DK2531502T3 - 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi - Google Patents
1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapiInfo
- Publication number
- DK2531502T3 DK2531502T3 DK11701856.4T DK11701856T DK2531502T3 DK 2531502 T3 DK2531502 T3 DK 2531502T3 DK 11701856 T DK11701856 T DK 11701856T DK 2531502 T3 DK2531502 T3 DK 2531502T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl
- imidazo
- yloxy
- pyrazol
- pyridin
- Prior art date
Links
- IBCZSSWQZVYRBN-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[2-fluoro-4-[(1-methyl-2-oxo-3h-imidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea Chemical compound C1=CN=C2NC(=O)N(C)C2=C1OC(C=C1F)=CC=C1NC(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC=C1 IBCZSSWQZVYRBN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30008510P | 2010-02-01 | 2010-02-01 | |
| PCT/GB2011/000106 WO2011092469A1 (en) | 2010-02-01 | 2011-01-27 | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2531502T3 true DK2531502T3 (da) | 2014-05-19 |
Family
ID=43629408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11701856.4T DK2531502T3 (da) | 2010-02-01 | 2011-01-27 | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8815896B2 (enExample) |
| EP (1) | EP2531502B1 (enExample) |
| JP (2) | JP5760010B2 (enExample) |
| CN (2) | CN102906090B (enExample) |
| AU (1) | AU2011209586B2 (enExample) |
| BR (1) | BR112012018415A2 (enExample) |
| CA (1) | CA2786834C (enExample) |
| DK (1) | DK2531502T3 (enExample) |
| ES (1) | ES2469367T3 (enExample) |
| NZ (2) | NZ601085A (enExample) |
| PL (1) | PL2531502T3 (enExample) |
| WO (1) | WO2011092469A1 (enExample) |
| ZA (1) | ZA201205181B (enExample) |
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| BRPI0821227A2 (pt) | 2007-12-19 | 2015-06-16 | Cancer Rec Tech Ltd | Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos |
| GB0807609D0 (en) | 2008-04-25 | 2008-06-04 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| EP2531502B1 (en) * | 2010-02-01 | 2014-04-02 | Cancer Research Technology Limited | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| GB201320729D0 (en) * | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| DK3113772T3 (da) | 2014-03-07 | 2020-12-07 | Biocryst Pharm Inc | Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma |
| US12042477B2 (en) | 2016-02-23 | 2024-07-23 | Cancer Research Technology Limited | Dietary product devoid of at least two non essential amino acids |
| EP3709991A1 (en) | 2017-11-13 | 2020-09-23 | Greg Hannon | Dietary product |
| GB201809295D0 (en) | 2018-06-06 | 2018-07-25 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| GB201818649D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| GB201818651D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| GB201818750D0 (en) | 2018-11-16 | 2019-01-02 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| EP3999057A1 (en) | 2019-07-19 | 2022-05-25 | Anagenesis Biotechnologies Sas | Polyaromatic urea derivatives and their use in the treatment of muscle diseases |
| JP2023530235A (ja) | 2020-06-03 | 2023-07-14 | フェス・セラピューティクス，インコーポレーテッド | 個別化された処置方法のための製剤 |
| JP2023528930A (ja) | 2020-06-04 | 2023-07-06 | フェス・セラピューティクス，インコーポレーテッド | がんを処置する個別化された方法 |
| EP4029501A1 (en) | 2021-01-19 | 2022-07-20 | Anagenesis Biotechnologies | Combination of polyaromatic urea derivatives and glucocorticoid or hdac inhibitor for the treatment of diseases or conditions associated with muscle cells and/or satellite cells |
| CN113189089B (zh) * | 2021-03-19 | 2022-05-17 | 四川轻化工大学 | 一种臭氧检测试剂及其制备装置和制备方法 |
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| GB202209622D0 (en) | 2022-06-30 | 2022-08-17 | Institute Of Cancer Res Royal Cancer Hospital | Compounds |
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| EP2981535B8 (en) | 2013-04-02 | 2021-03-10 | Oxular Acquisitions Limited | Urea derivatives useful as kinase inhibitors |
| WO2014162121A1 (en) | 2013-04-02 | 2014-10-09 | Topivert Pharma Limited | Kinase inhibitors based upon n-alkyl pyrazoles |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| EP3083604A1 (en) | 2013-12-20 | 2016-10-26 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
| JP6586098B2 (ja) | 2014-02-14 | 2019-10-02 | レスピバート・リミテツド | キナーゼ阻害剤としてのピラゾリル尿素 |
| WO2016051186A1 (en) | 2014-10-01 | 2016-04-07 | Respivert Limited | N-phenyl-3-quinazolin-6-yl-benzamide derivatives as p38 kinase inhibitors |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
-
2011
- 2011-01-27 EP EP11701856.4A patent/EP2531502B1/en active Active
- 2011-01-27 CN CN201180008030.1A patent/CN102906090B/zh not_active Expired - Fee Related
- 2011-01-27 CN CN201510266876.5A patent/CN104945401B/zh not_active Expired - Fee Related
- 2011-01-27 CA CA2786834A patent/CA2786834C/en not_active Expired - Fee Related
- 2011-01-27 PL PL11701856T patent/PL2531502T3/pl unknown
- 2011-01-27 AU AU2011209586A patent/AU2011209586B2/en not_active Ceased
- 2011-01-27 ES ES11701856.4T patent/ES2469367T3/es active Active
- 2011-01-27 DK DK11701856.4T patent/DK2531502T3/da active
- 2011-01-27 JP JP2012550510A patent/JP5760010B2/ja not_active Expired - Fee Related
- 2011-01-27 WO PCT/GB2011/000106 patent/WO2011092469A1/en not_active Ceased
- 2011-01-27 NZ NZ60108511A patent/NZ601085A/en not_active IP Right Cessation
- 2011-01-27 NZ NZ706154A patent/NZ706154A/en not_active IP Right Cessation
- 2011-01-27 US US13/520,613 patent/US8815896B2/en not_active Expired - Fee Related
- 2011-01-27 BR BR112012018415-6A patent/BR112012018415A2/pt not_active Application Discontinuation
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2012
- 2012-07-12 ZA ZA2012/05181A patent/ZA201205181B/en unknown
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2014
- 2014-07-15 US US14/331,653 patent/US9120789B2/en not_active Expired - Fee Related
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2015
- 2015-06-08 JP JP2015115366A patent/JP5956653B2/ja not_active Expired - Fee Related
- 2015-07-30 US US14/813,658 patent/US9439893B2/en not_active Expired - Fee Related
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2016
- 2016-09-01 US US15/254,103 patent/US9820976B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201205181B (en) | 2013-09-25 |
| JP2013518089A (ja) | 2013-05-20 |
| WO2011092469A1 (en) | 2011-08-04 |
| BR112012018415A2 (pt) | 2020-08-04 |
| CN104945401B (zh) | 2017-09-05 |
| CA2786834A1 (en) | 2011-04-08 |
| US20160030405A1 (en) | 2016-02-04 |
| EP2531502A1 (en) | 2012-12-12 |
| US20170079963A1 (en) | 2017-03-23 |
| US9820976B2 (en) | 2017-11-21 |
| US9120789B2 (en) | 2015-09-01 |
| CA2786834C (en) | 2018-10-16 |
| CN102906090A (zh) | 2013-01-30 |
| JP5956653B2 (ja) | 2016-07-27 |
| ES2469367T3 (es) | 2014-06-18 |
| AU2011209586B2 (en) | 2016-01-21 |
| US20140357663A1 (en) | 2014-12-04 |
| WO2011092469A8 (en) | 2012-08-16 |
| JP5760010B2 (ja) | 2015-08-05 |
| US20120283288A1 (en) | 2012-11-08 |
| AU2011209586A1 (en) | 2012-08-09 |
| NZ706154A (en) | 2016-09-30 |
| JP2015180675A (ja) | 2015-10-15 |
| CN104945401A (zh) | 2015-09-30 |
| US9439893B2 (en) | 2016-09-13 |
| NZ601085A (en) | 2015-04-24 |
| US8815896B2 (en) | 2014-08-26 |
| EP2531502B1 (en) | 2014-04-02 |
| CN102906090B (zh) | 2015-06-24 |
| PL2531502T3 (pl) | 2014-08-29 |
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