JP2012255026A5 - - Google Patents
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- Publication number
- JP2012255026A5 JP2012255026A5 JP2012196525A JP2012196525A JP2012255026A5 JP 2012255026 A5 JP2012255026 A5 JP 2012255026A5 JP 2012196525 A JP2012196525 A JP 2012196525A JP 2012196525 A JP2012196525 A JP 2012196525A JP 2012255026 A5 JP2012255026 A5 JP 2012255026A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutical composition
- compound
- composition according
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (5)
- 式１（化１）の化合物および生理学的に許容し得る担体を含む医薬組成物。
- 経口投与のために処方された請求項１に記載の医薬組成物。
- 前記医薬組成物が錠剤又はカプセル剤であることを特徴とする請求項２に記載の医薬組成物。
- 式１（化１）の化合物又はその薬学的に許容し得る塩が任意の他の活性成分と組み合わせられることを特徴とする請求項１乃至３のいずれか１つに記載の医薬組成物。
- 前立腺疾患を処置する際に使用するための式１（化１）の化合物、又はその薬学的に許容し得る塩。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65739005P | 2005-03-02 | 2005-03-02 | |
| US60/657,390 | 2005-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558143A Division JP5130453B2 (ja) | 2005-03-02 | 2006-03-02 | 新規なｃ−１７−ヘテロアリールステロイドｃｙｐ１７阻害剤／抗アンドロゲン：合成、インビトロ生物活性、薬物動態および抗腫瘍活性 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012255026A JP2012255026A (ja) | 2012-12-27 |
| JP2012255026A5 true JP2012255026A5 (ja) | 2013-02-21 |
| JP5613206B2 JP5613206B2 (ja) | 2014-10-22 |
Family
ID=36941503
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558143A Active JP5130453B2 (ja) | 2005-03-02 | 2006-03-02 | 新規なｃ−１７−ヘテロアリールステロイドｃｙｐ１７阻害剤／抗アンドロゲン：合成、インビトロ生物活性、薬物動態および抗腫瘍活性 |
| JP2012196525A Active JP5613206B2 (ja) | 2005-03-02 | 2012-09-06 | 新規なｃ−１７−ヘテロアリールステロイドｃｙｐ１７阻害剤／抗アンドロゲン：合成、インビトロ生物活性、薬物動態および抗腫瘍活性 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558143A Active JP5130453B2 (ja) | 2005-03-02 | 2006-03-02 | 新規なｃ−１７−ヘテロアリールステロイドｃｙｐ１７阻害剤／抗アンドロゲン：合成、インビトロ生物活性、薬物動態および抗腫瘍活性 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7875599B2 (ja) |
| EP (2) | EP2206719B1 (ja) |
| JP (2) | JP5130453B2 (ja) |
| KR (1) | KR101380959B1 (ja) |
| CN (2) | CN101155823A (ja) |
| AT (1) | ATE482969T1 (ja) |
| AU (1) | AU2006218711B2 (ja) |
| BR (1) | BRPI0607523A2 (ja) |
| CA (1) | CA2599953C (ja) |
| DE (1) | DE602006017175D1 (ja) |
| DK (2) | DK1853619T3 (ja) |
| EA (1) | EA019560B1 (ja) |
| ES (2) | ES2528055T3 (ja) |
| HK (1) | HK1115387A1 (ja) |
| IL (3) | IL185608A (ja) |
| MX (1) | MX2007010593A (ja) |
| NZ (1) | NZ561571A (ja) |
| PL (2) | PL1853619T3 (ja) |
| PT (2) | PT1853619E (ja) |
| SI (2) | SI2206719T1 (ja) |
| WO (1) | WO2006093993A1 (ja) |
| ZA (1) | ZA200708106B (ja) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
| SI2206719T1 (sl) | 2005-03-02 | 2015-03-31 | University Of Maryland, Baltimore | Farmacevtski sestavek obsegajoäś 3-beta-hidroksi-17-(1-h-benzimidazol-1-il)androsta-5,16-dien |
| CA2726734C (en) | 2007-06-06 | 2014-10-07 | University Of Maryland, Baltimore | Hdac inhibitor ms-275 and aromatase inhibitors for the treatment of cancer |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| US20100048524A1 (en) * | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009120565A2 (en) * | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| WO2009129208A2 (en) * | 2008-04-14 | 2009-10-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress reponse |
| US20110190323A1 (en) | 2008-08-28 | 2011-08-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses thereof |
| CN102282133A (zh) * | 2008-10-28 | 2011-12-14 | 生物马林药物股份有限公司 | 十氢-1h-茚并喹啉酮和十氢-3h-环戊并菲啶酮cyp17抑制剂 |
| AU2010210422A1 (en) * | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
| WO2010091303A1 (en) * | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel steroidal cyp17 inhibitors/antiandrogens |
| GB2479337A (en) * | 2009-02-05 | 2011-10-05 | Tokai Pharmaceuticals Inc | Combination of a 17 alpha-hydroxylase/c17, 20-lyase inhibitor with an additional therapeutic agent |
| ES2475945T3 (es) | 2009-06-26 | 2014-07-11 | Novartis Ag | Derivados imidazolidin-2 -ona 1,3-disustituida como inhibidores de CYP 17 |
| US8791094B2 (en) | 2009-08-07 | 2014-07-29 | Tokai Pharmaceuticals, Inc. | Treatment of prostate cancer |
| WO2011059969A2 (en) * | 2009-11-13 | 2011-05-19 | Tokai Pharmaceuticals, Inc. | Mammalian metabolites of steroids |
| EP2506855A4 (en) * | 2009-11-30 | 2014-07-30 | Harbor Biosciences Inc | ANTICARCINOMA COMPOUNDS AND SCREENING METHODS |
| WO2012035078A1 (en) | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
| CA2819515A1 (en) * | 2010-12-16 | 2012-06-21 | Biomarin Pharmaceutical Inc. | Cyp11b, cyp17, and/or cyp21 inhibitors |
| CA2834224A1 (en) | 2011-04-28 | 2012-11-01 | Novartis Ag | 17.alpha.-hydroxylase/c17,20-lyase inhibitors |
| WO2013012959A1 (en) * | 2011-07-18 | 2013-01-24 | Tokai Pharmaceuticals, Inc. | Novel compositions and methods for treating prostate cancer |
| US20150005265A1 (en) * | 2011-12-22 | 2015-01-01 | Susan Stewart | Methods and compositions for combination therapy using p13k/mtor inhibitores |
| EP4066841A1 (en) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| AU2014247941C1 (en) | 2013-04-04 | 2019-10-31 | University Of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
| SG11201600525XA (en) * | 2013-08-12 | 2016-02-26 | Tokai Pharmaceuticals Inc | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| EP3505521A1 (en) | 2013-12-24 | 2019-07-03 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| CN103694299A (zh) * | 2014-01-13 | 2014-04-02 | 中国药科大学 | 甾体类雄激素受体抑制剂、其制备方法及其医药用途 |
| CN105732759A (zh) * | 2015-01-29 | 2016-07-06 | 苏州晶云药物科技有限公司 | (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法 |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| EP3316889A4 (en) | 2015-07-01 | 2018-11-14 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2017066697A1 (en) | 2015-10-14 | 2017-04-20 | Dou Qingping | Treatments and diagnostics for cancers |
| IT201600083406A1 (it) * | 2016-08-08 | 2018-02-08 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE |
| IT201600121375A1 (it) * | 2016-11-30 | 2018-05-30 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE |
| CH714173B1 (it) * | 2016-08-08 | 2021-04-15 | Ind Chimica Srl | Processo per la preparazione di 3ß-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene. |
| US20200369715A1 (en) * | 2018-02-13 | 2020-11-26 | Dana-Farber Cancer Institute, Inc. | Cyclin-dependent kinase inhibitors and methods of use |
| WO2019160890A1 (en) * | 2018-02-13 | 2019-08-22 | Dana-Farber Cancer Institute, Inc. | Cyclin-dependent kinase degraders and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA27440A (en) | 1887-08-16 | James T. Walsh | Art of making sheet metal cans, for packing meats, fruits, vegetables, etc. | |
| CH621803A5 (ja) * | 1974-08-08 | 1981-02-27 | Siphar Sa | |
| US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| US5994335A (en) | 1997-10-17 | 1999-11-30 | The University Of Maryland, Baltimore | 17-azolyl steroids useful as androgen synthesis inhibitors |
| BRPI0412989A (pt) | 2003-07-29 | 2006-10-03 | Dompe Spa | combinação farmacêutica útil para mobilização de célula-tronco |
| SI2206719T1 (sl) | 2005-03-02 | 2015-03-31 | University Of Maryland, Baltimore | Farmacevtski sestavek obsegajoäś 3-beta-hidroksi-17-(1-h-benzimidazol-1-il)androsta-5,16-dien |
-
2006
- 2006-03-02 SI SI200631883T patent/SI2206719T1/sl unknown
- 2006-03-02 DE DE602006017175T patent/DE602006017175D1/de active Active
- 2006-03-02 BR BRPI0607523-1A patent/BRPI0607523A2/pt not_active IP Right Cessation
- 2006-03-02 CN CNA2006800064632A patent/CN101155823A/zh active Pending
- 2006-03-02 PL PL06736460T patent/PL1853619T3/pl unknown
- 2006-03-02 ES ES10150763.0T patent/ES2528055T3/es active Active
- 2006-03-02 DK DK06736460.4T patent/DK1853619T3/da active
- 2006-03-02 NZ NZ561571A patent/NZ561571A/en not_active IP Right Cessation
- 2006-03-02 CA CA2599953A patent/CA2599953C/en active Active
- 2006-03-02 PT PT06736460T patent/PT1853619E/pt unknown
- 2006-03-02 US US11/817,550 patent/US7875599B2/en active Active
- 2006-03-02 AT AT06736460T patent/ATE482969T1/de active
- 2006-03-02 EP EP10150763.0A patent/EP2206719B1/en active Active
- 2006-03-02 EA EA200701872A patent/EA019560B1/ru not_active IP Right Cessation
- 2006-03-02 AU AU2006218711A patent/AU2006218711B2/en active Active
- 2006-03-02 MX MX2007010593A patent/MX2007010593A/es active IP Right Grant
- 2006-03-02 CN CN2013101036754A patent/CN103349664A/zh active Pending
- 2006-03-02 WO PCT/US2006/007143 patent/WO2006093993A1/en active Application Filing
- 2006-03-02 SI SI200630861T patent/SI1853619T1/sl unknown
- 2006-03-02 EP EP06736460A patent/EP1853619B1/en active Active
- 2006-03-02 ES ES06736460T patent/ES2353413T3/es active Active
- 2006-03-02 JP JP2007558143A patent/JP5130453B2/ja active Active
- 2006-03-02 PT PT101507630T patent/PT2206719E/pt unknown
- 2006-03-02 KR KR1020077022440A patent/KR101380959B1/ko not_active IP Right Cessation
- 2006-03-02 PL PL10150763T patent/PL2206719T3/pl unknown
- 2006-03-02 DK DK10150763.0T patent/DK2206719T3/en active
-
2007
- 2007-08-30 IL IL185608A patent/IL185608A/en not_active IP Right Cessation
- 2007-09-20 ZA ZA200708106A patent/ZA200708106B/xx unknown
-
2008
- 2008-05-14 HK HK08105362.1A patent/HK1115387A1/xx not_active IP Right Cessation
-
2011
- 2011-01-06 IL IL210478A patent/IL210478A0/en unknown
- 2011-01-06 IL IL210480A patent/IL210480A/en not_active IP Right Cessation
-
2012
- 2012-09-06 JP JP2012196525A patent/JP5613206B2/ja active Active
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