JP2007302689A5 - - Google Patents
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- Publication number
- JP2007302689A5 JP2007302689A5 JP2007185746A JP2007185746A JP2007302689A5 JP 2007302689 A5 JP2007302689 A5 JP 2007302689A5 JP 2007185746 A JP2007185746 A JP 2007185746A JP 2007185746 A JP2007185746 A JP 2007185746A JP 2007302689 A5 JP2007302689 A5 JP 2007302689A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutical composition
- hexanoyl
- hexyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (3)
- 式Ｉａ：
〔式中、Ｒ 2 は、（Ｃ 2 〜Ｃ 8 ）アルキル、−ＯＣＨ 2 Ｒ 3 または（Ｃ 2 〜Ｃ 8 ）アルカノイルであり、Ｒ 3 は、水素、（Ｃ 1 〜Ｃ 6 ）アルキル、（Ｃ 2 〜Ｃ 6 ）アルケニルまたは（Ｃ 2 〜Ｃ 6 ）アルキニルである〕で示される化合物または薬学的に許容され得るその塩を含有する、気腫の治療のための医薬組成物。 - Ｒ 2 が、ｎ−ペンチル、ｎ−ヘキシル、ｎ−プロポキシ、ｎ−ペントキシまたはｎ−ヘキサノイルである、請求項１記載の医薬組成物。
- Ｒ 2 が、ｎ−ヘキシルまたはｎ−ヘキサノイルである、請求項１記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16041599P | 1999-10-19 | 1999-10-19 | |
| US60/160,415 | 1999-10-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Division JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007302689A JP2007302689A (ja) | 2007-11-22 |
| JP2007302689A5 true JP2007302689A5 (ja) | 2008-01-10 |
| JP4850791B2 JP4850791B2 (ja) | 2012-01-11 |
Family
ID=22576814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Expired - Fee Related JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
| JP2007185746A Expired - Fee Related JP4850791B2 (ja) | 1999-10-19 | 2007-07-17 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001532746A Expired - Fee Related JP4074458B2 (ja) | 1999-10-19 | 2000-10-13 | Ｒａｒ選択的レチノイド拮抗薬を用いた気腫の治療 |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6300350B1 (ja) |
| EP (1) | EP1225878B1 (ja) |
| JP (2) | JP4074458B2 (ja) |
| KR (1) | KR100485581B1 (ja) |
| CN (1) | CN1201730C (ja) |
| AR (1) | AR029648A1 (ja) |
| AT (1) | ATE344661T1 (ja) |
| AU (1) | AU777325B2 (ja) |
| BR (1) | BR0015225A (ja) |
| CA (1) | CA2387844C (ja) |
| CY (1) | CY1105941T1 (ja) |
| CZ (1) | CZ20021657A3 (ja) |
| DE (1) | DE60031790T2 (ja) |
| DK (1) | DK1225878T3 (ja) |
| ES (1) | ES2274810T3 (ja) |
| HK (1) | HK1051002A1 (ja) |
| HR (1) | HRP20020329A2 (ja) |
| HU (1) | HUP0203295A3 (ja) |
| IL (1) | IL149151A0 (ja) |
| JO (1) | JO2178B1 (ja) |
| MA (1) | MA26835A1 (ja) |
| MX (1) | MXPA02003843A (ja) |
| MY (1) | MY129001A (ja) |
| NO (1) | NO328738B1 (ja) |
| NZ (1) | NZ518118A (ja) |
| PE (1) | PE20010678A1 (ja) |
| PL (1) | PL357499A1 (ja) |
| PT (1) | PT1225878E (ja) |
| RS (1) | RS50165B (ja) |
| RU (1) | RU2257383C2 (ja) |
| TR (1) | TR200201071T2 (ja) |
| TW (1) | TWI288639B (ja) |
| WO (1) | WO2001030326A1 (ja) |
| ZA (1) | ZA200202576B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| AU2002329276B2 (en) | 2001-09-18 | 2008-04-24 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists I |
| PL209697B1 (pl) | 2001-09-18 | 2011-10-31 | Hoffmann La Roche | Pochodne mocznika, środek farmaceutyczny i zastosowanie pochodnych mocznika |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| JP4926707B2 (ja) | 2003-08-22 | 2012-05-09 | ダニスコ エイ／エス | 封入化抗菌材料 |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| EP2089023A2 (en) * | 2006-11-02 | 2009-08-19 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
| HUE059024T2 (hu) | 2010-09-01 | 2022-10-28 | Univ Jefferson | Összetétel és módszer az izom helyreállítására és regenerációjára |
| WO2012178108A1 (en) | 2011-06-24 | 2012-12-27 | Glycoregimmune, Inc. | Prevention and treatment of inflammatory conditions |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| EP2736332A4 (en) * | 2011-07-29 | 2015-03-18 | Tempero Pharmaceuticals Inc | CONNECTIONS AND METHODS |
| RU2015129065A (ru) | 2012-12-17 | 2017-01-25 | Пэрион Сайенсиз, Инк. | Производные хлор-пиразинкарбоксамида, обладающие активностью блокирования эпителиальных натриевых каналов |
| MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
| ES2909884T3 (es) | 2013-08-20 | 2022-05-10 | Univ Washington Through Its Center For Commercialization | Inhibidores nuevos y específicos de la hidroxilasa del ácido retinoico del citocromo P450 26 |
| WO2015041809A2 (en) | 2013-08-26 | 2015-03-26 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139216B1 (ko) * | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| KR20040031107A (ko) * | 1997-11-12 | 2004-04-09 | 에프. 호프만-라 로슈 아게 | 레티노이드 길항제를 이용한 제2형 ｔ-보조세포 중재면역질환의 치료 |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| WO2000061232A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist |
| AU4222400A (en) | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| AU4228000A (en) * | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| MXPA02000828A (es) * | 1999-08-02 | 2002-07-30 | Hoffmann La Roche | Nuevos antagonistas retinoiides selectivos. |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
-
2000
- 2000-10-12 JO JO2000172A patent/JO2178B1/en active
- 2000-10-13 EP EP00972754A patent/EP1225878B1/en not_active Expired - Lifetime
- 2000-10-13 WO PCT/EP2000/010076 patent/WO2001030326A1/en active IP Right Grant
- 2000-10-13 AT AT00972754T patent/ATE344661T1/de active
- 2000-10-13 DK DK00972754T patent/DK1225878T3/da active
- 2000-10-13 JP JP2001532746A patent/JP4074458B2/ja not_active Expired - Fee Related
- 2000-10-13 IL IL14915100A patent/IL149151A0/xx not_active IP Right Cessation
- 2000-10-13 HU HU0203295A patent/HUP0203295A3/hu unknown
- 2000-10-13 NZ NZ518118A patent/NZ518118A/en not_active IP Right Cessation
- 2000-10-13 CA CA002387844A patent/CA2387844C/en not_active Expired - Fee Related
- 2000-10-13 KR KR10-2002-7004950A patent/KR100485581B1/ko not_active IP Right Cessation
- 2000-10-13 DE DE60031790T patent/DE60031790T2/de not_active Expired - Lifetime
- 2000-10-13 BR BR0015225-0A patent/BR0015225A/pt not_active Application Discontinuation
- 2000-10-13 RU RU2002110289/04A patent/RU2257383C2/ru not_active IP Right Cessation
- 2000-10-13 PL PL00357499A patent/PL357499A1/xx not_active Application Discontinuation
- 2000-10-13 CN CNB008145466A patent/CN1201730C/zh not_active Expired - Fee Related
- 2000-10-13 PT PT00972754T patent/PT1225878E/pt unknown
- 2000-10-13 MX MXPA02003843A patent/MXPA02003843A/es active IP Right Grant
- 2000-10-13 TR TR2002/01071T patent/TR200201071T2/xx unknown
- 2000-10-13 CZ CZ20021657A patent/CZ20021657A3/cs unknown
- 2000-10-13 ES ES00972754T patent/ES2274810T3/es not_active Expired - Lifetime
- 2000-10-13 AU AU11374/01A patent/AU777325B2/en not_active Ceased
- 2000-10-13 RS YUP-290/02A patent/RS50165B/sr unknown
- 2000-10-17 MY MYPI20004872A patent/MY129001A/en unknown
- 2000-10-17 PE PE2000001108A patent/PE20010678A1/es not_active Application Discontinuation
- 2000-10-17 AR ARP000105436A patent/AR029648A1/es unknown
- 2000-10-18 US US09/691,967 patent/US6300350B1/en not_active Expired - Fee Related
- 2000-11-08 TW TW089121961A patent/TWI288639B/zh active
-
2002
- 2002-04-02 ZA ZA200202576A patent/ZA200202576B/en unknown
- 2002-04-12 HR HR20020329A patent/HRP20020329A2/xx not_active Application Discontinuation
- 2002-04-18 NO NO20021823A patent/NO328738B1/no not_active IP Right Cessation
- 2002-04-19 MA MA26610A patent/MA26835A1/fr unknown
-
2003
- 2003-05-06 HK HK03103206A patent/HK1051002A1/xx not_active IP Right Cessation
-
2007
- 2007-01-18 CY CY20071100077T patent/CY1105941T1/el unknown
- 2007-07-17 JP JP2007185746A patent/JP4850791B2/ja not_active Expired - Fee Related