AR092278A1 - Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados - Google Patents
Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionadosInfo
- Publication number
- AR092278A1 AR092278A1 ARP130103068A ARP130103068A AR092278A1 AR 092278 A1 AR092278 A1 AR 092278A1 AR P130103068 A ARP130103068 A AR P130103068A AR P130103068 A ARP130103068 A AR P130103068A AR 092278 A1 AR092278 A1 AR 092278A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- halogen
- alkyl
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Proceso enantio-selectivo para producir intermediarios útiles para la elaboración de inhibidores de NEP o pro-fármacos de los mismos, en particular de los inhibidores de NEP que comprenden una estructura base de ácido o éster de ácido g-amino-d-bifenil-a-metil-alcanoico. Reivindicación 1: Un proceso para la preparación de un compuesto de la fórmula (1), o de una sal del mismo, en donde X es halógeno, de preferencia cloro, u -O-R⁵, en donde R⁵ es alquilo C₁₋₆, de preferencia terbutilo; de preferencia en donde el compuesto de la fórmula (1) es de la fórmula (2), o una sal del mismo, en donde X es halógeno, de preferencia cloro, u -O-R⁵, en donde R⁵ es alquilo C₁₋₆, de preferencia terbutilo; el cual comprende hacer reaccionar un compuesto de la fórmula (3) en donde X es halógeno, de preferencia cloro, u -O-R⁵, en donde R⁵ es alquilo C₁₋₆, de preferencia terbutilo; de preferencia en donde el compuesto de la fórmula (3) es de la fórmula (4) en donde X es halógeno, de preferencia cloro, u -O-R⁵, en donde R⁵ es alquilo C₁₋₆, de preferencia terbutilo; con un compuesto bifenílico, de preferencia un compuesto bifenílico activado, para obtener un compuesto de la fórmula (1) o una sal del mismo, de preferencia de la fórmula (2) o una sal del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210317827 | 2012-08-31 | ||
| CN2013079565 | 2013-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092278A1 true AR092278A1 (es) | 2015-04-08 |
Family
ID=49080910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103068A AR092278A1 (es) | 2012-08-31 | 2013-08-29 | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9624163B2 (es) |
| EP (1) | EP2890672B1 (es) |
| JP (1) | JP6280119B2 (es) |
| KR (1) | KR20150048133A (es) |
| CN (1) | CN105026361B (es) |
| AR (1) | AR092278A1 (es) |
| AU (1) | AU2013307767B2 (es) |
| BR (1) | BR112015004121A2 (es) |
| CA (1) | CA2880194A1 (es) |
| ES (1) | ES2685621T3 (es) |
| IN (1) | IN2015DN00909A (es) |
| MX (1) | MX2015002640A (es) |
| RU (1) | RU2015111486A (es) |
| TW (1) | TW201414708A (es) |
| WO (1) | WO2014032627A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014181362A1 (en) * | 2013-05-09 | 2014-11-13 | Council Of Scientific & Industrial Research | A process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds |
| WO2015037460A1 (ja) * | 2013-09-10 | 2015-03-19 | 住友化学株式会社 | 光学活性な３－（ビフェニル－４－イル）－２－［（ｔ－ブトキシカルボニル）アミノ］プロパン－１－オールの製造方法 |
| CN104926704B (zh) * | 2014-03-18 | 2019-03-05 | 浙江九洲药物科技有限公司 | 氮杂环丙烷类化合物及其制备方法 |
| WO2015154673A1 (en) * | 2014-04-10 | 2015-10-15 | Zhaoyin Wang | Novel prodrugs and combinations for treatment of hypertension and cardiovascular diseases |
| WO2016074651A1 (en) | 2014-11-14 | 2016-05-19 | Zentiva, K.S. | A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377 |
| CN105985225A (zh) * | 2015-02-12 | 2016-10-05 | 博瑞生物医药（苏州）股份有限公司 | 一种lcz-696及其中间体的制备方法 |
| TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
| CN106187808A (zh) * | 2015-05-08 | 2016-12-07 | 苏州鹏旭医药科技有限公司 | Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法 |
| CN105017082B (zh) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | 一种心衰药Entresto 关键中间体(R)‑叔丁基 (1‑([1,1`‑联苯]‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法 |
| CN105085322B (zh) * | 2015-08-15 | 2017-10-03 | 浙江永宁药业股份有限公司 | Ahu‑377中间体的制备方法及其中间体和中间体的制备方法 |
| CN105168205A (zh) * | 2015-08-18 | 2015-12-23 | 泰力特医药（湖北）有限公司 | 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法 |
| CN105330569A (zh) * | 2015-09-11 | 2016-02-17 | 天台宜生生化科技有限公司 | 一种(r)-2-(n-叔丁氧羰基氨基)联苯丙醇的制备方法 |
| WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
| CN105198775B (zh) | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
| CN105237560B (zh) * | 2015-10-15 | 2018-07-06 | 上海博氏医药科技有限公司 | 一种lzc696中间体及其合成方法 |
| CN105254589B (zh) * | 2015-10-15 | 2018-07-31 | 上海博氏医药科技有限公司 | 一种制备心力衰竭药物中间体的方法 |
| CN105348209B (zh) | 2015-12-09 | 2017-12-26 | 浙江天宇药业股份有限公司 | 一种抗心衰药lcz696的制备方法 |
| CN105523964B (zh) * | 2015-12-09 | 2017-05-24 | 苏州楚凯药业有限公司 | 一种抗心衰药物中间体的制备方法 |
| US10377697B2 (en) | 2015-12-10 | 2019-08-13 | Novartis Ag | Process and intermediates |
| EP3386945A1 (en) | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
| CN105585511B (zh) * | 2016-01-08 | 2017-05-31 | 浙江大学 | (r)‑n‑叔丁氧羰基联苯丙氨醇的制备方法 |
| CN105820064A (zh) * | 2016-04-18 | 2016-08-03 | 浙江天宇药业股份有限公司 | 一种联苯基丙氨醇衍生物的合成方法及中间体 |
| CN105753741A (zh) * | 2016-04-26 | 2016-07-13 | 常州制药厂有限公司 | 一种抗心衰药物Sacubitril中间体的制备方法 |
| WO2017203474A1 (en) * | 2016-05-27 | 2017-11-30 | Dr. Reddy's Laboratories Limited | Process for preparation of sacubutril intermediate |
| WO2018007919A1 (en) | 2016-07-05 | 2018-01-11 | Novartis Ag | New process for early sacubitril intermediates |
| CN109563019A (zh) | 2016-08-17 | 2019-04-02 | 诺华股份有限公司 | Nep抑制剂合成的新方法和中间体 |
| CN107778192A (zh) * | 2016-08-26 | 2018-03-09 | 浙江九洲药业股份有限公司 | 一种n‑烷氧或苄氧羰基手性氨酸的制备方法 |
| CN106431993B (zh) * | 2016-09-14 | 2018-10-30 | 重庆市碚圣医药科技股份有限公司 | 一种lcz-696关键中间体的制备方法 |
| CN106565505A (zh) * | 2016-11-08 | 2017-04-19 | 重庆市碚圣医药科技股份有限公司 | (r)‑3‑([1,1’‑联苯]‑4‑基)‑2‑氨基丙‑1‑醇盐酸盐的制备方法 |
| CN106588698B (zh) * | 2016-11-18 | 2019-01-22 | 凯瑞斯德生化(苏州)有限公司 | 一种N-Boc联苯丙氨醛的制备方法 |
| JP7138106B2 (ja) * | 2016-12-23 | 2022-09-15 | ノバルティス アーゲー | 初期サクビトリル中間体のための新規な方法 |
| CN108238981A (zh) * | 2016-12-23 | 2018-07-03 | 宁波爱诺医药科技有限公司 | 一种lcz-696关键中间体的制备方法 |
| CN106946742A (zh) * | 2017-03-28 | 2017-07-14 | 常州沃腾化工科技有限公司 | 一种三苯基氧磷含量低的沙库必曲中间体的制备方法 |
| CN107011203B (zh) * | 2017-04-28 | 2019-03-29 | 江苏阿尔法药业有限公司 | 一种lcz696中间体ahu-377的制备方法 |
| CN107382779B (zh) * | 2017-07-27 | 2020-04-17 | 江苏中邦制药有限公司 | 一种沙库必曲中间体的制备方法 |
| CN107522628A (zh) * | 2017-09-20 | 2017-12-29 | 吉尔生化（上海）有限公司 | 一种l‑3‑（6‑乙酰基‑2‑萘胺基）‑2‑氨基丙酸的合成方法 |
| CN108047093A (zh) * | 2017-11-29 | 2018-05-18 | 南通常佑药业科技有限公司 | 一种联苯基氨基丙醛化合物的制备方法 |
| CN108047092A (zh) * | 2018-01-12 | 2018-05-18 | 重庆市碚圣医药科技股份有限公司 | 一种lcz696中间体的合成方法 |
| CN108191712A (zh) * | 2018-01-15 | 2018-06-22 | 重庆市碚圣医药科技股份有限公司 | 一种lcz696关键中间体母液回收方法 |
| CN108675943A (zh) * | 2018-06-13 | 2018-10-19 | 常州亚邦制药有限公司 | 一种沙库巴曲关键中间体的制备方法 |
| CN109336804B (zh) * | 2018-12-21 | 2021-03-30 | 浙江工业大学 | 一种管道化合成沙库必曲关键中间体的方法 |
| CN110183357B (zh) * | 2019-06-13 | 2021-09-24 | 甘肃皓天医药科技有限责任公司 | 一种用于制备沙库比曲中间体的制备方法 |
| CN113754565B (zh) * | 2021-11-09 | 2022-02-22 | 南京威凯尔生物医药科技有限公司 | 一种连续流微反应器中制备沙库巴曲中间体的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1040735A (en) * | 1964-07-23 | 1966-09-01 | British Drug Houses Ltd | 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof |
| US5587494A (en) * | 1992-03-17 | 1996-12-24 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Practical, cost-efficient chiral synthesis of dihydrosphingosines |
| US5962506A (en) * | 1997-07-07 | 1999-10-05 | Pharmacopeia, Inc. | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases |
| WO2007025284A1 (en) * | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP1903027A1 (en) * | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
| CN101362708B (zh) * | 2008-09-05 | 2012-05-16 | 浙江工业大学 | 叔丁基-[2-（联苯-4-基）-1-（羟甲基）乙基]氨基甲酸酯的合成方法 |
| WO2013026773A1 (en) | 2011-08-19 | 2013-02-28 | Dsm Ip Assets B.V. | Synthesis of r-biphenylalaninol |
-
2013
- 2013-08-29 AR ARP130103068A patent/AR092278A1/es unknown
- 2013-08-30 TW TW102131426A patent/TW201414708A/zh unknown
- 2013-09-02 BR BR112015004121A patent/BR112015004121A2/pt not_active IP Right Cessation
- 2013-09-02 AU AU2013307767A patent/AU2013307767B2/en not_active Ceased
- 2013-09-02 US US14/424,307 patent/US9624163B2/en active Active
- 2013-09-02 WO PCT/CN2013/082817 patent/WO2014032627A1/en active Application Filing
- 2013-09-02 CN CN201380056103.3A patent/CN105026361B/zh active Active
- 2013-09-02 ES ES13832514.7T patent/ES2685621T3/es active Active
- 2013-09-02 CA CA2880194A patent/CA2880194A1/en not_active Abandoned
- 2013-09-02 RU RU2015111486A patent/RU2015111486A/ru not_active Application Discontinuation
- 2013-09-02 KR KR1020157004866A patent/KR20150048133A/ko not_active Application Discontinuation
- 2013-09-02 MX MX2015002640A patent/MX2015002640A/es unknown
- 2013-09-02 IN IN909DEN2015 patent/IN2015DN00909A/en unknown
- 2013-09-02 JP JP2015528863A patent/JP6280119B2/ja active Active
- 2013-09-02 EP EP13832514.7A patent/EP2890672B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2880194A1 (en) | 2014-03-06 |
| BR112015004121A2 (pt) | 2017-07-04 |
| US9624163B2 (en) | 2017-04-18 |
| US20150210632A1 (en) | 2015-07-30 |
| WO2014032627A1 (en) | 2014-03-06 |
| AU2013307767A1 (en) | 2015-02-19 |
| KR20150048133A (ko) | 2015-05-06 |
| RU2015111486A (ru) | 2016-10-20 |
| TW201414708A (zh) | 2014-04-16 |
| CN105026361A (zh) | 2015-11-04 |
| EP2890672A1 (en) | 2015-07-08 |
| IN2015DN00909A (es) | 2015-06-12 |
| ES2685621T3 (es) | 2018-10-10 |
| CN105026361B (zh) | 2018-04-03 |
| JP6280119B2 (ja) | 2018-02-14 |
| EP2890672A4 (en) | 2016-04-20 |
| JP2015532648A (ja) | 2015-11-12 |
| MX2015002640A (es) | 2015-06-24 |
| AU2013307767B2 (en) | 2016-07-28 |
| EP2890672B1 (en) | 2018-05-30 |
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