JP2011527299A5 - - Google Patents

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Publication number
JP2011527299A5
JP2011527299A5 JP2011517026A JP2011517026A JP2011527299A5 JP 2011527299 A5 JP2011527299 A5 JP 2011527299A5 JP 2011517026 A JP2011517026 A JP 2011517026A JP 2011517026 A JP2011517026 A JP 2011517026A JP 2011527299 A5 JP2011527299 A5 JP 2011527299A5
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JP
Japan
Prior art keywords
compound
pharmaceutical composition
inhibiting
hcv
hcv replication
Prior art date
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JP2011517026A
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English (en)
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JP5426671B2 (ja
JP2011527299A (ja
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Priority claimed from PCT/EP2009/004942 external-priority patent/WO2010003658A1/en
Publication of JP2011527299A publication Critical patent/JP2011527299A/ja
Publication of JP2011527299A5 publication Critical patent/JP2011527299A5/ja
Application granted granted Critical
Publication of JP5426671B2 publication Critical patent/JP5426671B2/ja
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Claims (6)

  1. 下記式１
    Figure 2011527299
     で表される化合物、またはその立体異性体、塩、水和物もしくは溶媒和物。
  2. 担体、および有効成分として請求項１に記載の化合物を含んでなる製薬学的組成物。
  3. 少なくとも１種の他の抗ＨＣＶ化合物をさらに含んでなる、請求項２に記載の製薬学的組成物。
  4. 少なくとも１種の抗ＨＩＶ化合物をさらに含んでなる、請求項９もしくは１０に記載の製薬学的組成物。
  5. 請求項１に記載の化合物を有効成分として含んでなるＨＣＶ複製を阻害するための製薬学的組成物。
  6. ＨＣＶ複製を阻害するための薬剤の製造のための請求項１に記載の化合物の使用。
JP2011517026A 2008-07-08 2009-07-08 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体 Active JP5426671B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP08159965.6 2008-07-08
EP08159965 2008-07-08
EP08160254.2 2008-07-11
EP08160254 2008-07-11
EP08161743 2008-08-04
EP08161743.3 2008-08-04
PCT/EP2009/004942 WO2010003658A1 (en) 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitis c virus inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013176771A Division JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Publications (3)

Publication Number Publication Date
JP2011527299A JP2011527299A (ja) 2011-10-27
JP2011527299A5 true JP2011527299A5 (ja) 2013-10-17
JP5426671B2 JP5426671B2 (ja) 2014-02-26

Family

ID=40972916

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011517026A Active JP5426671B2 (ja) 2008-07-08 2009-07-08 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体
JP2013176771A Active JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Family Applications After (1)

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JP2013176771A Active JP5808370B2 (ja) 2008-07-08 2013-08-28 Ｃ型肝炎ウイルス阻害剤として有用な大環状インドール誘導体

Country Status (32)

Country Link
US (2) US8921355B2 (ja)
EP (1) EP2310396B1 (ja)
JP (2) JP5426671B2 (ja)
KR (1) KR101640374B1 (ja)
CN (1) CN102089314B (ja)
AP (1) AP2743A (ja)
AR (1) AR072726A1 (ja)
AU (1) AU2009267389B8 (ja)
BR (1) BRPI0915887B8 (ja)
CA (1) CA2729307C (ja)
CL (1) CL2011000032A1 (ja)
CO (1) CO6351793A2 (ja)
CR (1) CR20110076A (ja)
DK (1) DK2310396T3 (ja)
EA (1) EA019008B1 (ja)
EC (1) ECSP11010750A (ja)
ES (1) ES2651038T3 (ja)
HK (1) HK1155734A1 (ja)
HN (1) HN2011000072A (ja)
HR (1) HRP20171892T1 (ja)
HU (1) HUE035244T2 (ja)
IL (1) IL210086A (ja)
LT (1) LT2310396T (ja)
MX (1) MX2011000276A (ja)
NI (1) NI201100010A (ja)
NO (1) NO2310396T3 (ja)
NZ (2) NZ603343A (ja)
SI (1) SI2310396T1 (ja)
SV (1) SV2011003796A (ja)
TW (1) TWI454476B (ja)
UY (1) UY31973A (ja)
WO (1) WO2010003658A1 (ja)

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BRPI0821836A2 (pt) 2007-12-24 2015-06-16 Tibotec Pharm Ltd Indóis macrocíclicos como inibidores do vírus da hepatite c
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
CN102844028B (zh) * 2010-04-13 2016-04-06 杨森制药公司 Hcv大环抑制剂、非核苷和核苷的组合
EP2585438B1 (en) * 2010-06-24 2014-08-20 Janssen R&D Ireland PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
EP2760821B1 (en) 2011-09-02 2017-10-11 Novartis AG Choline salt of an anti-inflammatory substituted cyclobutenedione compound
US8716275B2 (en) * 2011-10-20 2014-05-06 Bristol-Myers Squibb Company Compound for the treatment of hepatitis C
RU2015111491A (ru) 2012-08-31 2016-10-20 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора протеазы hcv, ненуклеозидного ингибитора hcv и ритонавира
WO2014152275A1 (en) * 2013-03-14 2014-09-25 Concert Pharmaceuticals, Inc. Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
KR101974388B1 (ko) 2017-06-23 2019-05-02 (주)에니켐텍 알킬 디에틸렌 트리아민 유도체 및 이의 제조방법
US11066357B2 (en) 2017-12-26 2021-07-20 Southern Research Institute Benzoannulene derivatives as antiviral agents
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method

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US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US20050267836A1 (en) * 1996-03-25 2005-12-01 Cfph, Llc Method and system for transacting with a trading application
NZ332405A (en) 1996-04-23 2000-06-23 Vertex Pharma oxazolyl, thiazolyl or phenyl urea derivatives as inhibitors of inosine monophosphate dehydrogenase enzyme
ES2201452T3 (es) 1997-03-14 2004-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima impdh.
TR200103428T2 (tr) 1999-03-19 2002-04-22 Vertex Pharmaceuticals Incorporated IMPDH enzim inhibitörleri.
JP4778665B2 (ja) 2000-08-30 2011-09-21 パナソニック株式会社 プラズマディスプレイ表示装置の製造方法
WO2005073195A2 (en) 2004-01-30 2005-08-11 Medivir Ab Hcv ns-3 serine protease inhibitors
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
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AU2008277442A1 (en) * 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis C infections
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
TW201023858A (en) 2008-09-18 2010-07-01 Ortho Mcneil Janssen Pharm Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside
HUE031738T2 (en) 2009-02-27 2017-07-28 Janssen Pharmaceuticals Inc Amorphous salts of the HCV macrocyclic inhibitor
CN102844028B (zh) 2010-04-13 2016-04-06 杨森制药公司 Hcv大环抑制剂、非核苷和核苷的组合
EP2585438B1 (en) 2010-06-24 2014-08-20 Janssen R&D Ireland PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
RU2015111491A (ru) 2012-08-31 2016-10-20 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора протеазы hcv, ненуклеозидного ингибитора hcv и ритонавира

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