UA99308C2 - Аналог азацитидина и его применение - Google Patents
Аналог азацитидина и его применениеInfo
- Publication number
- UA99308C2 UA99308C2 UAA201004927A UAA201004927A UA99308C2 UA 99308 C2 UA99308 C2 UA 99308C2 UA A201004927 A UAA201004927 A UA A201004927A UA A201004927 A UAA201004927 A UA A201004927A UA 99308 C2 UA99308 C2 UA 99308C2
- Authority
- UA
- Ukraine
- Prior art keywords
- integer
- formula
- rchoc
- rchnhc
- ris
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Данное изобретение относится к соединениям формулы (I), которая приведена ниже, где R представляет собой Н, RC(O), RCHOC(O) или RCHNHC(O), Rпредставляет собой фрагмент, соответствующий формулам, приведенным ниже, где перекрещивающаяся пунктирная линия, показывает связь, образованную присоединением Rк молекуле формулы (I); Rи Rнезависимо представляет собой ОН или Н, при условии, что Rи Rодновременно не является ОН; Rпредставляет собой Н, RC(O), RCHOC(O) или RCHNHC(O), при условии, что R и Rодновременно не является Н, Rсоответствует общей формуле: CH(CH)(CH=CH-CH)-CH=CH-(CH); k представляет собой целое число от 0 до 7; m представляет собой целое число от 0 до 2; и n представляет собой целое число от 0 до 10; или их фармацевтически приемлемые соли. Раскрыты также способы получения и применения указанных соединений.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97543707P | 2007-09-26 | 2007-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA99308C2 true UA99308C2 (ru) | 2012-08-10 |
Family
ID=40511851
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201004927A UA99308C2 (ru) | 2007-09-26 | 2008-09-25 | Аналог азацитидина и его применение |
UAA201004928A UA99836C2 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogue and using thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201004928A UA99836C2 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogue and using thereof |
Country Status (15)
Country | Link |
---|---|
US (2) | US8399420B2 (ru) |
EP (2) | EP2205073A4 (ru) |
JP (2) | JP2010540556A (ru) |
KR (2) | KR20100072230A (ru) |
CN (2) | CN101815437A (ru) |
AU (2) | AU2008304381A1 (ru) |
BR (2) | BRPI0817269A2 (ru) |
CA (2) | CA2700207A1 (ru) |
IL (1) | IL204690A0 (ru) |
MX (2) | MX2010003261A (ru) |
NZ (2) | NZ583824A (ru) |
RU (1) | RU2488591C2 (ru) |
UA (2) | UA99308C2 (ru) |
WO (2) | WO2009042766A1 (ru) |
ZA (1) | ZA201001660B (ru) |
Families Citing this family (18)
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US8497292B2 (en) * | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
KR20100072230A (ko) * | 2007-09-26 | 2010-06-30 | 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 | 아자시티딘 유사체 및 이의 용도 |
PL2299984T3 (pl) | 2008-05-15 | 2019-07-31 | Celgene Corporation | Doustne formulacje analogów cytydyny i sposoby ich zastosowania |
WO2010014883A2 (en) * | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
AR076418A1 (es) * | 2009-04-27 | 2011-06-08 | Reddys Lab Inc Dr | Preparacion de decitabina |
JP2014503597A (ja) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
US20120264710A1 (en) * | 2011-04-15 | 2012-10-18 | Marit Liland Sandvold | Systems and Methods for Detecting hENT1 Expression in Hematological Disorders |
US9125884B2 (en) | 2011-11-01 | 2015-09-08 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
BR112014020786A2 (pt) | 2012-02-24 | 2020-10-27 | Signal Pharmaceuticals, Llc | método para tratamento de câncer de pulmão, método para alcançar um critério de avaliação de resposta em tumores sólidos, método para aumento da sobrevivência |
US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
EP2986321A1 (en) * | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | 5-アザシチジン又は其の2'-デオキシ体の5'位ジベンジル燐酸エステル |
EP3960182A1 (en) | 2015-12-03 | 2022-03-02 | Epidestiny, Inc. | Compositions containing decitabine, 5-azacytidine and tetrahydrouridine and uses thereof |
MX2019011130A (es) | 2017-03-20 | 2019-11-05 | Vaccinex Inc | Tratamiento del cancer con un anticuerpo semaforina-4d en combinacion con un agente de modulacion epigenetica. |
SG11201912403SA (en) | 2017-06-22 | 2020-01-30 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
CA3097003A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
WO2022035852A1 (en) * | 2020-08-10 | 2022-02-17 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
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KR20100072230A (ko) * | 2007-09-26 | 2010-06-30 | 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 | 아자시티딘 유사체 및 이의 용도 |
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2008
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Application Discontinuation
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Application Discontinuation
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en active Application Filing
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en active Application Filing
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
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2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown
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