JP2010540555A5 - - Google Patents
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- Publication number
- JP2010540555A5 JP2010540555A5 JP2010527139A JP2010527139A JP2010540555A5 JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5 JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5
- Authority
- JP
- Japan
- Prior art keywords
- der
- pharmaceutical composition
- formula
- alkenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- 230000004968 inflammatory condition Effects 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000001613 neoplastic effect Effects 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 210000002808 connective tissue Anatomy 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 210000005166 vasculature Anatomy 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000003932 urinary bladder Anatomy 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
- 230000007608 epigenetic mechanism Effects 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077669 WO2009042766A1 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogues and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540555A JP2010540555A (ja) | 2010-12-24 |
| JP2010540555A5 true JP2010540555A5 (enExample) | 2011-08-25 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527139A Pending JP2010540555A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8399420B2 (enExample) |
| EP (2) | EP2205073A4 (enExample) |
| JP (2) | JP2010540555A (enExample) |
| KR (2) | KR20100102092A (enExample) |
| CN (2) | CN101877964A (enExample) |
| AU (2) | AU2008304380A1 (enExample) |
| BR (2) | BRPI0817269A2 (enExample) |
| CA (2) | CA2700267A1 (enExample) |
| IL (1) | IL204690A0 (enExample) |
| MX (2) | MX2010003261A (enExample) |
| NZ (2) | NZ583824A (enExample) |
| RU (1) | RU2488591C2 (enExample) |
| UA (2) | UA99308C2 (enExample) |
| WO (2) | WO2009042767A1 (enExample) |
| ZA (1) | ZA201001660B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) * | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| WO2009042767A1 (en) | 2007-09-26 | 2009-04-02 | Mount Sinai School Of Medicine | Azacytidine analogues and uses thereof |
| PL3692983T3 (pl) | 2008-05-15 | 2021-12-27 | Celgene Corporation | Doustne formulacje analogów cytydyny i sposoby ich zastosowania |
| WO2010014883A2 (en) * | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| EP2424845A4 (en) * | 2009-04-27 | 2014-03-05 | Reddys Lab Ltd Dr | PREPARATION OF DECITABIN |
| JP2014503597A (ja) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
| WO2012142411A1 (en) * | 2011-04-15 | 2012-10-18 | Clavis Pharma Asa | Systems and methods for detecting hent1 expression in hematological disorders |
| TW201700103A (zh) | 2011-11-01 | 2017-01-01 | 西建公司 | 利用胞嘧啶核苷類似物之口服配方治療癌症的方法 |
| EP2817029B1 (en) | 2012-02-24 | 2019-07-10 | Signal Pharmaceuticals, LLC | Methods for treating non-small cell lung cancer using tor kinase inhibitor combination therapy |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| CA2908742C (en) * | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| WO2017096357A1 (en) | 2015-12-03 | 2017-06-08 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| ES2963046T3 (es) | 2017-03-20 | 2024-03-25 | Vaccinex Inc | Tratamiento del cáncer con un anticuerpo contra la semaforina-4d combinado con un agente modulador epigenético |
| TWI787284B (zh) | 2017-06-22 | 2022-12-21 | 美商西建公司 | 以b型肝炎病毒感染表徵之肝細胞癌之治療 |
| WO2019204637A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| WO2022035852A1 (en) * | 2020-08-10 | 2022-02-17 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
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| BE612384A (fr) | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
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| DE2012888C3 (de) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
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-
2008
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown