KR102469153B1 - 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체 - Google Patents

암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체 Download PDF

Info

Publication number
KR102469153B1
KR102469153B1 KR1020197028342A KR20197028342A KR102469153B1 KR 102469153 B1 KR102469153 B1 KR 102469153B1 KR 1020197028342 A KR1020197028342 A KR 1020197028342A KR 20197028342 A KR20197028342 A KR 20197028342A KR 102469153 B1 KR102469153 B1 KR 102469153B1
Authority
KR
South Korea
Prior art keywords
fluoro
methyl
imidazo
isopropyl
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020197028342A
Other languages
English (en)
Korean (ko)
Other versions
KR20190112852A (ko
Inventor
커트 고든 파이크
버나드 크리스토프 바를라암
토마스 앤서니 헌트
앤드류 존 애터르턴
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20190112852A publication Critical patent/KR20190112852A/ko
Application granted granted Critical
Publication of KR102469153B1 publication Critical patent/KR102469153B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020197028342A 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체 Active KR102469153B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1516504.6A GB201516504D0 (en) 2015-09-17 2015-09-17 Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB1516504.6 2015-09-17
PCT/EP2016/071782 WO2017046216A1 (en) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer
KR1020187010323A KR102028848B1 (ko) 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187010323A Division KR102028848B1 (ko) 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체

Publications (2)

Publication Number Publication Date
KR20190112852A KR20190112852A (ko) 2019-10-07
KR102469153B1 true KR102469153B1 (ko) 2022-11-22

Family

ID=54544418

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020197028342A Active KR102469153B1 (ko) 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체
KR1020187010323A Active KR102028848B1 (ko) 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187010323A Active KR102028848B1 (ko) 2015-09-17 2016-09-15 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체

Country Status (37)

Country Link
US (5) US9856255B2 (enExample)
EP (2) EP3350180B1 (enExample)
JP (1) JP6605130B2 (enExample)
KR (2) KR102469153B1 (enExample)
CN (1) CN108137576B (enExample)
AR (1) AR106053A1 (enExample)
AU (1) AU2016323399B2 (enExample)
BR (1) BR112018004325B1 (enExample)
CA (1) CA2997399C (enExample)
CL (1) CL2018000677A1 (enExample)
CO (1) CO2018002829A2 (enExample)
CR (1) CR20180172A (enExample)
CY (1) CY1124680T1 (enExample)
DK (2) DK3683220T3 (enExample)
DO (1) DOP2018000065A (enExample)
EA (1) EA033284B1 (enExample)
ES (2) ES2853924T3 (enExample)
GB (1) GB201516504D0 (enExample)
HR (1) HRP20210149T1 (enExample)
HU (2) HUE053066T2 (enExample)
IL (1) IL257847B (enExample)
LT (1) LT3350180T (enExample)
MX (1) MX384930B (enExample)
MY (2) MY195669A (enExample)
NI (1) NI201800033A (enExample)
PE (1) PE20181078A1 (enExample)
PH (1) PH12018500532A1 (enExample)
PL (2) PL3683220T3 (enExample)
PT (2) PT3683220T (enExample)
RS (1) RS61435B1 (enExample)
SI (1) SI3350180T1 (enExample)
SM (1) SMT202100071T1 (enExample)
SV (1) SV2018005655A (enExample)
TN (1) TN2018000078A1 (enExample)
TW (2) TWI714631B (enExample)
WO (1) WO2017046216A1 (enExample)
ZA (1) ZA202209171B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
WO2019057757A1 (en) 2017-09-20 2019-03-28 Astrazeneca Ab 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
US12226414B2 (en) 2018-09-14 2025-02-18 Suzhou Zanrong Pharma Limited 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
WO2021177728A1 (ko) * 2020-03-04 2021-09-10 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 난소암 예방, 개선 또는 치료 용도
US20230256110A1 (en) * 2020-06-24 2023-08-17 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atm inhibitor
AU2021349904B2 (en) * 2020-09-28 2024-02-15 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd A class of fused ring compounds, and preparation and use thereof
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022125614A1 (en) * 2020-12-09 2022-06-16 Stingray Therapeutics, Inc. Phosphonates as inhibitors of enpp1 and cdnp
WO2022193166A1 (en) * 2021-03-17 2022-09-22 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598B (zh) * 2021-08-25 2024-05-31 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
TW202340189A (zh) * 2022-01-26 2023-10-16 大陸商正大天晴藥業集團股份有限公司 含有肼基的化合物
WO2023200427A1 (en) * 2022-04-11 2023-10-19 Wei Zhong Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one derivative crystal form, salt crystal form, preparation method and application
WO2024214685A1 (ja) 2023-04-10 2024-10-17 第一三共株式会社 抗ｂ７－ｈ３抗体－薬物コンジュゲートとａｔｒ阻害剤又はａｔｍ阻害剤との組み合わせ
WO2025056741A1 (en) 2023-09-13 2025-03-20 Astrazeneca Ab Azd1390, or a pharmaceutically acceptable salt thereof, in combination with radiation for use in a method of treatment of a cns tumour
TW202535383A (zh) 2024-03-13 2025-09-16 瑞典商阿斯特捷利康公司 治療方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078756A2 (en) 2003-03-06 2004-09-16 Eisai Co., Ltd. Jnk inhibitors
WO2006122806A2 (en) 2005-05-20 2006-11-23 Novartis Ag 1,3-dihydro-imidazo [4,5-c] quinolin-2-ones as lipid kinase inhibitors
WO2010139731A1 (en) 2009-06-04 2010-12-09 Novartis Ag 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240313A (en) 1990-10-22 1994-04-27 Res Corp Technologies Inc Anti-retrovirus compositions containing aryl and heteroaryl derivatives
TW301607B (enExample) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
AU5509099A (en) 1998-08-03 2000-02-28 Basf Corporation Pyridinones for the treatment of sexual dysfunction
EP1150955A2 (en) 1999-02-04 2001-11-07 Millennium Pharmaceuticals, Inc. G-protein coupled heptahelical receptor binding compounds and methods of use thereof
US20020151712A1 (en) 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
US20020132836A1 (en) 2000-10-11 2002-09-19 Chemocentryx Inc. Compounds and methods for modulating CCR4 function
AU2002213467A1 (en) 2000-10-11 2002-04-22 Chemocentryx, Inc. Modulation of ccr4 function
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
WO2002076177A2 (en) 2001-03-23 2002-10-03 Bethesda Pharmaceuticals, Inc. Design and synthesis of optimized ligands for ppar
JP2002293745A (ja) 2001-03-29 2002-10-09 St Marianna Univ School Of Medicine 慢性関節リウマチ治療剤
WO2003084997A1 (en) 2001-04-10 2003-10-16 Transtech Pharma, Inc. Probes, systems and methods for drug discovery
WO2002087618A1 (en) 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
WO2002094264A1 (en) 2001-05-23 2002-11-28 Tularik Inc. Ccr4 antagonists
EP1270535A3 (de) 2001-06-20 2004-02-18 Clariant GmbH Verfahren zur Herstellung von substituierten aromatischen Verbindungen
JP4082888B2 (ja) 2001-10-17 2008-04-30 広栄化学工業株式会社 ビアリール化合物の製造法
CA2473740A1 (en) 2002-01-18 2003-07-31 David Solow-Cordero Methods of treating conditions associated with an edg receptor
JP4167848B2 (ja) 2002-04-10 2008-10-22 広栄化学工業株式会社 ビアリール化合物の製造法
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
EP1541563A4 (en) 2002-07-10 2007-11-07 Ono Pharmaceutical Co ANTAGONIST OF CCR4 AND CORRESPONDING MEDICINAL USE
AU2003265663A1 (en) 2002-08-23 2004-03-11 University Of Connecticut Keto cannabinoids with therapeutic indications
US20040087590A1 (en) 2002-08-23 2004-05-06 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
WO2004080943A1 (ja) 2003-03-11 2004-09-23 Ono Pharmaceutical Co., Ltd. シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤
WO2004113258A1 (ja) 2003-06-20 2004-12-29 Shionogi & Co., Ltd. 炭素−炭素結合生成反応
US7732442B2 (en) 2003-09-05 2010-06-08 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonist and medical use thereof
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
BRPI0416801A (pt) 2003-11-21 2007-01-09 Novartis Ag derivados de 1h-imidazoquinolina como inibidores de proteìna sinase
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
PT1826197E (pt) 2004-12-13 2012-03-06 Ono Pharmaceutical Co Derivado de ácido aminocarboxílico e sua utilização medicinal
US20070032522A1 (en) 2005-07-01 2007-02-08 Kumar Dange V Antiviral agents
EP1962861A2 (en) 2005-08-26 2008-09-03 Emory University Compounds and methods for modulating the silencing of a polynucleotide of interest
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
CL2008000191A1 (es) 2007-01-25 2008-08-22 Astrazeneca Ab Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
KR101472607B1 (ko) 2007-02-20 2014-12-15 노파르티스 아게 지질 키나제 및 ｍＴＯＲ의 이중 억제제로서의 이미다조퀴놀린
CA2680312A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9321730B2 (en) 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
CA2717948C (en) 2008-03-26 2016-09-06 Novartis Ag 5imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes
US8841462B2 (en) 2008-07-01 2014-09-23 Robert A. Heald Bicyclic heterocycles as MEK kinase inhibitors
TW201028381A (en) 2008-07-14 2010-08-01 Shionogi & Co Pyridine derivative having ttk inhibition activity
WO2010038165A1 (en) 2008-09-30 2010-04-08 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
KR101805754B1 (ko) 2008-12-08 2017-12-07 먼디파머 인터내셔널 코포레이션 리미티드 단백질 수용체 티로신 키나아제 억제제의 조성물
WO2010114919A2 (en) 2009-04-02 2010-10-07 Stc.Unm Metnase and intnase inhibitors and their use in treating cancer
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
JP2012528829A (ja) * 2009-06-04 2012-11-15 ノバルティス アーゲー １Ｈ−イミダゾ［４，５−ｃ］キノリノン化合物
PE20140918A1 (es) 2009-09-28 2014-08-06 Hoffmann La Roche Compuestos de benzoxepina inhibidores de la pi3k
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
WO2012025213A2 (en) 2010-08-23 2012-03-01 Grünenthal GmbH Novel therapeutic compounds
DE102010035744A1 (de) * 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
AR083267A1 (es) 2010-10-04 2013-02-13 Novartis Ag Combinaciones farmaceuticas
US20130245061A1 (en) 2010-12-03 2013-09-19 Novartis Ag Pharmaceutical compositions
KR20140014104A (ko) 2010-12-06 2014-02-05 피라말 엔터프라이지즈 리미티드 치환된 이미다조퀴놀린 유도체
CN102603628B (zh) 2010-12-22 2016-08-17 香港理工大学 作为抗癌试剂的喹啉衍生物
TWI450891B (zh) 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
JO3003B1 (ar) * 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
EP2694678A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
RU2017140639A (ru) 2011-05-23 2019-02-12 Элан Фармасьютикалз, Инк. Ингибиторы активности киназы lrrk2
US10533000B2 (en) 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof
WO2013022740A2 (en) 2011-08-05 2013-02-14 Corning Incorporated Gpr35 ligands and the uses thereof
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
JP6041886B2 (ja) 2011-11-07 2016-12-14 スノヴィオン ファーマシューティカルズ インコーポレイテッドＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． オピオイド受容体の調節物質およびそれを含む薬学的組成物
WO2013074965A1 (en) 2011-11-16 2013-05-23 Microbiotix, Inc. Aminoalkyl phenol ether inhibitors of influenza a virus
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
WO2013184621A1 (en) 2012-06-06 2013-12-12 Novartis Ag Combination of a 17 -alpha -hydroxylase (c17, 20 - lyase) inhibitor and a specific pi-3k inhibitor for treating a tumor disease
CN104870438A (zh) 2012-06-07 2015-08-26 佐治亚州立大学研究基金会公司 Seca抑制剂以及其制备和使用方法
WO2013192367A1 (en) 2012-06-22 2013-12-27 Novartis Ag Neuroendocrine tumor treatment
KR20210049187A (ko) 2012-08-16 2021-05-04 노파르티스 아게 Pi3k 억제제와 c-met 억제제의 조합물
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
US9713612B2 (en) 2013-03-12 2017-07-25 Curegenix, Inc. Compounds for treatment of cancer
GB201309180D0 (en) 2013-05-21 2013-07-03 Ucl Business Plc Compounds and Their Uses
US20160264570A1 (en) 2013-11-15 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Method of blocking transmission of malarial parasite
EP3077393A1 (en) * 2013-12-06 2016-10-12 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
NO2714752T3 (enExample) * 2014-05-08 2018-04-21
GB201409044D0 (en) 2014-05-21 2014-07-02 Ucl Business Plc New compounds
HUE054745T2 (hu) 2015-04-02 2021-09-28 Merck Patent Gmbh Imidazolonilkinolinok és alkalmazásuk ATM-kináz-inhibitorokként
CN104876912B (zh) 2015-04-08 2017-07-21 苏州云轩医药科技有限公司 Wnt信号通路抑制剂及其应用
EP3319938B1 (en) 2015-07-10 2022-04-06 University of Maryland, Baltimore Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
CN114539284A (zh) 2016-03-16 2022-05-27 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078756A2 (en) 2003-03-06 2004-09-16 Eisai Co., Ltd. Jnk inhibitors
WO2006122806A2 (en) 2005-05-20 2006-11-23 Novartis Ag 1,3-dihydro-imidazo [4,5-c] quinolin-2-ones as lipid kinase inhibitors
WO2010139731A1 (en) 2009-06-04 2010-12-09 Novartis Ag 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES

Also Published As

Publication number Publication date
TW201722946A (zh) 2017-07-01
NZ741661A (en) 2024-04-26
EP3683220A1 (en) 2020-07-22
BR112018004325A2 (enExample) 2018-10-02
US20180141943A1 (en) 2018-05-24
US10457679B2 (en) 2019-10-29
EA033284B1 (ru) 2019-09-30
TW202124381A (zh) 2021-07-01
SI3350180T1 (sl) 2021-03-31
US11613539B2 (en) 2023-03-28
PL3350180T3 (pl) 2021-05-17
HUE053066T2 (hu) 2021-06-28
IL257847A (en) 2018-04-30
LT3350180T (lt) 2021-02-25
DOP2018000065A (es) 2018-03-30
TWI762109B (zh) 2022-04-21
WO2017046216A1 (en) 2017-03-23
BR112018004325B1 (pt) 2023-10-17
KR20190112852A (ko) 2019-10-07
EA201890650A1 (ru) 2018-10-31
MX384930B (es) 2025-03-14
JP2018531226A (ja) 2018-10-25
PH12018500532A1 (en) 2018-08-29
RS61435B1 (sr) 2021-03-31
US20230286981A1 (en) 2023-09-14
PT3683220T (pt) 2022-06-24
US20170081325A1 (en) 2017-03-23
DK3683220T3 (da) 2022-07-04
US10882858B2 (en) 2021-01-05
AU2016323399A1 (en) 2018-05-10
KR102028848B1 (ko) 2019-10-04
TN2018000078A1 (en) 2019-07-08
MY195669A (en) 2023-02-03
ES2853924T3 (es) 2021-09-20
EP3350180B1 (en) 2020-11-11
EP3683220B1 (en) 2022-04-13
TWI714631B (zh) 2021-01-01
CN108137576A (zh) 2018-06-08
EP3350180A1 (en) 2018-07-25
CN108137576B (zh) 2020-09-22
PT3350180T (pt) 2021-02-08
JP6605130B2 (ja) 2019-11-13
IL257847B (en) 2020-08-31
CY1124680T1 (el) 2022-07-22
HUE058884T2 (hu) 2022-09-28
CR20180172A (es) 2018-05-25
AR106053A1 (es) 2017-12-06
PE20181078A1 (es) 2018-07-05
NI201800033A (es) 2018-10-18
CA2997399C (en) 2024-02-20
CA2997399A1 (en) 2017-03-23
US9856255B2 (en) 2018-01-02
ES2920876T3 (es) 2022-08-11
PL3683220T3 (pl) 2022-08-01
MY198813A (en) 2023-09-29
HRP20210149T1 (hr) 2021-03-19
CO2018002829A2 (es) 2018-05-31
US20200102302A1 (en) 2020-04-02
HK1257413A1 (en) 2019-10-18
KR20180052724A (ko) 2018-05-18
HK1255408A1 (zh) 2019-08-16
SMT202100071T1 (it) 2021-03-15
GB201516504D0 (en) 2015-11-04
US20210147416A1 (en) 2021-05-20
DK3350180T3 (da) 2021-02-15
AU2016323399B2 (en) 2019-04-18
MX2018003186A (es) 2018-05-17
ZA202209171B (en) 2023-11-29
CL2018000677A1 (es) 2018-08-17
SV2018005655A (es) 2018-04-27

Similar Documents

Publication Publication Date Title
KR102469153B1 (ko) 암의 치료를 위한 변이 혈관확장성 운동실조증(atm) 키나아제의 선택적 조절제로서의 8-[6-[3-(아미노)프로폭시]-3-피리딜]-1-이소프로필-이미다조[4,5-c]퀴놀린-2-온 유도체
JP6505131B2 (ja) イミダゾ［４，５−ｃ］キノリン−２−オン化合物および癌の処置におけるそれらの使用
JP2018531226A6 (ja) 癌の治療のための血管拡張性失調症変異（ａｔｍ）キナーゼの選択的モジュレーターとしての８−［６−［３−（アミノ）プロポキシ］−３−ピリジル］−１−イソプロピル−イミダゾ［４，５−ｃ］キノリン−２−オン誘導体
KR20180070703A (ko) 이미다조[4,5-c]퀴놀린-2-온 화합물 및 암 치료에서의 이의 용도
JP2019501873A (ja) イミダゾ［４，５−ｃ］キノリン−２−オン化合物及び癌の治療におけるその使用
WO2017153578A1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
KR20180127419A (ko) 신놀린-4-아민 화합물 및 암을 치료하는 이의 용도
HK1257413B (en) 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer
HK1255408B (en) 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-one derivatives

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190926

Application number text: 1020187010323

Filing date: 20180412

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210913

Comment text: Request for Examination of Application

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20221107

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20221116

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20221117

End annual number: 3

Start annual number: 1

PG1601 Publication of registration