DK3140310T3 - Syntese af boronatsalte og brug deraf - Google Patents

Syntese af boronatsalte og brug deraf Download PDF

Info

Publication number
DK3140310T3
DK3140310T3 DK15788682.1T DK15788682T DK3140310T3 DK 3140310 T3 DK3140310 T3 DK 3140310T3 DK 15788682 T DK15788682 T DK 15788682T DK 3140310 T3 DK3140310 T3 DK 3140310T3
Authority
DK
Denmark
Prior art keywords
synthesis
boronate salts
boronate
salts
Prior art date
Application number
DK15788682.1T
Other languages
English (en)
Inventor
Scott Hecker
Serge Boyer
Original Assignee
Rempex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rempex Pharmaceuticals Inc filed Critical Rempex Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3140310T3 publication Critical patent/DK3140310T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
DK15788682.1T 2014-05-05 2015-04-30 Syntese af boronatsalte og brug deraf DK3140310T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461988690P 2014-05-05 2014-05-05
PCT/US2015/028613 WO2015171430A1 (en) 2014-05-05 2015-04-30 Synthesis of boronate salts and uses thereof

Publications (1)

Publication Number Publication Date
DK3140310T3 true DK3140310T3 (da) 2019-10-21

Family

ID=54392864

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15788682.1T DK3140310T3 (da) 2014-05-05 2015-04-30 Syntese af boronatsalte og brug deraf

Country Status (14)

Country Link
US (2) US10385074B2 (da)
EP (3) EP3604316B1 (da)
CY (1) CY1122222T1 (da)
DK (1) DK3140310T3 (da)
ES (2) ES2972939T3 (da)
FI (1) FI3604316T3 (da)
HR (1) HRP20191932T1 (da)
HU (1) HUE046836T2 (da)
LT (2) LT3604316T (da)
PL (2) PL3604316T3 (da)
PT (1) PT3140310T (da)
RS (1) RS59488B1 (da)
SI (1) SI3140310T1 (da)
WO (1) WO2015171430A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2603514T3 (pl) 2010-08-10 2019-04-30 Rempex Pharmaceuticals Inc Cykliczne pochodne estrowe kwasu boronowego oraz ich zastosowania terapeutyczne
CN104994844A (zh) 2013-01-04 2015-10-21 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
CA2947041A1 (en) 2014-05-19 2015-11-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
PL3154989T3 (pl) 2014-06-11 2021-10-18 VenatoRx Pharmaceuticals, Inc. Inhibitory beta-laktamaz
CN106536529B (zh) 2014-07-01 2019-09-27 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2761778T3 (es) 2014-12-19 2020-05-21 Rempex Pharmaceuticals Inc Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2017044828A1 (en) 2015-09-11 2017-03-16 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2017100537A1 (en) 2015-12-10 2017-06-15 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
US10294249B2 (en) 2016-06-30 2019-05-21 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3494121B1 (en) 2016-08-04 2021-10-06 Venatorx Pharmaceuticals, Inc. Boron-containing compounds
JOP20190188A1 (ar) 2017-02-01 2019-08-01 Rempex Pharmaceuticals Inc جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك
WO2018218154A1 (en) 2017-05-26 2018-11-29 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
US11332485B2 (en) 2017-05-26 2022-05-17 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
CA3078627A1 (en) 2017-10-11 2019-04-18 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
US11999757B2 (en) * 2017-11-01 2024-06-04 Melinta Subsidiary Corp. Synthesis of boronate ester derivatives and uses thereof
JP7329260B2 (ja) 2018-04-20 2023-08-18 キューペックス バイオファーマ, インコーポレイテッド ボロン酸誘導体およびその治療的使用
CN111039965B (zh) * 2018-10-12 2020-12-01 新发药业有限公司 一种法硼巴坦的简便制备方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
FR2573070B1 (fr) 1984-11-13 1987-01-30 Rhone Poulenc Sante Procede de preparation de composes carbonyles
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
CA1283404C (en) 1986-07-01 1991-04-23 Shigeru Sanai Cephalosporin compounds, processes for their preparation and antibacterial agents
ZA893284B (en) 1988-05-04 1990-03-28 Igen Inc Peptide analogs and their use as haptens to elicit catalytic antibodies
US5442100A (en) 1992-08-14 1995-08-15 The Procter & Gamble Company β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
US5888998A (en) 1997-04-24 1999-03-30 Synphar Laboratories, Inc. 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors
CA2291055A1 (en) 1997-06-13 1998-12-17 Northwestern University Inhibitors of .beta.-lactamases and uses therefor
US6184363B1 (en) 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
AU2190400A (en) 1998-12-16 2000-07-03 Northwestern University Inhibitors of beta-lactamases and uses therefor
AU3124300A (en) 1998-12-16 2000-07-03 Northwestern University Inhibitors of beta-lactamases and uses therefor
DK1216239T3 (da) 1999-09-25 2004-06-14 Smithkline Beecham Plc Antagonister af piperazin-derivater AS 5-HT1B
EP1227722A1 (en) 1999-10-28 2002-08-07 Merck & Co., Inc. Novel succinic acid metallo-beta-lactamase inhibitors and their use in treating bacterial infections
AU2001292732A1 (en) 2000-09-12 2002-03-26 Larry C. Blasczcak Beta-lactam analogs and uses therefor
IL154593A0 (en) 2000-09-14 2003-09-17 Pantherix Ltd 3-(heteroaryl acetamido)-2-oxoazetidine-1-sulfonic acid derivatives as antibacterial agents
US6586615B1 (en) 2001-01-10 2003-07-01 Bristol-Myers Squibb Company α-aminoboronic acids prepared by novel synthetic methods
DE10118698A1 (de) 2001-04-17 2002-11-07 Jerini Ag Verfahren zur Immobilisierung und damit hergestellte Anordnungen von Verbindungen auf einer planaren Oberfläche
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
JP2003229277A (ja) 2002-02-04 2003-08-15 Matsushita Electric Ind Co Ltd 発光素子材料およびそれを用いた発光素子並びに装置
AUPS065102A0 (en) 2002-02-20 2002-03-14 Unisearch Limited Fluorous acetalation
JP3714948B2 (ja) 2002-09-11 2005-11-09 呉羽化学工業株式会社 アミン化合物及びその用途
EP2325224A1 (en) 2002-10-30 2011-05-25 Sumitomo Chemical Company, Limited Aryl copolymer compounds and polymer light emitting devices made by using the same
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7271186B1 (en) 2002-12-09 2007-09-18 Northwestern University Nanomolar β-lactamase inhibitors
BR0317613A (pt) 2002-12-20 2005-11-29 Migenix Corp Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos
TW200418791A (en) 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
JP4233365B2 (ja) 2003-03-25 2009-03-04 三井化学株式会社 アザジオール錯体化合物、及び該化合物を用いる光記録媒体
US7842941B2 (en) 2003-10-06 2010-11-30 Sumitomo Chemical Company, Limited Aromatic compound
DE602004008098T8 (de) 2003-10-10 2008-04-17 Pfizer Products Inc., Groton Substituierte 2h-[1,2,4]triazolo[4,3-a]pyrazine als gsk-3-inhibitoren
TW200600494A (en) 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
US20060019116A1 (en) 2004-07-22 2006-01-26 Eastman Kodak Company White electroluminescent device with anthracene derivative host
TW200618820A (en) 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
US20060178357A1 (en) 2005-02-10 2006-08-10 Buynak John D Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases
ES2540966T3 (es) 2005-02-16 2015-07-15 Anacor Pharmaceuticals, Inc. Compuestos biocidas de boronoftalida
EP1851206B1 (en) 2005-02-22 2012-08-15 Teva Pharmaceutical Industries, Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
WO2006101779A2 (en) 2005-03-15 2006-09-28 The University Of Chicago Non-aqueous electrolytes for lithium ion batteries
TW200734311A (en) 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
ATE529111T1 (de) 2005-12-07 2011-11-15 Basilea Pharmaceutica Ag Nützliche monobactam-antibiotika
DK2719388T3 (da) 2006-02-16 2019-05-13 Anacor Pharmaceuticals Inc Borholdige små molekyler som antiinflammatoriske midler
JP2010504967A (ja) 2006-09-27 2010-02-18 メルク エンド カムパニー インコーポレーテッド 新規なβ−ラクタマーゼ阻害剤
CN101641095B (zh) 2007-03-23 2012-10-31 巴斯利尔药物股份公司 用于治疗细菌感染的组合药物
GB0719366D0 (en) 2007-10-03 2007-11-14 Smithkline Beecham Corp Compounds
WO2009064413A1 (en) 2007-11-13 2009-05-22 Protez Pharmaceuticals, Inc. Beta-lactamase inhibitors
US20100120715A1 (en) 2007-11-13 2010-05-13 Burns Christopher J Beta-lactamase inhibitors
ES2433744T3 (es) 2008-01-18 2013-12-12 Merck Sharp & Dohme Corp. Inhibidores de beta-lactamasas
US8129398B2 (en) 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2285384A4 (en) 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
CN102098918A (zh) 2008-05-13 2011-06-15 帕纳德制药公司 用于治疗癌症和神经退行性疾病的生物活性化合物
US20120046242A1 (en) 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
WO2010097675A1 (en) 2009-02-27 2010-09-02 Dhanuka Laboratories Ltd. An improved preparation process for cefpodoxime proxetil
US20100292185A1 (en) 2009-05-12 2010-11-18 Burns Christopher J Beta-lactamase inhibitors
CN105175409A (zh) 2009-06-08 2015-12-23 南特生物科学公司 三嗪衍生物及其治疗应用
US8343944B2 (en) 2009-07-28 2013-01-01 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
US20120329770A1 (en) 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
US8513218B2 (en) 2010-03-31 2013-08-20 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid
US20110288063A1 (en) 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
PL2603514T3 (pl) 2010-08-10 2019-04-30 Rempex Pharmaceuticals Inc Cykliczne pochodne estrowe kwasu boronowego oraz ich zastosowania terapeutyczne
RS54750B1 (sr) 2010-10-26 2016-10-31 Mars Inc Borati kao inhibitori arginaze
AU2011329486A1 (en) 2010-11-18 2013-04-18 Glaxo Group Limited Compounds
WO2012067663A1 (en) * 2010-11-18 2012-05-24 Glaxo Group Limited Compounds
EP2487159A1 (en) 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
EP2508506A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Preparation of sitagliptin intermediates
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
WO2013053372A1 (en) 2011-10-13 2013-04-18 Therabor Pharmaceuticals Boronic acid inhibitors of beta-lactamases
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
BR112014015363A2 (pt) 2011-12-22 2017-06-13 Ares Trading Sa derivados de ácido alfa-amino borônico, inibidores de imunoproteassoma seletivos
WO2013104897A1 (en) 2012-01-09 2013-07-18 University of Tromsø Therapeutic boron-containing compounds
EP2615080A1 (en) 2012-01-12 2013-07-17 LEK Pharmaceuticals d.d. Preparation of Optically Pure ß-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof
WO2013122888A2 (en) 2012-02-15 2013-08-22 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9422314B2 (en) 2012-12-07 2016-08-23 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN104994844A (zh) 2013-01-04 2015-10-21 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
CA2894892A1 (en) 2013-01-04 2014-07-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US8999885B2 (en) 2013-01-09 2015-04-07 General Electric Company Methods of activating charcoal resulting from biomass gasification
US9040504B2 (en) 2013-01-10 2015-05-26 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2014151958A1 (en) 2013-03-14 2014-09-25 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
EP3139930B1 (en) 2014-05-05 2024-08-14 Melinta Therapeutics, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
CA2947041A1 (en) 2014-05-19 2015-11-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN106536529B (zh) 2014-07-01 2019-09-27 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
WO2016065282A1 (en) 2014-10-24 2016-04-28 The Regents Of The University Of Michigan Nasal formulation, nasal kit, and method for enhancing nasal nitric oxide (no) levels
JP6945452B2 (ja) 2015-04-24 2021-10-06 レンペックス・ファーマシューティカルズ・インコーポレイテッド 細菌感染症の処置方法

Also Published As

Publication number Publication date
PL3140310T3 (pl) 2020-01-31
FI3604316T3 (fi) 2024-02-29
EP3604316A1 (en) 2020-02-05
LT3604316T (lt) 2024-02-26
CY1122222T1 (el) 2020-11-25
EP4356736A2 (en) 2024-04-24
EP3140310A1 (en) 2017-03-15
EP3140310A4 (en) 2017-12-13
HRP20191932T1 (hr) 2020-01-24
EP4356736A3 (en) 2024-08-07
HUE046836T2 (hu) 2020-03-30
US10385074B2 (en) 2019-08-20
PT3140310T (pt) 2019-11-18
US20170057979A1 (en) 2017-03-02
RS59488B1 (sr) 2019-12-31
ES2972939T3 (es) 2024-06-17
US20200031851A1 (en) 2020-01-30
WO2015171430A1 (en) 2015-11-12
EP3140310B1 (en) 2019-08-07
SI3140310T1 (sl) 2020-01-31
ES2750805T3 (es) 2020-03-27
PL3604316T3 (pl) 2024-04-29
US10669292B2 (en) 2020-06-02
LT3140310T (lt) 2019-11-25
EP3604316B1 (en) 2023-12-06

Similar Documents

Publication Publication Date Title
DK3140310T3 (da) Syntese af boronatsalte og brug deraf
DK3259253T3 (da) Sulfonylureaer og relaterede forbindelser og brug af samme
DK3210977T3 (da) Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf
DK3160956T3 (da) Inhibitorer af lysin-specifik demethylase-1
DK3215147T3 (da) Neurodæmpende norketamin-forbindelser og fremgangsmåder
DK3205650T3 (da) Egfr-hæmmer og fremstilling og anvendelse deraf
DK3102576T3 (da) Dihydropyrrolopyridininhibitorer af ror-gamma
DK3179991T3 (da) Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor
DK3240785T3 (da) Småmolekylede hæmmere af laktasedehydrogenase og fremgangsmåder til brug deraf
DK3511319T3 (da) Hæmmere af lysinspecifik demethylase-1
DK3215493T3 (da) Syntese af copanlisib og dihydrochloridsalt deraf
DK3227310T3 (da) Heterobifunktionelle inhibitorer af e-selektiner og cxcr4-kemokin-receptorer
DK3015526T3 (da) Hydrofluorolefinbaseret sammensætning og anvendelse deraf
DK3144001T3 (da) Sammensætninger af selenoorganiske forbindelser og fremgangsmåder til anvendelse deraf
DK3218005T3 (da) Glycan-interagerende forbindelser og anvendelsesfremgangsmåder
DK2981541T3 (da) Syntese og anvendelse af isotopmærkede glycaner
DK3089971T3 (da) Forbindelser og fremgangsmåder til anvendelse
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
PT3215507T (pt) Síntese de copanlisib e seu sal de dicloridrato
DK3389669T3 (da) Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf
DK3476830T3 (da) Polymethinforbindelser og anvendelse deraf som fluorescerende markører
DK3204352T3 (da) Hæmmere af lysin-gingipain
DK3231793T3 (da) Dihydropyromidin-2-on-forbindelser og medicinske anvendelser deraf
DK3328395T3 (da) Ny brug af dextransulfat
DK3189045T3 (da) Hidtil ukendte salte af nilotinib og polymorfer deraf