ES2371832T3 - Pirimidodiazepinas sustituidas útiles como inhibidores de plk1. - Google Patents
Pirimidodiazepinas sustituidas útiles como inhibidores de plk1. Download PDFInfo
- Publication number
- ES2371832T3 ES2371832T3 ES08717594T ES08717594T ES2371832T3 ES 2371832 T3 ES2371832 T3 ES 2371832T3 ES 08717594 T ES08717594 T ES 08717594T ES 08717594 T ES08717594 T ES 08717594T ES 2371832 T3 ES2371832 T3 ES 2371832T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- plk1
- cyclopentyl
- methyl
- difluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
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| US919358P | 2007-03-22 |
Publications (1)
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| ES2371832T3 true ES2371832T3 (es) | 2012-01-10 |
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| HR (1) | HRP20110807T1 (enExample) |
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| MX (1) | MX2009010034A (enExample) |
| PE (1) | PE20120495A1 (enExample) |
| PL (1) | PL2139892T3 (enExample) |
| PT (1) | PT2139892E (enExample) |
| SI (1) | SI2139892T1 (enExample) |
| TW (1) | TWI363629B (enExample) |
| WO (1) | WO2008113711A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MX2010001677A (es) * | 2007-08-15 | 2010-03-11 | Vertex Pharma | Derivados de 4-(9-(3,3-difluorociclopentil)-5,7,7-trimetil-6-oxo-6 ,7,8,9-tetrahidro-5h-pirimido[4,5-b][1,4]diazepin-2-ilamino)-3-me toxibenzamida como inhibidores de las proteinas cinasas humanas plk1 a plk4 para el tratamiento de enfermedades proli |
| US20110201818A1 (en) | 2007-09-25 | 2011-08-18 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| PL2205603T3 (pl) * | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| US20090291938A1 (en) * | 2007-11-19 | 2009-11-26 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| EP2303889A1 (en) * | 2008-06-18 | 2011-04-06 | F. Hoffmann-La Roche AG | Halo-substituted pyrimidodiazepines as plkl inhibitors |
| BRPI0923305B1 (pt) | 2008-12-09 | 2019-01-22 | Gilead Sciences Inc | moduladores de receptores toll-like, seu uso e composição farmacêutica que os compreende |
| CA2748181C (en) | 2009-01-06 | 2019-07-16 | Nathanael S. Gray | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| TWI483941B (zh) | 2009-06-17 | 2015-05-11 | Vertex Pharma | 流感病毒複製之抑制劑 |
| SI2477987T1 (en) | 2009-09-14 | 2018-03-30 | Gilead Sciences, Inc. | MODULATORS TO TOLL OF LIKE RECEPTORS |
| MX2013006836A (es) | 2010-12-16 | 2013-09-26 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2970317A4 (en) | 2013-03-15 | 2016-11-02 | Dana Farber Cancer Inst Inc | PYRIMIDODIAZEPINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES |
| BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
| TWI652014B (zh) * | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
| SMT201900450T1 (it) | 2013-11-13 | 2019-09-09 | Vertex Pharma | Inibitori della replicazione di virus dell’influenza |
| MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
| JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体の使用 |
| WO2015117053A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| ES2930667T3 (es) | 2014-07-11 | 2022-12-21 | Gilead Sciences Inc | Moduladores de receptores de tipo Toll para el tratamiento de VIH |
| BR112017002369A2 (pt) | 2014-08-08 | 2017-12-05 | Dana Farber Cancer Inst Inc | derivados de diazepana e usos dos mesmos |
| TWI780423B (zh) | 2014-09-16 | 2022-10-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑的製備方法 |
| JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｏｌｌ様受容体モジュレーターの固体形態 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3307728A4 (en) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS |
| CN108472300A (zh) | 2015-09-11 | 2018-08-31 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |
| AU2016319785C1 (en) | 2015-09-11 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
| KR20180081809A (ko) | 2015-11-25 | 2018-07-17 | 다나-파버 캔서 인스티튜트 인크. | 2가 브로모도메인 억제제 및 그의 용도 |
| EP3440084B1 (en) * | 2016-04-07 | 2022-12-21 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders |
| WO2021061894A1 (en) * | 2019-09-27 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | Erk5 degraders as therapeutics in cancer and inflammatory diseases |
| JP7440940B2 (ja) * | 2020-03-27 | 2024-02-29 | オップテラ インコーポレイテッド | Ｐｌｋ１の選択的分解誘導化合物 |
| WO2022145989A1 (ko) * | 2020-12-31 | 2022-07-07 | (주) 업테라 | 선택적 plk1 억제제로서의 피리미도디아제핀 유도체 |
| IL310678A (en) * | 2021-08-10 | 2024-04-01 | Uppthera Inc | A new compound that induces PLK1 degradation |
| GB202313514D0 (en) | 2023-09-05 | 2023-10-18 | Cambridge Entpr Ltd | Treatment of inflammatory diseases |
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| ATE380814T1 (de) * | 1999-09-17 | 2007-12-15 | Abbott Gmbh & Co Kg | Kinaseinhibitoren als arzneimittel |
| NZ531928A (en) * | 2001-09-04 | 2005-10-28 | Boehringer Ingelheim Pharma | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
| CA2652648C (en) * | 2006-02-14 | 2016-10-25 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
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- 2008-03-11 PT PT08717594T patent/PT2139892E/pt unknown
- 2008-03-11 JP JP2009553997A patent/JP5087640B2/ja not_active Expired - Fee Related
- 2008-03-11 PL PL08717594T patent/PL2139892T3/pl unknown
- 2008-03-11 AU AU2008228303A patent/AU2008228303B2/en not_active Ceased
- 2008-03-18 CL CL2008000785A patent/CL2008000785A1/es unknown
- 2008-03-19 AR ARP080101142A patent/AR065794A1/es unknown
- 2008-03-19 PE PE2011001933A patent/PE20120495A1/es not_active Application Discontinuation
- 2008-03-19 US US12/051,000 patent/US7517873B2/en not_active Expired - Fee Related
- 2008-03-19 TW TW097109660A patent/TWI363629B/zh not_active IP Right Cessation
-
2009
- 2009-08-27 IL IL200617A patent/IL200617A/en not_active IP Right Cessation
-
2011
- 2011-11-30 CY CY20111101174T patent/CY1112102T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR065794A1 (es) | 2009-07-01 |
| CL2008000785A1 (es) | 2009-03-27 |
| US20080234255A1 (en) | 2008-09-25 |
| PT2139892E (pt) | 2011-11-21 |
| PE20120495A1 (es) | 2012-05-12 |
| US7517873B2 (en) | 2009-04-14 |
| PL2139892T3 (pl) | 2012-03-30 |
| SI2139892T1 (sl) | 2011-12-30 |
| CN101636399B (zh) | 2012-04-18 |
| EP2139892B1 (en) | 2011-09-14 |
| CY1112102T1 (el) | 2015-11-04 |
| HK1139936A1 (en) | 2010-09-30 |
| CN102746175B (zh) | 2014-01-15 |
| EP2139892A1 (en) | 2010-01-06 |
| JP2010521514A (ja) | 2010-06-24 |
| WO2008113711A1 (en) | 2008-09-25 |
| BRPI0809088A2 (pt) | 2014-09-09 |
| TWI363629B (en) | 2012-05-11 |
| CN102746175A (zh) | 2012-10-24 |
| ATE524472T1 (de) | 2011-09-15 |
| JP5087640B2 (ja) | 2012-12-05 |
| KR20090119913A (ko) | 2009-11-20 |
| DK2139892T3 (da) | 2011-12-12 |
| TW200843781A (en) | 2008-11-16 |
| IL200617A (en) | 2014-02-27 |
| CA2680757A1 (en) | 2008-09-25 |
| CN101636399A (zh) | 2010-01-27 |
| KR101157848B1 (ko) | 2012-07-11 |
| IL200617A0 (en) | 2010-05-17 |
| AU2008228303A1 (en) | 2008-09-25 |
| HRP20110807T1 (hr) | 2011-12-31 |
| MX2009010034A (es) | 2009-10-12 |
| AU2008228303B2 (en) | 2012-04-19 |
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