BRPI0817234A2 - Análogos de azacitidina e seus usos - Google Patents

Análogos de azacitidina e seus usos

Info

Publication number
BRPI0817234A2
BRPI0817234A2 BRPI0817234-0A2A BRPI0817234A BRPI0817234A2 BR PI0817234 A2 BRPI0817234 A2 BR PI0817234A2 BR PI0817234 A BRPI0817234 A BR PI0817234A BR PI0817234 A2 BRPI0817234 A2 BR PI0817234A2
Authority
BR
Brazil
Prior art keywords
azacitidine
analogs
azacitidine analogs
Prior art date
Application number
BRPI0817234-0A2A
Other languages
English (en)
Inventor
Lewis Silverman
James Holland
Ole Henrik Eriksen
Finn Myhren
Marit Liland Sandvold
Original Assignee
Sinai School Medicine
Clavis Pharma Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine, Clavis Pharma Asa filed Critical Sinai School Medicine
Publication of BRPI0817234A2 publication Critical patent/BRPI0817234A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
BRPI0817234-0A2A 2007-09-26 2008-09-25 Análogos de azacitidina e seus usos BRPI0817234A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97543707P 2007-09-26 2007-09-26
PCT/US2008/077673 WO2009042767A1 (en) 2007-09-26 2008-09-25 Azacytidine analogues and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0817234A2 true BRPI0817234A2 (pt) 2014-09-30

Family

ID=40511851

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0817234-0A2A BRPI0817234A2 (pt) 2007-09-26 2008-09-25 Análogos de azacitidina e seus usos
BRPI0817269-2A2A BRPI0817269A2 (pt) 2007-09-26 2008-09-25 Análogos de azacitidina e usos dos mesmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0817269-2A2A BRPI0817269A2 (pt) 2007-09-26 2008-09-25 Análogos de azacitidina e usos dos mesmos

Country Status (15)

Country Link
US (2) US8399420B2 (pt)
EP (2) EP2197274A4 (pt)
JP (2) JP2010540556A (pt)
KR (2) KR20100072230A (pt)
CN (2) CN101877964A (pt)
AU (2) AU2008304381A1 (pt)
BR (2) BRPI0817234A2 (pt)
CA (2) CA2700207A1 (pt)
IL (1) IL204690A0 (pt)
MX (2) MX2010003002A (pt)
NZ (2) NZ583824A (pt)
RU (1) RU2488591C2 (pt)
UA (2) UA99308C2 (pt)
WO (2) WO2009042766A1 (pt)
ZA (1) ZA201001660B (pt)

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NZ583824A (en) 2007-09-26 2012-06-29 Sinai School Medicine Azacytidine analogues and uses thereof
SI2299984T1 (sl) 2008-05-15 2019-04-30 Celgene Corporation Oralne formulacije analogov citidina in postopki njihove uporabe
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CN103338753A (zh) 2011-01-31 2013-10-02 细胞基因公司 胞苷类似物的药物组合物及其使用方法
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CA2853949A1 (en) 2011-11-01 2013-05-10 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
EA028462B1 (ru) 2012-02-24 2017-11-30 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
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WO2015195786A2 (en) 2014-06-17 2015-12-23 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
WO2017090264A1 (ja) 2015-11-27 2017-06-01 大原薬品工業株式会社 ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル
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MX2019011130A (es) 2017-03-20 2019-11-05 Vaccinex Inc Tratamiento del cancer con un anticuerpo semaforina-4d en combinacion con un agente de modulacion epigenetica.
BR112019027402A2 (pt) 2017-06-22 2020-07-07 Celgene Corporation tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b
AU2019256465A1 (en) * 2018-04-19 2020-11-26 Southern Research Institute 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer
US20230416294A1 (en) * 2020-08-10 2023-12-28 The Johns Hopkins University Decitabine analogs for immunological and oncological therapy

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Also Published As

Publication number Publication date
US20090209477A1 (en) 2009-08-20
CA2700207A1 (en) 2009-04-02
NZ583923A (en) 2012-05-25
JP2010540556A (ja) 2010-12-24
US20090209482A1 (en) 2009-08-20
EP2205073A4 (en) 2013-03-06
JP2010540555A (ja) 2010-12-24
EP2205073A1 (en) 2010-07-14
ZA201001660B (en) 2011-05-25
CA2700267A1 (en) 2009-04-02
AU2008304381A1 (en) 2009-04-02
KR20100072230A (ko) 2010-06-30
US8399420B2 (en) 2013-03-19
EP2197274A4 (en) 2013-03-06
IL204690A0 (en) 2010-11-30
MX2010003261A (es) 2010-08-18
EP2197274A1 (en) 2010-06-23
WO2009042767A1 (en) 2009-04-02
NZ583824A (en) 2012-06-29
US8158605B2 (en) 2012-04-17
AU2008304380A1 (en) 2009-04-02
CN101877964A (zh) 2010-11-03
RU2010116154A (ru) 2011-11-10
CN101815437A (zh) 2010-08-25
WO2009042766A9 (en) 2009-05-28
WO2009042766A1 (en) 2009-04-02
RU2488591C2 (ru) 2013-07-27
BRPI0817269A2 (pt) 2014-10-07
MX2010003002A (es) 2010-07-05
KR20100102092A (ko) 2010-09-20
UA99308C2 (ru) 2012-08-10
RU2010116274A (ru) 2011-11-10
UA99836C2 (en) 2012-10-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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