JP2010507589A5 - Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ピリジニルアミノ−１，５−ジヒドロピロリジン−２−オン - Google Patents
Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ピリジニルアミノ−１，５−ジヒドロピロリジン−２−オン Download PDFInfo
- Publication number
- JP2010507589A5 JP2010507589A5 JP2009533585A JP2009533585A JP2010507589A5 JP 2010507589 A5 JP2010507589 A5 JP 2010507589A5 JP 2009533585 A JP2009533585 A JP 2009533585A JP 2009533585 A JP2009533585 A JP 2009533585A JP 2010507589 A5 JP2010507589 A5 JP 2010507589A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydropyrrolidin
- pyridinylamino
- diphenyl
- receptor modulator
- pharmacologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 title 1
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 title 1
- 230000000051 modifying Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000003287 optical Effects 0.000 claims 1
Claims (5)
- 次式で表される化合物
- 次式を有する、請求項１記載の化合物
- 次式で表される中間体。
- 請求項１又は２記載の化合物と、薬理学的に許容できる担体、希釈剤又は賦形剤とを含んでなる医薬組成物。
- 請求項２記載の化合物が９０％ｅｅより高い光学純度で存在する、請求項４記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86254006P | 2006-10-23 | 2006-10-23 | |
| US60/862,540 | 2006-10-23 | ||
| PCT/US2007/082041 WO2008070305A2 (en) | 2006-10-23 | 2007-10-22 | 1, 5-diphenyl-3-pyridinylamino-1, 5-dihydropyrrolidin-2-one as cbl' receptor modulator |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507589A JP2010507589A (ja) | 2010-03-11 |
| JP2010507589A5 true JP2010507589A5 (ja) | 2010-11-25 |
| JP5331001B2 JP5331001B2 (ja) | 2013-10-30 |
Family
ID=39386481
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533586A Expired - Fee Related JP5331002B2 (ja) | 2006-10-23 | 2007-10-22 | Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ベンジルアミノ−１，５−ジヒドロピロリジン−２−オン |
| JP2009533585A Expired - Fee Related JP5331001B2 (ja) | 2006-10-23 | 2007-10-22 | Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ピリジニルアミノ−１，５−ジヒドロピロリジン−２−オン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533586A Expired - Fee Related JP5331002B2 (ja) | 2006-10-23 | 2007-10-22 | Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ベンジルアミノ−１，５−ジヒドロピロリジン−２−オン |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7998985B2 (ja) |
| EP (2) | EP2094684B1 (ja) |
| JP (2) | JP5331002B2 (ja) |
| KR (2) | KR101088236B1 (ja) |
| CN (2) | CN101528733B (ja) |
| AR (1) | AR063497A1 (ja) |
| AT (1) | ATE492543T1 (ja) |
| AU (1) | AU2007329808B2 (ja) |
| BR (1) | BRPI0717347A2 (ja) |
| CA (2) | CA2667210C (ja) |
| CL (1) | CL2007003002A1 (ja) |
| CY (1) | CY1111140T1 (ja) |
| DE (1) | DE602007011495D1 (ja) |
| DK (2) | DK2099784T3 (ja) |
| EA (2) | EA015175B1 (ja) |
| ES (2) | ES2398388T3 (ja) |
| MX (2) | MX2009004054A (ja) |
| PE (1) | PE20080926A1 (ja) |
| PL (2) | PL2099784T3 (ja) |
| PT (2) | PT2094684E (ja) |
| SI (2) | SI2094684T1 (ja) |
| TW (1) | TW200825067A (ja) |
| WO (2) | WO2008070306A2 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200825067A (en) * | 2006-10-23 | 2008-06-16 | Lilly Co Eli | CB1 compounds |
| ES2390560T3 (es) | 2008-04-22 | 2012-11-14 | Eli Lilly And Company | Compuestos de 1,5-difenil-pirrolidin-2-ona como ligandos CB-1 |
| AU2009238444B2 (en) | 2008-04-22 | 2013-08-29 | Eli Lilly And Company | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands |
| US20110280813A1 (en) * | 2008-11-13 | 2011-11-17 | Alice Prince | Neuraminidase inhibitors and uses thereof |
| ES2542042R1 (es) * | 2010-07-15 | 2015-10-06 | Oleg Iliich Epshtein | Composiciones farmacéuticas y uso para preparar un medicamento destinado al tratamiento de la obesidad, los trastornos metabólicos relacionados y la adicción a sustancias psicoactivas |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2022132803A1 (en) * | 2020-12-14 | 2022-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Cb2 receptor agonists |
| WO2023205180A1 (en) | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
| WO2023250097A1 (en) | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533657A (en) | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| PT1725536E (pt) * | 2004-02-19 | 2009-01-22 | Solvay Pharm Bv | Derivados de imidazolina apresentando actividade antagonista cb1 |
| US20060035245A1 (en) * | 2004-04-20 | 2006-02-16 | Ason Brandon L | Modulators of enzymatic nucleic acid elements mobilization |
| WO2007020502A2 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Cannabinoid receptor ligands and uses thereof |
| TW200825067A (en) * | 2006-10-23 | 2008-06-16 | Lilly Co Eli | CB1 compounds |
-
2007
- 2007-10-18 TW TW096139051A patent/TW200825067A/zh unknown
- 2007-10-18 PE PE2007001418A patent/PE20080926A1/es not_active Application Discontinuation
- 2007-10-18 CL CL200703002A patent/CL2007003002A1/es unknown
- 2007-10-18 AR ARP070104628A patent/AR063497A1/es unknown
- 2007-10-22 US US12/444,692 patent/US7998985B2/en not_active Expired - Fee Related
- 2007-10-22 US US12/441,570 patent/US8168659B2/en not_active Expired - Fee Related
- 2007-10-22 SI SI200730538T patent/SI2094684T1/sl unknown
- 2007-10-22 WO PCT/US2007/082042 patent/WO2008070306A2/en active Application Filing
- 2007-10-22 SI SI200731118T patent/SI2099784T1/sl unknown
- 2007-10-22 PT PT07871197T patent/PT2094684E/pt unknown
- 2007-10-22 PL PL07871196T patent/PL2099784T3/pl unknown
- 2007-10-22 DK DK07871196.7T patent/DK2099784T3/da active
- 2007-10-22 DE DE602007011495T patent/DE602007011495D1/de active Active
- 2007-10-22 MX MX2009004054A patent/MX2009004054A/es active IP Right Grant
- 2007-10-22 CN CN2007800394514A patent/CN101528733B/zh not_active Expired - Fee Related
- 2007-10-22 BR BRPI0717347-4A2A patent/BRPI0717347A2/pt not_active IP Right Cessation
- 2007-10-22 EP EP07871197A patent/EP2094684B1/en not_active Not-in-force
- 2007-10-22 PT PT78711967T patent/PT2099784E/pt unknown
- 2007-10-22 WO PCT/US2007/082041 patent/WO2008070305A2/en active Application Filing
- 2007-10-22 CN CN2007800394497A patent/CN101528732B/zh not_active Expired - Fee Related
- 2007-10-22 KR KR1020097008214A patent/KR101088236B1/ko not_active IP Right Cessation
- 2007-10-22 DK DK07871197.5T patent/DK2094684T3/da active
- 2007-10-22 MX MX2009004053A patent/MX2009004053A/es active IP Right Grant
- 2007-10-22 AU AU2007329808A patent/AU2007329808B2/en not_active Ceased
- 2007-10-22 AT AT07871197T patent/ATE492543T1/de active
- 2007-10-22 CA CA2667210A patent/CA2667210C/en not_active Expired - Fee Related
- 2007-10-22 CA CA2667372A patent/CA2667372C/en not_active Expired - Fee Related
- 2007-10-22 JP JP2009533586A patent/JP5331002B2/ja not_active Expired - Fee Related
- 2007-10-22 EP EP07871196A patent/EP2099784B1/en not_active Not-in-force
- 2007-10-22 PL PL07871197T patent/PL2094684T3/pl unknown
- 2007-10-22 JP JP2009533585A patent/JP5331001B2/ja not_active Expired - Fee Related
- 2007-10-22 EA EA200970405A patent/EA015175B1/ru not_active IP Right Cessation
- 2007-10-22 ES ES07871196T patent/ES2398388T3/es active Active
- 2007-10-22 EA EA200970404A patent/EA015745B1/ru not_active IP Right Cessation
- 2007-10-22 KR KR1020097008216A patent/KR101088229B1/ko not_active IP Right Cessation
- 2007-10-22 ES ES07871197T patent/ES2356025T3/es active Active
-
2011
- 2011-01-27 CY CY20111100093T patent/CY1111140T1/el unknown
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