IN2015DN00909A - - Google Patents

Info

Publication number
IN2015DN00909A
IN2015DN00909A IN909DEN2015A IN2015DN00909A IN 2015DN00909 A IN2015DN00909 A IN 2015DN00909A IN 909DEN2015 A IN909DEN2015 A IN 909DEN2015A IN 2015DN00909 A IN2015DN00909 A IN 2015DN00909A
Authority
IN
India
Prior art keywords
nep inhibitors
acid
prodrugs
biphenyl
amino
Prior art date
Application number
Inventor
Guoliang Zhu
Wenfa Ye
Hui Zheng
Lingfeng Qian
Junhui Wei
Lijun Yang
Yunguang Li
Lijun Luo
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN00909A publication Critical patent/IN2015DN00909A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided is a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof in particular NEP inhibitors comprising a ? amino d biphenyl a methylalkanoic acid or acid ester backbone.
IN909DEN2015 2012-08-31 2013-09-02 IN2015DN00909A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201210317827 2012-08-31
CN2013079565 2013-07-18
PCT/CN2013/082817 WO2014032627A1 (en) 2012-08-31 2013-09-02 New process

Publications (1)

Publication Number Publication Date
IN2015DN00909A true IN2015DN00909A (en) 2015-06-12

Family

ID=49080910

Family Applications (1)

Application Number Title Priority Date Filing Date
IN909DEN2015 IN2015DN00909A (en) 2012-08-31 2013-09-02

Country Status (15)

Country Link
US (1) US9624163B2 (en)
EP (1) EP2890672B1 (en)
JP (1) JP6280119B2 (en)
KR (1) KR20150048133A (en)
CN (1) CN105026361B (en)
AR (1) AR092278A1 (en)
AU (1) AU2013307767B2 (en)
BR (1) BR112015004121A2 (en)
CA (1) CA2880194A1 (en)
ES (1) ES2685621T3 (en)
IN (1) IN2015DN00909A (en)
MX (1) MX2015002640A (en)
RU (1) RU2015111486A (en)
TW (1) TW201414708A (en)
WO (1) WO2014032627A1 (en)

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WO2014181362A1 (en) * 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds
JPWO2015037460A1 (en) * 2013-09-10 2017-03-02 住友化学株式会社 Process for producing optically active 3- (biphenyl-4-yl) -2-[(t-butoxycarbonyl) amino] propan-1-ol
CN104926704B (en) * 2014-03-18 2019-03-05 浙江九洲药物科技有限公司 Aziridine class compound and preparation method thereof
WO2015154673A1 (en) * 2014-04-10 2015-10-15 Zhaoyin Wang Novel prodrugs and combinations for treatment of hypertension and cardiovascular diseases
EP3218351B1 (en) 2014-11-14 2019-06-19 Zentiva K.S. A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377
CN105985225A (en) * 2015-02-12 2016-10-05 博瑞生物医药（苏州）股份有限公司 Preparation methods for LCZ-696 and intermediate thereof
TW201632493A (en) 2015-02-13 2016-09-16 諾華公司 New process
CN106187808A (en) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 The preparation method of AHU-377, AHU-377 intermediate and the preparation method of AHU-377 intermediate
CN105017082B (en) * 2015-07-31 2017-09-19 上海皓元医药股份有限公司 Preparation of (R)-tert-butyl (1-([1,1`-biphenyl]-4-yl)-3-hydroxypropane-2-yl) carbamate, a key intermediate of heart failure drug Entresto method
CN105085322B (en) * 2015-08-15 2017-10-03 浙江永宁药业股份有限公司 The Preparation Method And Their Intermediate of the intermediates of AHU 377 and the preparation method of intermediate
CN105168205A (en) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 Preparation method for dual inhibitor LCZ696 of angiotensin II receptor and neprilysin
CN105330569A (en) * 2015-09-11 2016-02-17 天台宜生生化科技有限公司 Preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol
WO2017051326A1 (en) 2015-09-23 2017-03-30 Novartis Ag New processes and intermediates useful in synthesis of nep inhibitors
CN105198775B (en) 2015-10-10 2017-11-14 凯瑞斯德生化(苏州)有限公司 A kind of preparation method of chiral N Boc biphenyl Propanolamines
CN105237560B (en) * 2015-10-15 2018-07-06 上海博氏医药科技有限公司 A kind of LZC696 intermediates and its synthetic method
CN105254589B (en) * 2015-10-15 2018-07-31 上海博氏医药科技有限公司 A method of preparing heart failure drugs intermediate
CN105523964B (en) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 Preparation method of anti-heart-failure drug intermediate
CN105348209B (en) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 A kind of anti-heart failure medicine LCZ696 preparation method
HK1254367A1 (en) 2015-12-10 2019-07-19 Novartis Ag New process and intermediates
BR112018011788A2 (en) 2015-12-11 2018-12-04 Zentiva Ks (2r, 4s) -5- (biphenyl-4-yl) -4 - [(3-carboxypropionyl) amino] -2-methylpentanoic acid ethyl ester solid forms, their salts and a preparation method
CN105622460B (en) * 2016-01-08 2017-12-05 浙江大学 (R) synthetic method of N tertbutyloxycarbonyls biphenyl Propanolamine
CN105820064A (en) * 2016-04-18 2016-08-03 浙江天宇药业股份有限公司 Synthetic method of biphenylyl alaninol derivative and intermediate
CN105753741A (en) * 2016-04-26 2016-07-13 常州制药厂有限公司 Method for preparing Sacubitril intermediate of anti-heart-failure medicine
WO2017203474A1 (en) * 2016-05-27 2017-11-30 Dr. Reddy's Laboratories Limited Process for preparation of sacubutril intermediate
US20190256454A1 (en) * 2016-07-05 2019-08-22 Novartis Ag New process for early sacubitril intermediates
US10851059B2 (en) 2016-08-17 2020-12-01 Novartis Ag Processes and intermediates for NEP inhibitor synthesis
CN107778192A (en) * 2016-08-26 2018-03-09 浙江九洲药业股份有限公司 A kind of preparation method of N alcoxyls or benzyloxycarbonyl group chirality propylhomoserin
CN106431993B (en) * 2016-09-14 2018-10-30 重庆市碚圣医药科技股份有限公司 A kind of preparation method of LCZ-696 key intermediates
CN106565505A (en) * 2016-11-08 2017-04-19 重庆市碚圣医药科技股份有限公司 Preparation method for (R)-3-([1,1'-biphenyl]-4-radical)-2-aminopropionic-1-alcohol hydrochloride
CN106588698B (en) * 2016-11-18 2019-01-22 凯瑞斯德生化(苏州)有限公司 A kind of preparation method of the third ammonium aldehyde of N-Boc biphenyl
CN108238981A (en) * 2016-12-23 2018-07-03 宁波爱诺医药科技有限公司 A kind of preparation method of LCZ-696 key intermediates
WO2018116203A1 (en) 2016-12-23 2018-06-28 Novartis Ag New process for early sacubitril intermediates
CN106946742A (en) * 2017-03-28 2017-07-14 常州沃腾化工科技有限公司 A kind of preparation method of the bent intermediates of the low Sha Kubi of triphenylphosphinc oxide content
CN107011203B (en) * 2017-04-28 2019-03-29 江苏阿尔法药业有限公司 A kind of preparation method of LCZ696 intermediate A HU-377
CN107382779B (en) * 2017-07-27 2020-04-17 江苏中邦制药有限公司 Preparation method of shakubiqu intermediate
CN107522628A (en) * 2017-09-20 2017-12-29 吉尔生化（上海）有限公司 A kind of L 3（The naphthylamine base of 6 acetyl group 2）The synthetic method of 2 alanines
CN108047093A (en) * 2017-11-29 2018-05-18 南通常佑药业科技有限公司 A kind of preparation method of xenyl aminopropan aldehyde compound
CN108047092A (en) * 2018-01-12 2018-05-18 重庆市碚圣医药科技股份有限公司 A kind of synthetic method of LCZ696 intermediates
CN108191712A (en) * 2018-01-15 2018-06-22 重庆市碚圣医药科技股份有限公司 A kind of LCZ696 key intermediates mother liquor reclaiming method
CN108675943A (en) * 2018-06-13 2018-10-19 常州亚邦制药有限公司 The preparation method of one planting sand library Ba Qu key intermediates
CN109336804B (en) * 2018-12-21 2021-03-30 浙江工业大学 A kind of method for synthesizing key intermediate of Sacubitril by pipeline chemical
CN110183357B (en) * 2019-06-13 2021-09-24 甘肃皓天医药科技有限责任公司 A kind of preparation method for preparing Sacubitril intermediate
CN113754565B (en) * 2021-11-09 2022-02-22 南京威凯尔生物医药科技有限公司 Method for preparing Shakubaqu intermediate in continuous flow microreactor
CN114957043B (en) 2022-04-29 2023-09-08 凯特立斯（深圳）科技有限公司 Sabobiqu intermediate, preparation method and application thereof
CN117105821A (en) * 2023-04-18 2023-11-24 重庆普佑制药有限公司 A kind of preparation method of sacubitril intermediate
CN116589383B (en) * 2023-04-18 2025-09-05 重庆普佑制药有限公司 A preparation process of sacubitril intermediate
CN117658864A (en) * 2023-12-04 2024-03-08 新天地医药技术研究院(郑州)有限公司 A kind of preparation method of key intermediate of sacubitril
CN117964521A (en) * 2024-01-31 2024-05-03 江苏科本药业有限公司 A method for preparing a sacubitril intermediate

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GB1040735A (en) * 1964-07-23 1966-09-01 British Drug Houses Ltd 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof
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Also Published As

Publication number Publication date
ES2685621T3 (en) 2018-10-10
EP2890672A4 (en) 2016-04-20
US20150210632A1 (en) 2015-07-30
US9624163B2 (en) 2017-04-18
CN105026361B (en) 2018-04-03
AR092278A1 (en) 2015-04-08
WO2014032627A1 (en) 2014-03-06
KR20150048133A (en) 2015-05-06
MX2015002640A (en) 2015-06-24
JP6280119B2 (en) 2018-02-14
EP2890672B1 (en) 2018-05-30
AU2013307767A1 (en) 2015-02-19
AU2013307767B2 (en) 2016-07-28
BR112015004121A2 (en) 2017-07-04
TW201414708A (en) 2014-04-16
RU2015111486A (en) 2016-10-20
CA2880194A1 (en) 2014-03-06
CN105026361A (en) 2015-11-04
JP2015532648A (en) 2015-11-12
EP2890672A1 (en) 2015-07-08

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