AU2014253528B2 - Pyrido[2,3-b]pyrazine-8-substituted compounds and their use - Google Patents
Pyrido[2,3-b]pyrazine-8-substituted compounds and their useInfo
- Publication number
- AU2014253528B2 AU2014253528B2 AU2014253528A AU2014253528A AU2014253528B2 AU 2014253528 B2 AU2014253528 B2 AU 2014253528B2 AU 2014253528 A AU2014253528 A AU 2014253528A AU 2014253528 A AU2014253528 A AU 2014253528A AU 2014253528 B2 AU2014253528 B2 AU 2014253528B2
- Authority
- AU
- Australia
- Prior art keywords
- raf
- compounds
- inhibit
- activity
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention pertains generally to the field of therapeutic compounds for treating 5 proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin 8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, 10 to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2014253528A AU2014253528B2 (en) | 2007-12-19 | 2014-10-23 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61/015,019 | 2007-12-19 | ||
AU2008337286A AU2008337286B2 (en) | 2007-12-19 | 2008-12-19 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
AU2014253528A AU2014253528B2 (en) | 2007-12-19 | 2014-10-23 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2008337286A Division AU2008337286B2 (en) | 2007-12-19 | 2008-12-19 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2014253528A1 AU2014253528A1 (en) | 2014-11-13 |
AU2014253528B2 true AU2014253528B2 (en) | 2016-07-21 |
Family
ID=51869898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2014253528A Ceased AU2014253528B2 (en) | 2007-12-19 | 2014-10-23 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
Country Status (1)
Country | Link |
---|---|
AU (1) | AU2014253528B2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006067466A2 (en) * | 2004-12-22 | 2006-06-29 | The Wellcome Trust Limited | Pyrazines and pyridines and derivatives thereof as therapeutic compounds |
-
2014
- 2014-10-23 AU AU2014253528A patent/AU2014253528B2/en not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006067466A2 (en) * | 2004-12-22 | 2006-06-29 | The Wellcome Trust Limited | Pyrazines and pyridines and derivatives thereof as therapeutic compounds |
Also Published As
Publication number | Publication date |
---|---|
AU2014253528A1 (en) | 2014-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |