JP2010540556A5 - - Google Patents
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- JP2010540556A5 JP2010540556A5 JP2010527140A JP2010527140A JP2010540556A5 JP 2010540556 A5 JP2010540556 A5 JP 2010540556A5 JP 2010527140 A JP2010527140 A JP 2010527140A JP 2010527140 A JP2010527140 A JP 2010527140A JP 2010540556 A5 JP2010540556 A5 JP 2010540556A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- compound according
- pharmaceutical
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 claims 1
- 0 *C1C(*)(*)*(*)OC1CO* Chemical compound *C1C(*)(*)*(*)OC1CO* 0.000 description 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077673 WO2009042767A1 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogues and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540556A JP2010540556A (ja) | 2010-12-24 |
| JP2010540556A5 true JP2010540556A5 (enExample) | 2011-08-11 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
| JP2010527139A Pending JP2010540555A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527139A Pending JP2010540555A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8158605B2 (enExample) |
| EP (2) | EP2197274A4 (enExample) |
| JP (2) | JP2010540556A (enExample) |
| KR (2) | KR20100102092A (enExample) |
| CN (2) | CN101815437A (enExample) |
| AU (2) | AU2008304380A1 (enExample) |
| BR (2) | BRPI0817269A2 (enExample) |
| CA (2) | CA2700267A1 (enExample) |
| IL (1) | IL204690A0 (enExample) |
| MX (2) | MX2010003002A (enExample) |
| NZ (2) | NZ583923A (enExample) |
| RU (1) | RU2488591C2 (enExample) |
| UA (2) | UA99308C2 (enExample) |
| WO (2) | WO2009042766A1 (enExample) |
| ZA (1) | ZA201001660B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| JP2010540556A (ja) * | 2007-09-26 | 2010-12-24 | マウント サイナイ スクール オブ メディシン | アザシチジン類似体およびその使用 |
| ES2927556T3 (es) | 2008-05-15 | 2022-11-08 | Celgene Corp | Formulaciones orales de análogos de citidina y métodos de uso de los mismos |
| WO2010014883A2 (en) * | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| AR076418A1 (es) * | 2009-04-27 | 2011-06-08 | Reddys Lab Inc Dr | Preparacion de decitabina |
| JP2014503597A (ja) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
| TW201303295A (zh) * | 2011-04-15 | 2013-01-16 | 克雷維斯製藥公司 | 偵測血液失調中之人平衡型核苷轉運蛋白１（ｈＥＮＴ１）表現用之系統和方法 |
| JP6162709B2 (ja) | 2011-11-01 | 2017-07-12 | セルジーン コーポレイション | シチジンアナログの経口製剤を使用して癌を治療する方法 |
| MY174308A (en) | 2012-02-24 | 2020-04-06 | Signal Pharm Llc | Methods for treating non-small cell lung using tor kinase inhibitor combination therapy |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| BR112015026247B1 (pt) * | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de compostos em combinação com um análogo de citidina, composição farmacêutica que os compreende, e kit |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| LT3236972T (lt) * | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| CA3007357C (en) | 2015-12-03 | 2023-12-05 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| SG11201906404RA (en) | 2017-03-20 | 2019-08-27 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
| CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
| KR102810546B1 (ko) * | 2018-04-19 | 2025-05-20 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
| WO2022035852A1 (en) * | 2020-08-10 | 2022-02-17 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
Family Cites Families (69)
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| BE612384A (fr) | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
| GB1050899A (enExample) | 1963-12-22 | |||
| DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
| US3984396A (en) | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
| US3998807A (en) | 1972-03-03 | 1976-12-21 | Syntex (U.S.A.) Inc. | Arabinofuranosyl cytosines and methods of making |
| US4172889A (en) * | 1976-03-29 | 1979-10-30 | The Upjohn Company | Method of treating rheumatoid arthritis |
| US4405611A (en) | 1980-06-27 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Bisulfite stabilization of 5-azacytidine |
| DE3100478A1 (de) | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel |
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| US4981613A (en) | 1986-11-04 | 1991-01-01 | Fuji Photo Film Co., Ltd. | Laser light source |
| CS264456B1 (cs) | 1987-08-28 | 1989-08-14 | Piskala Alois | Způsob výroby 5,6-dihydro-S-azacytidinu |
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| US5994392A (en) | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
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| US5216142A (en) | 1989-04-17 | 1993-06-01 | Efamol Holdings Plc | Anti-virals |
| JP2559917B2 (ja) * | 1990-06-15 | 1996-12-04 | 三共株式会社 | ピリミジンヌクレオシド誘導体 |
| DE4026265A1 (de) | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
| EP0526646B1 (en) * | 1991-02-19 | 1997-04-23 | Fujitsu Limited | Semiconductor device having an isolation region enriched in oxygen and a fabrication process thereof |
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| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| HUT70144A (en) | 1991-08-14 | 1995-09-28 | Procter & Gamble Pharma | Cyclic urethaanes useful as antiarrhythmic and antifibrillatory agents, pharmaceutical compositions containing them, and process for their preparation |
| GB2260319B (en) | 1991-10-07 | 1995-12-06 | Norsk Hydro As | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
| GB9515279D0 (en) | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
| GB9307043D0 (en) | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| DE19505168A1 (de) | 1995-02-16 | 1996-08-22 | Boehringer Mannheim Gmbh | Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel |
| WO1997005143A1 (en) | 1995-07-25 | 1997-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel group 4 transition metal compounds |
| EP0871710A4 (en) | 1995-08-08 | 2001-03-07 | Univ Jefferson | RECOMBINANT C-PROTEINASE AND RELATED METHODS, METHODS AND APPLICATIONS |
| JPH11512440A (ja) | 1995-09-15 | 1999-10-26 | スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド | 抗菌剤として有用なアリールヒドラゾン誘導体 |
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| ES2151277T3 (es) | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| JPH10158192A (ja) | 1996-10-03 | 1998-06-16 | Eisai Co Ltd | 移植片対宿主疾患（ｇｖｈｄ）の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物 |
| PL186888B1 (pl) | 1997-01-24 | 2004-03-31 | Conpharma As | Pochodne gemcytabiny |
| GB2321455A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
| WO1998055493A1 (fr) * | 1997-06-03 | 1998-12-10 | Mori, Takahide | Substances naturelles antitumorales ou antivirales et leur utilisation |
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| WO2007035783A2 (en) * | 2005-09-19 | 2007-03-29 | Celator Pharmaceuticals, Inc. | Combination formulations of cytidine analogs and platinum agents |
| EP2407453A1 (en) | 2005-09-27 | 2012-01-18 | Shionogi & Co., Ltd. | PGD2 receptor antagonist |
| NO324263B1 (no) | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
| US20070225248A1 (en) | 2006-03-21 | 2007-09-27 | Clavis Pharma As | Oral dosage forms of gemcitabine derivatives |
| JP2010540556A (ja) * | 2007-09-26 | 2010-12-24 | マウント サイナイ スクール オブ メディシン | アザシチジン類似体およびその使用 |
-
2008
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown
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