JP2006511587A5 - - Google Patents
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- Publication number
- JP2006511587A5 JP2006511587A5 JP2004564036A JP2004564036A JP2006511587A5 JP 2006511587 A5 JP2006511587 A5 JP 2006511587A5 JP 2004564036 A JP2004564036 A JP 2004564036A JP 2004564036 A JP2004564036 A JP 2004564036A JP 2006511587 A5 JP2006511587 A5 JP 2006511587A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- aryl
- compound
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000000547 substituted alkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000014413 Maternally-inherited diabetes and deafness Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- -1 3,5-bis (p-tolyloxymethyl) salicylic acid Chemical compound 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000035177 MELAS Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000009028 early myoclonic encephalopathy Diseases 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 208000006443 lactic acidosis Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 230000004898 mitochondrial function Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43542002P | 2002-12-20 | 2002-12-20 | |
| PCT/US2003/041211 WO2004058679A2 (en) | 2002-12-20 | 2003-12-19 | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006511587A JP2006511587A (ja) | 2006-04-06 |
| JP2006511587A5 true JP2006511587A5 (enExample) | 2006-06-29 |
Family
ID=32682238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004564036A Pending JP2006511587A (ja) | 2002-12-20 | 2003-12-19 | アデニンヌクレオチドトランスロカーゼ（ａｎｔ）リガンドならびにそれに関連する組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6936638B2 (enExample) |
| EP (1) | EP1581472A2 (enExample) |
| JP (1) | JP2006511587A (enExample) |
| AU (1) | AU2003300358A1 (enExample) |
| BR (1) | BR0317613A (enExample) |
| CA (1) | CA2511178A1 (enExample) |
| MX (1) | MXPA05006798A (enExample) |
| WO (1) | WO2004058679A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7355049B2 (en) | 2003-06-24 | 2008-04-08 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US20110112147A1 (en) | 2009-11-11 | 2011-05-12 | David Robert Bolin | Indazolone analogs as glycogen synthase activators |
| US7947728B1 (en) | 2009-11-11 | 2011-05-24 | Hoffmann-La Roche Inc. | Indole and indazole analogs as glycogen synthase activators |
| US20110112158A1 (en) | 2009-11-11 | 2011-05-12 | David Robert Bolin | Benzisoxazole analogs as glycogen synthase activators |
| US8039495B2 (en) | 2009-11-16 | 2011-10-18 | Hoffman-La Roche Inc. | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators |
| US20110118314A1 (en) | 2009-11-16 | 2011-05-19 | Weiya Yun | Piperidine analogs as glycogen synthase activators |
| US7939569B1 (en) | 2009-12-01 | 2011-05-10 | Hoffmann-La Roche Inc. | Aniline analogs as glycogen synthase activators |
| US20110136792A1 (en) | 2009-12-04 | 2011-06-09 | David Robert Bolin | Novel carboxylic acid analogs as glycogen synthase activators |
| RU2599791C2 (ru) | 2010-08-10 | 2016-10-20 | Ремпекс Фармасьютикэлз, Инч. | Циклические бороновые кислотно-эфирные производные и их использование в терапии |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| AU2014204045B2 (en) | 2013-01-04 | 2018-10-18 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| KR20150103270A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10385074B2 (en) | 2014-05-05 | 2019-08-20 | Rempex Pharmaceuticals, Inc. | Synthesis of boronate salts and uses thereof |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| AU2015264418A1 (en) | 2014-05-19 | 2016-11-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| AU2015284307A1 (en) | 2014-07-01 | 2017-02-02 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN107531830B (zh) | 2015-08-26 | 2019-06-28 | 赢创德固赛有限公司 | 某些聚合物作为电荷存储器的用途 |
| WO2017032582A1 (de) | 2015-08-26 | 2017-03-02 | Evonik Degussa Gmbh | Verwendung bestimmter polymere als ladungsspeicher |
| AU2017290060B2 (en) | 2016-06-30 | 2021-07-22 | Qpex Biopharma, Inc | Boronic acid derivatives and therapeutic uses thereof |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| RS65576B1 (sr) | 2017-11-24 | 2024-06-28 | Jubilant Episcribe Llc | Heterociklična jedinjenja kao inhibitori prmt5 |
| CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
| CN112424209A (zh) | 2018-04-20 | 2021-02-26 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
| US12636297B2 (en) | 2019-06-19 | 2026-05-26 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US12637481B2 (en) | 2020-03-18 | 2026-05-26 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| IL297458A (en) | 2020-05-05 | 2022-12-01 | Qpex Biopharma Inc | Boronic acid derivatives and their synthesis, polymorphic forms and medicinal uses |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1198831B (de) * | 1962-03-21 | 1965-08-19 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung von 3-Aralkylsalicylsaeuren |
| GB966479A (en) * | 1962-03-21 | 1964-08-12 | Boehringer & Soehne Gmbh | New substituted salicylic acid derivatives |
| US3965145A (en) * | 1968-06-17 | 1976-06-22 | Pennwalt Corporation | Coupled peroxides |
| US3692828A (en) * | 1970-05-01 | 1972-09-19 | Gulf Research Development Co | Process for preparing phenyl sulfone carboxylic acids |
| US3886162A (en) * | 1972-07-19 | 1975-05-27 | Syntex Inc | Acridone carboxylic acids and derivatives |
| US3965146A (en) * | 1973-06-04 | 1976-06-22 | Raychem Corporation | Biphenylyloxy benzoic acid and esters thereof |
| DE3500972A1 (de) * | 1985-01-14 | 1986-07-17 | Henkel Kgaa | Sebosuppressive kosmetische mittel, enthaltend alkoxy- oder alkylbenzyloxy-benzoesaeuren oder deren salze |
| EP0253666A3 (en) * | 1986-07-16 | 1988-04-27 | Fuji Photo Film Co., Ltd. | Heat-sensitive recording material containing dye-forming components |
| DE3872937T2 (de) * | 1987-05-11 | 1993-01-21 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersaeure-derivate. |
| US4935240A (en) * | 1987-06-04 | 1990-06-19 | Ono Pharmaceutical Co., Ltd. | Benzoylaminophenoxybutanoic acid derivatives |
| US5217994A (en) * | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
| WO1993024442A1 (fr) | 1992-05-29 | 1993-12-09 | Yamanouchi Pharmaceutical Co., Ltd. | Medicament renfermant un derive d'acide benzoique, et nouveau derive d'acide benzoique |
| US5426196A (en) * | 1993-12-22 | 1995-06-20 | Glaxo Inc. | Synthesis of diaryl methanes |
| DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
| NZ301265A (en) * | 1995-02-02 | 1998-12-23 | Smithkline Beecham Plc | Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof |
| WO1997005131A1 (en) * | 1995-08-02 | 1997-02-13 | J. Uriach & Cia. S.A. | New carboxamides with antifungal activity |
| US6262113B1 (en) * | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| GB9800750D0 (en) | 1998-01-14 | 1998-03-11 | Lilly Co Eli | Pharmaceutical compound |
| US6344486B1 (en) * | 1998-04-03 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
| GB2352240A (en) | 1999-07-13 | 2001-01-24 | Lilly Co Eli | Novel sulphonamides useful in treating CNS disorders |
| US6680345B2 (en) * | 2001-09-14 | 2004-01-20 | Boehringer Ingelheim Pharma Kg | Salicylic acid salts of salmeterol |
| AU2003222278A1 (en) | 2002-03-20 | 2003-10-08 | Schering Aktiengesellschaft | Menthol substituted antithrombotic pai-1 inhibitors |
| US6855341B2 (en) * | 2002-11-04 | 2005-02-15 | Jeffrey B. Smith | Anti-viral compositions and methods of making and using the anti-viral compositions |
-
2003
- 2003-12-19 US US10/741,595 patent/US6936638B2/en not_active Expired - Fee Related
- 2003-12-19 EP EP03814376A patent/EP1581472A2/en not_active Withdrawn
- 2003-12-19 JP JP2004564036A patent/JP2006511587A/ja active Pending
- 2003-12-19 WO PCT/US2003/041211 patent/WO2004058679A2/en not_active Ceased
- 2003-12-19 AU AU2003300358A patent/AU2003300358A1/en not_active Abandoned
- 2003-12-19 CA CA002511178A patent/CA2511178A1/en not_active Abandoned
- 2003-12-19 MX MXPA05006798A patent/MXPA05006798A/es unknown
- 2003-12-19 US US10/539,539 patent/US20060194825A1/en not_active Abandoned
- 2003-12-19 BR BR0317613-4A patent/BR0317613A/pt not_active IP Right Cessation
-
2005
- 2005-06-07 US US11/146,933 patent/US20060004093A1/en not_active Abandoned