PT2206719E - Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno - Google Patents
Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno Download PDFInfo
- Publication number
- PT2206719E PT2206719E PT101507630T PT10150763T PT2206719E PT 2206719 E PT2206719 E PT 2206719E PT 101507630 T PT101507630 T PT 101507630T PT 10150763 T PT10150763 T PT 10150763T PT 2206719 E PT2206719 E PT 2206719E
- Authority
- PT
- Portugal
- Prior art keywords
- diene
- methods
- androsta
- benzimidazole
- beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65739005P | 2005-03-02 | 2005-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2206719E true PT2206719E (pt) | 2015-02-05 |
Family
ID=36941503
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT101507630T PT2206719E (pt) | 2005-03-02 | 2006-03-02 | Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno |
| PT06736460T PT1853619E (pt) | 2005-03-02 | 2006-03-02 | 3-beta-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno para utilização no tratamento de uma doença da próstata |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06736460T PT1853619E (pt) | 2005-03-02 | 2006-03-02 | 3-beta-hidroxi-17-(1h-benzimidazol-1-il)androsta-5,16-dieno para utilização no tratamento de uma doença da próstata |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7875599B2 (pt) |
| EP (2) | EP1853619B1 (pt) |
| JP (2) | JP5130453B2 (pt) |
| KR (1) | KR101380959B1 (pt) |
| CN (2) | CN101155823A (pt) |
| AT (1) | ATE482969T1 (pt) |
| AU (1) | AU2006218711B2 (pt) |
| BR (1) | BRPI0607523A2 (pt) |
| CA (1) | CA2599953C (pt) |
| DE (1) | DE602006017175D1 (pt) |
| DK (2) | DK1853619T3 (pt) |
| EA (1) | EA019560B1 (pt) |
| ES (2) | ES2353413T3 (pt) |
| HK (1) | HK1115387A1 (pt) |
| IL (3) | IL185608A (pt) |
| MX (1) | MX2007010593A (pt) |
| NZ (1) | NZ561571A (pt) |
| PL (2) | PL1853619T3 (pt) |
| PT (2) | PT2206719E (pt) |
| SI (2) | SI2206719T1 (pt) |
| WO (1) | WO2006093993A1 (pt) |
| ZA (1) | ZA200708106B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
| US20100047338A1 (en) * | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| AU2006218711B2 (en) | 2005-03-02 | 2010-11-11 | University Of Maryland, Baltimore | Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| WO2008154402A2 (en) | 2007-06-06 | 2008-12-18 | University Of Maryland, Baltimore | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| WO2009114658A2 (en) * | 2008-03-12 | 2009-09-17 | University Of Maryland, Baltimore | Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer |
| US20110118219A1 (en) | 2008-03-25 | 2011-05-19 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| WO2009129208A2 (en) * | 2008-04-14 | 2009-10-22 | University Of Maryland, Baltimore | Compositions and methods of inducing endoplasmic reticulum stress reponse |
| US20110190323A1 (en) | 2008-08-28 | 2011-08-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses thereof |
| BRPI0920681A2 (pt) * | 2008-10-28 | 2015-12-29 | Biomarin Pharm Inc | inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17 |
| GB2479693B (en) * | 2009-02-05 | 2014-04-09 | Tokai Pharmaceuticals Inc | Steroidal CYP17 inhibitors and their use in the treatment of cancer and prostate hyperplasia |
| US20110319369A1 (en) * | 2009-02-05 | 2011-12-29 | Tokai Pharmaceuticals, Inc. | Combination of a 17 alpha-hydroxylase/c17, 20-lyase inhibitor with an additional therapeutic agent |
| CN102686600A (zh) * | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| JO2892B1 (en) | 2009-06-26 | 2015-09-15 | نوفارتيس ايه جي | CYP inhibitors 17 |
| CA2770092A1 (en) * | 2009-08-07 | 2011-02-10 | Tokai Pharmaceuticals, Inc. | Treatment of prostate cancer |
| US20120282331A1 (en) * | 2009-11-13 | 2012-11-08 | Tokai Pharmaceuticals, Inc. | Mammalian metabolites of steroids |
| US20110129423A1 (en) * | 2009-11-30 | 2011-06-02 | Frincke James M | Anticancer compounds and screening method |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| WO2012083112A2 (en) * | 2010-12-16 | 2012-06-21 | Biomarin Pharmaceutical Inc. | Cyp11b, cyp17, and/or cyp21 inhibitors |
| US9029399B2 (en) | 2011-04-28 | 2015-05-12 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| JP2014523445A (ja) * | 2011-07-18 | 2014-09-11 | トーカイ ファーマシューティカルズ，インク． | 前立腺癌を処置するための新規な組成物及び方法 |
| WO2013096907A1 (en) * | 2011-12-22 | 2013-06-27 | Tokai Pharmaceuticals, Inc. | Methods and compositions for combination therapy using p13k/mtor inhibitors |
| EP2968370A4 (en) | 2013-03-14 | 2016-09-21 | Univ Maryland | AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF |
| CA3151555A1 (en) | 2013-04-04 | 2014-10-09 | University Of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
| JP2016528252A (ja) | 2013-08-12 | 2016-09-15 | トーカイ ファーマシューティカルズ， インコーポレイテッド | アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー |
| BR112016014760A2 (pt) | 2013-12-24 | 2017-12-12 | Harvard College | composto, composição farmacêutica, métodos para tratamento de uma condição, para inibir e validar atividade de cinase, para modular o trajeto de b-catenina e o trajeto de tgfb/bmp em uma célula, para modular a atividade de stat1 e de hif-1-alfa em uma célula, para aumentar a expressão de bim e para preparar um composto, mutante, e, proteína |
| CN103694299A (zh) * | 2014-01-13 | 2014-04-02 | 中国药科大学 | 甾体类雄激素受体抑制剂、其制备方法及其医药用途 |
| CN105732759A (zh) * | 2015-01-29 | 2016-07-06 | 苏州晶云药物科技有限公司 | (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法 |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| US10682362B2 (en) | 2015-10-14 | 2020-06-16 | Wayne State University | Treatments and diagnostics for cancers |
| IT201600083406A1 (it) * | 2016-08-08 | 2018-02-08 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE |
| IT201600121375A1 (it) * | 2016-11-30 | 2018-05-30 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE |
| US11390645B2 (en) | 2016-08-08 | 2022-07-19 | Industriale Chimica S.R.L. | Process for the preparation of 3β-hydroxy-17-(1H-benzimidazol-1-YL) androsta-5,16-diene |
| EP3752517A4 (en) * | 2018-02-13 | 2021-10-13 | Dana-Farber Cancer Institute, Inc. | CYCLINE DEPENDENT KINASE DEGRADATION AGENTS AND METHODS OF USE |
| AU2019222651A1 (en) * | 2018-02-13 | 2020-07-23 | Dana-Farber Cancer Institute, Inc. | Cyclin-dependent kinase inhibitors and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA27440A (en) | 1887-08-16 | James T. Walsh | Art of making sheet metal cans, for packing meats, fruits, vegetables, etc. | |
| CH621803A5 (pt) * | 1974-08-08 | 1981-02-27 | Siphar Sa | |
| US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| US5994335A (en) | 1997-10-17 | 1999-11-30 | The University Of Maryland, Baltimore | 17-azolyl steroids useful as androgen synthesis inhibitors |
| CA2526244C (en) | 2003-07-29 | 2012-03-20 | Dompe S.P.A. | Pharmaceutical combination of g-csf and plgf useful for blood stem cell mobilization |
| AU2006218711B2 (en) | 2005-03-02 | 2010-11-11 | University Of Maryland, Baltimore | Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
-
2006
- 2006-03-02 AU AU2006218711A patent/AU2006218711B2/en active Active
- 2006-03-02 DE DE602006017175T patent/DE602006017175D1/de active Active
- 2006-03-02 US US11/817,550 patent/US7875599B2/en active Active
- 2006-03-02 PT PT101507630T patent/PT2206719E/pt unknown
- 2006-03-02 KR KR1020077022440A patent/KR101380959B1/ko not_active IP Right Cessation
- 2006-03-02 CA CA2599953A patent/CA2599953C/en active Active
- 2006-03-02 EA EA200701872A patent/EA019560B1/ru not_active IP Right Cessation
- 2006-03-02 SI SI200631883T patent/SI2206719T1/sl unknown
- 2006-03-02 EP EP06736460A patent/EP1853619B1/en active Active
- 2006-03-02 MX MX2007010593A patent/MX2007010593A/es active IP Right Grant
- 2006-03-02 CN CNA2006800064632A patent/CN101155823A/zh active Pending
- 2006-03-02 DK DK06736460.4T patent/DK1853619T3/da active
- 2006-03-02 BR BRPI0607523-1A patent/BRPI0607523A2/pt not_active IP Right Cessation
- 2006-03-02 DK DK10150763.0T patent/DK2206719T3/en active
- 2006-03-02 EP EP10150763.0A patent/EP2206719B1/en active Active
- 2006-03-02 AT AT06736460T patent/ATE482969T1/de active
- 2006-03-02 PL PL06736460T patent/PL1853619T3/pl unknown
- 2006-03-02 SI SI200630861T patent/SI1853619T1/sl unknown
- 2006-03-02 JP JP2007558143A patent/JP5130453B2/ja active Active
- 2006-03-02 PT PT06736460T patent/PT1853619E/pt unknown
- 2006-03-02 CN CN2013101036754A patent/CN103349664A/zh active Pending
- 2006-03-02 PL PL10150763T patent/PL2206719T3/pl unknown
- 2006-03-02 ES ES06736460T patent/ES2353413T3/es active Active
- 2006-03-02 ES ES10150763.0T patent/ES2528055T3/es active Active
- 2006-03-02 WO PCT/US2006/007143 patent/WO2006093993A1/en active Application Filing
- 2006-03-02 NZ NZ561571A patent/NZ561571A/en not_active IP Right Cessation
-
2007
- 2007-08-30 IL IL185608A patent/IL185608A/en not_active IP Right Cessation
- 2007-09-20 ZA ZA200708106A patent/ZA200708106B/xx unknown
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2008
- 2008-05-14 HK HK08105362.1A patent/HK1115387A1/xx not_active IP Right Cessation
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2011
- 2011-01-06 IL IL210478A patent/IL210478A0/en unknown
- 2011-01-06 IL IL210480A patent/IL210480A/en not_active IP Right Cessation
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2012
- 2012-09-06 JP JP2012196525A patent/JP5613206B2/ja active Active
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