PL2206719T3 - Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien - Google Patents

Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien

Info

Publication number
PL2206719T3
PL2206719T3 PL10150763T PL10150763T PL2206719T3 PL 2206719 T3 PL2206719 T3 PL 2206719T3 PL 10150763 T PL10150763 T PL 10150763T PL 10150763 T PL10150763 T PL 10150763T PL 2206719 T3 PL2206719 T3 PL 2206719T3
Authority
PL
Poland
Prior art keywords
diene
methods
androsta
benzimidazole
beta
Prior art date
Application number
PL10150763T
Other languages
English (en)
Inventor
Angela Brodie
Vincent Njar
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Publication of PL2206719T3 publication Critical patent/PL2206719T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL10150763T 2005-03-02 2006-03-02 Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien PL2206719T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65739005P 2005-03-02 2005-03-02
EP10150763.0A EP2206719B1 (en) 2005-03-02 2006-03-02 Pharmaceutical composition comprising 3-beta-hydroxy-17-(1-h-benzimidazole-1-yl)androsta-5,16-diene
EP06736460A EP1853619B1 (en) 2005-03-02 2006-03-02 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androsta-5,16-diene for use in the treatment of a prostate disease

Publications (1)

Publication Number Publication Date
PL2206719T3 true PL2206719T3 (pl) 2015-03-31

Family

ID=36941503

Family Applications (2)

Application Number Title Priority Date Filing Date
PL06736460T PL1853619T3 (pl) 2005-03-02 2006-03-02 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty
PL10150763T PL2206719T3 (pl) 2005-03-02 2006-03-02 Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL06736460T PL1853619T3 (pl) 2005-03-02 2006-03-02 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty

Country Status (22)

Country Link
US (1) US7875599B2 (pl)
EP (2) EP1853619B1 (pl)
JP (2) JP5130453B2 (pl)
KR (1) KR101380959B1 (pl)
CN (2) CN101155823A (pl)
AT (1) ATE482969T1 (pl)
AU (1) AU2006218711B2 (pl)
BR (1) BRPI0607523A2 (pl)
CA (1) CA2599953C (pl)
DE (1) DE602006017175D1 (pl)
DK (2) DK1853619T3 (pl)
EA (1) EA019560B1 (pl)
ES (2) ES2353413T3 (pl)
HK (1) HK1115387A1 (pl)
IL (3) IL185608A (pl)
MX (1) MX2007010593A (pl)
NZ (1) NZ561571A (pl)
PL (2) PL1853619T3 (pl)
PT (2) PT2206719E (pl)
SI (2) SI2206719T1 (pl)
WO (1) WO2006093993A1 (pl)
ZA (1) ZA200708106B (pl)

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US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
ES2353413T3 (es) 2005-03-02 2011-03-01 University Of Maryland 3-beta-hidroxi-17-(1h-bencimidazol-1-il)androsta-5,16-dieno para uso en el tratamiento de una enfermedad de la próstata.
EP2167090A4 (en) 2007-06-06 2010-08-25 Univ Maryland HDAC INHIBITORS AND HORMONE TREATMENT MEDICAMENTS
WO2009114658A2 (en) * 2008-03-12 2009-09-17 University Of Maryland, Baltimore Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer
US20100048524A1 (en) * 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009120565A2 (en) 2008-03-25 2009-10-01 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2009129208A2 (en) * 2008-04-14 2009-10-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress reponse
EP2334686B1 (en) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
US20100105700A1 (en) * 2008-10-28 2010-04-29 Lead Therapeutics, Inc. Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors
GB2479693B (en) * 2009-02-05 2014-04-09 Tokai Pharmaceuticals Inc Steroidal CYP17 inhibitors and their use in the treatment of cancer and prostate hyperplasia
AU2010210422A1 (en) * 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
WO2010091299A2 (en) * 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel combination cancer therapies
GEP20156250B (en) 2009-06-26 2015-02-25 Novartis Ag 1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
EP2461814A4 (en) * 2009-08-07 2012-12-05 Tokai Pharmaceuticals Inc PROSTATE CANCER TREATMENT
CA2780365A1 (en) * 2009-11-13 2011-05-19 Tokai Pharmaceuticals, Inc. Mammalian metabolites of steroids
WO2011066582A1 (en) * 2009-11-30 2011-06-03 Harbor Biosciences, Inc. Anticancer compounds and screening method
CN103108871B (zh) 2010-09-16 2014-09-10 诺华股份有限公司 17α-羟化酶/C17,20-裂合酶抑制剂
EP2651916A2 (en) * 2010-12-16 2013-10-23 BioMarin Pharmaceutical Inc. C-17-heteroaryl steroidal compounds as inhibitors of cyp11b, cyp17, and/or cyp21
JP6002210B2 (ja) 2011-04-28 2016-10-05 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
JP2014523445A (ja) * 2011-07-18 2014-09-11 トーカイ ファーマシューティカルズ，インク． 前立腺癌を処置するための新規な組成物及び方法
US20150005265A1 (en) * 2011-12-22 2015-01-01 Susan Stewart Methods and compositions for combination therapy using p13k/mtor inhibitores
EP4066841A1 (en) 2013-03-14 2022-10-05 University of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
WO2014165815A2 (en) * 2013-04-04 2014-10-09 University Of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
MX2016001901A (es) 2013-08-12 2016-10-13 Tokai Pharmaceuticals Inc Biomarcadores para tratamiento de trastornos neoplasicos usando terapias dirigidas con andrógeno.
AP2016009324A0 (en) 2013-12-24 2016-07-31 Harvard College Cortistatin analogues and syntheses and uses thereof
CN103694299A (zh) * 2014-01-13 2014-04-02 中国药科大学 甾体类雄激素受体抑制剂、其制备方法及其医药用途
CN105732759A (zh) * 2015-01-29 2016-07-06 苏州晶云药物科技有限公司 (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
WO2017004411A1 (en) 2015-07-01 2017-01-05 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
WO2017066697A1 (en) 2015-10-14 2017-04-20 Dou Qingping Treatments and diagnostics for cancers
IT201600083406A1 (it) * 2016-08-08 2018-02-08 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
IT201600121375A1 (it) * 2016-11-30 2018-05-30 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
RU2749134C1 (ru) * 2016-08-08 2021-06-04 Индустриале Кимика С.Р.Л. СПОСОБ ПОЛУЧЕНИЯ 3β-ГИДРОКСИ-17-(1Н-БЕНЗИМИДАЗОЛ-1-ИЛ)АНДРОСТА-5,16-ДИЕНА
US20200369715A1 (en) * 2018-02-13 2020-11-26 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase inhibitors and methods of use
WO2019160890A1 (en) * 2018-02-13 2019-08-22 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase degraders and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA27440A (en) 1887-08-16 James T. Walsh Art of making sheet metal cans, for packing meats, fruits, vegetables, etc.
CH621803A5 (pl) * 1974-08-08 1981-02-27 Siphar Sa
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
US5994335A (en) * 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
BRPI0412989A (pt) 2003-07-29 2006-10-03 Dompe Spa combinação farmacêutica útil para mobilização de célula-tronco
ES2353413T3 (es) * 2005-03-02 2011-03-01 University Of Maryland 3-beta-hidroxi-17-(1h-bencimidazol-1-il)androsta-5,16-dieno para uso en el tratamiento de una enfermedad de la próstata.

Also Published As

Publication number Publication date
US20080280864A1 (en) 2008-11-13
WO2006093993A1 (en) 2006-09-08
CN103349664A (zh) 2013-10-16
ZA200708106B (en) 2008-12-31
MX2007010593A (es) 2008-02-20
CN101155823A (zh) 2008-04-02
NZ561571A (en) 2009-09-25
IL210480A (en) 2015-06-30
IL210480A0 (en) 2011-03-31
JP5613206B2 (ja) 2014-10-22
AU2006218711B2 (en) 2010-11-11
US7875599B2 (en) 2011-01-25
IL210478A0 (en) 2011-03-31
EP1853619A1 (en) 2007-11-14
IL185608A (en) 2016-06-30
KR20070120119A (ko) 2007-12-21
KR101380959B1 (ko) 2014-04-04
DK1853619T3 (da) 2011-01-10
ATE482969T1 (de) 2010-10-15
PT2206719E (pt) 2015-02-05
DK2206719T3 (en) 2015-01-26
JP5130453B2 (ja) 2013-01-30
AU2006218711A2 (en) 2006-09-08
EP2206719A3 (en) 2011-01-05
EP1853619A4 (en) 2009-08-26
EP2206719A2 (en) 2010-07-14
EP2206719B1 (en) 2014-10-22
JP2012255026A (ja) 2012-12-27
ES2353413T3 (es) 2011-03-01
JP2008536807A (ja) 2008-09-11
CA2599953C (en) 2013-08-13
CA2599953A1 (en) 2006-09-08
ES2528055T3 (es) 2015-02-03
HK1115387A1 (pl) 2008-11-28
SI1853619T1 (sl) 2011-01-31
DE602006017175D1 (de) 2010-11-11
SI2206719T1 (sl) 2015-03-31
IL185608A0 (en) 2008-01-06
EA200701872A1 (ru) 2008-06-30
AU2006218711A1 (en) 2006-09-08
BRPI0607523A2 (pt) 2009-09-08
EA019560B1 (ru) 2014-04-30
PT1853619E (pt) 2011-01-03
PL1853619T3 (pl) 2011-03-31
EP1853619B1 (en) 2010-09-29

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