SI3452465T1 - Substituirani derivati 2,4-diamino-kinolina za uporabo v zdravljenju proliferativnih bolezni - Google Patents
Substituirani derivati 2,4-diamino-kinolina za uporabo v zdravljenju proliferativnih bolezniInfo
- Publication number
- SI3452465T1 SI3452465T1 SI201730626T SI201730626T SI3452465T1 SI 3452465 T1 SI3452465 T1 SI 3452465T1 SI 201730626 T SI201730626 T SI 201730626T SI 201730626 T SI201730626 T SI 201730626T SI 3452465 T1 SI3452465 T1 SI 3452465T1
- Authority
- SI
- Slovenia
- Prior art keywords
- diamino
- substituted
- treatment
- proliferative diseases
- quinoline derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331844P | 2016-05-04 | 2016-05-04 | |
| PCT/IB2017/052614 WO2017191599A1 (en) | 2016-05-04 | 2017-05-04 | Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases |
| EP17731278.2A EP3452465B1 (en) | 2016-05-04 | 2017-05-04 | Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3452465T1 true SI3452465T1 (sl) | 2021-04-30 |
Family
ID=59078115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201730626T SI3452465T1 (sl) | 2016-05-04 | 2017-05-04 | Substituirani derivati 2,4-diamino-kinolina za uporabo v zdravljenju proliferativnih bolezni |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10577362B2 (sl) |
| EP (1) | EP3452465B1 (sl) |
| JP (1) | JP6969800B2 (sl) |
| CN (1) | CN109415343A (sl) |
| CA (1) | CA3023032A1 (sl) |
| DK (1) | DK3452465T3 (sl) |
| ES (1) | ES2849560T3 (sl) |
| HR (1) | HRP20210169T1 (sl) |
| SI (1) | SI3452465T1 (sl) |
| WO (1) | WO2017191599A1 (sl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108456183A (zh) * | 2018-03-09 | 2018-08-28 | 上海工程技术大学 | Gedatolisib的制备方法及中间体 |
| EP3620164A1 (en) * | 2018-09-05 | 2020-03-11 | Genoscience Pharma SAS | Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases |
| US12084419B2 (en) | 2020-06-27 | 2024-09-10 | Crescenta Biosciences | Cell metabolism modulating compounds and uses thereof |
| EP4349336A1 (en) * | 2022-10-04 | 2024-04-10 | Genoscience Pharma | Combination of substituted 2,4 diamino-quinoline compounds and mek inhibitors for use in the treatment of liver cancers |
| CN116751186A (zh) * | 2022-12-23 | 2023-09-15 | 南京知和医药科技有限公司 | 一种雌激素受体调节剂的制备及其用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US5266573A (en) | 1989-08-07 | 1993-11-30 | Elf Sanofi | Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| EP0647450A1 (en) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| US6262059B1 (en) * | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6339093B1 (en) * | 1999-10-08 | 2002-01-15 | Hoffmann-La Roche Inc. | Isoquinoline derivatives |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| US6548508B2 (en) * | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6787558B2 (en) * | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| EA008379B1 (ru) | 2002-02-01 | 2007-04-27 | Ариад Джин Терапьютикс, Инк. | Фосфорсодержащие соединения и их применения |
| PL215865B1 (pl) | 2002-03-05 | 2014-02-28 | Axys Pharmaceuticals | Zwiazek, kompozycja farmaceutyczna i zastosowanie zwiazku |
| TWI275390B (en) | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| CN1678586A (zh) * | 2002-06-27 | 2005-10-05 | 舍林股份公司 | 取代的喹啉ccr5受体拮抗剂 |
| PA8580301A1 (es) | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
| US7759336B2 (en) * | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
| US20080119515A1 (en) * | 2003-03-10 | 2008-05-22 | M Arshad Siddiqui | Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis |
| CN1784229A (zh) * | 2003-03-10 | 2006-06-07 | 先灵公司 | 杂环激酶抑制剂:使用方法与合成 |
| JP2006519846A (ja) * | 2003-03-10 | 2006-08-31 | シェーリング コーポレイション | 複素環式キナーゼインヒビター：使用および合成の方法 |
| US7399865B2 (en) | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
| KR20130083488A (ko) | 2004-09-02 | 2013-07-22 | 제넨테크, 인크. | 헤지호그 신호전달에 대한 피리딜 억제제 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CN101300249A (zh) * | 2005-06-10 | 2008-11-05 | 詹森药业有限公司 | 氨基喹啉和氨基喹唑啉激酶调节剂 |
| US20070116643A1 (en) | 2005-07-01 | 2007-05-24 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| US20070032555A1 (en) | 2005-07-01 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel aryloxyphenyl-propanamines |
| KR101380190B1 (ko) | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| JP2009502961A (ja) | 2005-07-29 | 2009-01-29 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規な医薬組成物 |
| JPWO2007114323A1 (ja) * | 2006-04-04 | 2009-08-20 | 大正製薬株式会社 | アミノピロリジン化合物 |
| TWI471134B (zh) | 2007-09-12 | 2015-02-01 | Genentech Inc | 肌醇磷脂３－激酶抑制劑化合物及化療劑之組合及使用方法 |
| EP2214675B1 (en) | 2007-10-25 | 2013-11-20 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| JP2012531436A (ja) * | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびそれらのｐｉ３ｋ活性阻害剤としての使用 |
| CN102127070A (zh) * | 2010-01-15 | 2011-07-20 | 山东轩竹医药科技有限公司 | 吡啶并环衍生物 |
| MX2015013396A (es) * | 2013-03-18 | 2016-07-08 | Genoscience Pharma | Derivados de quinolinas como nuevos agentes contra el cancer. |
| MA40875B1 (fr) * | 2014-10-31 | 2019-01-31 | Genoscience Pharma Sas | 2,4-diamino-quinoléine substituée servant de nouveaux agents anticancéreux |
-
2017
- 2017-05-04 ES ES17731278T patent/ES2849560T3/es active Active
- 2017-05-04 WO PCT/IB2017/052614 patent/WO2017191599A1/en unknown
- 2017-05-04 DK DK17731278.2T patent/DK3452465T3/da active
- 2017-05-04 JP JP2018557419A patent/JP6969800B2/ja active Active
- 2017-05-04 EP EP17731278.2A patent/EP3452465B1/en active Active
- 2017-05-04 CA CA3023032A patent/CA3023032A1/en active Pending
- 2017-05-04 CN CN201780038986.3A patent/CN109415343A/zh active Pending
- 2017-05-04 SI SI201730626T patent/SI3452465T1/sl unknown
- 2017-05-04 US US16/098,546 patent/US10577362B2/en active Active
-
2021
- 2021-02-02 HR HRP20210169TT patent/HRP20210169T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019514951A (ja) | 2019-06-06 |
| HRP20210169T1 (hr) | 2021-03-19 |
| DK3452465T3 (da) | 2021-02-08 |
| US20190144437A1 (en) | 2019-05-16 |
| JP6969800B2 (ja) | 2021-11-24 |
| CA3023032A1 (en) | 2017-11-09 |
| WO2017191599A1 (en) | 2017-11-09 |
| EP3452465A1 (en) | 2019-03-13 |
| ES2849560T3 (es) | 2021-08-19 |
| CN109415343A (zh) | 2019-03-01 |
| US10577362B2 (en) | 2020-03-03 |
| EP3452465B1 (en) | 2020-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL264049A (en) | Compounds, preparations and methods for treating the disease | |
| IL264156A (en) | Compounds, preparations and methods for treating the disease | |
| HRP20210518T1 (hr) | Derivati 2,4-tiazolidindiona, namijenjeni liječenju poremećaja središnjeg živčanog sustava | |
| SI3452465T1 (sl) | Substituirani derivati 2,4-diamino-kinolina za uporabo v zdravljenju proliferativnih bolezni | |
| HRP20180788T1 (hr) | [1,2,4]triazolo[4,3-b]piridazini za uporabu za liječenje proliferativnih bolesti | |
| EP3310358A4 (en) | COMPOSITIONS AND METHODS FOR TREATING SUBSTANCE ABUSE, SEARCH AND PSYCHIATRIC DISORDER | |
| EP3440052C0 (en) | COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | |
| HK1251476A1 (zh) | 用於治療癌症的氨基硫羥酸酯化合物或其藥學上可接受的鹽 | |
| HRP20181123T1 (hr) | Spojevi 3,4-diamino-6-kloropirazin-2-karboksamida za liječenje bolesti posredovanih s enac | |
| PL3370727T3 (pl) | Nieulegające biokonwersji c3-podstawione pochodne pregnenolonu do zastosowania w leczeniu zaburzeń związanych z nadużywaniem substancji |