SMT202100071T1 - Derivati di 8-[6-[3-(ammino)propossi]-3-piridil]-1-isopropil-imidazo[4,5-c]chinolin-2-one come modulatori selettivi della ghinasi mutata dell'atassia teleangiectasia (atm) per il trattamento di un cancro - Google Patents
Derivati di 8-[6-[3-(ammino)propossi]-3-piridil]-1-isopropil-imidazo[4,5-c]chinolin-2-one come modulatori selettivi della ghinasi mutata dell'atassia teleangiectasia (atm) per il trattamento di un cancroInfo
- Publication number
- SMT202100071T1 SMT202100071T1 SM20210071T SMT202100071T SMT202100071T1 SM T202100071 T1 SMT202100071 T1 SM T202100071T1 SM 20210071 T SM20210071 T SM 20210071T SM T202100071 T SMT202100071 T SM T202100071T SM T202100071 T1 SMT202100071 T1 SM T202100071T1
- Authority
- SM
- San Marino
- Prior art keywords
- quinolin
- imidazo
- propoxy
- pyridyl
- atm
- Prior art date
Links
- ORPRVKFUBPPFIQ-UHFFFAOYSA-N 8-[6-(3-aminopropoxy)pyridin-3-yl]-1-propan-2-yl-3H-imidazo[4,5-c]quinolin-2-one Chemical class NCCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1)NC(N3C(C)C)=O ORPRVKFUBPPFIQ-UHFFFAOYSA-N 0.000 title 1
- 102000000872 ATM Human genes 0.000 title 1
- 101150065175 Atm gene Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1516504.6A GB201516504D0 (en) | 2015-09-17 | 2015-09-17 | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| EP16770461.8A EP3350180B1 (en) | 2015-09-17 | 2016-09-15 | 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer |
| PCT/EP2016/071782 WO2017046216A1 (en) | 2015-09-17 | 2016-09-15 | 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT202100071T1 true SMT202100071T1 (it) | 2021-03-15 |
Family
ID=54544418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20210071T SMT202100071T1 (it) | 2015-09-17 | 2016-09-15 | Derivati di 8-[6-[3-(ammino)propossi]-3-piridil]-1-isopropil-imidazo[4,5-c]chinolin-2-one come modulatori selettivi della ghinasi mutata dell'atassia teleangiectasia (atm) per il trattamento di un cancro |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US9856255B2 (it) |
| EP (2) | EP3350180B1 (it) |
| JP (1) | JP6605130B2 (it) |
| KR (2) | KR102469153B1 (it) |
| CN (1) | CN108137576B (it) |
| AR (1) | AR106053A1 (it) |
| AU (1) | AU2016323399B2 (it) |
| BR (1) | BR112018004325B1 (it) |
| CA (1) | CA2997399C (it) |
| CL (1) | CL2018000677A1 (it) |
| CO (1) | CO2018002829A2 (it) |
| CR (1) | CR20180172A (it) |
| CY (1) | CY1124680T1 (it) |
| DK (2) | DK3350180T3 (it) |
| DO (1) | DOP2018000065A (it) |
| EA (1) | EA033284B1 (it) |
| ES (2) | ES2920876T3 (it) |
| GB (1) | GB201516504D0 (it) |
| HR (1) | HRP20210149T1 (it) |
| HU (2) | HUE058884T2 (it) |
| IL (1) | IL257847B (it) |
| LT (1) | LT3350180T (it) |
| MX (1) | MX384930B (it) |
| MY (2) | MY198813A (it) |
| NI (1) | NI201800033A (it) |
| PE (1) | PE20181078A1 (it) |
| PH (1) | PH12018500532A1 (it) |
| PL (2) | PL3350180T3 (it) |
| PT (2) | PT3350180T (it) |
| RS (1) | RS61435B1 (it) |
| SI (1) | SI3350180T1 (it) |
| SM (1) | SMT202100071T1 (it) |
| SV (1) | SV2018005655A (it) |
| TN (1) | TN2018000078A1 (it) |
| TW (2) | TWI714631B (it) |
| WO (1) | WO2017046216A1 (it) |
| ZA (1) | ZA202209171B (it) |
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| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| WO2019057757A1 (en) | 2017-09-20 | 2019-03-28 | Astrazeneca Ab | 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
| CN112752758B (zh) * | 2018-09-14 | 2023-05-23 | 苏州赞荣医药科技有限公司 | 作为ATM激酶选择性调节剂的咪唑并[4,5-c]噌啉-2-酮化合物及其用途 |
| WO2021139814A1 (zh) * | 2020-01-09 | 2021-07-15 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| EP4115883A4 (en) * | 2020-03-04 | 2024-04-10 | Pharos Ibio Co., Ltd. | USE OF A 2,3,5-SUBSTITUTED THIOPHENE COMPOUND TO PREVENT, MITIGATE OR TREAT OVARIAN CANCER |
| US20230256110A1 (en) * | 2020-06-24 | 2023-08-17 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and atm inhibitor |
| CN116322699B (zh) * | 2020-09-28 | 2025-02-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一类并环化合物及其制备和应用 |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
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| CN115304598B (zh) * | 2021-08-25 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种杂环类化合物及其制备方法和用途 |
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