JP2016501221A5 - - Google Patents
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- JP2016501221A5 JP2016501221A5 JP2015545145A JP2015545145A JP2016501221A5 JP 2016501221 A5 JP2016501221 A5 JP 2016501221A5 JP 2015545145 A JP2015545145 A JP 2015545145A JP 2015545145 A JP2015545145 A JP 2015545145A JP 2016501221 A5 JP2016501221 A5 JP 2016501221A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- pharmaceutical composition
- composition according
- cdk4
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 4
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 claims 4
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 4
- 229940124302 mTOR inhibitor Drugs 0.000 claims 4
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 4
- 229940126062 Compound A Drugs 0.000 claims 2
- 102000013698 Cyclin-Dependent Kinase 6 Human genes 0.000 claims 2
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 2
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims 2
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 1
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims 1
Claims (10)
- サイクリン依存性キナーゼ４またはサイクリン依存性キナーゼ６（ＣＤＫ４／６）阻害剤である第１の薬剤、およびｍＴＯＲ阻害剤である第２の薬剤を含む、ＥＲ＋乳癌の治療のための医薬組成物。
- 前記薬剤が、同時に、別個に、または逐次的に投与される、請求項１に記載の医薬組成物。
- 前記ＣＤＫ阻害剤が、ＣＤＫ４／６阻害剤である、請求項１または２に記載の医薬組成物。
- 前記ＣＤＫ４／６阻害剤が、下式Ａ：
によって表される化合物Ａ、またはその薬学的に許容される塩である、請求項３に記載の医薬組成物。 - 前記ｍＴＯＲ阻害剤が、エベロリムスである、請求項１または２に記載の医薬組成物。
- サイクリン依存性キナーゼ４またはサイクリン依存性キナーゼ６（ＣＤＫ４／６）阻害剤である第１の薬剤、およびｍＴＯＲ阻害剤である第２の薬剤を含む、悪性ラブドイド腫瘍の治療のための医薬組成物。
- 前記薬剤が、同時に、別個に、または逐次的に投与される、請求項６に記載の医薬組成物。
- 前記ＣＤＫ阻害剤が、ＣＤＫ４／６阻害剤である、請求項６または７に記載の医薬組成物。
- 前記ＣＤＫ４／６阻害剤が、下式Ａ：
によって表される化合物Ａ、またはその薬学的に許容される塩である、請求項８に記載の医薬組成物。 - 前記ｍＴＯＲ阻害剤が、エベロリムスである、請求項６または７に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730661P | 2012-11-28 | 2012-11-28 | |
| US61/730,661 | 2012-11-28 | ||
| PCT/US2013/071659 WO2014085318A1 (en) | 2012-11-28 | 2013-11-25 | Combination therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018176231A Division JP2019031500A (ja) | 2012-11-28 | 2018-09-20 | 併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016501221A JP2016501221A (ja) | 2016-01-18 |
| JP2016501221A5 true JP2016501221A5 (ja) | 2017-01-12 |
Family
ID=49753505
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545145A Withdrawn JP2016501221A (ja) | 2012-11-28 | 2013-11-25 | 併用療法 |
| JP2018176231A Withdrawn JP2019031500A (ja) | 2012-11-28 | 2018-09-20 | 併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018176231A Withdrawn JP2019031500A (ja) | 2012-11-28 | 2018-09-20 | 併用療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9408847B2 (ja) |
| EP (1) | EP2925365A1 (ja) |
| JP (2) | JP2016501221A (ja) |
| KR (1) | KR20150089053A (ja) |
| CN (1) | CN104812414A (ja) |
| AU (4) | AU2013352406A1 (ja) |
| BR (1) | BR112015012197A8 (ja) |
| CA (1) | CA2891938A1 (ja) |
| HK (1) | HK1211475A1 (ja) |
| MX (1) | MX2015006809A (ja) |
| RU (1) | RU2015125307A (ja) |
| WO (1) | WO2014085318A1 (ja) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013033940A2 (pt) * | 2011-07-01 | 2017-02-14 | Novartis Ag | terapia combinada compreendendo um inibidor de cdk4/6 e um inibidor de pi3k para uso no tratamento de câncer |
| US9487530B2 (en) | 2013-03-15 | 2016-11-08 | G1 Therapeutics, Inc. | Transient protection of normal cells during chemotherapy |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| KR20220126813A (ko) | 2014-03-14 | 2022-09-16 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| RS64115B1 (sr) | 2014-03-28 | 2023-04-28 | Univ Duke | Lečenje kancera dojke upotrebom selektivnih modulatora receptora estrogena |
| WO2016040880A1 (en) | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies of alk inhibitors |
| KR20170066546A (ko) | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| AU2015333687B2 (en) | 2014-10-14 | 2021-03-18 | Dana-Farber Cancer Institute, Inc. | Antibody molecules to PD-L1 and uses thereof |
| JP6692826B2 (ja) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法 |
| CN106336412A (zh) * | 2015-07-10 | 2017-01-18 | 南开大学 | 作为cdk4/6抑制剂的2-(n-氧化芳环-2基氨基)-吡咯并嘧啶及嘌呤类化合物 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
| EP3156406A1 (en) * | 2015-10-14 | 2017-04-19 | ratiopharm GmbH | Crystalline forms of ribociclib free base |
| LT3370768T (lt) | 2015-11-03 | 2022-05-25 | Janssen Biotech, Inc. | Antikūnai, specifiškai surišantys pd-1, ir jų panaudojimas |
| AU2016369537B2 (en) | 2015-12-17 | 2024-03-14 | Novartis Ag | Antibody molecules to PD-1 and uses thereof |
| KR20220035276A (ko) * | 2016-06-22 | 2022-03-21 | 일립시스 파마 리미티드 | Ar+ 유방암 치료 방법 |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| WO2018081211A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide |
| JP7219224B2 (ja) | 2017-03-16 | 2023-02-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 乳癌の治療のための組合せ療法 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
| EA202090104A1 (ru) | 2017-06-22 | 2020-04-09 | Новартис Аг | Молекулы антител к cd73 и пути их применения |
| US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2020103922A1 (en) | 2018-11-23 | 2020-05-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Novel pharmaceutical composition and use thereof |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2589696C2 (ru) * | 2010-04-13 | 2016-07-10 | Новартис Аг | КОМБИНАЦИЯ, ВКЛЮЧАЮЩАЯ ИНГИБИТОР ЦИКЛИНЗАВИСИМОЙ КИНАЗЫ 4 ИЛИ ЦИКЛИНЗАВИСИМОЙ КИНАЗЫ 6 (CDK4/6) И ИНГИБИТОР mTOR, ДЛЯ ЛЕЧЕНИЯ РАКА |
-
2013
- 2013-11-25 CN CN201380061379.0A patent/CN104812414A/zh active Pending
- 2013-11-25 EP EP13802807.1A patent/EP2925365A1/en not_active Withdrawn
- 2013-11-25 KR KR1020157016810A patent/KR20150089053A/ko not_active Application Discontinuation
- 2013-11-25 JP JP2015545145A patent/JP2016501221A/ja not_active Withdrawn
- 2013-11-25 WO PCT/US2013/071659 patent/WO2014085318A1/en active Application Filing
- 2013-11-25 BR BR112015012197A patent/BR112015012197A8/pt not_active IP Right Cessation
- 2013-11-25 MX MX2015006809A patent/MX2015006809A/es unknown
- 2013-11-25 RU RU2015125307A patent/RU2015125307A/ru not_active Application Discontinuation
- 2013-11-25 CA CA2891938A patent/CA2891938A1/en not_active Abandoned
- 2013-11-25 AU AU2013352406A patent/AU2013352406A1/en not_active Abandoned
- 2013-11-25 US US14/646,206 patent/US9408847B2/en not_active Expired - Fee Related
-
2015
- 2015-12-14 HK HK15112282.5A patent/HK1211475A1/xx unknown
-
2016
- 2016-11-25 AU AU2016262781A patent/AU2016262781A1/en not_active Abandoned
-
2018
- 2018-01-15 AU AU2018200323A patent/AU2018200323A1/en not_active Abandoned
- 2018-09-20 JP JP2018176231A patent/JP2019031500A/ja not_active Withdrawn
-
2019
- 2019-02-08 AU AU2019200881A patent/AU2019200881A1/en not_active Ceased
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