DK3389669T3 - Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf - Google Patents
Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf Download PDFInfo
- Publication number
- DK3389669T3 DK3389669T3 DK16876910.7T DK16876910T DK3389669T3 DK 3389669 T3 DK3389669 T3 DK 3389669T3 DK 16876910 T DK16876910 T DK 16876910T DK 3389669 T3 DK3389669 T3 DK 3389669T3
- Authority
- DK
- Denmark
- Prior art keywords
- triterpensaponine
- variants
- synthesis
- methods
- triterpensaponine variants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268837P | 2015-12-17 | 2015-12-17 | |
| PCT/US2016/067530 WO2017106836A1 (en) | 2015-12-17 | 2016-12-19 | Triterpene saponin variants, methods of synthesis and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3389669T3 true DK3389669T3 (da) | 2023-05-01 |
Family
ID=59057688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16876910.7T DK3389669T3 (da) | 2015-12-17 | 2016-12-19 | Triterpensaponinvarianter, syntesefremgangsmåder og anvendelse deraf |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11629162B2 (da) |
| EP (1) | EP3389669B1 (da) |
| DK (1) | DK3389669T3 (da) |
| ES (1) | ES2944947T3 (da) |
| WO (1) | WO2017106836A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL286493B (en) | 2015-11-06 | 2022-07-01 | Memorial Sloan Kettering Cancer Center | Triterpene saponin analogs, methods for their production, preparations containing them and their uses |
| JP2020516657A (ja) * | 2017-04-13 | 2020-06-11 | アジュバンス・テクノロジーズ・インコーポレーテッド | トリテルペンサポニン合成、中間体及びアジュバントの組み合わせ |
| CA3075822A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| BR112021024277A2 (pt) * | 2019-06-03 | 2022-04-26 | Pi Hui Liang | Conjugado de saponina e vacina ou composição farmacêutica compreendendo o mesmo |
| CN113896757A (zh) * | 2020-07-07 | 2022-01-07 | 中国科学院上海药物研究所 | 一类五环三萜类碳苷化合物及其制备方法和用途 |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023139145A1 (en) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060915A2 (en) * | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
| US20050026982A1 (en) | 2003-06-10 | 2005-02-03 | Soenke Johannsen | Composition that consists of alkanedicarboxylic acids and a pharmaceutical active ingredient |
| AU2015203675B2 (en) * | 2008-04-08 | 2017-12-07 | Sloan-Kettering Institute For Cancer Research | Triterpene saponins, methods of synthesis, and uses thereof |
| DK3149015T3 (da) | 2014-05-30 | 2021-09-27 | Memorial Sloan Kettering Cancer Center | Minimale saponin-analoger, syntese og anvendelse deraf |
-
2016
- 2016-12-19 EP EP16876910.7A patent/EP3389669B1/en active Active
- 2016-12-19 DK DK16876910.7T patent/DK3389669T3/da active
- 2016-12-19 ES ES16876910T patent/ES2944947T3/es active Active
- 2016-12-19 WO PCT/US2016/067530 patent/WO2017106836A1/en active Application Filing
- 2016-12-19 US US16/063,608 patent/US11629162B2/en active Active
-
2023
- 2023-04-17 US US18/135,592 patent/US20230357302A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11629162B2 (en) | 2023-04-18 |
| EP3389669A4 (en) | 2019-10-09 |
| US20190010181A1 (en) | 2019-01-10 |
| EP3389669B1 (en) | 2023-03-15 |
| EP3389669A1 (en) | 2018-10-24 |
| US20230357302A1 (en) | 2023-11-09 |
| ES2944947T3 (es) | 2023-06-27 |
| WO2017106836A1 (en) | 2017-06-22 |
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