NO328738B1 - Anvendelse av RAR-agonist for fremstilling av medikamenter. - Google Patents
Anvendelse av RAR-agonist for fremstilling av medikamenter. Download PDFInfo
- Publication number
- NO328738B1 NO328738B1 NO20021823A NO20021823A NO328738B1 NO 328738 B1 NO328738 B1 NO 328738B1 NO 20021823 A NO20021823 A NO 20021823A NO 20021823 A NO20021823 A NO 20021823A NO 328738 B1 NO328738 B1 NO 328738B1
- Authority
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- Norway
- Prior art keywords
- rarγ
- selective
- agonist
- rar
- lung
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16041599P | 1999-10-19 | 1999-10-19 | |
| PCT/EP2000/010076 WO2001030326A1 (en) | 1999-10-19 | 2000-10-13 | Treatment of emphysema using rar selective retinoid agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021823L NO20021823L (no) | 2002-04-18 |
| NO20021823D0 NO20021823D0 (no) | 2002-04-18 |
| NO328738B1 true NO328738B1 (no) | 2010-05-03 |
Family
ID=22576814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021823A NO328738B1 (no) | 1999-10-19 | 2002-04-18 | Anvendelse av RAR-agonist for fremstilling av medikamenter. |
Country Status (34)
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| US (1) | US6300350B1 (ja) |
| EP (1) | EP1225878B1 (ja) |
| JP (2) | JP4074458B2 (ja) |
| KR (1) | KR100485581B1 (ja) |
| CN (1) | CN1201730C (ja) |
| AR (1) | AR029648A1 (ja) |
| AT (1) | ATE344661T1 (ja) |
| AU (1) | AU777325B2 (ja) |
| BR (1) | BR0015225A (ja) |
| CA (1) | CA2387844C (ja) |
| CY (1) | CY1105941T1 (ja) |
| CZ (1) | CZ20021657A3 (ja) |
| DE (1) | DE60031790T2 (ja) |
| DK (1) | DK1225878T3 (ja) |
| ES (1) | ES2274810T3 (ja) |
| HK (1) | HK1051002A1 (ja) |
| HR (1) | HRP20020329A2 (ja) |
| HU (1) | HUP0203295A3 (ja) |
| IL (1) | IL149151A0 (ja) |
| JO (1) | JO2178B1 (ja) |
| MA (1) | MA26835A1 (ja) |
| MX (1) | MXPA02003843A (ja) |
| MY (1) | MY129001A (ja) |
| NO (1) | NO328738B1 (ja) |
| NZ (1) | NZ518118A (ja) |
| PE (1) | PE20010678A1 (ja) |
| PL (1) | PL357499A1 (ja) |
| PT (1) | PT1225878E (ja) |
| RS (1) | RS50165B (ja) |
| RU (1) | RU2257383C2 (ja) |
| TR (1) | TR200201071T2 (ja) |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| WO2003024920A1 (en) | 2001-09-18 | 2003-03-27 | F. Hoffmann-La Roche Ag | Substituted urea retinoid agonists ii |
| WO2003024921A1 (en) * | 2001-09-18 | 2003-03-27 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists i |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| JP4926707B2 (ja) | 2003-08-22 | 2012-05-09 | ダニスコ エイ／エス | 封入化抗菌材料 |
| WO2008057933A2 (en) * | 2006-11-02 | 2008-05-15 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways |
| HUE059024T2 (hu) | 2010-09-01 | 2022-10-28 | Univ Jefferson | Összetétel és módszer az izom helyreállítására és regenerációjára |
| KR102055395B1 (ko) | 2011-06-24 | 2019-12-12 | 쥐알아이 바이오,아이엔씨. | 염증 질환의 예방 및 치료 |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US20140155381A1 (en) * | 2011-07-29 | 2014-06-05 | Erkan Baloglu | Compounds and methods |
| KR20150095870A (ko) | 2012-12-17 | 2015-08-21 | 패리온 사이언스 인코퍼레이티드 | 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물 |
| EP3150585A1 (en) | 2012-12-17 | 2017-04-05 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity |
| EP4083029A1 (en) | 2013-08-20 | 2022-11-02 | University of Washington through its Center for Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydroxylase |
| US10500232B2 (en) | 2013-08-26 | 2019-12-10 | The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139216B1 (ko) | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| BR9814957A (pt) * | 1997-11-12 | 2000-10-03 | Hoffmann La Roche | Tratamento de doenças imune mediadas por célula auxiliar "t" tipo 2 com antagonistas retinóides |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| AU4222400A (en) | 1999-04-14 | 2000-11-14 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease |
| WO2000061232A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist |
| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| EP1206436B1 (en) * | 1999-08-02 | 2004-10-13 | F. Hoffmann-La Roche Ag | Retinoids for the treatment of emphysema |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
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