BR0317613A - Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos - Google Patents

Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos

Info

Publication number
BR0317613A
BR0317613A BR0317613-4A BR0317613A BR0317613A BR 0317613 A BR0317613 A BR 0317613A BR 0317613 A BR0317613 A BR 0317613A BR 0317613 A BR0317613 A BR 0317613A
Authority
BR
Brazil
Prior art keywords
methods
ant
adenine
binders
related compositions
Prior art date
Application number
BR0317613-4A
Other languages
English (en)
Inventor
Soumitra S Ghosh
Yazhong Pei
Xiao-Qing Tang
Spiros J Liras
Michael K Ahlijanian
Original Assignee
Migenix Corp
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Migenix Corp, Pfizer filed Critical Migenix Corp
Publication of BR0317613A publication Critical patent/BR0317613A/pt

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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
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    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
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    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

"LIGANTES DE ADENINA NUCLEOTìDEO TRANSLOCASE (ANT) E COMPOSIçõES E MéTODOS RELACIONADOS AOS MESMOS". Compostos que possuem utilidade no tratamento de condições associadas a funções mitocondriais alteradas. Os compostos possuen estrutura (I) , incluindo esterioisómeros, pró-drogas e seus sais farmaceuticamente aceitáveis, em que R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~ e R~ 6~ são como aqui definidos. Composições farmacêuticas contendo um composto de estrutura (I), bem como métodos relacionado ao uso das mesmas são descritos.
BR0317613-4A 2002-12-20 2003-12-19 Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos BR0317613A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43542002P 2002-12-20 2002-12-20
PCT/US2003/041211 WO2004058679A2 (en) 2002-12-20 2003-12-19 Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto

Publications (1)

Publication Number Publication Date
BR0317613A true BR0317613A (pt) 2005-11-29

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ID=32682238

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BR0317613-4A BR0317613A (pt) 2002-12-20 2003-12-19 Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos

Country Status (8)

Country Link
US (3) US20060194825A1 (pt)
EP (1) EP1581472A2 (pt)
JP (1) JP2006511587A (pt)
AU (1) AU2003300358A1 (pt)
BR (1) BR0317613A (pt)
CA (1) CA2511178A1 (pt)
MX (1) MXPA05006798A (pt)
WO (1) WO2004058679A2 (pt)

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US6855341B2 (en) * 2002-11-04 2005-02-15 Jeffrey B. Smith Anti-viral compositions and methods of making and using the anti-viral compositions

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US6936638B2 (en) 2005-08-30
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US20060194825A1 (en) 2006-08-31
CA2511178A1 (en) 2004-07-15
JP2006511587A (ja) 2006-04-06
MXPA05006798A (es) 2006-03-09
WO2004058679A2 (en) 2004-07-15
US20040192740A1 (en) 2004-09-30
AU2003300358A1 (en) 2004-07-22
WO2004058679A3 (en) 2004-08-26

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