JP2010501572A5 - - Google Patents

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Publication number
JP2010501572A5
JP2010501572A5 JP2009525631A JP2009525631A JP2010501572A5 JP 2010501572 A5 JP2010501572 A5 JP 2010501572A5 JP 2009525631 A JP2009525631 A JP 2009525631A JP 2009525631 A JP2009525631 A JP 2009525631A JP 2010501572 A5 JP2010501572 A5 JP 2010501572A5
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JP
Japan
Prior art keywords
cancer
compound according
deuterium
formulation
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009525631A
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English (en)
Japanese (ja)
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JP2010501572A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/018655 external-priority patent/WO2008024439A2/en
Publication of JP2010501572A publication Critical patent/JP2010501572A/ja
Publication of JP2010501572A5 publication Critical patent/JP2010501572A5/ja
Pending legal-status Critical Current

Links

JP2009525631A 2006-08-22 2007-08-22 ４−アミノキナゾリン誘導体およびその使用方法 Pending JP2010501572A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83950306P 2006-08-22 2006-08-22
PCT/US2007/018655 WO2008024439A2 (en) 2006-08-22 2007-08-22 4-aminoquinazoline derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2010501572A JP2010501572A (ja) 2010-01-21
JP2010501572A5 true JP2010501572A5 (enExample) 2010-09-30

Family

ID=39107412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009525631A Pending JP2010501572A (ja) 2006-08-22 2007-08-22 ４−アミノキナゾリン誘導体およびその使用方法

Country Status (9)

Country Link
US (2) US20080051422A1 (enExample)
EP (1) EP2054063A4 (enExample)
JP (1) JP2010501572A (enExample)
KR (1) KR20090042994A (enExample)
CN (1) CN101594870A (enExample)
AU (1) AU2007288204A1 (enExample)
CA (1) CA2661223A1 (enExample)
MX (1) MX2009001814A (enExample)
WO (1) WO2008024439A2 (enExample)

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EP2054063A4 (en) * 2006-08-22 2010-10-27 Concert Pharmaceuticals Inc 4-AMINOCHINAZOLINE DERIVATIVES AND METHOD FOR THEIR USE
US20110053964A1 (en) * 2006-08-22 2011-03-03 Roger Tung 4-aminoquinazoline derivatives and methods of use thereof
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
US8604044B2 (en) 2006-09-11 2013-12-10 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
US20090215802A1 (en) * 2007-09-13 2009-08-27 Protia, Llc Deuterium-enriched lapatinib
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
US20090269354A1 (en) * 2008-03-28 2009-10-29 Concert Pharmaceuticals, Inc. Quinazoline derivatives and methods of treatment
WO2009137714A2 (en) * 2008-05-07 2009-11-12 Teva Pharmaceutical Industries Ltd. Forms of lapatinib ditosylate and processes for preparation thereof
WO2010027848A2 (en) * 2008-08-26 2010-03-11 Teva Pharmaceutical Industries Ltd. Forms of lapatinib compounds and processes for the preparation thereof
CA2735549A1 (en) * 2008-08-29 2010-03-04 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
US8541419B2 (en) * 2008-09-02 2013-09-24 Actimis Pharmaceuticals, Inc. Isotopically enriched pyrimidin-5-yl acetic acid derivatives as CRTH2 antagonists
CN102143949A (zh) * 2008-09-03 2011-08-03 泰华制药工业有限公司 2-羰基-1，2-二氢喹啉免疫功能调节剂
CN101735200B (zh) * 2008-11-17 2013-01-02 岑均达 喹唑啉类化合物
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
KR101648787B1 (ko) 2009-09-28 2016-08-17 치루 파머수티컬 컴퍼니 리미티드 타이로신 키나제 억제제로서 유용한 4－（치환된 아닐리노）－퀴나졸린 유도체
US20110195066A1 (en) * 2010-02-05 2011-08-11 Auspex Pharmaceuticals, Inc. Quinoline inhibitors of tyrosine kinase
UY33226A (es) * 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
CN102453025B (zh) * 2010-10-18 2014-08-13 齐鲁制药有限公司 拉帕替尼中间体晶型及其制备方法
EP2654754B1 (en) * 2010-12-17 2016-12-21 Novartis AG Combination for treating osteosarcoma, rhabdomyosarcoma and neuroblastoma
CN102321076B (zh) * 2011-07-07 2013-08-21 中国科学技术大学 拉帕替尼中间体及其类似物的制备方法
CN102659764A (zh) * 2012-04-16 2012-09-12 中国科学院广州生物医药与健康研究院 酪氨酸激酶不可逆抑制剂及其制备方法和用途
CZ2012712A3 (cs) 2012-10-17 2014-04-30 Zentiva, K.S. Nový způsob výroby klíčového intermediátu výroby lapatinibu
CN102911164A (zh) * 2012-11-07 2013-02-06 江苏金桥盐化集团利海化工有限公司 一种拉帕替尼关键中间体的制备方法
US9024023B2 (en) 2013-01-14 2015-05-05 F.I.S.—Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates
ITVI20130003A1 (it) * 2013-01-14 2014-07-14 F I S Fabbrica Italiana Sint I S P A Procedimento per la preparazione di lapatinib e suoi sali mediante nuovi intermedi.
CN104513231A (zh) * 2015-01-09 2015-04-15 安润医药科技（苏州）有限公司 拉帕替尼及其中间体的合成方法
GB201611580D0 (en) * 2016-07-01 2016-08-17 Aslan Pharmaceuticals Pte Ltd Method
WO2019067543A1 (en) * 2017-09-26 2019-04-04 The Regents Of The University Of California COMPOSITIONS AND METHODS OF TREATING CANCER
CN107827877B (zh) * 2017-11-21 2021-05-07 陕西师范大学 二烷基氨基喹唑啉类化合物及其在制备抗肿瘤药物中的应用
CN108285421A (zh) * 2018-01-26 2018-07-17 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成拉帕替尼中间体的方法
CN108187055B (zh) * 2018-03-06 2019-12-27 北京大学 一种具有协同增效作用的抗癌组合物
CN108690001A (zh) * 2018-06-26 2018-10-23 苏州市贝克生物科技有限公司 拉帕替尼类似物的合成

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MXPA06013635A (es) * 2004-06-03 2007-02-28 Smithkline Beecam Cork Ltd Metodo para el tratamiento de cancer.
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EP2054063A4 (en) * 2006-08-22 2010-10-27 Concert Pharmaceuticals Inc 4-AMINOCHINAZOLINE DERIVATIVES AND METHOD FOR THEIR USE
US20110053964A1 (en) * 2006-08-22 2011-03-03 Roger Tung 4-aminoquinazoline derivatives and methods of use thereof
CA2661404A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
US20090215802A1 (en) * 2007-09-13 2009-08-27 Protia, Llc Deuterium-enriched lapatinib
WO2010005585A2 (en) * 2008-07-09 2010-01-14 Concert Pharmaceuticals Inc. 4-aminoquinazoline prodrugs

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