DK3140310T3 - Syntese af boronatsalte og brug deraf - Google Patents
Syntese af boronatsalte og brug deraf Download PDFInfo
- Publication number
- DK3140310T3 DK3140310T3 DK15788682.1T DK15788682T DK3140310T3 DK 3140310 T3 DK3140310 T3 DK 3140310T3 DK 15788682 T DK15788682 T DK 15788682T DK 3140310 T3 DK3140310 T3 DK 3140310T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- boronate salts
- boronate
- salts
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461988690P | 2014-05-05 | 2014-05-05 | |
PCT/US2015/028613 WO2015171430A1 (en) | 2014-05-05 | 2015-04-30 | Synthesis of boronate salts and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3140310T3 true DK3140310T3 (da) | 2019-10-21 |
Family
ID=54392864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15788682.1T DK3140310T3 (da) | 2014-05-05 | 2015-04-30 | Syntese af boronatsalte og brug deraf |
Country Status (14)
Country | Link |
---|---|
US (2) | US10385074B2 (da) |
EP (3) | EP3604316B1 (da) |
CY (1) | CY1122222T1 (da) |
DK (1) | DK3140310T3 (da) |
ES (2) | ES2972939T3 (da) |
FI (1) | FI3604316T3 (da) |
HR (1) | HRP20191932T1 (da) |
HU (1) | HUE046836T2 (da) |
LT (2) | LT3604316T (da) |
PL (2) | PL3604316T3 (da) |
PT (1) | PT3140310T (da) |
RS (1) | RS59488B1 (da) |
SI (1) | SI3140310T1 (da) |
WO (1) | WO2015171430A1 (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2603514T3 (pl) | 2010-08-10 | 2019-04-30 | Rempex Pharmaceuticals Inc | Cykliczne pochodne estrowe kwasu boronowego oraz ich zastosowania terapeutyczne |
CN104994844A (zh) | 2013-01-04 | 2015-10-21 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
CA2947041A1 (en) | 2014-05-19 | 2015-11-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
PL3154989T3 (pl) | 2014-06-11 | 2021-10-18 | VenatoRx Pharmaceuticals, Inc. | Inhibitory beta-laktamaz |
CN106536529B (zh) | 2014-07-01 | 2019-09-27 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
ES2761778T3 (es) | 2014-12-19 | 2020-05-21 | Rempex Pharmaceuticals Inc | Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
WO2017044828A1 (en) | 2015-09-11 | 2017-03-16 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
US10294249B2 (en) | 2016-06-30 | 2019-05-21 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
JOP20190188A1 (ar) | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك |
WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
CA3078627A1 (en) | 2017-10-11 | 2019-04-18 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
US11999757B2 (en) * | 2017-11-01 | 2024-06-04 | Melinta Subsidiary Corp. | Synthesis of boronate ester derivatives and uses thereof |
JP7329260B2 (ja) | 2018-04-20 | 2023-08-18 | キューペックス バイオファーマ, インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
CN111039965B (zh) * | 2018-10-12 | 2020-12-01 | 新发药业有限公司 | 一种法硼巴坦的简便制备方法 |
Family Cites Families (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4194047A (en) | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
US4260543A (en) | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
US4409214A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
FR2573070B1 (fr) | 1984-11-13 | 1987-01-30 | Rhone Poulenc Sante | Procede de preparation de composes carbonyles |
US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
CA1283404C (en) | 1986-07-01 | 1991-04-23 | Shigeru Sanai | Cephalosporin compounds, processes for their preparation and antibacterial agents |
ZA893284B (en) | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
US5442100A (en) | 1992-08-14 | 1995-08-15 | The Procter & Gamble Company | β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids |
US5888998A (en) | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
CA2291055A1 (en) | 1997-06-13 | 1998-12-17 | Northwestern University | Inhibitors of .beta.-lactamases and uses therefor |
US6184363B1 (en) | 1997-06-13 | 2001-02-06 | Northwestern University | Inhibitors of β-lactamases and uses therefor |
AU2190400A (en) | 1998-12-16 | 2000-07-03 | Northwestern University | Inhibitors of beta-lactamases and uses therefor |
AU3124300A (en) | 1998-12-16 | 2000-07-03 | Northwestern University | Inhibitors of beta-lactamases and uses therefor |
DK1216239T3 (da) | 1999-09-25 | 2004-06-14 | Smithkline Beecham Plc | Antagonister af piperazin-derivater AS 5-HT1B |
EP1227722A1 (en) | 1999-10-28 | 2002-08-07 | Merck & Co., Inc. | Novel succinic acid metallo-beta-lactamase inhibitors and their use in treating bacterial infections |
AU2001292732A1 (en) | 2000-09-12 | 2002-03-26 | Larry C. Blasczcak | Beta-lactam analogs and uses therefor |
IL154593A0 (en) | 2000-09-14 | 2003-09-17 | Pantherix Ltd | 3-(heteroaryl acetamido)-2-oxoazetidine-1-sulfonic acid derivatives as antibacterial agents |
US6586615B1 (en) | 2001-01-10 | 2003-07-01 | Bristol-Myers Squibb Company | α-aminoboronic acids prepared by novel synthetic methods |
DE10118698A1 (de) | 2001-04-17 | 2002-11-07 | Jerini Ag | Verfahren zur Immobilisierung und damit hergestellte Anordnungen von Verbindungen auf einer planaren Oberfläche |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
JP2003229277A (ja) | 2002-02-04 | 2003-08-15 | Matsushita Electric Ind Co Ltd | 発光素子材料およびそれを用いた発光素子並びに装置 |
AUPS065102A0 (en) | 2002-02-20 | 2002-03-14 | Unisearch Limited | Fluorous acetalation |
JP3714948B2 (ja) | 2002-09-11 | 2005-11-09 | 呉羽化学工業株式会社 | アミン化合物及びその用途 |
EP2325224A1 (en) | 2002-10-30 | 2011-05-25 | Sumitomo Chemical Company, Limited | Aryl copolymer compounds and polymer light emitting devices made by using the same |
US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
BR0317613A (pt) | 2002-12-20 | 2005-11-29 | Migenix Corp | Ligantes de adenina nucleotìdeo translocase (ant) e composições e métodos relacionados aos mesmos |
TW200418791A (en) | 2003-01-23 | 2004-10-01 | Bristol Myers Squibb Co | Pharmaceutical compositions for inhibiting proteasome |
JP4233365B2 (ja) | 2003-03-25 | 2009-03-04 | 三井化学株式会社 | アザジオール錯体化合物、及び該化合物を用いる光記録媒体 |
US7842941B2 (en) | 2003-10-06 | 2010-11-30 | Sumitomo Chemical Company, Limited | Aromatic compound |
DE602004008098T8 (de) | 2003-10-10 | 2008-04-17 | Pfizer Products Inc., Groton | Substituierte 2h-[1,2,4]triazolo[4,3-a]pyrazine als gsk-3-inhibitoren |
TW200600494A (en) | 2004-03-08 | 2006-01-01 | Chugai Pharmaceutical Co Ltd | Bisphenyl compounds useful as vitamin d3 receptor agonists |
US20060019116A1 (en) | 2004-07-22 | 2006-01-26 | Eastman Kodak Company | White electroluminescent device with anthracene derivative host |
TW200618820A (en) | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
US20060178357A1 (en) | 2005-02-10 | 2006-08-10 | Buynak John D | Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases |
ES2540966T3 (es) | 2005-02-16 | 2015-07-15 | Anacor Pharmaceuticals, Inc. | Compuestos biocidas de boronoftalida |
EP1851206B1 (en) | 2005-02-22 | 2012-08-15 | Teva Pharmaceutical Industries, Ltd. | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
WO2006101779A2 (en) | 2005-03-15 | 2006-09-28 | The University Of Chicago | Non-aqueous electrolytes for lithium ion batteries |
TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
ATE529111T1 (de) | 2005-12-07 | 2011-11-15 | Basilea Pharmaceutica Ag | Nützliche monobactam-antibiotika |
DK2719388T3 (da) | 2006-02-16 | 2019-05-13 | Anacor Pharmaceuticals Inc | Borholdige små molekyler som antiinflammatoriske midler |
JP2010504967A (ja) | 2006-09-27 | 2010-02-18 | メルク エンド カムパニー インコーポレーテッド | 新規なβ−ラクタマーゼ阻害剤 |
CN101641095B (zh) | 2007-03-23 | 2012-10-31 | 巴斯利尔药物股份公司 | 用于治疗细菌感染的组合药物 |
GB0719366D0 (en) | 2007-10-03 | 2007-11-14 | Smithkline Beecham Corp | Compounds |
WO2009064413A1 (en) | 2007-11-13 | 2009-05-22 | Protez Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
US20100120715A1 (en) | 2007-11-13 | 2010-05-13 | Burns Christopher J | Beta-lactamase inhibitors |
ES2433744T3 (es) | 2008-01-18 | 2013-12-12 | Merck Sharp & Dohme Corp. | Inhibidores de beta-lactamasas |
US8129398B2 (en) | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
EP2285384A4 (en) | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
CN102098918A (zh) | 2008-05-13 | 2011-06-15 | 帕纳德制药公司 | 用于治疗癌症和神经退行性疾病的生物活性化合物 |
US20120046242A1 (en) | 2008-12-24 | 2012-02-23 | Massachusetts Institute Of Technology | Molecular activators of the wnt/beta-catenin pathway |
WO2010097675A1 (en) | 2009-02-27 | 2010-09-02 | Dhanuka Laboratories Ltd. | An improved preparation process for cefpodoxime proxetil |
US20100292185A1 (en) | 2009-05-12 | 2010-11-18 | Burns Christopher J | Beta-lactamase inhibitors |
CN105175409A (zh) | 2009-06-08 | 2015-12-23 | 南特生物科学公司 | 三嗪衍生物及其治疗应用 |
US8343944B2 (en) | 2009-07-28 | 2013-01-01 | Anacor Pharmaceuticals, Inc. | Trisubstituted boron-containing molecules |
US20120329770A1 (en) | 2010-02-26 | 2012-12-27 | Gary Igor Dmitrienko | Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof |
US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
US20110288063A1 (en) | 2010-05-19 | 2011-11-24 | Naeja Pharmaceutical Inc. | Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors |
PL2603514T3 (pl) | 2010-08-10 | 2019-04-30 | Rempex Pharmaceuticals Inc | Cykliczne pochodne estrowe kwasu boronowego oraz ich zastosowania terapeutyczne |
RS54750B1 (sr) | 2010-10-26 | 2016-10-31 | Mars Inc | Borati kao inhibitori arginaze |
AU2011329486A1 (en) | 2010-11-18 | 2013-04-18 | Glaxo Group Limited | Compounds |
WO2012067663A1 (en) * | 2010-11-18 | 2012-05-24 | Glaxo Group Limited | Compounds |
EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
EP2508506A1 (en) | 2011-04-08 | 2012-10-10 | LEK Pharmaceuticals d.d. | Preparation of sitagliptin intermediates |
US9012491B2 (en) | 2011-08-31 | 2015-04-21 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2013053372A1 (en) | 2011-10-13 | 2013-04-18 | Therabor Pharmaceuticals | Boronic acid inhibitors of beta-lactamases |
WO2013056163A1 (en) | 2011-10-14 | 2013-04-18 | The Regents Of The University Of California | Beta-lactamase inhibitors |
BR112014015363A2 (pt) | 2011-12-22 | 2017-06-13 | Ares Trading Sa | derivados de ácido alfa-amino borônico, inibidores de imunoproteassoma seletivos |
WO2013104897A1 (en) | 2012-01-09 | 2013-07-18 | University of Tromsø | Therapeutic boron-containing compounds |
EP2615080A1 (en) | 2012-01-12 | 2013-07-17 | LEK Pharmaceuticals d.d. | Preparation of Optically Pure ß-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof |
WO2013122888A2 (en) | 2012-02-15 | 2013-08-22 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
US9422314B2 (en) | 2012-12-07 | 2016-08-23 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN104994844A (zh) | 2013-01-04 | 2015-10-21 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
CA2894892A1 (en) | 2013-01-04 | 2014-07-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US8999885B2 (en) | 2013-01-09 | 2015-04-07 | General Electric Company | Methods of activating charcoal resulting from biomass gasification |
US9040504B2 (en) | 2013-01-10 | 2015-05-26 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP3139930B1 (en) | 2014-05-05 | 2024-08-14 | Melinta Therapeutics, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
CA2947041A1 (en) | 2014-05-19 | 2015-11-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
CN106536529B (zh) | 2014-07-01 | 2019-09-27 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
WO2016065282A1 (en) | 2014-10-24 | 2016-04-28 | The Regents Of The University Of Michigan | Nasal formulation, nasal kit, and method for enhancing nasal nitric oxide (no) levels |
JP6945452B2 (ja) | 2015-04-24 | 2021-10-06 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | 細菌感染症の処置方法 |
-
2015
- 2015-04-30 PT PT157886821T patent/PT3140310T/pt unknown
- 2015-04-30 HU HUE15788682A patent/HUE046836T2/hu unknown
- 2015-04-30 ES ES19186092T patent/ES2972939T3/es active Active
- 2015-04-30 WO PCT/US2015/028613 patent/WO2015171430A1/en active Application Filing
- 2015-04-30 US US15/305,954 patent/US10385074B2/en active Active
- 2015-04-30 RS RS20191368A patent/RS59488B1/sr unknown
- 2015-04-30 PL PL19186092.3T patent/PL3604316T3/pl unknown
- 2015-04-30 EP EP19186092.3A patent/EP3604316B1/en active Active
- 2015-04-30 EP EP15788682.1A patent/EP3140310B1/en active Active
- 2015-04-30 DK DK15788682.1T patent/DK3140310T3/da active
- 2015-04-30 LT LTEP19186092.3T patent/LT3604316T/lt unknown
- 2015-04-30 FI FIEP19186092.3T patent/FI3604316T3/fi active
- 2015-04-30 SI SI201530973T patent/SI3140310T1/sl unknown
- 2015-04-30 LT LT15788682T patent/LT3140310T/lt unknown
- 2015-04-30 ES ES15788682T patent/ES2750805T3/es active Active
- 2015-04-30 PL PL15788682T patent/PL3140310T3/pl unknown
- 2015-04-30 EP EP23214076.4A patent/EP4356736A3/en active Pending
-
2019
- 2019-08-02 US US16/530,625 patent/US10669292B2/en active Active
- 2019-10-23 HR HRP20191932TT patent/HRP20191932T1/hr unknown
- 2019-11-01 CY CY20191101140T patent/CY1122222T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL3140310T3 (pl) | 2020-01-31 |
FI3604316T3 (fi) | 2024-02-29 |
EP3604316A1 (en) | 2020-02-05 |
LT3604316T (lt) | 2024-02-26 |
CY1122222T1 (el) | 2020-11-25 |
EP4356736A2 (en) | 2024-04-24 |
EP3140310A1 (en) | 2017-03-15 |
EP3140310A4 (en) | 2017-12-13 |
HRP20191932T1 (hr) | 2020-01-24 |
EP4356736A3 (en) | 2024-08-07 |
HUE046836T2 (hu) | 2020-03-30 |
US10385074B2 (en) | 2019-08-20 |
PT3140310T (pt) | 2019-11-18 |
US20170057979A1 (en) | 2017-03-02 |
RS59488B1 (sr) | 2019-12-31 |
ES2972939T3 (es) | 2024-06-17 |
US20200031851A1 (en) | 2020-01-30 |
WO2015171430A1 (en) | 2015-11-12 |
EP3140310B1 (en) | 2019-08-07 |
SI3140310T1 (sl) | 2020-01-31 |
ES2750805T3 (es) | 2020-03-27 |
PL3604316T3 (pl) | 2024-04-29 |
US10669292B2 (en) | 2020-06-02 |
LT3140310T (lt) | 2019-11-25 |
EP3604316B1 (en) | 2023-12-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3140310T3 (da) | Syntese af boronatsalte og brug deraf | |
DK3259253T3 (da) | Sulfonylureaer og relaterede forbindelser og brug af samme | |
DK3210977T3 (da) | Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf | |
DK3160956T3 (da) | Inhibitorer af lysin-specifik demethylase-1 | |
DK3215147T3 (da) | Neurodæmpende norketamin-forbindelser og fremgangsmåder | |
DK3205650T3 (da) | Egfr-hæmmer og fremstilling og anvendelse deraf | |
DK3102576T3 (da) | Dihydropyrrolopyridininhibitorer af ror-gamma | |
DK3179991T3 (da) | Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor | |
DK3240785T3 (da) | Småmolekylede hæmmere af laktasedehydrogenase og fremgangsmåder til brug deraf | |
DK3511319T3 (da) | Hæmmere af lysinspecifik demethylase-1 | |
DK3215493T3 (da) | Syntese af copanlisib og dihydrochloridsalt deraf | |
DK3227310T3 (da) | Heterobifunktionelle inhibitorer af e-selektiner og cxcr4-kemokin-receptorer | |
DK3015526T3 (da) | Hydrofluorolefinbaseret sammensætning og anvendelse deraf | |
DK3144001T3 (da) | Sammensætninger af selenoorganiske forbindelser og fremgangsmåder til anvendelse deraf | |
DK3218005T3 (da) | Glycan-interagerende forbindelser og anvendelsesfremgangsmåder | |
DK2981541T3 (da) | Syntese og anvendelse af isotopmærkede glycaner | |
DK3089971T3 (da) | Forbindelser og fremgangsmåder til anvendelse | |
DK3161139T3 (da) | Tlr-4-specifikke aptamerer og anvendelser heraf | |
PT3215507T (pt) | Síntese de copanlisib e seu sal de dicloridrato | |
DK3389669T3 (da) | Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf | |
DK3476830T3 (da) | Polymethinforbindelser og anvendelse deraf som fluorescerende markører | |
DK3204352T3 (da) | Hæmmere af lysin-gingipain | |
DK3231793T3 (da) | Dihydropyromidin-2-on-forbindelser og medicinske anvendelser deraf | |
DK3328395T3 (da) | Ny brug af dextransulfat | |
DK3189045T3 (da) | Hidtil ukendte salte af nilotinib og polymorfer deraf |