CA2786834C - 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy - Google Patents

1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy Download PDF

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Publication number
CA2786834C
CA2786834C CA2786834A CA2786834A CA2786834C CA 2786834 C CA2786834 C CA 2786834C CA 2786834 A CA2786834 A CA 2786834A CA 2786834 A CA2786834 A CA 2786834A CA 2786834 C CA2786834 C CA 2786834C
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CA
Canada
Prior art keywords
compound
treatment
cancer
mutant ras
medicament
Prior art date
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Expired - Fee Related
Application number
CA2786834A
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English (en)
French (fr)
Other versions
CA2786834A1 (en
Inventor
Caroline Springer
Ion Niculescu-Duvaz
Richard Marais
Dan Niculescu-Duvaz
Alfonso Zambon
Delphine Menard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Institute of Cancer Research: Royal Cancer Hospital
Cancer Research Technology Ltd
Original Assignee
The Institute of Cancer Research: Royal Cancer Hospital
Cancer Research Technology Ltd
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Application filed by The Institute of Cancer Research: Royal Cancer Hospital, Cancer Research Technology Ltd filed Critical The Institute of Cancer Research: Royal Cancer Hospital
Publication of CA2786834A1 publication Critical patent/CA2786834A1/en
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Publication of CA2786834C publication Critical patent/CA2786834C/en
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2786834A 2010-02-01 2011-01-27 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy Expired - Fee Related CA2786834C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30008510P 2010-02-01 2010-02-01
US61/300,085 2010-02-01
PCT/GB2011/000106 WO2011092469A1 (en) 2010-02-01 2011-01-27 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy

Publications (2)

Publication Number Publication Date
CA2786834A1 CA2786834A1 (en) 2011-04-08
CA2786834C true CA2786834C (en) 2018-10-16

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CA2786834A Expired - Fee Related CA2786834C (en) 2010-02-01 2011-01-27 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy

Country Status (13)

Country Link
US (4) US8815896B2 (enExample)
EP (1) EP2531502B1 (enExample)
JP (2) JP5760010B2 (enExample)
CN (2) CN102906090B (enExample)
AU (1) AU2011209586B2 (enExample)
BR (1) BR112012018415A2 (enExample)
CA (1) CA2786834C (enExample)
DK (1) DK2531502T3 (enExample)
ES (1) ES2469367T3 (enExample)
NZ (2) NZ601085A (enExample)
PL (1) PL2531502T3 (enExample)
WO (1) WO2011092469A1 (enExample)
ZA (1) ZA201205181B (enExample)

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WO2011092469A1 (en) 2011-08-04
CN102906090B (zh) 2015-06-24
AU2011209586B2 (en) 2016-01-21
JP5956653B2 (ja) 2016-07-27
CN102906090A (zh) 2013-01-30
US9820976B2 (en) 2017-11-21
JP2013518089A (ja) 2013-05-20
PL2531502T3 (pl) 2014-08-29
CA2786834A1 (en) 2011-04-08
US8815896B2 (en) 2014-08-26
ES2469367T3 (es) 2014-06-18
US9120789B2 (en) 2015-09-01
ZA201205181B (en) 2013-09-25
CN104945401A (zh) 2015-09-30
NZ706154A (en) 2016-09-30
DK2531502T3 (da) 2014-05-19
NZ601085A (en) 2015-04-24
US20120283288A1 (en) 2012-11-08
US9439893B2 (en) 2016-09-13
AU2011209586A1 (en) 2012-08-09
CN104945401B (zh) 2017-09-05
US20170079963A1 (en) 2017-03-23
EP2531502A1 (en) 2012-12-12
JP2015180675A (ja) 2015-10-15
US20160030405A1 (en) 2016-02-04
WO2011092469A8 (en) 2012-08-16
US20140357663A1 (en) 2014-12-04
JP5760010B2 (ja) 2015-08-05
BR112012018415A2 (pt) 2020-08-04
EP2531502B1 (en) 2014-04-02

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