AR076418A1 - Preparacion de decitabina - Google Patents

Preparacion de decitabina

Info

Publication number
AR076418A1
AR076418A1 ARP100101387A ARP100101387A AR076418A1 AR 076418 A1 AR076418 A1 AR 076418A1 AR P100101387 A ARP100101387 A AR P100101387A AR P100101387 A ARP100101387 A AR P100101387A AR 076418 A1 AR076418 A1 AR 076418A1
Authority
AR
Argentina
Prior art keywords
formula
compound
decitabine
prepare
independently
Prior art date
Application number
ARP100101387A
Other languages
English (en)
Inventor
Srinivas Gangula
Uday Kumar Neelam
Naveen Kumar Kolla
Sudhakar Reddy Baddam
Original Assignee
Reddys Lab Inc Dr
Reddys Lab Ltd Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Inc Dr, Reddys Lab Ltd Dr filed Critical Reddys Lab Inc Dr
Publication of AR076418A1 publication Critical patent/AR076418A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procesos para preparar y purificar decitabina y procesos para preparar una forma cristalina de la decitabina. Decitabina pura. Reivindicacion 1: Un proceso para preparar decitabina, caracterizado porque comprende a) sililar 5-azacitosina en un solvente de nitrilo para producir un compuesto de formula (1) donde cada R es independientemente un grupo alquilo C1-6 opcionalmente sustituido; b) unir el compuesto de formula (1) con entre aproximadamente 0,9 y aproximadamente 1,2 equivalentes molares de un compuesto de formula (2) por equivalente molar del compuesto de formula (1) donde R1 representa un grupo alquilo que tiene entre 1 y 6 átomos de carbono, y donde cada R2 es independientemente un grupo acilo o arilo opcionalmente sustituido, en presencia de entre aproximadamente 1 y aproximadamente 1,2 equivalentes molares de un ácido de Lewis no metálico por equivalente molar del compuesto de formula (1), y con un solvente orgánico, para proveer un compuesto enriquecido en el anomero b de formula (3); y c) desproteger el compuesto de formula (3) para obtener la decitabina.
ARP100101387A 2009-04-27 2010-04-26 Preparacion de decitabina AR076418A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN971CH2009 2009-04-27
IN2372CH2009 2009-09-30
US25656209P 2009-10-30 2009-10-30
US31154110P 2010-03-08 2010-03-08

Publications (1)

Publication Number Publication Date
AR076418A1 true AR076418A1 (es) 2011-06-08

Family

ID=43050703

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101387A AR076418A1 (es) 2009-04-27 2010-04-26 Preparacion de decitabina

Country Status (4)

Country Link
US (1) US20120046457A1 (es)
EP (1) EP2424845A4 (es)
AR (1) AR076418A1 (es)
WO (1) WO2010129211A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012071508A1 (en) * 2010-11-23 2012-05-31 Johnson Matthew Public Limited Company Process for the preparation of (2r.3s)-2-(hydroxymethyl) -5-methoxytetrahydrofuran-3-ol and acetylated derivatives thereof, free of pyranose compounds
CN103130855B (zh) * 2011-11-30 2015-04-29 连云港润众制药有限公司 一种地西他滨的制备方法
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
WO2014053897A1 (en) * 2012-10-01 2014-04-10 Johnson Matthey Public Limited Company Method for the purification of decitabine
CN104211743A (zh) * 2013-05-29 2014-12-17 南京工业大学 一种地西他宾的合成
CN103884809B (zh) * 2013-08-28 2016-01-27 鲁南制药集团股份有限公司 一种地西他滨中间体的分析检测方法
CN104761605B (zh) * 2014-01-03 2019-03-26 江苏豪森药业集团有限公司 地西他滨母液回收生产工艺方法
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
CN106117290A (zh) * 2016-06-27 2016-11-16 青岛云天生物技术有限公司 一种抗癌药物地西他滨的制备方法
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN117105996B (zh) * 2023-10-24 2024-02-06 北京瑞博奥医药科技有限公司 一种脱氧核糖衍生物的制备的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
CZ2007136A3 (cs) * 2007-02-20 2008-08-27 Ústav organické chemie a biochemie AV CR, v.v.i. Zpusob výroby 1-(2-deoxy-alfa-D-erythro-pentofuranosyl)-5-azacytosinu
WO2009042766A1 (en) * 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
WO2009086687A1 (zh) * 2008-01-03 2009-07-16 Nanjing Zhongshi Chemical Co., Ltd. 一种合成地西他滨的方法
CN101307084A (zh) * 2008-07-08 2008-11-19 贵州大学 地西他滨(Decitabine)的合成工艺
WO2010014883A2 (en) * 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs

Also Published As

Publication number Publication date
WO2010129211A2 (en) 2010-11-11
WO2010129211A3 (en) 2011-02-24
US20120046457A1 (en) 2012-02-23
EP2424845A4 (en) 2014-03-05
EP2424845A2 (en) 2012-03-07

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