IN2015DN00909A - - Google Patents
Info
- Publication number
- IN2015DN00909A IN2015DN00909A IN909DEN2015A IN2015DN00909A IN 2015DN00909 A IN2015DN00909 A IN 2015DN00909A IN 909DEN2015 A IN909DEN2015 A IN 909DEN2015A IN 2015DN00909 A IN2015DN00909 A IN 2015DN00909A
- Authority
- IN
- India
- Prior art keywords
- nep inhibitors
- acid
- prodrugs
- biphenyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided is a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof in particular NEP inhibitors comprising a ? amino d biphenyl a methylalkanoic acid or acid ester backbone.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210317827 | 2012-08-31 | ||
CN2013079565 | 2013-07-18 | ||
PCT/CN2013/082817 WO2014032627A1 (en) | 2012-08-31 | 2013-09-02 | New process |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN00909A true IN2015DN00909A (en) | 2015-06-12 |
Family
ID=49080910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN909DEN2015 IN2015DN00909A (en) | 2012-08-31 | 2013-09-02 |
Country Status (15)
Country | Link |
---|---|
US (1) | US9624163B2 (en) |
EP (1) | EP2890672B1 (en) |
JP (1) | JP6280119B2 (en) |
KR (1) | KR20150048133A (en) |
CN (1) | CN105026361B (en) |
AR (1) | AR092278A1 (en) |
AU (1) | AU2013307767B2 (en) |
BR (1) | BR112015004121A2 (en) |
CA (1) | CA2880194A1 (en) |
ES (1) | ES2685621T3 (en) |
IN (1) | IN2015DN00909A (en) |
MX (1) | MX2015002640A (en) |
RU (1) | RU2015111486A (en) |
TW (1) | TW201414708A (en) |
WO (1) | WO2014032627A1 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9550719B2 (en) * | 2013-05-09 | 2017-01-24 | Council Of Scientific And Industrial Research | Process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds |
WO2015037460A1 (en) * | 2013-09-10 | 2015-03-19 | 住友化学株式会社 | METHOD FOR PRODUCING OPTICALLY ACTIVE 3-(BIPHENYL-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL |
CN104926704B (en) * | 2014-03-18 | 2019-03-05 | 浙江九洲药物科技有限公司 | Aziridine class compound and preparation method thereof |
WO2015154673A1 (en) * | 2014-04-10 | 2015-10-15 | Zhaoyin Wang | Novel prodrugs and combinations for treatment of hypertension and cardiovascular diseases |
DK3218351T3 (en) | 2014-11-14 | 2019-09-16 | Zentiva Ks | PROCEDURE FOR MANUFACTURING, INSULATING AND CLEANING PHARMACEUTICAL APPLICABLE FORMS OF AHU-377 |
CN105985225A (en) * | 2015-02-12 | 2016-10-05 | 博瑞生物医药(苏州)股份有限公司 | Preparation methods for LCZ-696 and intermediate thereof |
TW201632493A (en) | 2015-02-13 | 2016-09-16 | 諾華公司 | New process |
CN106187808A (en) * | 2015-05-08 | 2016-12-07 | 苏州鹏旭医药科技有限公司 | The preparation method of AHU-377, AHU-377 intermediate and the preparation method of AHU-377 intermediate |
CN105017082B (en) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | A kind of preparation method of heart failure medicine Entresto key intermediates (R) tert-butyl group (base of 1 ([1,1` biphenyl] 4 bases) 3 hydroxy propane 2) carbamate |
CN105085322B (en) * | 2015-08-15 | 2017-10-03 | 浙江永宁药业股份有限公司 | The Preparation Method And Their Intermediate of the intermediates of AHU 377 and the preparation method of intermediate |
CN105168205A (en) * | 2015-08-18 | 2015-12-23 | 泰力特医药(湖北)有限公司 | Preparation method for dual inhibitor LCZ696 of angiotensin II receptor and neprilysin |
CN105330569A (en) * | 2015-09-11 | 2016-02-17 | 天台宜生生化科技有限公司 | Preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol |
WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
CN105198775B (en) | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | A kind of preparation method of chiral N Boc biphenyl Propanolamines |
CN105237560B (en) * | 2015-10-15 | 2018-07-06 | 上海博氏医药科技有限公司 | A kind of LZC696 intermediates and its synthetic method |
CN105254589B (en) * | 2015-10-15 | 2018-07-31 | 上海博氏医药科技有限公司 | A method of preparing heart failure drugs intermediate |
CN105523964B (en) * | 2015-12-09 | 2017-05-24 | 苏州楚凯药业有限公司 | Preparation method of anti-heart-failure drug intermediate |
CN105348209B (en) | 2015-12-09 | 2017-12-26 | 浙江天宇药业股份有限公司 | A kind of anti-heart failure medicine LCZ696 preparation method |
RU2769445C2 (en) | 2015-12-10 | 2022-03-31 | Новартис Аг | New method and new intermediate compounds |
BR112018011788A2 (en) | 2015-12-11 | 2018-12-04 | Zentiva Ks | (2r, 4s) -5- (biphenyl-4-yl) -4 - [(3-carboxypropionyl) amino] -2-methylpentanoic acid ethyl ester solid forms, their salts and a preparation method |
CN105585511B (en) * | 2016-01-08 | 2017-05-31 | 浙江大学 | (R) preparation method of N tertbutyloxycarbonyls biphenyl Propanolamine |
CN105820064A (en) * | 2016-04-18 | 2016-08-03 | 浙江天宇药业股份有限公司 | Synthetic method of biphenylyl alaninol derivative and intermediate |
CN105753741A (en) * | 2016-04-26 | 2016-07-13 | 常州制药厂有限公司 | Method for preparing Sacubitril intermediate of anti-heart-failure medicine |
WO2017203474A1 (en) * | 2016-05-27 | 2017-11-30 | Dr. Reddy's Laboratories Limited | Process for preparation of sacubutril intermediate |
JP6944473B2 (en) * | 2016-07-05 | 2021-10-06 | ノバルティス アーゲー | A new method for early sacubitril intermediates |
EP3500549B1 (en) | 2016-08-17 | 2020-12-16 | Novartis AG | New processes and intermediates for nep inhibitor synthesis |
CN107778192A (en) * | 2016-08-26 | 2018-03-09 | 浙江九洲药业股份有限公司 | A kind of preparation method of N alcoxyls or benzyloxycarbonyl group chirality propylhomoserin |
CN106431993B (en) * | 2016-09-14 | 2018-10-30 | 重庆市碚圣医药科技股份有限公司 | A kind of preparation method of LCZ-696 key intermediates |
CN106565505A (en) * | 2016-11-08 | 2017-04-19 | 重庆市碚圣医药科技股份有限公司 | Preparation method for (R)-3-([1,1'-biphenyl]-4-radical)-2-aminopropionic-1-alcohol hydrochloride |
CN106588698B (en) * | 2016-11-18 | 2019-01-22 | 凯瑞斯德生化(苏州)有限公司 | A kind of preparation method of the third ammonium aldehyde of N-Boc biphenyl |
CN110088079A (en) * | 2016-12-23 | 2019-08-02 | 诺华股份有限公司 | New method for early stage husky card cloth song intermediate |
CN108238981A (en) * | 2016-12-23 | 2018-07-03 | 宁波爱诺医药科技有限公司 | A kind of preparation method of LCZ-696 key intermediates |
CN106946742A (en) * | 2017-03-28 | 2017-07-14 | 常州沃腾化工科技有限公司 | A kind of preparation method of the bent intermediates of the low Sha Kubi of triphenylphosphinc oxide content |
CN107011203B (en) * | 2017-04-28 | 2019-03-29 | 江苏阿尔法药业有限公司 | A kind of preparation method of LCZ696 intermediate A HU-377 |
CN107382779B (en) * | 2017-07-27 | 2020-04-17 | 江苏中邦制药有限公司 | Preparation method of shakubiqu intermediate |
CN107522628A (en) * | 2017-09-20 | 2017-12-29 | 吉尔生化(上海)有限公司 | A kind of L 3(The naphthylamine base of 6 acetyl group 2)The synthetic method of 2 alanines |
CN108047093A (en) * | 2017-11-29 | 2018-05-18 | 南通常佑药业科技有限公司 | A kind of preparation method of xenyl aminopropan aldehyde compound |
CN108047092A (en) * | 2018-01-12 | 2018-05-18 | 重庆市碚圣医药科技股份有限公司 | A kind of synthetic method of LCZ696 intermediates |
CN108191712A (en) * | 2018-01-15 | 2018-06-22 | 重庆市碚圣医药科技股份有限公司 | A kind of LCZ696 key intermediates mother liquor reclaiming method |
CN108675943A (en) * | 2018-06-13 | 2018-10-19 | 常州亚邦制药有限公司 | The preparation method of one planting sand library Ba Qu key intermediates |
CN109336804B (en) * | 2018-12-21 | 2021-03-30 | 浙江工业大学 | Method for synthesizing key intermediate of shakubiqu through pipelining |
CN110183357B (en) * | 2019-06-13 | 2021-09-24 | 甘肃皓天医药科技有限责任公司 | Preparation method for preparing Sacubitril intermediate |
CN113754565B (en) * | 2021-11-09 | 2022-02-22 | 南京威凯尔生物医药科技有限公司 | Method for preparing Shakubaqu intermediate in continuous flow microreactor |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1040735A (en) * | 1964-07-23 | 1966-09-01 | British Drug Houses Ltd | 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof |
US5587494A (en) * | 1992-03-17 | 1996-12-24 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Practical, cost-efficient chiral synthesis of dihydrosphingosines |
US5962506A (en) * | 1997-07-07 | 1999-10-05 | Pharmacopeia, Inc. | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases |
US8278281B2 (en) * | 2005-08-24 | 2012-10-02 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
CN101362708B (en) * | 2008-09-05 | 2012-05-16 | 浙江工业大学 | Synthesis method of tert-butyl-[2-(biphenyl-4-yl)-1-(hydroxymethyl)ethyl] carbamate |
US9139515B2 (en) * | 2011-08-19 | 2015-09-22 | Dpx Holdings B.V. | Synthesis of R-biphenylalaninol |
-
2013
- 2013-08-29 AR ARP130103068A patent/AR092278A1/en unknown
- 2013-08-30 TW TW102131426A patent/TW201414708A/en unknown
- 2013-09-02 BR BR112015004121A patent/BR112015004121A2/en not_active IP Right Cessation
- 2013-09-02 MX MX2015002640A patent/MX2015002640A/en unknown
- 2013-09-02 RU RU2015111486A patent/RU2015111486A/en not_active Application Discontinuation
- 2013-09-02 CN CN201380056103.3A patent/CN105026361B/en active Active
- 2013-09-02 US US14/424,307 patent/US9624163B2/en active Active
- 2013-09-02 ES ES13832514.7T patent/ES2685621T3/en active Active
- 2013-09-02 CA CA2880194A patent/CA2880194A1/en not_active Abandoned
- 2013-09-02 IN IN909DEN2015 patent/IN2015DN00909A/en unknown
- 2013-09-02 EP EP13832514.7A patent/EP2890672B1/en active Active
- 2013-09-02 WO PCT/CN2013/082817 patent/WO2014032627A1/en active Application Filing
- 2013-09-02 KR KR1020157004866A patent/KR20150048133A/en not_active Application Discontinuation
- 2013-09-02 AU AU2013307767A patent/AU2013307767B2/en not_active Ceased
- 2013-09-02 JP JP2015528863A patent/JP6280119B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX2015002640A (en) | 2015-06-24 |
ES2685621T3 (en) | 2018-10-10 |
AU2013307767B2 (en) | 2016-07-28 |
CN105026361A (en) | 2015-11-04 |
CA2880194A1 (en) | 2014-03-06 |
RU2015111486A (en) | 2016-10-20 |
JP6280119B2 (en) | 2018-02-14 |
TW201414708A (en) | 2014-04-16 |
EP2890672A1 (en) | 2015-07-08 |
US20150210632A1 (en) | 2015-07-30 |
EP2890672A4 (en) | 2016-04-20 |
CN105026361B (en) | 2018-04-03 |
AR092278A1 (en) | 2015-04-08 |
WO2014032627A1 (en) | 2014-03-06 |
EP2890672B1 (en) | 2018-05-30 |
AU2013307767A1 (en) | 2015-02-19 |
BR112015004121A2 (en) | 2017-07-04 |
US9624163B2 (en) | 2017-04-18 |
KR20150048133A (en) | 2015-05-06 |
JP2015532648A (en) | 2015-11-12 |
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