A1 (de) * 1999-07-10 2001-01-11 Merck Patent Gmbh Benzofuranderivate
WO2002020008A1 (en) * 2000-09-06 2002-03-14 The Scripps Research Institute Inhibitors of nadh:ubiquinone oxidoreductase
NZ570524A (en) * 2006-03-28 2011-08-26 High Point Pharmaceuticals Llc Benzothiazoles having histamine H3 receptor activity
US7432255B2 (en) * 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
AU2008339572B2 (en) * 2007-12-21 2012-05-10 Astrazeneca Ab Bicyclic derivatives for use in the treatment of androgen receptor associated conditions
WO2009082667A1 (en) * 2007-12-21 2009-07-02 3M Innovative Properties Company Microbiological systems and methods of fluid sample analysis
WO2009132136A1 (en) * 2008-04-23 2009-10-29 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
ES2823350T3 (es) * 2010-07-29 2021-05-06 Rigel Pharmaceuticals Inc Compuestos heterocíclicos que activan AMPK y métodos de uso de los mismos
US9409884B2 (en) 2012-02-01 2016-08-09 Rigel Pharmaceuticals, Inc. 5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them

Also Published As

Publication number Publication date
EA028545B1 (ru) 2017-11-30
IL242997A (en) 2017-04-30
PH12015502744A1 (en) 2016-03-21
EP3009424A4 (en) 2016-11-30
PT3009424T (pt) 2018-01-16
CA2914982A1 (en) 2014-12-18
HK1220446A1 (zh) 2017-05-05
WO2014199933A1 (ja) 2014-12-18
SG11201510125WA (en) 2016-01-28
CN105308024A (zh) 2016-02-03
US20150266869A1 (en) 2015-09-24
US9428501B2 (en) 2016-08-30
PL3009424T3 (pl) 2018-03-30
ES2661259T3 (es) 2018-03-28
EA201592301A1 (ru) 2016-05-31
TW201536771A (zh) 2015-10-01
CN105308024B (zh) 2017-10-27
JPWO2014199933A1 (ja) 2017-02-23
JP5924453B2 (ja) 2016-05-25
EP3009424B1 (en) 2017-12-20
MX2015016965A (es) 2016-04-25
KR20160018686A (ko) 2016-02-17
SA515370253B1 (ar) 2017-03-06
EP3009424A1 (en) 2016-04-20
BR112015030248A2 (pt) 2017-07-25
AU2014279240A1 (en) 2016-01-07

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