JP2018531226A5 - - Google Patents
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- Publication number
- JP2018531226A5 JP2018531226A5 JP2018513812A JP2018513812A JP2018531226A5 JP 2018531226 A5 JP2018531226 A5 JP 2018531226A5 JP 2018513812 A JP2018513812 A JP 2018513812A JP 2018513812 A JP2018513812 A JP 2018513812A JP 2018531226 A5 JP2018531226 A5 JP 2018531226A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- fluoro
- imidazo
- pyridyl
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 18
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- VQSZIPCGAGVRRP-UHFFFAOYSA-N 7-fluoro-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC=1C(=CC=2C3=C(C=NC=2C=1)N(C(N3C(C)C)=O)C)C=1C=NC(=CC=1)OCCCN1CCCCC1 VQSZIPCGAGVRRP-UHFFFAOYSA-N 0.000 claims 4
- 108010006654 Bleomycin Proteins 0.000 claims 4
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 4
- 229930192392 Mitomycin Natural products 0.000 claims 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 4
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 4
- 229960002707 bendamustine Drugs 0.000 claims 4
- 229960001561 bleomycin Drugs 0.000 claims 4
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 229960005243 carmustine Drugs 0.000 claims 4
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 4
- 229960004630 chlorambucil Drugs 0.000 claims 4
- 229960004679 doxorubicin Drugs 0.000 claims 4
- 229960005420 etoposide Drugs 0.000 claims 4
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 4
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 4
- 229960001101 ifosfamide Drugs 0.000 claims 4
- 229960004768 irinotecan Drugs 0.000 claims 4
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 4
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 4
- 229960001924 melphalan Drugs 0.000 claims 4
- 229960004857 mitomycin Drugs 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 229960000303 topotecan Drugs 0.000 claims 4
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 4
- BKWJAKQVGHWELA-UHFFFAOYSA-N 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(CC=C)N(C=3N=C(C=CC=3)C(C)(C)O)C2=N1 BKWJAKQVGHWELA-UHFFFAOYSA-N 0.000 claims 2
- SMWJFSPLUJFWQK-UHFFFAOYSA-N 3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1H-imidazo[4,5-c]quinolin-2-one Chemical compound CN1C(NC2=C1C=NC=1C=CC(=CC2=1)C=1C=NC(=CC=1)OCCCN1CCCCC1)=O SMWJFSPLUJFWQK-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 2
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 2
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- -1 MEDI 4736 Chemical compound 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- KMSKQZKKOZQFFG-HSUXVGOQSA-N Pirarubicin Chemical compound O([C@H]1[C@@H](N)C[C@@H](O[C@H]1C)O[C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1CCCCO1 KMSKQZKKOZQFFG-HSUXVGOQSA-N 0.000 claims 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 229950009557 adavosertib Drugs 0.000 claims 2
- 229960002550 amrubicin Drugs 0.000 claims 2
- VJZITPJGSQKZMX-XDPRQOKASA-N amrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C(O)=C21)(N)C(=O)C)[C@H]1C[C@H](O)[C@H](O)CO1 VJZITPJGSQKZMX-XDPRQOKASA-N 0.000 claims 2
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 2
- 229960004562 carboplatin Drugs 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- OHUHVTCQTUDPIJ-JYCIKRDWSA-N ceralasertib Chemical compound C[C@@H]1COCCN1C1=CC(C2(CC2)[S@](C)(=N)=O)=NC(C=2C=3C=CNC=3N=CC=2)=N1 OHUHVTCQTUDPIJ-JYCIKRDWSA-N 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 229960001904 epirubicin Drugs 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 229960000908 idarubicin Drugs 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229960000572 olaparib Drugs 0.000 claims 2
- FAQDUNYVKQKNLD-UHFFFAOYSA-N olaparib Chemical compound FC1=CC=C(CC2=C3[CH]C=CC=C3C(=O)N=N2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FAQDUNYVKQKNLD-UHFFFAOYSA-N 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 229960001221 pirarubicin Drugs 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 229960000653 valrubicin Drugs 0.000 claims 2
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 claims 2
- DOGAIAZHLPAWOB-UHFFFAOYSA-N 3-methyl-1-propan-2-yl-8-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one Chemical compound C(C)(C)N1C(N(C=2C=NC=3C=CC(=CC=3C=21)C=1C=NC(=CC=1)OCCCN1CCCC1)C)=O DOGAIAZHLPAWOB-UHFFFAOYSA-N 0.000 claims 1
- OPEBBRSWFSOLFL-UHFFFAOYSA-N 3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound C(C)(C)N1C(N(C=2C=NC=3C=CC(=CC=3C=21)C=1C=NC(=CC=1)OCCCN1CCCCC1)C)=O OPEBBRSWFSOLFL-UHFFFAOYSA-N 0.000 claims 1
- AFDZKIWZQWNJPY-UHFFFAOYSA-N 7-fluoro-3-methyl-1-propan-2-yl-8-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one Chemical compound FC=1C(=CC=2C3=C(C=NC=2C=1)N(C(N3C(C)C)=O)C)C=1C=NC(=CC=1)OCCCN1CCCC1 AFDZKIWZQWNJPY-UHFFFAOYSA-N 0.000 claims 1
- AQUKIPBUIHTXQN-UHFFFAOYSA-N 7-fluoro-8-[2-fluoro-6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC=1C(=CC=2C3=C(C=NC=2C=1)N(C(N3C(C)C)=O)C)C=1C(=NC(=CC=1)OCCCN1CCCCC1)F AQUKIPBUIHTXQN-UHFFFAOYSA-N 0.000 claims 1
- QXPYFMIBIUEUPJ-UHFFFAOYSA-N 7-fluoro-8-[2-fluoro-6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC=1C(=CC=2C3=C(C=NC=2C=1)N(C(N3C(C)C)=O)C)C=1C(=NC(=CC=1)OCCCN1CCCC1)F QXPYFMIBIUEUPJ-UHFFFAOYSA-N 0.000 claims 1
- IGSBSYICFBNYEI-UHFFFAOYSA-N 8-[2-fluoro-6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC1=NC(=CC=C1C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C)OCCCN1CCCCC1 IGSBSYICFBNYEI-UHFFFAOYSA-N 0.000 claims 1
- CBDTWZFMJGLGSU-UHFFFAOYSA-N 8-[2-fluoro-6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC1=NC(=CC=C1C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C)OCCCN1CCCC1 CBDTWZFMJGLGSU-UHFFFAOYSA-N 0.000 claims 1
- UMFCCRZZAJALOB-UHFFFAOYSA-N 8-[6-[3-(azetidin-1-yl)propoxy]-2-fluoropyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound N1(CCC1)CCCOC1=CC=C(C(=N1)F)C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C UMFCCRZZAJALOB-UHFFFAOYSA-N 0.000 claims 1
- WPHRPDQRTRXCQZ-UHFFFAOYSA-N 8-[6-[3-(azetidin-1-yl)propoxy]-2-fluoropyridin-3-yl]-7-fluoro-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound N1(CCC1)CCCOC1=CC=C(C(=N1)F)C1=CC=2C3=C(C=NC=2C=C1F)N(C(N3C(C)C)=O)C WPHRPDQRTRXCQZ-UHFFFAOYSA-N 0.000 claims 1
- CPCSHQZZPYJWLE-UHFFFAOYSA-N 8-[6-[3-(azetidin-1-yl)propoxy]pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound N1(CCC1)CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C CPCSHQZZPYJWLE-UHFFFAOYSA-N 0.000 claims 1
- HDIIITHLDJJITK-UHFFFAOYSA-N 8-[6-[3-(azetidin-1-yl)propoxy]pyridin-3-yl]-7-fluoro-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound N1(CCC1)CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1F)N(C(N3C(C)C)=O)C HDIIITHLDJJITK-UHFFFAOYSA-N 0.000 claims 1
- VQEKWOAURYLYMQ-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]-2-fluoropyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C(=N1)F)C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C)C VQEKWOAURYLYMQ-UHFFFAOYSA-N 0.000 claims 1
- SWANNNYJQNIWLY-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]-2-fluoropyridin-3-yl]-7-fluoro-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C(=N1)F)C1=CC=2C3=C(C=NC=2C=C1F)N(C(N3C(C)C)=O)C)C SWANNNYJQNIWLY-UHFFFAOYSA-N 0.000 claims 1
- FBYDIXCPNMJMEZ-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1)N(C(N3C(C)C)=O)C)C FBYDIXCPNMJMEZ-UHFFFAOYSA-N 0.000 claims 1
- LXCVHNGRPAMZTG-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-1-propan-2-yl-3H-imidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1F)NC(N3C(C)C)=O)C LXCVHNGRPAMZTG-UHFFFAOYSA-N 0.000 claims 1
- WJGVVHLQSBDKMS-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1F)N(C(N3C(C)C)=O)C)C WJGVVHLQSBDKMS-UHFFFAOYSA-N 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1516504.6A GB201516504D0 (en) | 2015-09-17 | 2015-09-17 | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB1516504.6 | 2015-09-17 | ||
| PCT/EP2016/071782 WO2017046216A1 (en) | 2015-09-17 | 2016-09-15 | 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531226A JP2018531226A (ja) | 2018-10-25 |
| JP2018531226A6 JP2018531226A6 (ja) | 2018-12-13 |
| JP2018531226A5 true JP2018531226A5 (enExample) | 2019-05-16 |
| JP6605130B2 JP6605130B2 (ja) | 2019-11-13 |
Family
ID=54544418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513812A Active JP6605130B2 (ja) | 2015-09-17 | 2016-09-15 | 癌の治療のための血管拡張性失調症変異（ａｔｍ）キナーゼの選択的モジュレーターとしての８−［６−［３−（アミノ）プロポキシ］−３−ピリジル］−１−イソプロピル−イミダゾ［４，５−ｃ］キノリン−２−オン誘導体 |
Country Status (37)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| WO2019057757A1 (en) | 2017-09-20 | 2019-03-28 | Astrazeneca Ab | 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
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