CU24410B1 - Benzimidazol-2-aminas como inhibidores de midh1 - Google Patents
Benzimidazol-2-aminas como inhibidores de midh1Info
- Publication number
- CU24410B1 CU24410B1 CU2016000120A CU20160120A CU24410B1 CU 24410 B1 CU24410 B1 CU 24410B1 CU 2016000120 A CU2016000120 A CU 2016000120A CU 20160120 A CU20160120 A CU 20160120A CU 24410 B1 CU24410 B1 CU 24410B1
- Authority
- CU
- Cuba
- Prior art keywords
- sup
- benzimidazol
- aminas
- midh1
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
<p>La presente invención se refiere a benzimidazol-2-aminas con la fórmula general (I):</p> <p>ESPACIO PARA FÓRMULA</p> <p>que inhiben a la isocitrato deshidrogenasa 1 mutada (mIDH1 R132H), donde R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, R<sup>5</sup>, R<sup>6</sup>, R<sup>7</sup>, R<sup>8</sup>, R<sup>9</sup>, R<sup>10</sup>, R<sup>11 </sup>y R<sup>12 </sup>son según se los define aquí, métodos para elaborarlos y compuestos intermediarios útiles en su elaboración. Los compuestos de fórmula I son útiles en la profilaxis o el tratamiento de diversas enfermedades, particularmente de los neoplasmas.</p>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14154680 | 2014-02-11 | ||
EP14182002 | 2014-08-22 | ||
PCT/EP2015/052676 WO2015121210A1 (en) | 2014-02-11 | 2015-02-10 | Benzimidazol-2-amines as midh1 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160120A7 CU20160120A7 (es) | 2016-12-23 |
CU24410B1 true CU24410B1 (es) | 2019-05-03 |
Family
ID=52462928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000120A CU24410B1 (es) | 2014-02-11 | 2015-02-10 | Benzimidazol-2-aminas como inhibidores de midh1 |
Country Status (23)
Country | Link |
---|---|
US (2) | US9957235B2 (es) |
EP (1) | EP3105209B1 (es) |
JP (1) | JP6534675B2 (es) |
KR (1) | KR20160115991A (es) |
CN (1) | CN106573897B (es) |
AP (1) | AP2016009371A0 (es) |
AU (1) | AU2015217788B2 (es) |
BR (1) | BR112016018604A2 (es) |
CA (1) | CA2939026A1 (es) |
CL (1) | CL2016002033A1 (es) |
CR (1) | CR20160361A (es) |
CU (1) | CU24410B1 (es) |
DO (1) | DOP2016000208A (es) |
EA (1) | EA031655B1 (es) |
IL (1) | IL246785A0 (es) |
MX (1) | MX2016010474A (es) |
PE (1) | PE20170143A1 (es) |
PH (1) | PH12016501581A1 (es) |
SG (1) | SG11201605810WA (es) |
SV (1) | SV2016005257A (es) |
TW (1) | TWI666202B (es) |
UY (1) | UY35991A (es) |
WO (1) | WO2015121210A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015121209A1 (en) | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
SI3194376T1 (sl) | 2014-09-19 | 2019-03-29 | Forma Therapeutics, Inc. | Derivati piridin-2(1H)-on kinolona kot inhibitorji mutirane izocitrat dehidrogenaze |
AU2015317321B2 (en) | 2014-09-19 | 2020-03-12 | Forma Therapeutics, Inc. | Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors |
CA2965213A1 (en) * | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as midh1 inhibitors for the treatment of tumors |
CN107108522B (zh) * | 2014-10-23 | 2020-12-01 | 德国癌症研究中心 | 作为mIDH1抑制剂的苯并咪唑-2-胺 |
CN107810176B (zh) * | 2015-06-08 | 2020-10-16 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的N-薄荷基苯并咪唑类化合物 |
ES2877424T3 (es) * | 2015-07-07 | 2021-11-16 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | 2-Aril- y 2-arilalquil-bencimidazoles como inhibidores de MIDH1 |
JP6824954B2 (ja) * | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | mIDH1阻害剤としての5−ヒドロキシアルキルベンズイミダゾール |
EP3121166A1 (en) | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
TW201708193A (zh) | 2015-07-27 | 2017-03-01 | 拜耳製藥公司 | 突變之異檸檬酸脫氫酶idh1 r132h之抑制劑 |
TW201718513A (zh) * | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之3-(2-苯胺-1-環己基-1h-苯并咪唑-5-基)丙酸衍生物之方法 |
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JP2020535112A (ja) * | 2017-08-01 | 2020-12-03 | ドイッチェス・クレープスフォルシュングスツェントルムDeutsches Krebsforschungszentrum | Midh1阻害剤とdna低メチル化剤(hma)との組合せ |
US11311527B2 (en) | 2018-05-16 | 2022-04-26 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
US11013733B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) |
US11013734B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation |
PT3720442T (pt) | 2018-05-16 | 2023-03-13 | Forma Therapeutics Inc | Inibição de idh-1 mutante |
US10532047B2 (en) | 2018-05-16 | 2020-01-14 | Forma Therapeutics, Inc. | Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile |
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EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
CA2965213A1 (en) | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as midh1 inhibitors for the treatment of tumors |
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JP6824954B2 (ja) | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | mIDH1阻害剤としての5−ヒドロキシアルキルベンズイミダゾール |
EP3121166A1 (en) | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
TW201708193A (zh) | 2015-07-27 | 2017-03-01 | 拜耳製藥公司 | 突變之異檸檬酸脫氫酶idh1 r132h之抑制劑 |
TW201718513A (zh) | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之3-(2-苯胺-1-環己基-1h-苯并咪唑-5-基)丙酸衍生物之方法 |
EP3423439A4 (en) | 2016-03-02 | 2019-08-14 | Translational Drug Development Llc | aminobenzimidazole derivatives |
-
2015
- 2015-02-10 EA EA201691590A patent/EA031655B1/ru not_active IP Right Cessation
- 2015-02-10 KR KR1020167024825A patent/KR20160115991A/ko not_active Application Discontinuation
- 2015-02-10 CU CU2016000120A patent/CU24410B1/es unknown
- 2015-02-10 BR BR112016018604A patent/BR112016018604A2/pt not_active Application Discontinuation
- 2015-02-10 WO PCT/EP2015/052676 patent/WO2015121210A1/en active Application Filing
- 2015-02-10 US US15/118,154 patent/US9957235B2/en active Active
- 2015-02-10 CR CR20160361A patent/CR20160361A/es unknown
- 2015-02-10 EP EP15703288.9A patent/EP3105209B1/en active Active
- 2015-02-10 MX MX2016010474A patent/MX2016010474A/es unknown
- 2015-02-10 JP JP2016551221A patent/JP6534675B2/ja not_active Expired - Fee Related
- 2015-02-10 AP AP2016009371A patent/AP2016009371A0/en unknown
- 2015-02-10 AU AU2015217788A patent/AU2015217788B2/en not_active Ceased
- 2015-02-10 PE PE2016001465A patent/PE20170143A1/es unknown
- 2015-02-10 CA CA2939026A patent/CA2939026A1/en not_active Abandoned
- 2015-02-10 SG SG11201605810WA patent/SG11201605810WA/en unknown
- 2015-02-10 CN CN201580019265.9A patent/CN106573897B/zh not_active Expired - Fee Related
- 2015-02-11 TW TW104104623A patent/TWI666202B/zh not_active IP Right Cessation
- 2015-02-11 UY UY0001035991A patent/UY35991A/es not_active Application Discontinuation
-
2016
- 2016-07-14 IL IL246785A patent/IL246785A0/en unknown
- 2016-08-10 PH PH12016501581A patent/PH12016501581A1/en unknown
- 2016-08-11 DO DO2016000208A patent/DOP2016000208A/es unknown
- 2016-08-11 SV SV2016005257A patent/SV2016005257A/es unknown
- 2016-08-11 CL CL2016002033A patent/CL2016002033A1/es unknown
-
2018
- 2018-03-16 US US15/923,895 patent/US10442772B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US10442772B2 (en) | 2019-10-15 |
CR20160361A (es) | 2016-10-03 |
US20170197921A1 (en) | 2017-07-13 |
EA201691590A1 (ru) | 2017-02-28 |
CN106573897B (zh) | 2019-09-24 |
UY35991A (es) | 2015-09-30 |
AU2015217788B2 (en) | 2019-06-27 |
US9957235B2 (en) | 2018-05-01 |
PH12016501581A1 (en) | 2017-02-06 |
EA031655B1 (ru) | 2019-02-28 |
JP2017505790A (ja) | 2017-02-23 |
SV2016005257A (es) | 2018-10-02 |
AU2015217788A1 (en) | 2016-08-04 |
EP3105209A1 (en) | 2016-12-21 |
CN106573897A (zh) | 2017-04-19 |
WO2015121210A1 (en) | 2015-08-20 |
JP6534675B2 (ja) | 2019-06-26 |
TWI666202B (zh) | 2019-07-21 |
DOP2016000208A (es) | 2016-09-15 |
AP2016009371A0 (en) | 2016-08-31 |
BR112016018604A2 (pt) | 2017-08-08 |
MX2016010474A (es) | 2016-10-31 |
US20190062285A1 (en) | 2019-02-28 |
IL246785A0 (en) | 2016-08-31 |
KR20160115991A (ko) | 2016-10-06 |
EP3105209B1 (en) | 2019-08-21 |
TW201613874A (en) | 2016-04-16 |
CA2939026A1 (en) | 2015-08-20 |
PE20170143A1 (es) | 2017-03-19 |
CL2016002033A1 (es) | 2017-03-31 |
SG11201605810WA (en) | 2016-08-30 |
CU20160120A7 (es) | 2016-12-23 |
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