ATE482969T1 - 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androst - 5,16-dien zur anwendung in der behandlung von prostata-erkrankungen - Google Patents

3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androst - 5,16-dien zur anwendung in der behandlung von prostata-erkrankungen

Info

Publication number
ATE482969T1
ATE482969T1 AT06736460T AT06736460T ATE482969T1 AT E482969 T1 ATE482969 T1 AT E482969T1 AT 06736460 T AT06736460 T AT 06736460T AT 06736460 T AT06736460 T AT 06736460T AT E482969 T1 ATE482969 T1 AT E482969T1
Authority
AT
Austria
Prior art keywords
diene
treatment
methods
androst
benzimidazole
Prior art date
Application number
AT06736460T
Other languages
English (en)
Inventor
Angela Brodie
Vincent Njar
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE482969T1 publication Critical patent/ATE482969T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06736460T 2005-03-02 2006-03-02 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androst - 5,16-dien zur anwendung in der behandlung von prostata-erkrankungen ATE482969T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65739005P 2005-03-02 2005-03-02
PCT/US2006/007143 WO2006093993A1 (en) 2005-03-02 2006-03-02 Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity

Publications (1)

Publication Number Publication Date
ATE482969T1 true ATE482969T1 (de) 2010-10-15

Family

ID=36941503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06736460T ATE482969T1 (de) 2005-03-02 2006-03-02 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androst - 5,16-dien zur anwendung in der behandlung von prostata-erkrankungen

Country Status (22)

Country Link
US (1) US7875599B2 (de)
EP (2) EP2206719B1 (de)
JP (2) JP5130453B2 (de)
KR (1) KR101380959B1 (de)
CN (2) CN103349664A (de)
AT (1) ATE482969T1 (de)
AU (1) AU2006218711B2 (de)
BR (1) BRPI0607523A2 (de)
CA (1) CA2599953C (de)
DE (1) DE602006017175D1 (de)
DK (2) DK2206719T3 (de)
EA (1) EA019560B1 (de)
ES (2) ES2528055T3 (de)
HK (1) HK1115387A1 (de)
IL (3) IL185608A (de)
MX (1) MX2007010593A (de)
NZ (1) NZ561571A (de)
PL (2) PL2206719T3 (de)
PT (2) PT2206719E (de)
SI (2) SI1853619T1 (de)
WO (1) WO2006093993A1 (de)
ZA (1) ZA200708106B (de)

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US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
NZ561571A (en) * 2005-03-02 2009-09-25 Univ Maryland Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
GB2454118B (en) 2007-06-06 2010-06-02 Univ Maryland Hdac inhibitors and hormone targeted drugs for the treatment of cancer
WO2009114658A2 (en) * 2008-03-12 2009-09-17 University Of Maryland, Baltimore Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer
US20100048912A1 (en) * 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009120565A2 (en) * 2008-03-25 2009-10-01 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
US8785423B2 (en) * 2008-04-14 2014-07-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases
US20110190323A1 (en) 2008-08-28 2011-08-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses thereof
CN102282133A (zh) * 2008-10-28 2011-12-14 生物马林药物股份有限公司 十氢-1h-茚并喹啉酮和十氢-3h-环戊并菲啶酮cyp17抑制剂
US8791095B2 (en) 2009-02-05 2014-07-29 Tokai Pharmaceuticals, Inc. Steroidal CYP17 inhibitors/antiandrogens
GB2514957A (en) * 2009-02-05 2014-12-10 Tokai Pharmaceuticals Inc Combination of a 17 alpha-hydroxylase/c17, 20-lyase inhibitor with an additional therapeutic agent
ES2552087T3 (es) * 2009-02-05 2015-11-25 Tokai Pharmaceuticals, Inc. Nuevos profármacos de inhibidores de CYP17 esteroidales/antiandrógenos
MA33451B1 (fr) 2009-06-26 2012-07-03 Novartis Ag Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
KR20120056267A (ko) * 2009-08-07 2012-06-01 토카이 파마슈티컬, 아이엔씨. 전립선 암의 치료
JP5956928B2 (ja) * 2009-11-13 2016-07-27 トーカイ ファーマシューティカルズ，インク． 哺乳類のステロイドの代謝物質
WO2011066582A1 (en) * 2009-11-30 2011-06-03 Harbor Biosciences, Inc. Anticancer compounds and screening method
EP2627648A1 (de) 2010-09-16 2013-08-21 Novartis AG 17a-HYDROXYLASE-C17, 20-LYASE-INHIBITOREN
RU2013132766A (ru) * 2010-12-16 2015-01-27 Байомарин Фармасьютикал Инк. Ингибиторы cyp11b, cyp17 и/или cyp21
US9029399B2 (en) 2011-04-28 2015-05-12 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
CN103813794A (zh) * 2011-07-18 2014-05-21 拓凯制药公司 用于治疗前列腺癌的新型组合物及方法
CA2859986A1 (en) * 2011-12-22 2013-06-27 Tokai Pharmaceuticals, Inc. Methods and compositions for combination therapy using pi3k/mtor inhibitors
EP2968370A4 (de) * 2013-03-14 2016-09-21 Univ Maryland Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
EP2991644B1 (de) * 2013-04-04 2020-03-25 University of Maryland, Baltimore Nichtsteroidale und steroidale verbindungen mit potenter androgenrezeptor-verminderungsregulation und wirkung gegen prostatakrebs
JP2016528252A (ja) * 2013-08-12 2016-09-15 トーカイ ファーマシューティカルズ， インコーポレイテッド アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー
MY180383A (en) 2013-12-24 2020-11-28 Harvard College Cortistatin analogues and syntheses and uses thereof
CN103694299A (zh) * 2014-01-13 2014-04-02 中国药科大学 甾体类雄激素受体抑制剂、其制备方法及其医药用途
CN105732759A (zh) * 2015-01-29 2016-07-06 苏州晶云药物科技有限公司 (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法
EP3294298A4 (de) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin-analoga, synthese und verwendungen
EP3316889A4 (de) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin-analoga sowie synthese und verwendungen davon
WO2017066697A1 (en) 2015-10-14 2017-04-20 Dou Qingping Treatments and diagnostics for cancers
IT201600121375A1 (it) * 2016-11-30 2018-05-30 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
IT201600083406A1 (it) * 2016-08-08 2018-02-08 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
ES2700901B2 (es) * 2016-08-08 2019-08-06 Ind Chimica Srl Proceso para la preparación de 3ß-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno.
AU2019222652B2 (en) * 2018-02-13 2021-09-02 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase degraders and methods of use
WO2019160889A1 (en) * 2018-02-13 2019-08-22 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase inhibitors and methods of use

Family Cites Families (6)

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CA27440A (en) 1887-08-16 James T. Walsh Art of making sheet metal cans, for packing meats, fruits, vegetables, etc.
CH621803A5 (de) * 1974-08-08 1981-02-27 Siphar Sa
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
US5994335A (en) 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
ATE513555T1 (de) 2003-07-29 2011-07-15 Dompe Spa Pharmazeutische kombination aus g-csf und plgf für blutstammzellen
NZ561571A (en) * 2005-03-02 2009-09-25 Univ Maryland Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity

Also Published As

Publication number Publication date
EA200701872A1 (ru) 2008-06-30
EP1853619A4 (de) 2009-08-26
JP5613206B2 (ja) 2014-10-22
AU2006218711A1 (en) 2006-09-08
NZ561571A (en) 2009-09-25
CA2599953C (en) 2013-08-13
MX2007010593A (es) 2008-02-20
KR101380959B1 (ko) 2014-04-04
BRPI0607523A2 (pt) 2009-09-08
SI2206719T1 (sl) 2015-03-31
DK2206719T3 (en) 2015-01-26
PL2206719T3 (pl) 2015-03-31
PT2206719E (pt) 2015-02-05
EA019560B1 (ru) 2014-04-30
US20080280864A1 (en) 2008-11-13
CN101155823A (zh) 2008-04-02
DK1853619T3 (da) 2011-01-10
JP2008536807A (ja) 2008-09-11
PL1853619T3 (pl) 2011-03-31
IL210478A0 (en) 2011-03-31
SI1853619T1 (sl) 2011-01-31
IL210480A (en) 2015-06-30
PT1853619E (pt) 2011-01-03
US7875599B2 (en) 2011-01-25
WO2006093993A1 (en) 2006-09-08
ES2353413T3 (es) 2011-03-01
CN103349664A (zh) 2013-10-16
IL185608A0 (en) 2008-01-06
IL185608A (en) 2016-06-30
CA2599953A1 (en) 2006-09-08
KR20070120119A (ko) 2007-12-21
EP2206719A3 (de) 2011-01-05
HK1115387A1 (de) 2008-11-28
AU2006218711A2 (en) 2006-09-08
EP1853619A1 (de) 2007-11-14
EP2206719A2 (de) 2010-07-14
AU2006218711B2 (en) 2010-11-11
ES2528055T3 (es) 2015-02-03
EP2206719B1 (de) 2014-10-22
JP2012255026A (ja) 2012-12-27
ZA200708106B (en) 2008-12-31
DE602006017175D1 (de) 2010-11-11
JP5130453B2 (ja) 2013-01-30
EP1853619B1 (de) 2010-09-29
IL210480A0 (en) 2011-03-31

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