|
US4082845A
(en)
|
1977-04-25 |
1978-04-04 |
Merck & Co., Inc. |
3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
|
|
JPS5665863U
(enExample)
|
1979-10-25 |
1981-06-02 |
|
|
|
JPS5665863A
(en)
|
1979-10-31 |
1981-06-03 |
Tokyo Organ Chem Ind Ltd |
Novel aniline derivative, its preparation and pesticide containing the same
|
|
JPS625888Y2
(enExample)
|
1980-08-14 |
1987-02-10 |
|
|
|
JPS5738777A
(en)
|
1980-08-19 |
1982-03-03 |
Sogo Yatsukou Kk |
2-sufanilamidopyrathyn derivative
|
|
US4666828A
(en)
|
1984-08-15 |
1987-05-19 |
The General Hospital Corporation |
Test for Huntington's disease
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4801531A
(en)
|
1985-04-17 |
1989-01-31 |
Biotechnology Research Partners, Ltd. |
Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
|
|
US5272057A
(en)
|
1988-10-14 |
1993-12-21 |
Georgetown University |
Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
|
|
US5192659A
(en)
|
1989-08-25 |
1993-03-09 |
Genetype Ag |
Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
|
|
US5879672A
(en)
|
1994-10-07 |
1999-03-09 |
Regeneron Pharmaceuticals, Inc. |
Tie-2 ligand 1
|
|
US5643755A
(en)
|
1994-10-07 |
1997-07-01 |
Regeneron Pharmaceuticals Inc. |
Nucleic acid encoding tie-2 ligand
|
|
ATE294236T1
(de)
|
1994-09-22 |
2005-05-15 |
Licentia Ltd |
Promotor der tie rezeptor protein kinase
|
|
US6218529B1
(en)
|
1995-07-31 |
2001-04-17 |
Urocor, Inc. |
Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
|
|
ZA971896B
(en)
|
1996-03-26 |
1998-09-07 |
Du Pont Merck Pharma |
Aryloxy-and arythio-fused pyridines and pyrimidines and derivatives
|
|
CA2744096C
(en)
|
1996-07-31 |
2013-07-30 |
Laboratory Corporation Of America Holdings |
Biomarkers and targets for diagnosis, prognosis and management of prostate disease
|
|
AU733551B2
(en)
|
1996-09-25 |
2001-05-17 |
Astrazeneca Ab |
Qinoline derivatives inhibiting the effect of growth factors such as VEGF
|
|
US6030831A
(en)
|
1997-09-19 |
2000-02-29 |
Genetech, Inc. |
Tie ligand homologues
|
|
CA2305370C
(en)
|
1997-09-26 |
2006-11-28 |
Zentaris Gmbh |
Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
|
|
GB9721437D0
(en)
|
1997-10-10 |
1997-12-10 |
Glaxo Group Ltd |
Heteroaromatic compounds and their use in medicine
|
|
IL143236A0
(en)
|
1998-12-16 |
2002-04-21 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
|
DE69924641D1
(de)
|
1999-01-07 |
2005-05-12 |
Warner Lambert Company Llc Mor |
Behandlung von asthma anhand von mek-inhibitoren
|
|
AU3475900A
(en)
|
1999-01-29 |
2000-08-18 |
University Of Akron, The |
Polyimides used as microelectronic coatings
|
|
KR20020012315A
(ko)
|
1999-07-16 |
2002-02-15 |
로즈 암스트롱, 크리스틴 에이. 트러트웨인 |
Ｍｅｋ 저해제를 사용한 만성 통증의 치료 방법
|
|
GB2356398A
(en)
|
1999-11-18 |
2001-05-23 |
Lilly Dev Ct S A |
Preparation of arylsulfamides
|
|
CA2395520A1
(en)
|
1999-12-21 |
2001-06-28 |
Sugen, Inc. |
4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
|
|
US6492529B1
(en)
|
2000-01-18 |
2002-12-10 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Bis pyrazole-1H-pyrazole intermediates and their synthesis
|
|
AU2002232439A1
(en)
|
2000-11-29 |
2002-06-11 |
Glaxo Group Limited |
Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
|
|
KR20020096367A
(ko)
|
2001-06-19 |
2002-12-31 |
주식회사 티지 바이오텍 |
관절염 예방 또는 치료제 및 그것의 스크리닝 방법
|
|
EP1408950B1
(en)
*
|
2001-07-11 |
2007-04-25 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Methods of treating cytokine mediated diseases
|
|
WO2003056036A2
(en)
|
2001-12-21 |
2003-07-10 |
The Wellcome Trust |
Genes
|
|
WO2003068223A1
(en)
*
|
2002-02-11 |
2003-08-21 |
Bayer Corporation |
Aryl ureas with raf kinase and angiogenesis inhibiting activity
|
|
TW200406374A
(en)
*
|
2002-05-29 |
2004-05-01 |
Novartis Ag |
Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
|
|
US20060128783A1
(en)
|
2002-08-09 |
2006-06-15 |
Dinsmore Christopher J |
Tyrosine kinase inhibitors
|
|
WO2004083458A1
(en)
|
2003-03-20 |
2004-09-30 |
Universite Catholique De Louvain |
Medical use of ras antagonists for the treatment of capillary malformation
|
|
PL1635835T3
(pl)
|
2003-06-13 |
2010-06-30 |
Novartis Ag |
Pochodne 2-aminopirymidyny jako inhibitory kinazy RAF
|
|
WO2005080377A1
(ja)
|
2004-02-20 |
2005-09-01 |
Kirin Beer Kabushiki Kaisha |
TGFβ阻害活性を有する化合物およびそれを含んでなる医薬組成物
|
|
TW200616974A
(en)
|
2004-07-01 |
2006-06-01 |
Astrazeneca Ab |
Chemical compounds
|
|
MX2007002434A
(es)
|
2004-08-31 |
2007-05-04 |
Astrazeneca Ab |
Derivados de quinazolinona y su uso como inhibidores de b-raf.
|
|
JP2008516939A
(ja)
|
2004-10-15 |
2008-05-22 |
アストラゼネカ アクチボラグ |
化学化合物
|
|
GB0423554D0
(en)
*
|
2004-10-22 |
2004-11-24 |
Cancer Rec Tech Ltd |
Therapeutic compounds
|
|
GB0428082D0
(en)
|
2004-12-22 |
2005-01-26 |
Welcome Trust The Ltd |
Therapeutic compounds
|
|
WO2006071940A2
(en)
|
2004-12-23 |
2006-07-06 |
Deciphera Pharmaceuticals, Llc |
Enzyme modulators and treatments
|
|
CA2629468A1
(en)
|
2005-11-15 |
2007-05-24 |
Bayer Pharmaceuticals Corporation |
Pyrazolyl urea derivatives useful in the treatment of cancer
|
|
US20110195110A1
(en)
*
|
2005-12-01 |
2011-08-11 |
Roger Smith |
Urea compounds useful in the treatment of cancer
|
|
AU2006322094A1
(en)
|
2005-12-08 |
2007-06-14 |
Millennium Pharmaceuticals, Inc. |
Bicyclic compounds with kinase inhibitory activity
|
|
US7989461B2
(en)
|
2005-12-23 |
2011-08-02 |
Amgen Inc. |
Substituted quinazolinamine compounds for the treatment of cancer
|
|
CA2649994A1
(en)
|
2006-04-26 |
2007-11-08 |
Cancer Research Technology Limited |
Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
|
|
EP1992628A1
(en)
|
2007-05-18 |
2008-11-19 |
Glaxo Group Limited |
Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
|
|
US7790756B2
(en)
*
|
2006-10-11 |
2010-09-07 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
|
|
WO2008044688A1
(en)
|
2006-10-11 |
2008-04-17 |
Daiichi Sankyo Company, Limited |
Urea derivative
|
|
CA2692861A1
(en)
|
2007-07-10 |
2009-01-15 |
Neurim Pharmaceuticals (1991) Ltd. |
Cd44 splice variants in neurodegenerative diseases
|
|
AU2008337286B2
(en)
|
2007-12-19 |
2014-08-07 |
Cancer Research Technology Limited |
Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
|
|
GB0807609D0
(en)
|
2008-04-25 |
2008-06-04 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
KR20110070887A
(ko)
|
2008-10-02 |
2011-06-24 |
레스피버트 리미티드 |
Ｐ38 엠에이피 키나제 억제제
|
|
GB0818033D0
(en)
|
2008-10-02 |
2008-11-05 |
Respivert Ltd |
Novel compound
|
|
JP5670912B2
(ja)
|
2008-12-11 |
2015-02-18 |
レスピバート・リミテツド |
ｐ３８ＭＡＰキナーゼ阻害剤
|
|
GB0905955D0
(en)
|
2009-04-06 |
2009-05-20 |
Respivert Ltd |
Novel compounds
|
|
WO2011004276A1
(en)
|
2009-07-06 |
2011-01-13 |
Pfizer Limited |
Hepatitis c virus inhibitors
|
|
MY165154A
(en)
|
2009-08-24 |
2018-02-28 |
Genentech Inc |
Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels
|
|
GB0918249D0
(en)
|
2009-10-19 |
2009-12-02 |
Respivert Ltd |
Compounds
|
|
GB0921731D0
(en)
|
2009-12-11 |
2010-01-27 |
Respivert Ltd |
Theraputic uses
|
|
GB0921730D0
(en)
|
2009-12-11 |
2010-01-27 |
Respivert Ltd |
Method of treatment
|
|
JP5760010B2
(ja)
*
|
2010-02-01 |
2015-08-05 |
キャンサー・リサーチ・テクノロジー・リミテッド |
１−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用
|
|
GB201005589D0
(en)
|
2010-04-01 |
2010-05-19 |
Respivert Ltd |
Novel compounds
|
|
EP2556067B1
(en)
|
2010-04-08 |
2016-02-24 |
Respivert Limited |
Pyrazolyl ureas as p38 map kinase inhibitors
|
|
EP2556068B1
(en)
|
2010-04-08 |
2019-01-23 |
Respivert Limited |
P38 map kinase inhibitors
|
|
US8933228B2
(en)
|
2010-06-17 |
2015-01-13 |
Respivert, Ltd. |
Respiratory formulations and compounds for use therein
|
|
GB201010193D0
(en)
|
2010-06-17 |
2010-07-21 |
Respivert Ltd |
Medicinal use
|
|
GB201010196D0
(en)
|
2010-06-17 |
2010-07-21 |
Respivert Ltd |
Methods
|
|
WO2012008564A1
(ja)
|
2010-07-16 |
2012-01-19 |
協和発酵キリン株式会社 |
含窒素芳香族複素環誘導体
|
|
UY33337A
(es)
|
2010-10-18 |
2011-10-31 |
Respivert Ltd |
DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
|
|
WO2012149547A1
(en)
|
2011-04-28 |
2012-11-01 |
Duke University |
Methods of treating hemoglobinopathies
|
|
EA201490052A1
(ru)
|
2011-06-23 |
2014-04-30 |
Вайамет Фармасьютикалс, Инк. |
Соединения, ингибирующие металлоферменты
|
|
WO2013001372A2
(en)
|
2011-06-30 |
2013-01-03 |
University Of Oslo |
Methods and compositions for inhibition of activation of regulatory t cells
|
|
RU2014112324A
(ru)
|
2011-09-01 |
2015-10-10 |
Новартис Аг |
Применение органического соединения для лечения синдрома нунан
|
|
EP2578582A1
(en)
|
2011-10-03 |
2013-04-10 |
Respivert Limited |
1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
|
|
PE20142355A1
(es)
|
2011-10-03 |
2015-01-10 |
Respivert Ltd |
1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de proteinas cinasas activadas por mitogeno p38
|
|
GB201214750D0
(en)
|
2012-08-17 |
2012-10-03 |
Respivert Ltd |
Compounds
|
|
GB201215357D0
(en)
|
2012-08-29 |
2012-10-10 |
Respivert Ltd |
Compounds
|
|
US20150225373A1
(en)
|
2012-08-29 |
2015-08-13 |
Respivert Limited |
Kinase inhibitors
|
|
US20150210722A1
(en)
|
2012-08-29 |
2015-07-30 |
Respivert Limited |
Kinase inhibitors
|
|
US9783556B2
(en)
|
2012-08-29 |
2017-10-10 |
Respivert Limited |
Kinase inhibitors
|
|
WO2014076484A1
(en)
|
2012-11-16 |
2014-05-22 |
Respivert Limited |
Kinase inhibitors
|
|
WO2014140582A1
(en)
|
2013-03-14 |
2014-09-18 |
Respivert Limited |
Kinase inhibitors
|
|
JO3279B1
(ar)
|
2013-03-15 |
2018-09-16 |
Respivert Ltd |
مشتقات 2-((4- امينو -3- (3- فلورو-5- هيدروكسي فينيل)-h1- بيرازولو [d-3,4] بيرمدين-1-يل )ميثيل )- 3- (2- تراي فلورو ميثيل ) بينزيل ) كوينازولين -4 (h3)- واحد واستخدامها كمثبطات فوسفواينوسيتايد 3- كاينيز
|
|
BR112015024671A2
(pt)
|
2013-04-02 |
2017-07-18 |
Respivert Ltd |
derivados de ureia úteis como inibidores de quinase
|
|
US9771353B2
(en)
|
2013-04-02 |
2017-09-26 |
Topivert Pharma Limited |
Kinase inhibitors based upon N-alkyl pyrazoles
|
|
GB201320729D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
WO2015092423A1
(en)
|
2013-12-20 |
2015-06-25 |
Respivert Limited |
Urea derivatives useful as kinase inhibitors
|
|
PT3357919T
(pt)
|
2014-02-14 |
2020-02-20 |
Respivert Ltd |
Compostos heterocíclicos aromáticos como compostos antiinflamatórios
|
|
US20170209445A1
(en)
|
2014-10-01 |
2017-07-27 |
Respivert Limited |
Kinase inhibitors
|
|
MA40774A
(fr)
|
2014-10-01 |
2017-08-08 |
Respivert Ltd |
Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
|