PE20181078A1 - Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer - Google Patents
Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancerInfo
- Publication number
- PE20181078A1 PE20181078A1 PE2018000343A PE2018000343A PE20181078A1 PE 20181078 A1 PE20181078 A1 PE 20181078A1 PE 2018000343 A PE2018000343 A PE 2018000343A PE 2018000343 A PE2018000343 A PE 2018000343A PE 20181078 A1 PE20181078 A1 PE 20181078A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase
- quinolin
- pyridyl
- isopropylimidazo
- atm
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 3
- 102000020233 phosphotransferase Human genes 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- -1 AMINO Chemical class 0.000 title 1
- 125000001145 hydrido group Chemical group *[H] 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- VQSZIPCGAGVRRP-UHFFFAOYSA-N 7-fluoro-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound FC=1C(=CC=2C3=C(C=NC=2C=1)N(C(N3C(C)C)=O)C)C=1C=NC(=CC=1)OCCCN1CCCCC1 VQSZIPCGAGVRRP-UHFFFAOYSA-N 0.000 abstract 1
- ORPRVKFUBPPFIQ-UHFFFAOYSA-N 8-[6-(3-aminopropoxy)pyridin-3-yl]-1-propan-2-yl-3H-imidazo[4,5-c]quinolin-2-one Chemical class NCCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1)NC(N3C(C)C)=O ORPRVKFUBPPFIQ-UHFFFAOYSA-N 0.000 abstract 1
- WJGVVHLQSBDKMS-UHFFFAOYSA-N 8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-7-fluoro-3-methyl-1-propan-2-ylimidazo[4,5-c]quinolin-2-one Chemical compound CN(CCCOC1=CC=C(C=N1)C1=CC=2C3=C(C=NC=2C=C1F)N(C(N3C(C)C)=O)C)C WJGVVHLQSBDKMS-UHFFFAOYSA-N 0.000 abstract 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1516504.6A GB201516504D0 (en) | 2015-09-17 | 2015-09-17 | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181078A1 true PE20181078A1 (es) | 2018-07-05 |
Family
ID=54544418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018000343A PE20181078A1 (es) | 2015-09-17 | 2016-09-15 | Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer |
Country Status (37)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| CN111344293A (zh) | 2017-09-20 | 2020-06-26 | 阿斯利康(瑞典)有限公司 | 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途 |
| WO2020052688A1 (en) * | 2018-09-14 | 2020-03-19 | Suzhou Zanrong Pharma Limited | 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF |
| WO2021139814A1 (zh) * | 2020-01-09 | 2021-07-15 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| EP4115883A4 (en) | 2020-03-04 | 2024-04-10 | Pharos Ibio Co., Ltd. | USE OF 2,3,5-SUBSTITUTED THIOPHENE COMPOUND FOR PREVENTING, MITIGATING OR TREATING OVARIAN CANCER |
| CN116194109A (zh) | 2020-06-24 | 2023-05-30 | 阿斯利康(英国)有限公司 | 抗体-药物缀合物和atm抑制剂的组合 |
| KR102985456B1 (ko) * | 2020-09-28 | 2026-07-01 | 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 | 축합 고리 화합물 및 그 제조 및 응용 |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| WO2022125614A1 (en) * | 2020-12-09 | 2022-06-16 | Stingray Therapeutics, Inc. | Phosphonates as inhibitors of enpp1 and cdnp |
| AU2021433713A1 (en) * | 2021-03-17 | 2023-09-28 | Suzhou Zanrong Pharma Limited | Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof |
| CN115304598B (zh) * | 2021-08-25 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种杂环类化合物及其制备方法和用途 |
| GB202114704D0 (en) | 2021-10-14 | 2021-12-01 | Univ Birmingham | ATM inhibition |
| CN118434736A (zh) * | 2022-01-26 | 2024-08-02 | 正大天晴药业集团股份有限公司 | 含有肼基的化合物 |
| CN118984706A (zh) * | 2022-04-11 | 2024-11-19 | 钟卫 | 一种取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮衍生物的晶型、其盐的晶型、制备方法及应用 |
| CN121038817A (zh) | 2023-04-10 | 2025-11-28 | 第一三共株式会社 | 抗-b7-h3抗体-药物缀合物和atr抑制剂或atm抑制剂的组合 |
| EP4777108A1 (en) | 2023-09-13 | 2026-07-22 | AstraZeneca AB | Azd1390, or a pharmaceutically acceptable salt thereof, in combination with radiation for use in a method of treatment of a cns tumour |
| TW202535383A (zh) | 2024-03-13 | 2025-09-16 | 瑞典商阿斯特捷利康公司 | 治療方法 |
| WO2026120558A1 (en) | 2024-12-06 | 2026-06-11 | Sun Pharma Advanced Research Company Limited | Macrocyclic compounds as atm inhibitors |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ240313A (en) | 1990-10-22 | 1994-04-27 | Res Corp Technologies Inc | Anti-retrovirus compositions containing aryl and heteroaryl derivatives |
| TW301607B (enExample) | 1993-03-09 | 1997-04-01 | Takeda Pharm Industry Co Ltd | |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| EP1107759A1 (en) | 1998-08-03 | 2001-06-20 | Basf Corporation | Pyridinones for the treatment of sexual dysfunction |
| EP1150955A2 (en) | 1999-02-04 | 2001-11-07 | Millennium Pharmaceuticals, Inc. | G-protein coupled heptahelical receptor binding compounds and methods of use thereof |
| US20020151712A1 (en) | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| WO2002030357A2 (en) | 2000-10-11 | 2002-04-18 | Chemocentryx, Inc. | Compounds and methods for modulating ccr4 function |
| AU2002213467A1 (en) | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
| EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| AU2002303156A1 (en) | 2001-03-23 | 2002-10-08 | Bethesda Pharmaceuticals, Inc. | Design and synthesis of optimized ligands for ppar |
| JP2002293745A (ja) | 2001-03-29 | 2002-10-09 | St Marianna Univ School Of Medicine | 慢性関節リウマチ治療剤 |
| CA2442654A1 (en) | 2001-04-10 | 2002-10-10 | Transtech Pharma, Inc. | Probes, systems, and methods for drug discovery |
| WO2002087618A1 (en) | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Preventive/therapeutic method for cancer |
| WO2002094264A1 (en) | 2001-05-23 | 2002-11-28 | Tularik Inc. | Ccr4 antagonists |
| EP1270535A3 (de) | 2001-06-20 | 2004-02-18 | Clariant GmbH | Verfahren zur Herstellung von substituierten aromatischen Verbindungen |
| JP4082888B2 (ja) | 2001-10-17 | 2008-04-30 | 広栄化学工業株式会社 | ビアリール化合物の製造法 |
| CA2473740A1 (en) | 2002-01-18 | 2003-07-31 | David Solow-Cordero | Methods of treating conditions associated with an edg receptor |
| JP4167848B2 (ja) | 2002-04-10 | 2008-10-22 | 広栄化学工業株式会社 | ビアリール化合物の製造法 |
| GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| WO2004007472A1 (ja) | 2002-07-10 | 2004-01-22 | Ono Pharmaceutical Co., Ltd. | Ｃｃｒ４アンタゴニストおよびその医薬用途 |
| WO2004017920A2 (en) | 2002-08-23 | 2004-03-04 | University Of Connecticut | Novel biphenyl and biphenyl-like cannabinoids |
| AU2003265663A1 (en) | 2002-08-23 | 2004-03-11 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| US7432375B2 (en) | 2003-03-06 | 2008-10-07 | Eisai R & D Management Co., Ltd. | JNK inhibitors |
| JPWO2004080943A1 (ja) | 2003-03-11 | 2006-06-08 | 小野薬品工業株式会社 | シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| WO2004113258A1 (ja) | 2003-06-20 | 2004-12-29 | Shionogi & Co., Ltd. | 炭素−炭素結合生成反応 |
| EP1661889A4 (en) | 2003-09-05 | 2009-08-05 | Ono Pharmaceutical Co | ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES |
| JP2005170939A (ja) | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
| RU2006121646A (ru) | 2003-11-21 | 2008-01-10 | Новартис АГ (CH) | Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| CA2591399C (en) | 2004-12-13 | 2014-05-20 | Ono Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative and medicinal use thereof |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US20070032522A1 (en) | 2005-07-01 | 2007-02-08 | Kumar Dange V | Antiviral agents |
| EP1962861A2 (en) | 2005-08-26 | 2008-09-03 | Emory University | Compounds and methods for modulating the silencing of a polynucleotide of interest |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| JP2009023986A (ja) | 2006-11-08 | 2009-02-05 | Pharma Ip | 抗癌剤としてのビアリール誘導体 |
| CL2008000191A1 (es) | 2007-01-25 | 2008-08-22 | Astrazeneca Ab | Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer. |
| RU2478387C2 (ru) | 2007-02-20 | 2013-04-10 | Новартис Аг | ИМИДАЗОХИНОЛИНЫ В КАЧЕСТВЕ ДВОЙНЫХ ИНГИБИТОРОВ ЛИПИДКИНАЗЫ И mTOR |
| AU2008223348A1 (en) | 2007-03-07 | 2008-09-12 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors containing a heterocyclic moiety |
| US8039505B2 (en) | 2007-04-11 | 2011-10-18 | University Of Utah Research Foundation | Compounds for modulating T-cells |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| US7928111B2 (en) | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| US9321730B2 (en) | 2007-08-21 | 2016-04-26 | The Hong Kong Polytechnic University | Method of making and administering quinoline derivatives as anti-cancer agents |
| EP2474323A3 (en) | 2008-03-26 | 2012-10-10 | Novartis AG | Imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes |
| CA2727250A1 (en) | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| TW201028381A (en) | 2008-07-14 | 2010-08-01 | Shionogi & Co | Pyridine derivative having ttk inhibition activity |
| US8791131B2 (en) | 2008-09-30 | 2014-07-29 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
| RU2016116516A (ru) | 2008-12-08 | 2018-12-07 | Мандифарма Интернэшнл Корпорейшн Лимитед | Композиции ингибиторов тирозинкиназных рецепторов белков |
| US20120093917A1 (en) | 2009-04-02 | 2012-04-19 | Robert Hromas | Metnase and intnase inhibitors and their use in treating cancer |
| TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| MA33332B1 (fr) * | 2009-06-04 | 2012-06-01 | Novartis Ag | Dérivés de la 1h-imidazo[4,5-c]quinolinone |
| CN102803259A (zh) * | 2009-06-04 | 2012-11-28 | 诺瓦提斯公司 | 用于治疗增殖性疾病的1H-咪唑并[4,5-c]喹啉酮化合物 |
| US8263633B2 (en) | 2009-09-28 | 2012-09-11 | F. Hoffman-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| CN102199152A (zh) | 2010-03-25 | 2011-09-28 | 高大新 | 杂环咪唑类磷脂激酶抑制剂 |
| CN102372711B (zh) * | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| WO2012025213A2 (en) | 2010-08-23 | 2012-03-01 | Grünenthal GmbH | Novel therapeutic compounds |
| DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| CN102399218A (zh) | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| AR083267A1 (es) | 2010-10-04 | 2013-02-13 | Novartis Ag | Combinaciones farmaceuticas |
| WO2012075253A2 (en) | 2010-12-03 | 2012-06-07 | Novartis Ag | Pharmaceutical compositions |
| AR084731A1 (es) | 2010-12-06 | 2013-06-05 | Piramal Life Sciences Ltd | Derivados de imidazoquinolina sustituidos |
| WO2012083866A1 (en) | 2010-12-22 | 2012-06-28 | The Hong Kong Polytechnic University | Quinoline derivatives as anti-cancer agents |
| TWI450891B (zh) | 2010-12-29 | 2014-09-01 | Dev Center Biotechnology | 新穎微管蛋白抑制劑 |
| JO3003B1 (ar) * | 2011-01-14 | 2016-09-05 | Lilly Co Eli | مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor |
| WO2012138789A2 (en) | 2011-04-04 | 2012-10-11 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
| WO2012162254A1 (en) | 2011-05-23 | 2012-11-29 | Elan Pharmaceuticals, Inc. | Inhibitors of lrrk2 kinase activity |
| AU2012258618B2 (en) | 2011-05-26 | 2017-05-25 | Sunovion Pharmaceuticals Inc. | Metabotropic glutamate receptors 5 modulators and methods of use thereof |
| WO2013022740A2 (en) | 2011-08-05 | 2013-02-14 | Corning Incorporated | Gpr35 ligands and the uses thereof |
| JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| US9580409B2 (en) | 2011-11-07 | 2017-02-28 | Sunovion Pharmaceuticals, Inc. | Modulators of opioid receptors and methods of use thereof |
| WO2013074965A1 (en) | 2011-11-16 | 2013-05-23 | Microbiotix, Inc. | Aminoalkyl phenol ether inhibitors of influenza a virus |
| WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
| CA2872541A1 (en) | 2012-06-06 | 2013-12-12 | Novartis Ag | Combination of a 17 -alpha -hydroxylase (c17, 20 - lyase) inhibitor and a specific pi-3k inhibitor for treating a tumor disease |
| CA2985787A1 (en) | 2012-06-07 | 2013-12-12 | Georgia State University Research Foundation, Inc. | Seca inhibitors and methods of making and using thereof |
| WO2013192367A1 (en) | 2012-06-22 | 2013-12-27 | Novartis Ag | Neuroendocrine tumor treatment |
| CA2879704A1 (en) | 2012-08-16 | 2014-02-20 | Novartis Ag | Combination of pi3k inhibitor and c-met inhibitor |
| WO2014031872A2 (en) | 2012-08-23 | 2014-02-27 | The Broad Institute, Inc. | Small molecule inhibitors for treating parasitic infections |
| JP2016518328A (ja) | 2013-03-12 | 2016-06-23 | キュアジェニックス インコーポレイテッド | 癌治療のための化合物 |
| GB201309180D0 (en) | 2013-05-21 | 2013-07-03 | Ucl Business Plc | Compounds and Their Uses |
| WO2015073804A2 (en) | 2013-11-15 | 2015-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of blocking transmission of malarial parasite |
| EP3077393A1 (en) * | 2013-12-06 | 2016-10-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| NO2714752T3 (enExample) * | 2014-05-08 | 2018-04-21 | ||
| GB201409044D0 (en) | 2014-05-21 | 2014-07-02 | Ucl Business Plc | New compounds |
| PL3277681T3 (pl) | 2015-04-02 | 2019-10-31 | Merck Patent Gmbh | Imidazolonylochinoliny i ich zastosowanie jako inhibitorów kinazy atm |
| CN104876912B (zh) | 2015-04-08 | 2017-07-21 | 苏州云轩医药科技有限公司 | Wnt信号通路抑制剂及其应用 |
| WO2017011323A1 (en) | 2015-07-10 | 2017-01-19 | University Of Maryland, Baltimore | Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof |
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| WO2017161028A1 (en) | 2016-03-16 | 2017-09-21 | Kura Oncology, Inc. | Substituted inhibitors of menin-mll and methods of use |
-
2015
- 2015-09-17 GB GBGB1516504.6A patent/GB201516504D0/en not_active Ceased
-
2016
- 2016-09-14 TW TW109145998A patent/TWI762109B/zh active
- 2016-09-14 TW TW105129931A patent/TWI714631B/zh active
- 2016-09-15 PL PL20156172.7T patent/PL3683220T3/pl unknown
- 2016-09-15 CA CA2997399A patent/CA2997399C/en active Active
- 2016-09-15 CR CR20180172A patent/CR20180172A/es unknown
- 2016-09-15 PT PT201561727T patent/PT3683220T/pt unknown
- 2016-09-15 WO PCT/EP2016/071782 patent/WO2017046216A1/en not_active Ceased
- 2016-09-15 MY MYPI2023000366A patent/MY198813A/en unknown
- 2016-09-15 CN CN201680052951.0A patent/CN108137576B/zh active Active
- 2016-09-15 LT LTEP16770461.8T patent/LT3350180T/lt unknown
- 2016-09-15 ES ES20156172T patent/ES2920876T3/es active Active
- 2016-09-15 DK DK16770461.8T patent/DK3350180T3/da active
- 2016-09-15 ES ES16770461T patent/ES2853924T3/es active Active
- 2016-09-15 PE PE2018000343A patent/PE20181078A1/es unknown
- 2016-09-15 EP EP16770461.8A patent/EP3350180B1/en active Active
- 2016-09-15 HU HUE16770461A patent/HUE053066T2/hu unknown
- 2016-09-15 SI SI201631074T patent/SI3350180T1/sl unknown
- 2016-09-15 PT PT167704618T patent/PT3350180T/pt unknown
- 2016-09-15 HU HUE20156172A patent/HUE058884T2/hu unknown
- 2016-09-15 AU AU2016323399A patent/AU2016323399B2/en active Active
- 2016-09-15 SM SM20210071T patent/SMT202100071T1/it unknown
- 2016-09-15 DK DK20156172.7T patent/DK3683220T3/da active
- 2016-09-15 MY MYPI2018701049A patent/MY195669A/en unknown
- 2016-09-15 PL PL16770461T patent/PL3350180T3/pl unknown
- 2016-09-15 RS RS20210170A patent/RS61435B1/sr unknown
- 2016-09-15 TN TNP/2018/000078A patent/TN2018000078A1/en unknown
- 2016-09-15 KR KR1020187010323A patent/KR102028848B1/ko active Active
- 2016-09-15 EA EA201890650A patent/EA033284B1/ru not_active IP Right Cessation
- 2016-09-15 JP JP2018513812A patent/JP6605130B2/ja active Active
- 2016-09-15 HR HRP20210149TT patent/HRP20210149T1/hr unknown
- 2016-09-15 EP EP20156172.7A patent/EP3683220B1/en active Active
- 2016-09-15 KR KR1020197028342A patent/KR102469153B1/ko active Active
- 2016-09-15 BR BR112018004325-7A patent/BR112018004325B1/pt active IP Right Grant
- 2016-09-15 MX MX2018003186A patent/MX384930B/es unknown
- 2016-09-16 US US15/267,398 patent/US9856255B2/en active Active
- 2016-09-16 AR ARP160102832A patent/AR106053A1/es active IP Right Grant
-
2017
- 2017-11-27 US US15/822,617 patent/US10457679B2/en active Active
-
2018
- 2018-02-26 NI NI201800033A patent/NI201800033A/es unknown
- 2018-03-04 IL IL257847A patent/IL257847B/en active IP Right Grant
- 2018-03-06 DO DO2018000065A patent/DOP2018000065A/es unknown
- 2018-03-12 PH PH12018500532A patent/PH12018500532A1/en unknown
- 2018-03-14 CL CL2018000677A patent/CL2018000677A1/es unknown
- 2018-03-16 SV SV2018005655A patent/SV2018005655A/es unknown
- 2018-03-16 CO CONC2018/0002829A patent/CO2018002829A2/es unknown
-
2019
- 2019-09-27 US US16/584,996 patent/US10882858B2/en active Active
-
2020
- 2020-12-01 US US17/108,117 patent/US11613539B2/en active Active
-
2021
- 2021-02-11 CY CY20211100117T patent/CY1124680T1/el unknown
-
2022
- 2022-08-16 ZA ZA2022/09171A patent/ZA202209171B/en unknown
-
2023
- 2023-02-21 US US18/171,735 patent/US20230286981A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124680T1 (el) | Παραγωγα 8-[6-[3-(αμινο)προποξυ]-3-πυριδυλο]-1-ισοπροπυλο-ιμιδαζο[4,5-c]κινολιν-2-ονης ως εκλεκτiκοι ρυθμιστες κινασης μεταλλαγμενης αταξιας τελαγγειεκτασιας (atm) για τη θεραπευτικη αγωγη του καρκινου | |
| CY1121706T1 (el) | Ενωσεις υποκατασταθεισες διυδροϊσοκινολινονης | |
| CR20170237A (es) | Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales. | |
| PE20191245A1 (es) | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim | |
| PE20180508A1 (es) | Amidas heterociclicas como inhibidores de quinasa | |
| CO2017012267A2 (es) | Compuestos de naftiridina como inhibidores de la quinasa jak | |
| NI201600152A (es) | Compuestos de heteroarilo o arilo bicíclicos fusionados y su uso como inhibidores de irak4 | |
| UY37310A (es) | Compuestos de indol sustituidos con [1,2,4]triazolo[1,5-a]piridinilo | |
| UY35675A (es) | Derivados sustituidos de quinazolin-4-ona | |
| CR20140413A (es) | Inhibidores de serina/treonina cinasa | |
| AR102204A1 (es) | Compuestos derivados de amino-alquilbenzotiazepinas | |
| TW201613872A (en) | IRAK4 inhibiting agents | |
| EA202192151A1 (ru) | Применение пиразолпиримидиновых производных для лечения нарушений, связанных с pi3k | |
| PE20151280A1 (es) | Compuestos y metodos para la modulacion de quinasas y sus indicaciones | |
| PE20180024A1 (es) | Triazolopirazinonas como inhibidores de pde1 | |
| UY36226A (es) | Ácidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble | |
| MX362383B (es) | Moduladores de acido oxabiciclo[2.2.2] gpr120. | |
| PE20160689A1 (es) | Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas | |
| CU20160192A7 (es) | Derivados de indano e indolina útiles como activadores de la guanilato ciclasa soluble | |
| CO2019001181A2 (es) | Compuestos de heteroarilcarboxamida como inhibidores de ripk2 | |
| CU20170007A7 (es) | Compuestos de imidazopiridazina | |
| PE20191486A1 (es) | COMPUESTOS DE TIPO IMIDAZO[4,5-c]QUINOLIN-2-ONA DEUTERADOS Y SU USO EN EL TRATAMIENTO DEL CANCER | |
| UY36228A (es) | Derivados de heteroarilo como inhibidores de aldosterona sintasa (cyp11b2) y composiciones farmacéuticas que los contienen | |
| CL2019001023A1 (es) | Derivados de naftiridinona y su uso en el tratamiento de la arritmia. | |
| CO2020010306A2 (es) | Compuestos de sulfonimidoilpurinona 7-sustituida y derivados para el tratamiento y profilaxis de cáncer de hígado. |