JP2011102304A5 - - Google Patents
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- JP2011102304A5 JP2011102304A5 JP2010286329A JP2010286329A JP2011102304A5 JP 2011102304 A5 JP2011102304 A5 JP 2011102304A5 JP 2010286329 A JP2010286329 A JP 2010286329A JP 2010286329 A JP2010286329 A JP 2010286329A JP 2011102304 A5 JP2011102304 A5 JP 2011102304A5
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- 0 CC[C@](CC1[C@](C)C1Cc(cc([C@](CC1)(C2N1CC=C[C@@]2(CC)[C@@]([C@@]1(*)O)O)C1(C)N1C)c1c1)c1OC)(CN(*)CCc1c(CC(OC)=O)[n]c2ccccc12)O Chemical compound CC[C@](CC1[C@](C)C1Cc(cc([C@](CC1)(C2N1CC=C[C@@]2(CC)[C@@]([C@@]1(*)O)O)C1(C)N1C)c1c1)c1OC)(CN(*)CCc1c(CC(OC)=O)[n]c2ccccc12)O 0.000 description 1
- CAAKXFHZUSSLMC-PTVYPEDCSA-N NCCCC(C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NC(CSSCCO)C(O)=O)=O)=O)=O)NC(C(CC(O)=O)NC(CC[C@@H](C(O)=O)NC(c(cc1)ccc1NCc(cn1)nc2c1N=C(N)NC2=O)=O)=O)=O Chemical compound NCCCC(C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NC(CSSCCO)C(O)=O)=O)=O)=O)NC(C(CC(O)=O)NC(CC[C@@H](C(O)=O)NC(c(cc1)ccc1NCc(cn1)nc2c1N=C(N)NC2=O)=O)=O)=O CAAKXFHZUSSLMC-PTVYPEDCSA-N 0.000 description 1
Claims (11)
- 下式の化合物、または、その薬理学的に受容可能な塩：
（式中、Ｄは、ビンクリスチン、ビンブラスチン、または、デアセチルビンブラスチンモノヒドラジドである。）
- Ｄは、デアセチルビンブラスチンモノヒドラジドであることを特徴とする、請求項１に記載の化合物。
- 下式の化合物、または、その薬理学的に受容可能な塩。
- 請求項１〜３のいずれか１項に記載の化合物と、一つ以上の、担体、希釈剤、または賦形剤、または、それらの組み合わせとを含む、製薬組成物。
- 請求項１〜３のいずれか１項に記載の化合物を含む単位投与剤であって、化合物は、宿主動物において病原性細胞集団によって引き起こされる病気の治療のために、治療学的に有効な量で存在することを特徴とする、単位投与剤。
- さらに、一つ以上の、担体、希釈剤、または賦形剤、または、それらの組み合わせを含む、請求項５に記載の単位投与剤。
- 病原性細胞集団がガンであることを特徴とする、請求項５または６に記載の単位投与剤。
- 宿主動物が人間であることを特徴とする、請求項５〜７のいずれか１項に記載の単位投与剤。
- 請求項１〜３のいずれか１項に記載の化合物、請求項４に記載の製薬組成物、または、請求項５〜８のいずれか１項に記載の単位投与剤の使用であって、宿主動物において病原性細胞集団を除去する薬を製造するための使用。
- 病原性細胞集団がガンであることを特徴とする、請求項９に記載の使用。
- 宿主動物が人間であることを特徴とする、請求項９または１０に記載の使用。
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44284503P | 2003-01-27 | 2003-01-27 | |
| US60/442,845 | 2003-01-27 | ||
| US49211903P | 2003-08-01 | 2003-08-01 | |
| US60/492,119 | 2003-08-01 | ||
| US51618803P | 2003-10-31 | 2003-10-31 | |
| US60/516,188 | 2003-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Division JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011102304A JP2011102304A (ja) | 2011-05-26 |
| JP2011102304A5 true JP2011102304A5 (ja) | 2011-09-15 |
| JP4815009B2 JP4815009B2 (ja) | 2011-11-16 |
Family
ID=32854293
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Expired - Fee Related JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
| JP2010286329A Expired - Fee Related JP4815009B2 (ja) | 2003-01-27 | 2010-12-22 | ビタミン受容体結合性薬剤送達結合体 |
| JP2011165553A Expired - Fee Related JP5721580B2 (ja) | 2003-01-27 | 2011-07-28 | ビタミン受容体結合性薬剤送達結合体 |
| JP2014246193A Withdrawn JP2015078215A (ja) | 2003-01-27 | 2014-12-04 | ビタミン受容体結合性薬剤送達結合体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Expired - Fee Related JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011165553A Expired - Fee Related JP5721580B2 (ja) | 2003-01-27 | 2011-07-28 | ビタミン受容体結合性薬剤送達結合体 |
| JP2014246193A Withdrawn JP2015078215A (ja) | 2003-01-27 | 2014-12-04 | ビタミン受容体結合性薬剤送達結合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US7601332B2 (ja) |
| EP (4) | EP1592457B1 (ja) |
| JP (4) | JP5576007B2 (ja) |
| AR (1) | AR042942A1 (ja) |
| AU (1) | AU2004210136C1 (ja) |
| CA (1) | CA2512867C (ja) |
| CY (1) | CY1113258T1 (ja) |
| DK (1) | DK1592457T3 (ja) |
| ES (1) | ES2395082T3 (ja) |
| IL (2) | IL169469A (ja) |
| NZ (1) | NZ541846A (ja) |
| PT (1) | PT1592457E (ja) |
| TW (3) | TWI367096B (ja) |
| WO (1) | WO2004069159A2 (ja) |
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