BRPI0718182A2 - Oligorribonucleotídeos e seus usos. - Google Patents
Oligorribonucleotídeos e seus usos.Info
- Publication number
- BRPI0718182A2 BRPI0718182A2 BRPI0718182-5A2A BRPI0718182A BRPI0718182A2 BR PI0718182 A2 BRPI0718182 A2 BR PI0718182A2 BR PI0718182 A BRPI0718182 A BR PI0718182A BR PI0718182 A2 BRPI0718182 A2 BR PI0718182A2
- Authority
- BR
- Brazil
- Prior art keywords
- oligorribonucleotids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/336—Modified G
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85458506P | 2006-10-26 | 2006-10-26 | |
| PCT/IB2007/004593 WO2008139262A2 (en) | 2006-10-26 | 2007-10-26 | Oligoribonucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0718182A2 true BRPI0718182A2 (pt) | 2014-02-25 |
Family
ID=40002694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718182-5A2A BRPI0718182A2 (pt) | 2006-10-26 | 2007-10-26 | Oligorribonucleotídeos e seus usos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100144846A1 (pt) |
| EP (1) | EP2104738A2 (pt) |
| JP (1) | JP2010507386A (pt) |
| KR (1) | KR20090058584A (pt) |
| CN (1) | CN101558157A (pt) |
| AU (1) | AU2007353120A1 (pt) |
| BR (1) | BRPI0718182A2 (pt) |
| CA (1) | CA2667297A1 (pt) |
| MX (1) | MX2009004510A (pt) |
| NO (1) | NO20092023L (pt) |
| RU (1) | RU2009115687A (pt) |
| WO (1) | WO2008139262A2 (pt) |
| ZA (1) | ZA200902823B (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DK1077722T3 (da) | 1998-05-22 | 2006-11-27 | Ottawa Health Research Inst | Fremgangsmåder og produkter til induktion af mukosaimmunitet |
| KR100991644B1 (ko) | 2001-08-17 | 2010-11-02 | 콜리 파마슈티칼 게엠베하 | 활성이 개량된 조합 모티프 면역자극성 올리고뉴클레오티드 |
| US8153141B2 (en) | 2002-04-04 | 2012-04-10 | Coley Pharmaceutical Gmbh | Immunostimulatory G, U-containing oligoribonucleotides |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| EP2241325B1 (en) | 2002-10-29 | 2012-02-08 | Coley Pharmaceutical Group, Inc. | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
| JP2006512927A (ja) | 2002-12-11 | 2006-04-20 | コーリー ファーマシューティカル グループ，インコーポレイテッド | ５’ｃｐｇ核酸およびその使用方法 |
| SG123799A1 (en) | 2003-10-30 | 2006-07-26 | Coley Pharm Gmbh | C-class oligonucleotide analogs with enchanced immunostimulatory potency |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| JP2010507361A (ja) * | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤／アジュバントとしての、一般式（Ｉ）：ＧｌＸｍＧｎ、または一般式（ＩＩ）：ＣｌＸｍＣｎで表される核酸 |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| HUE025027T2 (en) * | 2008-01-31 | 2016-07-28 | Curevac Gmbh | (NuGiXmGnNv) nucleic acids and derivatives of the formula as immunostimulants / adjuvants |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| AU2010213795A1 (en) * | 2009-02-10 | 2011-08-04 | Idera Pharmaceuticals, Inc. | Synthetic RNA-based agonists of TLR7 |
| WO2010105819A1 (en) * | 2009-03-17 | 2010-09-23 | Gunther Hartmann | Tlr7 ligand and uses thereof |
| GB0910723D0 (en) * | 2009-06-22 | 2009-08-05 | Sylentis Sau | Novel drugs for inhibition of gene expression |
| MX342945B (es) * | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| EP2651445A2 (en) * | 2010-12-16 | 2013-10-23 | SPRNA GmbH | Pharmaceutical composition consisting of rna having alkali metal as counter ion and formulated with dications |
| WO2013012758A1 (en) | 2011-07-19 | 2013-01-24 | Ontorii, Inc. | Methods for the synthesis of functionalized nucleic acids |
| US20140286998A1 (en) * | 2011-10-31 | 2014-09-25 | Riboxx Gmbh | Double-Stranded RNA For Immunostimulation |
| WO2013151771A1 (en) | 2012-04-05 | 2013-10-10 | Massachusetts Institute Of Technology | Immunostimulatory compositions and methods of use thereof |
| RU2677639C2 (ru) | 2012-07-13 | 2019-01-18 | Шин Ниппон Биомедикал Лэбораториз, Лтд. | Хиральный адъювант нуклеиновой кислоты |
| CN104684893B (zh) | 2012-07-13 | 2016-10-26 | 日本波涛生命科学公司 | 不对称辅助基团 |
| KR102450907B1 (ko) | 2012-07-13 | 2022-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| US10149905B2 (en) | 2014-01-15 | 2018-12-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| KR20230152178A (ko) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| JP6698069B2 (ja) * | 2015-03-20 | 2020-05-27 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途 |
| WO2017065369A1 (ko) * | 2015-10-15 | 2017-04-20 | 한국과학기술원 | Rna 올리고뉴클레오티드 및 이를 포함하는 면역 활성제 |
| KR101899057B1 (ko) * | 2015-10-15 | 2018-09-14 | 한국과학기술원 | Rna 올리고뉴클레오티드를 포함하는 암 치료용 약학 조성물 |
| US11826422B2 (en) | 2016-11-09 | 2023-11-28 | Board Of Regents, The University Of Texas System | Methods and compositions for adaptive immune modulation |
| CN114057816A (zh) * | 2020-07-30 | 2022-02-18 | 浙江柏拉阿图医药科技有限公司 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| EP4104830A1 (en) | 2021-06-16 | 2022-12-21 | Burghardt Wittig | Sequential innate and adaptive immune modulation for cancer treatment |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523389A (en) * | 1992-09-29 | 1996-06-04 | Isis Pharmaceuticals, Inc. | Inhibitors of human immunodeficiency virus |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| PT772619E (pt) * | 1994-07-15 | 2006-10-31 | Univ Iowa Res Found | Oligonucleotidos imunomoduladores |
| JP2001513776A (ja) * | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| AU7690898A (en) * | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| ATE356630T1 (de) * | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| DE19935756A1 (de) * | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
| WO2001022990A2 (en) * | 1999-09-27 | 2001-04-05 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| KR100991644B1 (ko) * | 2001-08-17 | 2010-11-02 | 콜리 파마슈티칼 게엠베하 | 활성이 개량된 조합 모티프 면역자극성 올리고뉴클레오티드 |
| US20050187176A1 (en) * | 2003-10-10 | 2005-08-25 | Bates Paula J. | Method for inhibiting NF-kappa B signaling and use to treat or prevent human diseases |
| AU2006241149A1 (en) * | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
| EP1931694A4 (en) * | 2005-10-04 | 2009-12-16 | Univ Mcgill | APTAMERS COMPRISING ARABINOSE-MODIFIED NUCLEOTIDES |
-
2007
- 2007-10-26 US US12/447,107 patent/US20100144846A1/en not_active Abandoned
- 2007-10-26 JP JP2009533983A patent/JP2010507386A/ja not_active Withdrawn
- 2007-10-26 RU RU2009115687/10A patent/RU2009115687A/ru unknown
- 2007-10-26 KR KR1020097008487A patent/KR20090058584A/ko not_active Application Discontinuation
- 2007-10-26 CN CNA2007800399749A patent/CN101558157A/zh active Pending
- 2007-10-26 BR BRPI0718182-5A2A patent/BRPI0718182A2/pt not_active Application Discontinuation
- 2007-10-26 WO PCT/IB2007/004593 patent/WO2008139262A2/en active Application Filing
- 2007-10-26 MX MX2009004510A patent/MX2009004510A/es not_active Application Discontinuation
- 2007-10-26 EP EP07874026A patent/EP2104738A2/en not_active Withdrawn
- 2007-10-26 AU AU2007353120A patent/AU2007353120A1/en not_active Abandoned
- 2007-10-26 CA CA002667297A patent/CA2667297A1/en not_active Abandoned
-
2009
- 2009-04-23 ZA ZA200902823A patent/ZA200902823B/xx unknown
- 2009-05-25 NO NO20092023A patent/NO20092023L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008139262A8 (en) | 2009-03-12 |
| CA2667297A1 (en) | 2008-11-20 |
| JP2010507386A (ja) | 2010-03-11 |
| WO2008139262A2 (en) | 2008-11-20 |
| KR20090058584A (ko) | 2009-06-09 |
| AU2007353120A1 (en) | 2008-11-20 |
| RU2009115687A (ru) | 2010-11-10 |
| US20100144846A1 (en) | 2010-06-10 |
| MX2009004510A (es) | 2009-05-12 |
| EP2104738A2 (en) | 2009-09-30 |
| ZA200902823B (en) | 2010-03-31 |
| WO2008139262A3 (en) | 2009-06-04 |
| NO20092023L (no) | 2009-06-23 |
| CN101558157A (zh) | 2009-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0718182A2 (pt) | Oligorribonucleotídeos e seus usos. | |
| BRPI0813244A2 (pt) | Compostos e seus usos 708 | |
| BRPI0808098A2 (pt) | 4-aril-1,4-di-hidro-1,6-naftiridinamidas substituídas e seu uso | |
| BRPI0710878A2 (pt) | Compostos orgânicos e seus usos | |
| BRPI0817881A2 (pt) | Compostos orgânicos e seus usos | |
| BRPI1016150A2 (pt) | compostos heterocíclicos e seus usos. | |
| DE602006004866D1 (de) | Katheter | |
| DE502006007967D1 (de) | Wirkstoffkombinationen | |
| BRPI0817685A2 (pt) | Polissacarídeos com funcionalidade azetidínio e seus usos | |
| DE502006008090D1 (de) | Wirkstoffkombinationen | |
| DE602006012647D1 (de) | Teilchenförmiges wasserabsorptionsmittel, wasserabsorbierender kern und absorbierender artikel | |
| BRPI0719345A2 (pt) | Di-hidroimidazóis substituídos e seu uso no tratamento de tumores. | |
| ATE410985T1 (de) | Saugfähiger artikel | |
| BRPI0821244A2 (pt) | Proteína de cereal hipoalergênica e seus usos | |
| DE102005001875B4 (de) | Sessel | |
| BRPI0719708A2 (pt) | Novos moduladores de proteína quinase e seus usos terapêuticos. | |
| BRPI0810047A2 (pt) | Compostos e seus usos 707 | |
| BRPI0716733A2 (pt) | Compostos orgânicos e seus usos | |
| BRPI0813187A2 (pt) | 13-hidroperóxido liases modificadas e respectivos usos. | |
| DE112006001760A5 (de) | Katheter | |
| BRPI0812340A2 (pt) | Macrociclos e seus usos | |
| BRPI0821138A2 (pt) | Aminotiazóis e seus usos | |
| BRPI0922288A2 (pt) | anticorpos monoclonais anti-ferroportina 1 e seus usos. | |
| BRPI0812535A2 (pt) | derivado de 17beta-ciano-19-androst-4-eno, seu uso e medicamentos compreendendo o derivado | |
| DE202005000833U1 (de) | Sitzmöbel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |